Journal of Natural Remedies

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ISSN 0972-5547

Publications in this journal

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    ABSTRACT: The Seed Oil of Balanites aegyptiaca L. (Del) Zygophyllaceae was tested for its inhibitory activity against lethal and inflammatory effect of Vipera russellii (Russell’s viper) venom. The seed oil of the plant displayed significant inhibitory action against the lethal toxic and inflammatory effects of the viper venom. The present findings suggest that the seed oil of Balanites aegyptiaca possess compound(s) which inhibit the lethal and inflammatory effects of viper venom.
    No preview · Article · Jul 2014 · Journal of Natural Remedies
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    ABSTRACT: Curcuma longa (Turmeric) is a bright yellow ancient spice native to Asian countries. It has been used as traditional remedy dating back to 600 BC. Turmeric is well known for its applications as a cosmetic, condiment and flavoring agent. The present study was an attempt to explore the protective effect of Curcuma longa rhizomes against physical stress-induced perturbations in rats. Animals were pre-treated with extracts of C. longa rhizomes (crystallized ethylacetate extract; and byproduct-oleoresin) at doses of 200 and 400 mg/kg for 21 days. The effect on swimming endurance followed by post-swimming muscle co-ordination and spontaneous motor activity was evaluated. Estimation of brain monoamine levels in rats and HPLC analysis were carried out. Pre-treated rats with C. longa extracts showed dose dependant significant enhancement in swimming endurance time, increased the duration (sec) of stay on rota-rod apparatus and increased the count (actophotometer score) in spontaneous motor activity. In addition, the pre-treated rats were found to possess normalizing activity against physical stress induced changes in norepinephrine, dopamine and serotonin. Curcuminoids was identified by HPLC analysis and it was one of the active principles responsible for the adaptogenic activity. Extracts of C. longa rhizomes exhibited adaptogenic activity against physical stress model followed by post-swimming muscle co-ordination and spontaneous motor activity, which could be due to the presence of curcuminoids content. In conclusion, the results of the present investigation emphasized the protective effect of C. longa rhizomes against physical stress-induced perturbations in rats.
    No preview · Article · Jan 2014 · Journal of Natural Remedies
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    ABSTRACT: Catechins especially Epigallocatechin Gallate (EGCG) and its isomers have been shown to constitute the most important and effective antimicrobial part of tea polyphenols. Antimicrobial effects of EGCG on a variety of pathogens have been published previously. The anti-microbial mechanism of green tea polyphenols has also been studied. Effects of green tea extracts on bacterial surviving tactics such as Quorum Sensing (QS) have showed significant inhibitory effects. However, there are no literatures that demonstrate a quantitative assay that would establish the Minimum Inhibitory Concentration (MIC) that can interfere with QS regulated factors. Also, there is no published data that clearly demonstrates which components of green tea or black tea is responsible for the inhibition of QS-regulated virulence factors. In this study we prove that EGCG which constitutes 5% of dry weight of green tea and 10% in green tea is effective in inhibiting the biofilm production of Psuedomonas aeruginosa and Psuedomonas fluorescens by down-regulating its virulence factors. Our study established a Minimum Inhibitory Concentration (MIC) of 8mM (~4 mg/ml) concentration of EGCG for inhibition of biofilm production in both organisms. QS regulated virulent factors such as pyocyanin, protease and elastase production also decreased with increase in the EGCG concentration.
    No preview · Article · Jan 2014 · Journal of Natural Remedies
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    ABSTRACT: Ixora coccinea L. (Rubiaceae) is a traditional herbal medicine for various ailments like cutaneous wounds, infection, hypertension, menstrual irregularities, sprain, chronic ulcer and other skin diseases. The present study investigated the anti-inflammatory effects of I. coccinea leaves methanol extract (IxME) on RAW 246.7 macrophage and its effect on Prostagladins E2 (PGE2), Nitric Oxide (NO) and pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) production. The experimental findings revealed that IxME treatment inhibited the Cyclooxygenase 2 (COX-2) mediated PGE2 and Nitric Oxide Synthsae (NOS) catalyzed NO production in LPS-treated RAW 246.7 macrophages in a dose dependent manner. On the other hand, production of pro-inflammatory cytokines including TNF-α, IL-6 and IL-1β was significantly decreased as compared to negative control LPS-treated RAW 246.7 macrophages. The findings data coincides and correlated the in vitro anti-inflammatory activity of I. coccinea with previous reports of in vivo anti-inflammatory property.
    No preview · Article · Jan 2014 · Journal of Natural Remedies
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    ABSTRACT: Speed of healing is an important factor in wound healing. It is very important to find the natural drug that decrease this time. In current study effect of essential oil of Achillea millefolium on wound healing in 60 male chickens was study as a model for wound healing. Different concentration of essential oil of Achillea millefolium tested topically on full thickness excision wound with 25 mm diameter compared to phenytoin cream (1%) as a standard healing agent and geometrical study were done for 6 days. Result of this study show that higher concentrations (12% and 18%) have significant healing properties on chicken’s wound. Treated groups with higher concentrations and also positive control group that treated with phenytoin cream have significant differences with negative controls and lower concentrations (1% and 6%). This study and same studies can help us to find the natural alternative components for wound healing without any side effects. Keywords: Achillea millefolium, chicken, essential oil, wound healing
    No preview · Article · Jan 2014 · Journal of Natural Remedies
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    ABSTRACT: Experiments were conducted the xerophytic Aloe vera (L.) Burm. f. plant samples of three age group viz. 20 days, 40 days and 60 days old plants in order to estimate the change in productivity (total yield) and protein content under differential water stress conditions. The plantlets were subjected to different water stress conditions under excess, optimum and deficient water supply under water-logging, daily-watering, alternate-day, bi-weekly, once-a-week water supply conditions. It was found that the total productivity and protein content was maximum in once-a-week watered plants and minimum in daily-watered plants indicating that the cultivation practice adopted for best production of the crop should be based on intermittent weekly rather than continuous water supply to the plants. Water-logged conditions were detrimental for their survival.
    No preview · Article · Jan 2014 · Journal of Natural Remedies