International Journal of Obesity (INT J OBESITY)

Publisher: International Association for the Study of Obesity, Nature Publishing Group

Journal description

Multi-disciplinary forum for research describing: basic clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders.

Current impact factor: 5.00

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 5.004
2013 Impact Factor 5.386
2012 Impact Factor 5.221
2011 Impact Factor 4.691
2010 Impact Factor 5.125
2009 Impact Factor 4.343
2008 Impact Factor 3.64
2007 Impact Factor 3.56
2006 Impact Factor 4.055
2005 Impact Factor 4.482
2004 Impact Factor 3.459
2003 Impact Factor 2.794
2002 Impact Factor 2.363
2001 Impact Factor 2.196
2000 Impact Factor 2.982
1999 Impact Factor 3.199
1998 Impact Factor 3.003
1997 Impact Factor 2.476
1996 Impact Factor 1.759
1995 Impact Factor 1.832
1994 Impact Factor 1.568
1993 Impact Factor 1.776
1992 Impact Factor 1.607

Impact factor over time

Impact factor

Additional details

5-year impact 5.28
Cited half-life 8.60
Immediacy index 1.11
Eigenfactor 0.03
Article influence 1.82
Website International Journal of Obesity website
Other titles International journal of obesity
ISSN 0307-0565
OCLC 26074170
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

Nature Publishing Group

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 6 months embargo
  • Conditions
    • Authors retain copyright
    • Published source must be acknowledged and DOI cited
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • On author's personal website and institutional repository
    • If funding agency rules apply, authors may post authors version to their relevant funding body's archive, 6 months after publication
    • This policy is an exception to the default policies of 'Nature Publishing Group'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: We have previously shown that antagonism of the mineralocorticoid receptor (MR) results in a potent antiadipogenic activity, in vitro and in vivo. Excessive glucocorticoid exposure is associated with obesity and related disorders in humans and mice. Methods: In this study responses to a novel combined glucocorticoid receptor (GR)/MR antagonist were investigated in a model of diet-induced obesity. Female 10-week-old C57BL/6J mice were fed with normal chow or a high fat diet (HFD) for 9 weeks. Mice fed a HFD were concomitantly treated for 9 weeks with the GR antagonist mifepristone (80 mg/kg/day) or the novel combined GR/MR antagonist CORT118335 (80 mg/kg/day). Male, juvenile 6-week-old C57BL/6J mice fed HFD were treated with CORT118335 for 4 weeks. Results: Mice fed a HFD showed a significant increase in total body weight and white fat mass, with impaired glucose tolerance and increased fat infiltration in livers. Interestingly, only CORT118335 completely prevented the HFD-induced weight gain and white fat deposition, whereas mifepristone showed no effect on body weight and modestly increased subcutaneous fat mass. Importantly, food intake was not affected by either treatment, and CORT118335 dramatically increased PGC-1α protein expression in adipose tissue, without any effect on UCP1. Both CORT118335 and mifepristone produced metabolic benefit, improving glucose tolerance, increasing adiponectin plasma levels, decreasing leptin and reducing mean adipocyte size. When tested in vitro, CORT118335 markedly reduced 3T3-L1 differentiation and reversed MR-mediated pro-adipogenic effects of aldosterone; differently, GR-mediated effects of dexamethasone were not antagonised by CORT118335, suggesting that it mostly acts as an antagonist of MR in cultured preadipocytes. Conclusions: Combined GR/MR pharmacological antagonism markedly reduced HFD-driven weight gain and fat mass expansion in mice through the increase in adipose PGC-1α, suggesting that both receptors represent strategic therapeutic targets to fight obesity. The effects of CORT118335 in adipocytes seem predominantly mediated by MR antagonism.International Journal of Obesity accepted article preview online, 02 February 2016. doi:10.1038/ijo.2016.13.
    No preview · Article · Feb 2016 · International Journal of Obesity
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    ABSTRACT: International Journal of Obesity is a monthly, multi-disciplinary forum for papers describing basic, clinical and applied studies in biochemistry, genetics and nutrition, together with molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders
    No preview · Article · Feb 2016 · International Journal of Obesity
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    ABSTRACT: Background: Worldwide overweight and obesity rates are on the rise, with about 1900 billion adults being defined as overweight and about 600 million adults being defined as obese by the World Health Organization. Increasing exposure to artificial light-at-night (ALAN) may influence body mass, by suppression of melatonin production and disruption of daily rhythms, resulting in physiological or behavioral changes in the human body, and may thus become a driving force behind worldwide overweight and obesity pandemic. Study goal and methods: We analyzed most recent satellite images of nighttime illumination, available from the U.S. Defense Meteorological Satellite Program (DMSP), combining them with country-level data on female and male overweight and obesity prevalence rates, reported by the World Health Organization (WHO). The study aims to identify and measure the strength of association between ALAN and country-wide overweight and obesity rates, controlling for per capita GDP, level of urbanization, birth rate, food consumption and regional differences. Results: ALAN emerged as a statistically significant and positive predictor of overweight and obesity (t>1.97; P<0.05), helping to explain, together with other factors, about 70% of the observed variation of overweight and obesity prevalence rates among females and males in more than 80 countries worldwide. Regional differences in the strength of association between ALAN and excessive body mass were also noted. Conclusion: This study is the first population-level study that confirms the results of laboratory research and cohort studies in which ALAN was found to be a contributing factor to excessive body mass in humans.
    No preview · Article · Jan 2016 · International Journal of Obesity
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    ABSTRACT: Background: The chronic effects of high intensity endurance training on metabolic health outcomes in overweight adolescents remains poorly understood.
    No preview · Article · Nov 2015 · International Journal of Obesity
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    ABSTRACT: Background/objectives: Pregnancy is accompanied by fat gain and insulin resistance. Changes in adipose tissue morphology and function during pregnancy and factors contributing to gestational insulin resistance are incompletely known. We sought to characterize adipose tissue in trimesters 1 and 3 (T1/T3) in normal weight (NW) and obese pregnant women, and identify adipose tissue-related factors associated with gestational insulin resistance. Subjects/methods: Twenty-two NW and 11 obese women were recruited early in pregnancy for the Pregnancy Obesity Nutrition and Child Health study. Examinations and sampling of blood and abdominal adipose tissue were performed longitudinally in T1/T3 to determine fat mass (air-displacement plethysmography); insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR); size, number, and lipolytic activity of adipocytes; and adipokine release and density of immune cells and blood vessels in adipose tissue. Results: Fat mass and HOMA-IR increased similarly between T1 and T3 in the groups; all remained normoglycemic. Adipocyte size increased in NW women. Adipocyte number was not influenced, but proportions of small and large adipocytes changed oppositely in the groups. Lipolytic activity and circulating adipocyte fatty acid-binding protein increased in both groups. Adiponectin release was reduced in NW women. Fat mass and the proportion of very large adipocytes were most strongly associated with T3 HOMA-IR by multivariable linear regression (R(2)=0.751, P<0.001). Conclusions: During pregnancy, adipose tissue morphology and function change comprehensively. NW women accumulated fat in existing adipocytes, accompanied by reduced adiponectin release. In comparison with the normal weight group, obese women had signs of adipocyte recruitment and maintained adiponectin levels. Body fat and large adipocytes may contribute significantly to gestational insulin resistance.International Journal of Obesity accepted article preview online, 13 November 2015. doi:10.1038/ijo.2015.232.
    No preview · Article · Nov 2015 · International Journal of Obesity
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    ABSTRACT: Objectives: The neurobiological mechanisms linking obesity to emotional distress remain largely undiscovered. Methods: In this pilot study, we combined positron emission tomography, using the norepinephrine transporter (NET) tracer [(11)C]-O-methylreboxetine, with functional connectivity magnetic resonance imaging, the Beck depression inventory (BDI), and the impact of weight on quality of life-Lite questionnaire (IWQOL-Lite), to investigate the role of norepinephrine in the severity of depression (BDI), as well as in the loss of emotional well-being with body weight (IWQOL-Lite). Results: In a small group of lean-to-morbidly obese individuals (n=20), we show that an increased body mass index (BMI) is related to a lowered NET availability within the hypothalamus, known as the brain's homeostatic control site. The hypothalamus displayed a strengthened connectivity in relation to the individual hypothalamic NET availability to the anterior insula/frontal operculum, as well as the medial orbitofrontal cortex, assumed to host the primary and secondary gustatory cortex, respectively (n=19). The resting-state activity in these two regions was correlated positively to the BMI and IWQOL-Lite scores, but not to the BDI, suggesting that the higher the resting-state activity in these regions, and hence the higher the BMI, the stronger the negative impact of the body weight on the individual's emotional well-being was. Conclusions: This pilot study suggests that the loss in emotional well-being with weight is embedded within the central norepinephrine network.International Journal of Obesity advance online publication, 1 December 2015; doi:10.1038/ijo.2015.216.
    No preview · Article · Oct 2015 · International Journal of Obesity
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    ABSTRACT: Objectives:To construct waist-to-height ratio (WC/Ht) reference values and centile curves for Japanese children and to compare these references with those from other countries.Methods:The 1978–1981 national survey data were used for reference and the 1992–1994 national survey data were used for validation. The former included 19 233 children, and the latter included 10 446 children, aged 6 to 18 years. Waist circumferences (WC) were measured at the level of maximum waist narrowing in girls, and at the level of the top of the iliac crest in boys. Age- and sex-specific reference curves were fitted with the LMS method. Cut-off points were arbitrarily set at 85th, 90th, 95th and 97th centiles, and compared with WC/Ht 0.50.Results:The proportion of children in whom WC/Ht exceeded 0.50 was 18.7% of boys and 1.9% of girls, whereas the proportion of children exceeding 90th centile was 42.4% for boys and 17.3% for girls. The reference values decreased with age in girls but varied by age without a clear trend in boys.Conclusions:The first reference values for WC/Ht are provided for Japanese youth based on the 1978–1981 national survey data. These curves are age- and sex-dependent, precluding the use of universal cut-off for WC/Ht of 0.50.International Journal of Obesity advance online publication, 3 November 2015; doi:10.1038/ijo.2015.203.
    No preview · Article · Oct 2015 · International Journal of Obesity
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    ABSTRACT: Inflammation, oxidative stress, and dysregulation of adipokines are thought to be pathophysiological mechanisms linking obesity to the development of insulin resistance and atherosclerosis. In adults, bariatric surgery reduces inflammation and oxidative stress, and beneficially changes levels of several adipokines, but little is known about post-surgical changes among adolescents. In two separate longitudinal cohorts we evaluated change from baseline of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), monocyte chemo-attractant protein-1 (MCP-1), oxidized LDL cholesterol (oxLDL), adiponectin, leptin, and resistin up to 12 months following elective laparoscopic roux en Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) surgery in adolescents with severe obesity. In cohort 1, which consisted of 39 adolescents (mean age 16.5±1.6; 29 females) undergoing either RYGB or VSG, IL-6 (baseline: 2.3±3.4 pg/ml vs 12 months: 0.8±0.6 pg/ml, P<0.01), leptin (baseline: 178±224 ng/ml vs 12 months: 41.4±31.9 ng/ml, P<0.001), and oxLDL (baseline: 41.6±11.6 U/l vs 12 months: 35.5±11.1 U/l, P=0.001) significantly decreased and adiponectin significantly increased (baseline: 5.4±2.4 μg/ml vs 12 months: 13.5±8.9 μg/ml, P<0.001). In cohort 2, which consisted of 13 adolescents (mean age 16.5±1.6 years; 10 females) undergoing RYGB, results were similar: IL-6 (baseline: 1.7±0.9 pg/ml/ml vs 12 months: 0.4±0.9 pg/ml, P<0.05) and leptin (baseline: 92.9±31.3 ng/ml vs 12 months: 37.3±33.4 ng/ml, P<0.001) significantly decreased and adiponectin significantly increased (baseline: 6.1±2.9 μg/ml vs 12 months: 15.4±8.0 μg/ml, P<0.001). When the cohorts were combined to evaluate changes at 12 months, oxLDL also significantly decreased (baseline: 39.8±16.7 U/l vs 12 months: 32.7±11.9 U/l, P=0.03). Bariatric surgery produced robust improvements in markers of inflammation, oxidative stress, and several adipokines among adolescents with severe obesity, suggesting potential reductions in risk for type 2 diabetes and cardiovascular disease.International Journal of Obesity accepted article preview online, 28 August 2015. doi:10.1038/ijo.2015.174.
    No preview · Article · Aug 2015 · International Journal of Obesity
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    ABSTRACT: In response to luminal food stimuli during meals, enteroendocrine cells release gastrointestinal (GI) peptides that have long been known to control secretory and motor functions of the gut, pancreas and liver. Glucagon-like peptide-1 (GLP-1) has emerged as one of the most important GI peptides because of a combination of functions not previously ascribed to any other molecule. GLP-1 potentiates glucose-induced insulin secretion, suppresses glucagon release, slows gastric emptying and may serve as a satiation signal, although the physiological status of the latter function has not been fully established yet. Here we review the available evidence for intestinal GLP-1 to fulfill a number of established empirical criteria for assessing whether a hormone inhibits eating by eliciting physiological satiation in man and rodents.International Journal of Obesity accepted article preview online, 28 August 2015. doi:10.1038/ijo.2015.172.
    No preview · Article · Aug 2015 · International Journal of Obesity
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    ABSTRACT: Activation of Notch signaling pathologically enhances lipogenesis and gluconeogenesis in the liver causing non-alcoholic fatty liver disease (NAFLD) and diabetes. Delta-like 1 homolog (DLK1), an imprinted gene that can modulate adipogenesis and muscle development in mice, was found as an inhibitory regulator of Notch signaling. Therefore, we investigated the metabolic effect of exogenous DLK1 in vitro and in vivo. A soluble DLK1 peptide was generated with fusion between a human Fc fragment and extracellular domain of DLK1. Male db/db mice were randomly assigned to two groups: vehicle-treated and DLK1-treated group (25 mg/kg, intraperitoneal injection, twice a week for 4 weeks). Primary mice hepatocytes and HepG2 cells were used for in vitro experiments. After 4 weeks of DLK1 administration, hepatic triglyceride content and lipid droplets in liver tissues, as well as serum levels of liver enzymes, were markedly decreased in db/db mice. DLK1 treatment induced phosphorylation of AMPK and ACC and suppressed nuclear expression of SREBP-1c in the mouse liver or hepatocytes, indicating regulation of fatty acid oxidation and synthesis pathways. Furthermore, DLK1-treated mice showed significantly lower levels of fasting and random glucose, with improved glucose and insulin tolerance compared to the vehicle-treated group. Macrophage infiltration and proinflammatory cytokine levels in the epididymal fat were decreased in DLK1-treated db/db mice. Moreover, DLK1 suppressed glucose production from hepatocytes, which was blocked after co-administration of an AMPK inhibitor, compound C. DLK1-treated hepatocytes and mouse liver tissues showed lower PEPCK and G6Pase expression. DLK1 triggered AKT phosphorylation followed by cytosolic translocation of FOXO1 from the nucleus in hepatocytes. The present study demonstrated that exogenous administration of DLK1 reduced hepatic steatosis and hyperglycemia via AMPK activation in the liver. This result suggests that DLK1 may be a novel therapeutic approach for treating NAFLD and diabetes.International Journal of Obesity accepted article preview online, 28 August 2015. doi:10.1038/ijo.2015.173.
    No preview · Article · Aug 2015 · International Journal of Obesity
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    ABSTRACT: Human adenovirus 36 (Adv36) increases adiposity and is more prevalent in overweight and obese children. Dietary intake in animal models is comparable regardless of Adv36 status. The effects of Adv36 on obesity treatment outcomes have not been clarified. The aim of the study is to investigate the pre-treatment dietary intake and the response to a 4-week in-patient weight management in 184 obese adolescent girls aged 13.0-17.9 years with respect to the presence of Adv36 antibodies. Evaluation of 3-day dietary records did not show any difference in daily intake of energy and essential nutrients between Adv36 antibody positive and negative girls. After the intervention Adv36 positive girls presented with significantly greater decrease of waist circumference (P=0.020), z-score of waist circumference (P=0.024), waist-to-hip ratio (P=0.007) and weight-to-height ratio (P=0.019) compared to Adv36 negative girls. On the contrary, the sum of four skinfolds decreased significantly more in Adv36 negative than in Adv36 positive individuals (P=0.013). Neither body fat percentage nor metabolic and hormonal parameters showed any significant relevance to Adv36 status in response to weight loss intervention. In conclusion energy restriction in Adv36 antibody positive girls was associated with greater decrease of abdominal obesity and preservation of subcutaneous fat tissue than in those antibody negative.International Journal of Obesity accepted article preview online, 25 August 2015. doi:10.1038/ijo.2015.167.
    No preview · Article · Aug 2015 · International Journal of Obesity