Trends in Genetics (TRENDS GENET)

Publisher: Elsevier

Journal description

Now the highest-cited journal in Genetics. (ISI/SCI Journal Citation Reports 11.313.1998). Multi-faceted and highly-cited, from developmental biology to genomics. Each monthly issue contains concise, lively and up-to-date Reviews as well as a section for Comment on the latest developments, a journal monitoring feature, Genetwork (a column about Internet resources), Meeting Reports, and Book, Software and CD-ROM reviews, and new in 98 - genetics and society. Most articles are commissioned, and all review articles are peer-reviewed. Trends in Genetics' prestigious Editorial Board attests to the journal's established reputation as essential reading for all those interested in the molecular themes of genetics, differentiation and development. Trends in Genetics' readers use the journal to keep up with the latest developments in both their own and related fields, and as a valuable resource for teaching.

Current impact factor: 9.92

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 9.918
2013 Impact Factor 11.597
2012 Impact Factor 9.772
2011 Impact Factor 10.064
2010 Impact Factor 11.364
2009 Impact Factor 8.689
2008 Impact Factor 8.659
2007 Impact Factor 9.729
2006 Impact Factor 9.95
2005 Impact Factor 12.047
2004 Impact Factor 14.643
2003 Impact Factor 12.016
2002 Impact Factor 13.216
2001 Impact Factor 12.417
2000 Impact Factor 12.912
1999 Impact Factor 16.342
1998 Impact Factor 11.313
1997 Impact Factor 9.978
1996 Impact Factor 10.781
1995 Impact Factor 10.446
1994 Impact Factor 10.11
1993 Impact Factor 9.976
1992 Impact Factor 11.497

Impact factor over time

Impact factor

Additional details

5-year impact 9.86
Cited half-life 8.90
Immediacy index 2.16
Eigenfactor 0.03
Article influence 4.82
Website Trends in Genetics website
Other titles Trends in genetics, Genetics, TIG, Trends in biochemical sciences., Trends in cell biology
ISSN 0168-9525
OCLC 11747206
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author cannot archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On non-commercial hosting platforms including institutional repository
    • Published source must be acknowledged
    • Must link to journal homepage with DOI
    • Publisher's version/PDF cannot be used
    • Publisher last reviewed on 05/08/2015
    • 'Elsevier (Cell Press)' is an imprint of 'Elsevier'
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Compelling evidence that KAI2 and D14 are karrikin (KAR) and strigolactone (SL) receptors with hydrolytic activity has been provided through recent genetic, biochemical, and structural studies in several plant species. Ligand hydrolysis promotes protein–protein interactions.
    No preview · Article · Feb 2016 · Trends in Genetics
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    ABSTRACT: The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal core particles'. These histone proteins have tails that project from the nucleosome and many residues in these tails can be post-translationally modified, influencing all DNA-based processes, including chromatin compaction, nucleosome dynamics, and transcription. In contrast to those present in histone tails, modifications in the core regions of the histones had remained largely uncharacterised until recently, when some of these modifications began to be analysed in detail. Overall, recent work has shown that histone core modifications can not only directly regulate transcription, but also influence processes such as DNA repair, replication, stemness, and changes in cell state. In this review, we focus on the most recent developments in our understanding of histone modifications, particularly those on the lateral surface of the nucleosome. This region is in direct contact with the DNA and is formed by the histone cores. We suggest that these lateral surface modifications represent a key insight into chromatin regulation in the cell. Therefore, lateral surface modifications form a key area of interest and a focal point of ongoing study in epigenetics.
    No preview · Article · Jan 2016 · Trends in Genetics
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    ABSTRACT: Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
    No preview · Article · Jan 2016 · Trends in Genetics
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    ABSTRACT: Post-transcriptional RNA modification by adenosine to inosine (A-to-I) editing expands the functional output of many important neuronally expressed genes. The mechanism provides flexibility in the proteome by expanding the variety of isoforms, and is a requisite for neuronal function. Indeed, targets for editing include key mediators of synaptic transmission with an overall significant effect on neuronal signaling. In addition, editing influences splice-site choice and miRNA targeting capacity, and thereby regulates neuronal gene expression. Editing efficiency at most of these sites increases during neuronal differentiation and brain maturation in a spatiotemporal manner. This editing-induced dynamics in the transcriptome is essential for normal brain development, and we are only beginning to understand its role in neuronal function. In this review we discuss the impact of RNA editing in the brain, with special emphasis on the physiological consequences for neuronal development and plasticity.
    No preview · Article · Jan 2016 · Trends in Genetics
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    ABSTRACT: Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Various experimental and computational approaches including chromatin signature profiling have been developed to predict enhancers on a genome-wide scale, although each method has its advantages and disadvantages. Here we overview an emerging method to identify transcribed enhancers at exceedingly high nucleotide resolution based on enhancer RNA transcripts captured by Cap Analysis of Gene Expression (CAGE) technology. We further argue that disease-causative regulatory mutations at enhancers are increasingly recognized, emphasizing the importance of enhancer identification in functional and clinical genomics including, but not limited to, genome-wide association studies (GWASs) and cancer genomics studies.
    No preview · Article · Jan 2016 · Trends in Genetics
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    ABSTRACT: Genetic background effects have long been recognized and, in some cases studied, but they are often viewed as a nuisance by molecular biologists. We suggest that genetic variation currently represents a critical frontier for molecular studies. Human genetics has seen a surge of interest in genetic variation and its contributions to disease, but insights into disease mechanisms are difficult since information about gene function is lacking. By contrast, model organism genetics has excelled at revealing molecular mechanisms of cellular processes, but often de-emphasizes genetic variation and its functional consequences. We argue that model organism biology would benefit from incorporating natural variation, both to capture how well laboratory lines exemplify the species they represent and to inform on molecular processes and their variability. Such a synthesis would also greatly expand the relevance of model systems for studies of complex trait variation, including disease. Laboratory lines of model organisms have provided a wealth of information about biological functions. Many of these lines are derived from species with significant genetic and functional variation in nature.The longstanding focus on particular genetic backgrounds has enabled the elucidation of core biological functions, but has limited our understanding of the levels and impacts of natural variation found in wild populations.A broader synthesis incorporating natural variation into model organism research would illuminate biological mechanisms, reveal the genetic basis for phenotypic variation, and solidify the importance of model organisms for understanding both basic and personalized genetics.
    No preview · Article · Jan 2016 · Trends in Genetics
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    ABSTRACT: Adult organisms rely on tissue stem cells for maintenance and repair. During homeostasis, the concerted action of local niche signals and epigenetic regulators establish stable gene expression patterns to ensure that stem cells are not lost over time. However, stem cells also provide host tissues with a remarkable plasticity to respond to perturbations. How adult stem cells choose and acquire new fates is unknown, but the genome-wide mapping of epigenetic landscapes suggests a critical role for chromatin remodeling in these processes. Here, we explore the emerging role of chromatin modifiers and pioneer transcription factors in adult stem cell fate decisions and plasticity, which ensure that selective lineage choices are only made when environmentally cued. Adult stem cells coordinate niche signals and chromatin states to choose appropriate fates. Upon changes in the local niche environment, stem cells remodel chromatin to survive in transitional states, before undergoing fate selection.Epigenetic repressors put a brake on precocious lineage commitment. DNA methylation and Polycomb-silencing complexes cooperate to ensure that stem cells are robustly maintained during homeostasis.Cell identity depends on combinatorial transcription factor complexes on lineage-specific enhancers. Pioneer factors select unique enhancer repertoires by making condensed chromatin accessible for robust gene activation.Epigenetic memory is achieved by coupling pioneer factors with super-enhancers, allowing stem cells to retain their unique identities in different microenvironments.
    No preview · Article · Dec 2015 · Trends in Genetics
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    ABSTRACT: A major obstacle in precision cancer medicine is the inevitable resistance to targeted therapies. Tremendous effort and progress has been made over the past few years to understand the biochemical and genetic mechanisms underlying drug resistance, with the goal to eventually overcome such daunting challenges. Diverse mechanisms, such as secondary mutations, oncogene bypass, and epigenetic alterations, can all lead to drug resistance, and the number of known involved genes is growing rapidly, thus providing many possibilities to overcome resistance. The finding of these mechanisms and genes invariably requires the application of genomic and functional genomic approaches to tumors or cancer models. In this review, we briefly highlight the major drug-resistance mechanisms known today, and then focus primarily on the technological approaches leading to the advancement of this field.
    No preview · Article · Dec 2015 · Trends in Genetics
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    ABSTRACT: Establishing and maintaining cell identity depends on the proper regulation of gene expression, as specified by transcription factors and reinforced by epigenetic mechanisms. Among the epigenetic mechanisms, heterochromatin formation is crucial for the preservation of genome stability and the cell type-specific silencing of genes. The heterochromatin-associated histone mark H3K9me3, although traditionally associated with the noncoding portions of the genome, has emerged as a key player in repressing lineage-inappropriate genes and shielding them from activation by transcription factors. Here we describe the role of H3K9me3 heterochromatin in impeding the reprogramming of cell identity and the mechanisms by which H3K9me3 is reorganized during development and cell fate determination.
    No preview · Article · Dec 2015 · Trends in Genetics
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    ABSTRACT: Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology.
    No preview · Article · Dec 2015 · Trends in Genetics
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    ABSTRACT: Computation is critical for enabling us to process data volumes and model data complexities that are unthinkable by manual means. However, we are far from automating the sense-making process. Human knowledge and reasoning are critical for discovery. Visualization offers a powerful interface between mind and machine that should be further exploited in future genome analysis tools.
    No preview · Article · Dec 2015 · Trends in Genetics
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    ABSTRACT: Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters. Free link until 18 Jan 2016:
    No preview · Article · Nov 2015 · Trends in Genetics
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    ABSTRACT: Microbial communities are complex and constitute important parts of our environment. Genomic analysis of these populations is a dynamic research area but remains limited by the difficulty in assembling full genomes of individual species. Recently, a new method for metagenome assembly/analysis based on chromosome conformation capture has emerged (meta3C). This approach quantifies the collisions experienced by DNA molecules to identify those sharing the same cellular compartments, allowing the characterization of genomes present within complex mixes of species. The exploitation of these chromosome 3D signatures holds promising perspectives for genome sequencing of discrete species in complex populations. It also has the potential to assign correctly extra-chromosomal elements, such as plasmids, mobile elements and phages, to their host cells.
    No preview · Article · Nov 2015 · Trends in Genetics
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    ABSTRACT: Information warfare is not limited to the cyber world because it is waged within our cells as well. The unique AID (activation-induced cytidine deaminase)/APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) family comprises proteins that alter DNA sequences by converting deoxycytidines to deoxyuridines through deamination. This C-to-U DNA editing enables them to inhibit parasitic viruses and retrotransposons by disrupting their genomic content. In addition to attacking genomic invaders, APOBECs can target their host genome, which can be beneficial by initiating processes that create antibody diversity needed for the immune system or by accelerating the rate of evolution. AID can also alter gene regulation by removing epigenetic modifications from genomic DNA. However, when uncontrolled, these powerful agents of change can threaten genome stability and eventually lead to cancer.
    No preview · Article · Nov 2015 · Trends in Genetics
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    ABSTRACT: Chemoreception is essential for survival. Feeding, mating, and avoidance of predators depend on detection of sensory cues. Drosophila contains diverse families of chemoreceptors that detect odors, tastants, pheromones, and noxious stimuli, including receptors of the odor receptor (Or), gustatory receptor (Gr), ionotropic receptor (IR), Pickpocket (Ppk), and Trp families. We consider recent progress in understanding chemoreception in the fly, including the identification of new receptors, the discovery of novel biological functions for receptors, and the localization of receptors in unexpected places. We discuss major unsolved problems and suggest areas that may be particularly ripe for future discoveries, including the roles of these receptors in driving the circuits and behaviors that are essential to the survival and reproduction of the animal.
    No preview · Article · Oct 2015 · Trends in Genetics