Current impact factor: 1.26
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ABSTRACT: Introduction: Diabetes mellitus is a metabolic disorder affecting millions of people around the world. α-amylase inhibition strategies have been shown to be an effective one for Non-insulin dependent diabetes mellitus, NIDDM. Objective: In the present study, the photochemical constituents and the α-amylase inhibition potential of leaf galls of T. chebula are evaluated to exemplify its further potential development as medicine. Materials and Methods: Extracts of T. chebula galls was tested for α-amylase inhibition and also total content of polyphenols with phytochemical analysis of the extract were determined. Results: The presence of highest total phenolic and flavonoid content of 478 ± 2.2 mg of GAE/g d.w and 538 ± 1.4 mg of QUE/g d.w and maximal α-amylase inhibitory activity (92%) at 1000 μg/ml concentrations were identified in the ethanolic extracts of leaf galls of T. chebula. The higher α-amylase inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. Conclusion: ethanolic extracts of leaf galls of T. chebula shows significant α-amylase inhibitory activity. The results of this study confirm the folklore use of T. chebula leaves gall extracts as an anti-diabetic agent and justifies its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food and nutraceutical applications.
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