Fitoterapia (FITOTERAPIA)

Publisher: Indena (Firm), Elsevier

Journal description

Fitoterapia is an international journal publishing original research in chemistry, pharmacology and use of medicinal plants and their derivatives. The journal accepts Reviews, Full Papers, Short Reports, Phytochemical Communications, Safety Data Reviews and Book Reviews. Reviews can be full-length state-of-the-art articles or mini reviews providing a short overview of a particular matter. Short Reports allow preliminary, concise reporting of pharmacological activities. Results of antibacterial and antifungal screenings are published as Short Reports only. Phytochemical Communications are brief contributions on the isolation of known products from new plant sources (original contribution, such as unpublished spectral data or new activity, is required) or new simple products identified on the basis of spectral data. Safety Data Reviews are open to contributions from members of official international committees. Table of Contents for the 1996 - 1998 issues of Fitoterapia can be found at the Indena SpA site.

Current impact factor: 2.35

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 2.345
2013 Impact Factor 2.216
2012 Impact Factor 2.231
2011 Impact Factor 1.848
2010 Impact Factor 1.899
2009 Impact Factor 1.363
2008 Impact Factor 1.2
2007 Impact Factor 1.106
2006 Impact Factor 0.908
2005 Impact Factor 0.845
2004 Impact Factor 1.042
2003 Impact Factor 0.848
2002 Impact Factor 0.584
2001 Impact Factor 0.486
2000 Impact Factor 0.278

Impact factor over time

Impact factor

Additional details

5-year impact 2.47
Cited half-life 6.70
Immediacy index 0.41
Eigenfactor 0.01
Article influence 0.53
Website Fitoterapia website
Other titles Fitoterapia (Online)
ISSN 0367-326X
OCLC 41377497
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors pre-print on any website, including arXiv and RePEC
    • Author's post-print on author's personal website immediately
    • Author's post-print on open access repository after an embargo period of between 12 months and 48 months
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months
    • Author's post-print may be used to update arXiv and RepEC
    • Publisher's version/PDF cannot be used
    • Must link to publisher version with DOI
    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 03/06/2015
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Impatiens glandulifera has been imported from Himalaya in Europe and is considered as an invasive alien plant whose spreading arouses increasing interest among scientific literature. Via anti-cancer bioguiding, two new glucosylated steroids, named glanduliferins A and B, were isolated from dried stem of Impatiens glandulifera plants, together with the well-known α-spinasterol and 2-methoxy-1,4-naphthoquinone, which is also isolated from roots and leaves. They were characterized as 17-(2-hydroxy-2-pentamethylcyclopropyl-ethyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-O-(4-O-acetyl)-α-D-glucopyranoside and 17-(4-ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-O-(6-O-acetyl)-β-D-glucopyranoside using various NMR and HRESI MS techniques and chemical methods. In vitro determination of the growth inhibitory activity of the four isolated compounds using the MTT colorimetric assay revealed mean IC50 growth inhibitory value of ~30μM for glanduliferin A while glanduliferin B and α-spinasterol were poorly active till 100μM. 2- methoxy-1,4-naphthoquinone revealed to be active in the single micromolar digit range as previously described. Quantitative videomicroscopy analyses of the effects of glanduliferins A and B suggested cytostatic rather than cytotoxic activity in U373 glioblastoma (GBM) cells.
    No preview · Article · Dec 2015 · Fitoterapia
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ginkgolide B, one of the important components of Ginkgo biloba extracts, has been revealed to exhibit great potential in therapy of cerebrovascular diseases. However the lack of permeability greatly limited it from further clinical application. Based on the prediction model for blood brain barrier (BBB) permeation, herein a potential brain-targeting analog ginkgolide B cinnamate (GBC) was successfully synthesized and characterized. After intravenous administration of GBC or GB, liquid chromatography tandem mass spectrometry (LC-MS/MS) was conducted to determine the analog in rat plasma and brain. The results showed that GBC had a significant increase in BBB permeability. A significant 1.61-times increase in half-life was observed for GBC and the drug targeting index (DTI) value was calculated to be 9.91. The experiment results matched well with the predicted one, which revealed that BBB permeability prediction model combined with in vivo study could be used as a quick, feasible and efficient tool for brain-targeting drug design. Copyright © 2015 Elsevier B.V. All rights reserved.
    No preview · Article · Aug 2015 · Fitoterapia
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    ABSTRACT: Black chokeberry has been known to play a protective role in human health due to its high polyphenolic content including anthocyanins and caffeic acid derivatives. In the present study, we first characterized the polyphenolic content of a commercial chokeberry concentrate and investigated its effect on LPS-induced NF-κB activation and release of pro-inflammatory mediators in macrophages in the presence or the absence of sodium selenite. Examination of the phytochemical profile of the juice concentrate revealed high content of polyphenols (3.3%), including anthocyanins, proanthocyanidins, phenolic acids, and flavonoids. Among them, cyanidin-3-O-galactoside and caffeoylquinic acids were identified as the major compounds. Data indicated that chokeberry concentrate inhibited both the release of TNFα, IL-6 and IL-8 in human peripheral monocytes and the activation of the NF-κB pathway in RAW 264.7 macrophage cells. Furthermore, chokeberry synergizes with sodium selenite to inhibit NF-κB activation, cytokine release and PGE2 synthesis. These findings suggest that selenium added to chokeberry juice enhances significantly its anti-inflammatory activity, thus revealing a sound approach in order to tune the use of traditional herbals by combining them with micronutrients. Copyright © 2015. Published by Elsevier B.V.
    No preview · Article · Jun 2015 · Fitoterapia
  • [Show abstract] [Hide abstract]
    ABSTRACT: Enterolacaciamine (1), a new potential O-GlcNAcase activator, along with three known triterpenoid saponins, concinnoside B (2), concinnoside D (3), and julibroside A3 (4) were isolated from the leaves of Enterolobium cyclocarpum. Their sturctures were elucidated by chemical and spectroscopic methods (UV, MS, 1D and 2D NMR). Their effects on O-GlcNAcase activity were evaluated using O-GlcNAcase enzymatic assay, the results showed that compound 1 could obviously enhance the activity of O-GlcNAcase. Copyright © 2015. Published by Elsevier B.V.
    No preview · Article · Jun 2015 · Fitoterapia
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    ABSTRACT: Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol's effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions. Copyright © 2015. Published by Elsevier B.V.
    No preview · Article · Jun 2015 · Fitoterapia