World Journal of Gastroenterology (WORLD J GASTROENTERO)

Publisher: Zhongguo Zhong xi yi jie he yan jiu hui

Journal description

WJG is an international learned journal of gastroenterology. It is published in English bimonthly and distributed worldwide, and it aims to strengthen international exchanges of modern and traditional gastroenterology, to promote the development of gastroenterology, and to make contributions to human health. WJG is the only international journal of gastroenterology published in English based in China. It mainly publishes original papers of basic research and clinical studies in gastroenterology from all of the world. Original articles with international competitiveness, articles from projects supported by scientific grants, original articles of traditional Chinese digestive medicine and herbs, of acupuncture, of ethinomedicine, and of combined traditional and modern digestive medicine are published with priority. Commentaries, literature reviews, rapid reports, clinical experience, and case reports of rare diseases are published preferentially as well.

Current impact factor: 2.37

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 2.369
2013 Impact Factor 2.433
2012 Impact Factor 2.547
2011 Impact Factor 2.471
2010 Impact Factor 2.24
2009 Impact Factor 2.092
2008 Impact Factor 2.081
2003 Impact Factor 3.318
2002 Impact Factor 2.532
2001 Impact Factor 1.445
2000 Impact Factor 0.993

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.67
Cited half-life 5.80
Immediacy index 0.35
Eigenfactor 0.05
Article influence 0.65
Website World Journal of Gastroenterology website
Other titles World journal of gastroenterology (Online), WJG, Shih chieh wei ch'ang ping hsüeh tsa chih
ISSN 1007-9327
OCLC 60638475
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publications in this journal

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    Preview · Article · Feb 2016 · World Journal of Gastroenterology

  • No preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Chronic hepatitis-C virus (HCV) infection is world wide problem and is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. However, recent studies have shown that HCV infection is also linked with a varied spectrum of extrahepatic manifestations, affecting various organs in the human body including Central nervous systems (CNS). A large number of HCV chronic patients show neurological problems from cognitive impairment to peripheral neuropathy. Several lines of evidence suggest that brain accommodate viral replication. This was evidenced from quasispecies analysis and the detection of replicative intermediate forms of HCV RNA and viral proteins within the CNS. The major pathogenetic mechanism responsible for nervous system dysfunction in viral infected patients seems to be the upregulation of the host immune response which results in production of immune complexes, cryoglobulins, and auto- antibodies. Alternate mechanisms may include the effects of circulating chemokines and inflammatory cytokines. Therefore, HCV infection should be considered in the differential diagnosis of a variety of neurologic disorders. This review will provide an impetus to understand the various neurologic complications, identify definite pathophysiologic mechanisms, and thereby providing clear guidelines for the understanding and the management of various HCV related nervous system disorders.
    No preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Complete response to chemoradiotherapy for rectal cancer is becoming a common clinical entity. Techniques to diagnose complete response and how to survey these patients without operative intervention are still unclear. We review the most recent evidence. Barriers to firm conclusions regarding this are heterogeneity of diagnostic definitions, differing surveillance protocols, and a lack of randomised studies. © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Colorectal cancer (CRC) constitutes a major public health problem as the third most commonly diagnosed and third most lethal malignancy worldwide. The prevalence and the physical accessibility to colorectal tumors have made CRC an ideal model for the study of tumor genetics. Early research efforts using patient derived CRC samples led to the discovery of several highly penetrant mutations (e.g., APC, KRAS, MMR genes) in both hereditary and sporadic CRC tumors. This knowledge has enabled researchers to develop genetically engineered and chemically induced tumor models of CRC, both of which have had a substantial impact on our understanding of the molecular basis of CRC. Despite these advances, the morbidity and mortality of CRC remains a cause for concern and highlight the need to uncover novel genetic drivers of CRC. This review focuses on mouse models of CRC with particular emphasis on a newly developed cancer gene discovery tool, the Sleeping Beauty transposon-based mutagenesis model of CRC. © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Nonampullary duodenal adenomas are relatively common in familial adenomatous polyposis (FAP), but nonampullary sporadic duodenal adenomas (SDAs) are rare. Emerging evidence shows that duodenal adenomas, regardless of their anatomic location and whether they are sporadic or FAP-related, share morphologic and molecular features with colorectal adenomas. The available data suggest that duodenal adenomas develop to duodenal adenocarcinomas via similar mechanisms. The optimal approach for management of duodenal adenomas remains to be determined. The techniques for endoscopic resection of duodenal adenoma include snare polypectomy, endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and argon plasma coagulation ablation. EMR may facilitate removal of large duodenal polyps. Although several studies have reported cases of successful ESD for duodenal adenomas, the procedure is technically difficult to perform safely because of the anatomical properties of the duodenum. Although current clinical practice recommends endoscopic resection of all large duodenal adenomas in patients with FAP, endoscopic treatment is usually insufficient to guarantee a polyp-free duodenum. Surgery is indicated for FAP patients with severe polyposis or nonampullary SDAs or FAP-related polyps not amenable to endoscopic resection. Further studies are needed to develop newer endoscopic techniques to guide diagnostic and therapeutic decisions for future management of nonampullary duodenal adenomas.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Relatively little is known about the oncologic safety of laparoscopic surgery for advanced rectal cancer. Recently, large randomized clinical trials showed that laparoscopic surgery was not inferior to open surgery, as evidenced by survival and local control rates. However, patients with T4 tumors were excluded from these trials. Technological advances in the instrumentation and techniques used by laparoscopic surgery have increased the use of laparoscopic surgery for advanced rectal cancer. High-definition, illuminated, and magnified images obtained by laparoscopy may enable more precise laparoscopic surgery than open techniques, even during extended surgery for T4 or locally recurrent rectal cancer. To date, the quality of evidence regarding the usefulness of laparoscopy for extended surgery beyond total mesorectal excision has been low because most studies have been uncontrolled series, with small sample sizes, and long-term data are lacking. Nevertheless, laparoscopic extended surgery for rectal cancer, when performed by specialized laparoscopic colorectal surgeons, has been reported safe in selected patients, with significant advantages, including a clear visual field and less blood loss. This review summarizes current knowledge on laparoscopic extended surgery beyond total mesorectal excision for primary or locally recurrent rectal cancer. © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is an almost uniformly lethal disease with less than 5% survival at five years. This is largely due to metastatic disease, which is already present in the majority of patients when diagnosed. Even when the primary cancer can be removed by radical surgery, local recurrence occurs within one year in 50%-80% of cases. Therefore, it is imperative to develop new approaches for the treatment of advanced cancer and the prevention of recurrence after surgery. Tumour-targeted oncolytic viruses (TOVs) have become an attractive therapeutic agent as TOVs can kill cancer cells through multiple mechanisms of action, especially via virus-induced engagement of the immune response specifically against tumour cells. To attack tumour cells effectively, tumour-specific T cells need to overcome negative regulatory signals that suppress their activation or that induce tolerance programmes such as anergy or exhaustion in the tumour microenvironment. In this regard, the recent breakthrough in immunotherapy achieved with immune checkpoint blockade agents, such as anti-cytotoxic T-lymphocyte-associate protein 4, programmed death 1 (PD-1) or PD-L1 antibodies, has demonstrated the possibility of relieving immune suppression in PDAC. Therefore, the combination of oncolytic virotherapy and immune checkpoint blockade agents may synergistically function to enhance the antitumour response, lending the opportunity to be the future for treatment of pancreatic cancer.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology
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    ABSTRACT: Since the development of uncovered self-expanding metal stents (SEMS) in the 1990s, endoscopic stents have evolved dramatically. Application of new materials and new designs has expanded the indications for enteral SEMS. At present, enteral stents are considered the first-line modality for palliative care, and numerous types of enteral stents are under development for extended clinical usage, beyond a merely palliative purpose. Herein, we will discuss the current status and the future development of lower enteral stents.
    Preview · Article · Jan 2016 · World Journal of Gastroenterology