FEMS Microbiology Letters (FEMS MICROBIOL LETT)

Publisher: Federation of European Microbiological Societies, Oxford University Press (OUP)

Journal description

FEMS Microbiology Letters publishes original articles and MiniReviews on all aspects of microbiology except virology (other than bacteriophages). The Editors give priority to concise papers that merit urgent publication by virtue of their originality, general interest and their contribution to new developments in microbiology. Areas of special interest include: molecular biology and genetics; genomics; microbial biochemistry and physiology; structure and development; pathogenicity; medical and veterinary microbiology; plant-microbial interactions; applied microbiology and microbial biotechnology; systematics, genomics and bioinformatics. Papers can deal with any sort of microorganisms: bacteria and bacteriophage, filamentous fungi and yeasts, or protozoa.

Current impact factor: 2.12

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 2.121
2013 Impact Factor 2.723
2012 Impact Factor 2.049
2011 Impact Factor 2.044
2010 Impact Factor 2.04
2009 Impact Factor 2.199
2008 Impact Factor 2.021
2007 Impact Factor 2.274
2006 Impact Factor 2.068
2005 Impact Factor 2.057
2004 Impact Factor 1.84
2003 Impact Factor 1.932
2002 Impact Factor 1.804
2001 Impact Factor 1.806
2000 Impact Factor 1.615
1999 Impact Factor 1.673
1998 Impact Factor 1.581
1997 Impact Factor 1.56
1996 Impact Factor 1.735
1995 Impact Factor 1.488
1994 Impact Factor 1.597
1993 Impact Factor 1.296
1992 Impact Factor 1.334

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.17
Cited half-life >10.0
Immediacy index 0.36
Eigenfactor 0.02
Article influence 0.70
Website FEMS Microbiology Letters website
Other titles FEMS microbiology letters, Federation of European Microbiological Societies microbiology letters, Microbiology letters, FEMS microbiology ecology, FEMS microbiology reviews, FEMS microbiology index, FEMS microbiology immunology
ISSN 0378-1097
OCLC 3217327
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Oxford University Press (OUP)

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Pre-print can only be posted prior to acceptance
    • Pre-print must be accompanied by set statement (see link)
    • Pre-print must not be replaced with post-print, instead a link to published version with amended set statement should be made
    • Pre-print on author's personal website, employer website, free public server or pre-prints in subject area
    • Post-print in Institutional repositories or Central repositories
    • Publisher's version/PDF cannot be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany archived copy (see policy)
    • Eligible authors may deposit in OpenDepot
    • The publisher will deposit in PubMed Central on behalf of NIH authors
    • Publisher last contacted on 19/02/2015
    • This policy is an exception to the default policies of 'Oxford University Press (OUP)'
  • Classification
    yellow

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Type II toxin-antitoxin systems (TAs) are small autoregulated bicistronic operons which encode a toxin protein with potential to inhibit metabolic processes and an antitoxin protein to neutralize the toxin. Most of the bacterial genomes encode multiple TAs. However, the diversity and accumulation of TAs on bacterial genomes and its physiological implications are highly debated. Here we provide evidence that Escherichia coli chromosomal TAs (encoding RNAse toxins) are “acquired” DNA originated likely from heterologous DNA and are the smallest known autoregulated operons with potential for horizontal propagation. Sequence analyses revealed that integration of TAs into the bacterial genome is unique and contributes to variations in the coding and/or regulatory regions of flanking host genome sequences. Plasmids and genomes encoding identical TAs of natural isolates are mutually exclusive. Chromosomal TAs might play significant roles in the evolution and ecology of bacteria by contributing to host genome variation and by moderation of plasmid maintenance.
    No preview · Article · Dec 2015 · FEMS Microbiology Letters

  • No preview · Article · Dec 2015 · FEMS Microbiology Letters
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    ABSTRACT: Marine organic aggregates are sites of high of viral accumulation, however, still little is known about their colonisation processes and interactions with their local bacterial hosts. By taking advantage of a novel approach (paramagnetic functionalized microsphere method) to create and incubate artificial macroaggregates, we examined the small-scale movements of viruses and bacteria between such marine snow particles and the surrounding water. The examination of the co-dynamics of both free-living and attached viral and bacterial abundance, over 12-hours of incubation in virus-free water, suggests that aggregates are rather comparable to viral factories than to viral traps where a significant part of the virions production might be locally diverted to the water column. Also, the near-zero proportion of lysogenized cells measured in aggregates after mitomycin-C induction seems to indicate that lysogeny is not a prominent viral reproduction pathway in organic aggregates where most viruses might rather be virulent. Finally, we hypothesize that, contrary to bacteria, which can use both strong attachment and detachment from aggregates (two-way motion of bacteria), the adsorption of planktonic viruses appears to be numerically negligible compared to their massive export from the aggregates into the water column (one-way motion of viruses).
    No preview · Article · Nov 2015 · FEMS Microbiology Letters
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    ABSTRACT: Serratia marcescens is a common pathogenic bacterium which can cause infections both in human and animals. It can cause a range of diseases, from slight wound infections to life-threatened bacteraemia and pneumonia. The emergence of antimicrobial resistance has limited the treatment caused by the bacterium to a great extent. Consequently, there is an urgent need in developing novel antimicrobial strategies against this pathogen. Synergistic strategy is a new approach against the infections caused by drug resistant bacterium. In this paper, we isolated and identified the first multi-resistant pathogenic Serratia marcescens strain from diseased Soft-shelled turtle in China. Then we performed the checkerboard assay, the results showed that fisetin from 10 tested natural products had the synergistic effects against Serratia marcescens when combined with norfloxacin. The time-kill curve assay was further confirmed the results of checkerboard assay. We found that this novel synergistic effect could significantly reduce the dosage of norfloxacin against Serratia marcescens.
    No preview · Article · Nov 2015 · FEMS Microbiology Letters

  • No preview · Article · Nov 2015 · FEMS Microbiology Letters
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    ABSTRACT: Since 1989 blown pack spoilage has been recognized as a special form of spoilage in vacuum-packed raw and cooked beef. However, only limited information concerning the occurrences of bacteria causing blown pack spoilage on chilled fresh meat is available. In this study a total of 63 beef and 33 lamb commercially available samples from different countries and without any signs of spoilage were examined for contamination with psychrophilic and psychrotolerant Clostridium spp. using different PCR systems. In total, 34.4% of the chilled fresh vacuum-packed meats were PCR positive. A higher number of lamb samples were identified as PCR positive compared with beef. A geographical relationship between positive results and the origin of the samples could not be determined. With PCR system described by Brightwell and Clemens (2012) gave the highest number of positive detections compared with the Broda PCR system (2003a).. Eight clostridia isolates from two German beef and four Welsh lamb samples were isolated overall. Three of these clostridia isolates were identified as Clostridium estertheticum whereas five clostridia isolates remain unidentified. The study shows that psychrophilic and psychrotolerant Clostridium spp. are more prevalent in retail samples than previously suspected.
    No preview · Article · Nov 2015 · FEMS Microbiology Letters
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    ABSTRACT: Streptomyces clavuligerus produces simultaneously cephamycin C (CephC) and clavulanic acid (CA). Adding 1,3-diaminopropane to culture medium stimulates production of beta-lactam antibiotics. However, there are no studies on the influence of this diamine on coordinated production of CephC and CA. This study indicates that 1,3-diaminopropane can dissociate CephC and CA productions. Results indicated that low diamine concentrations (below 1.25 g l(-1)) in culture medium increased CA production by 200%, but not that of CephC. Conversely, CephC production increased by 300% when 10 g l(-1) 1,3-diaminopropane was added to culture medium. Addition of just L-lysine (18.3 g l(-1)) to culture medium increased both biocompounds. On the other hand, while L-lysine plus 7.5 g l(-1) 1,3-diaminopropane increased volumetric production of CephC by 1100%, its impact on CA production was insignificant. The combined results suggest that extracellular concentration of 1,3-diaminopropane may trigger the dissociation of CephC and CA biosynthesis in S. clavuligerus.
    No preview · Article · Nov 2015 · FEMS Microbiology Letters

  • No preview · Article · Nov 2015 · FEMS Microbiology Letters

  • No preview · Article · Nov 2015 · FEMS Microbiology Letters
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    ABSTRACT: Phytophthora capsici is a virulent oomycete pathogen of many vegetable crops. Recently, it has been demonstrated that the recognition of the RXLR effector AVR3a1 of P. capsici (PcAVR3a1) triggers a hypersensitive response and plays a critical role in mediating nonhost resistance. Here, we analyzed the occurrence of PcAVR3a1 in 57 isolates of P. capsici derived from globe squash, eggplant, tomato and bell pepper co-cultivated in a small geographical area. The occurrence of PcAVR3a1 in environmental strains of P. capsici was confirmed by PCR in only 21 of these pathogen isolates. To understand the presence-absence pattern of PcAVR3a1 in environmental strains, the flanking region of this gene was sequenced. PcAVR3a1 was found within a genetic element that we named PcAVR3a1-GI (PcAVR3a1 genomic island). PcAVR3a1-GI was flanked by a 22-bp direct repeat, which is related to its site-specific recombination site. In addition to the PcAVR3a1 gene, PcAVR3a1-GI also encoded a phage integrase probably associated with the excision and integration of this mobile element. Exposure to plant induced the presence of an episomal circular intermediate of PcAVR3a1-GI, indicating that this mobile element is functional.
    No preview · Article · Oct 2015 · FEMS Microbiology Letters
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    ABSTRACT: In Clostridium perfringens, a 5-membered thiolactone peptide acts as an autoinducing peptide (AIPCp) to activate the VirSR two-component signal transduction system, which in turn controls the expression of genes encoding multiple toxins, including α, θ, and κ. To develop anti-pathogenic agents against virulent C. perfringens, quorum-quenching peptides were rationally designed based on the structure-activity relationship (SAR) data on AIPCp. Alanine scanning study of AIPCp suggested that Trp3 and Phe4 are involved in receptor binding and activation, respectively. On the basis of the SAR, we designed two quorum-quenching peptides with different modes of action: Z-AIPCp-L2A/T5A (partial agonist) and Z-AIPCp-F4A/T5S (partial antagonist). Both peptides significantly attenuated transcription of  toxin gene (pfoA) in a virulent strain of C. perfringens with IC50 = 0.32 and 0.72 µM, respectively.
    No preview · Article · Oct 2015 · FEMS Microbiology Letters
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    ABSTRACT: Urinary tract infection (UTI) is one of the most prevalent infections in humans. In ≥80% of cases, the etiologic agents are strains of uropathogenic Escherichia coli (UPEC), which commonly reside in the gastrointestinal tract. Lactobacilli have been shown to prevent UTI reoccurrence by restoring the urogenital microbiota when administered vaginally or orally. The goal of this study was to determine if commercial probiotic Lactobacillus spp. reduce or clear uropathogenic Escherichia coli in vitro. Results show that it is likely that lactobacilli may, in addition to restoring a healthy urogenital microbiota through acidification of their environment, also displace adhering UPEC and cause a reduction of infection. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
    No preview · Article · Jun 2015 · FEMS Microbiology Letters