Journal of Toxicology and Environmental Health (J Toxicol Environ Health)
Discontinued in 1996. Split into Journal of Toxicology and Environmental Health Part A (1528-7394) and Journal of Toxicology and Environmental Health Part B: Critical Reviews (1093-7404).
Current impact factor: 2.35
Impact Factor Rankings
|2016 Impact Factor||Available summer 2017|
|2014 / 2015 Impact Factor||2.351|
|2008 Impact Factor||1.805|
|2007 Impact Factor||1.805|
|2006 Impact Factor||1.811|
|2005 Impact Factor||1.892|
|2004 Impact Factor||1.548|
|2003 Impact Factor||1.795|
|2002 Impact Factor||1.673|
|1999 Impact Factor||0.525|
|1998 Impact Factor||1.689|
|1997 Impact Factor||1.299|
Impact factor over time
|Other titles||Journal of toxicology and environmental health (Online), Journal of toxicology and environmental health|
|Material type||Document, Periodical, Internet resource|
|Document type||Internet Resource, Computer File, Journal / Magazine / Newspaper|
- Author can archive a pre-print version
- Author can archive a post-print version
- Some individual journals may have policies prohibiting pre-print archiving
- On author's personal website or departmental website immediately
- On institutional repository or subject-based repository after either 12 months embargo for STM, Behavioural Science and Public Health Journals or 18 months embargo for SSH journals
- Publisher's version/PDF cannot be used
- On a non-profit server
- Published source must be acknowledged
- Must link to publisher version
- Set statements to accompany deposits (see policy)
- The publisher will deposit in on behalf of authors to a designated institutional repository including PubMed Central, where a deposit agreement exists with the repository
- STM: Science, Technology and Medicine
- SSH: Social Science and Humanities
- Publisher last contacted on 25/03/2014
- 'Taylor & Francis (Psychology Press)' is an imprint of 'Taylor & Francis'
Publications in this journal
- [Show abstract] [Hide abstract] ABSTRACT: Approximately 200 female Swiss-Webster mice, six to eight weeks of age, were divided into eight groups. Three of these groups were fed 10, 100, or 250 ppm Aroclor 1254. One group was treated with 1000 ppm lead. Three groups were exposed simultaneously to lead and Aroclor 1254 at concentrations of 10 ppm PCB + 1000 ppm Pb, 100 ppm PCB + 1000 ppm Pb, and 250 ppm PCB + 1000 ppm Pb. Control mice received deionized water and rat food only. All groups were exposed for a period of 12 wk, then bred, with exposure continued throughout gestation and lactation. Offspring were weaned onto the control diet at 3 wk of age. Results from this study indicate a varied effect of lead and/or PCBs on body and organ weights of both dams and their pups, no noticeable detrimental effect on reproduction, and very little effect on the pups' ability to mount an immune response upon challenge with foreign antigens.
- [Show abstract] [Hide abstract] ABSTRACT: Air and dust samples from iron foundries were analyzed for polycyclic aromatic hydrocarbons (PAH) by glass capillary gas chromatography, mass spectrometry, and thin-layer chromatography. Fifty compounds were identified as PAH, among them known carcinogens and cocarcinogens. Benzo[a]pyrene (B[a]P) was measured quantitatively. The results were grouped according to the types of organic additives in the molding sand. The B[a]P concentrations were highest in foundries using coal tar pitch and in the work phases of shake-out, casting, and molding. In the Ames assay the dust samples showed mutagenic activity, but in most cases lower than that calculated from the concentration of B[a]P. It is suggested that B[a]P can be used as a hygienic marker in branches of industry with PAH problems.
- [Show abstract] [Hide abstract] ABSTRACT: A new technique for removing the ferruginous coating from ferruginous bodies is described. The tissue from occupationally exposed individuals was digested in bleach and the material collected on a Nucleopore filter. The ferruginous bodies were localized by light microscopy and either cleaned on the marked filter or transferred to a marked area on a clean filter. The chemical treatment consisted of an 8% oxalic acid bath used at various temperatures. It was determined that at 75 degrees C the reaction resulted in removal of the ferruginous coat, leaving an exposed core for further analysis. This procedure overcomes the previous analytical problems of core analysis caused by the ferruginous coating.
Article: Radiation carcinogenesis[Show abstract] [Hide abstract] ABSTRACT: In radiation-induced carcinogenesis the stages of initiation, transformation, and promotion can be identified. Radiation carcinogenesis is a stochastic phenomenon that does not exhibit any threshold in the dose-response relationship. The most important risk to be controlled is that of the population--either industrial or medical--exposed to radiation at low levels and low dose rates. Despite the expanding use of radiation, the average doses in most industrialized societies have not been increasing during the last few years. However, sensitive subpopulations with high cancer risks are included within the present low-level average exposure figures.
- [Show abstract] [Hide abstract] ABSTRACT: Rabbits were exposed to submicometer sulfuric acid mist (H2SO4) for 1 h/d, 5 d/w for 4 wk, during which time mucociliary clearance was monitored by external in vivo measurements of tagged tracer aerosol retention. One group was exposed orally to 250 micrograms/m3, another to the same concentration via the nose, and a third to 500 micrograms/m3 also via nasal breathing. Clearance was accelerated on specific individual days during the course of the acid exposures, especially at 500 micrograms/m3. In all series, clearance was significantly faster, compared to preexposure controls, during a 2-wk follow-up period after acid exposures had ceased. At the end of this period, the rabbits were sacrificed, and histological sections were obtained from the tracheobronchial tree. Significantly increased epithelial thickness of small conducting airways, compared to sham exposure controls, occurred in rabbits exposed orally at 250 micrograms/m3 or nasally at 500 micrograms/m3, and additionally the lumen of the smallest airways of the former group was narrower than control. The number of airways containing epithelial secretory cells was also significantly greater in these acid exposure groups compared to sham controls. The only change in the rabbits exposed nasally at 250 micrograms/m3 was a significant increase in the number of airways with epithelial secretory cells in the smallest airway classification. The histological alterations provide a basis for observed changes in clearance, and are similar to those found in chronic bronchitis in humans and experimental animals. Differences in site and degree of histological response and degree of physiological change between the two groups exposed to identical acid concentrations appear to have been due to differences in exposure mode, with resultant effects on breathing pattern, aerosol size distribution, and concentration penetrating beyond the upper respiratory tract to specific lung sites.
- [Show abstract] [Hide abstract] ABSTRACT: An experimental protocol was designed to assess humoral immune responses in animals antigenically challenged without the aid of adjuvants. The antigen selected was keyhole limpet hemocyanin (KLH). An enzyme-linked immunosorbent assay (ELISA) was utilized as the technique to measure serum antibody levels. The procedure was tested for sensitivity by use of a known immunosuppressant (cyclophosphamide), two metals (lead and selenium), and three chlorinated hydrocarbons (polychlorinated biphenyls, pentachlorophenol, and toxaphene). KLH without adjuvant provoked an adequate humoral immune response when assessed by the ELISA. The antibody response was greater on d 15 than on d 8 following primary KLH challenge, while secondary challenge resulted in an additional 10-fold increase in antibody levels. Cyclophosphamide suppressed the later primary response (d 15) and the secondary response more so than the early primary response (d 8). Of the 5 chemicals tested, 4 resulted in significantly impaired antibody levels to KLH at some time during the response. The magnitude of the immune response elicited to KLH is compared to that reported for bovine serum albumin and ovalbumin administered with Freund's adjuvant.
- [Show abstract] [Hide abstract] ABSTRACT: Cadmium was injected sc into female Wistar rats at a dose of 3.0 mg Cd/kg body weight, 4 times a week for 1, 2, 3, 4, 5, and 6 wk. Concentrations of cadmium in the spleen and pancreas were determined, together with essential metals, by inductively coupled plasma-atomic emission spectrometry. Cadmium in both tissues increased even after maximum concentration was attained in the liver. Contents of zinc, calcium, and magnesium in the spleen increased with splenomegaly, while content of iron decreased. Concentrations of calcium, magnesium, and iron decreased in the pancreas, while concentration of zinc showed a transitory increase. Cadmium in the spleen and pancreas supernatants was mostly bound to metallothionein, and metallothionein in the pancreas was highly susceptible to oxidation reaction. The spleen and pancreas were histologically less affected by cadmium loading compared to the liver and kidney, and the pancreas showed only slight alterations after injections for 5 and 6 wk.
- [Show abstract] [Hide abstract] ABSTRACT: Cigarettes prepared from tobacco grown in pots of soils amended with soft coal fly ash were smoked, and the mainstream and gaseous fractions were analyzed for total selenium concentration. Fly-ash-grown and control (soil-grown) tobaccos contained, respectively, 0.79 and 0.03 ppm selenium. The quantities of selenium (ng per cigarette) found in the mainstream particulate and gaseous fractions were, respectively, 62.4 and 246.0 for the fly-ash-grown and 8.6 and 12.0 for the control treatments. Studies of the absorption, retention, effects, metabolism, and excretion of selenium in the body are reviewed.
- [Show abstract] [Hide abstract] ABSTRACT: Male rats, 5 and 90 d of age, continuously inhaled 500 ppm CO [40% carboxyhemoglobin (COHb)] for 5.5-8.0 wk. Cardiomegaly and polycythemia developed as previously reported. Heart weight gain in young and old rats treated with CO was accompanied by increased cytochrome c content (nmol) in both left ventricle (LV) and right ventricle (RV) relative to controls. Cytochrome c concentration (nmol/g wet weight), however, was significantly depressed in LV and RV of young CO-exposed rats relative to controls, while there was no change in LV and RV of the old CO-exposed group. LV cytochrome c concentration was significantly higher than that of RV in both young and old, CO-exposed and control rats. On the other hand, cytochrome c concentration in young and old control LVs was similar, as was cytochrome c concentration in RVs of young and old control rats. Three additional experiments were carried out with 5-d-old rats inhaling 500 ppm CO, for 47 and 25 d. These also showed the increase in myocardial cytochrome c content and compromise of cytochrome c concentration, and both changes were greater with longer exposure.
- [Show abstract] [Hide abstract] ABSTRACT: Five different dose levels of 2-acetylaminofluorene (2-AAF) were fed to weanling mice of 4 different genotypes from three unrelated F1 hybrids for 13 wk to determine differences in susceptibility to induction of bladder hyperplasia. Differences in the prevalence of hyperplasia per se and in the average grade of hyperplasia were interpreted as indicating greater susceptibility. On this basis, males of all genotypes were more susceptible than females. Among the genotypes, (AEX YS)F1 mice (AY) were most susceptible, followed closely by yellow A vy/A(BALB/cXVY)F1 mice (CV). Agouti A/a(BALB/cXVY)F1 mice were less susceptible than their yellow siblings and similar to the (C57BL/6XC3H)F1 mice. Neither body weight gain nor any of the biochemical parameters measured appeared to be affected at any dose level of 2-AAF. However, quantitative differences in several biochemical characteristics were detected among the genotypes. Serum gamma-glutamyl transpeptidase activity was higher in the AY mice than in the other hybrids. Among the CV mice, the yellow animals had lower glutathione S-transferase (GST) activity than their agouti siblings. Hepatic GST activity was lower in CV mice than in either of the other hybrids. Hepatic cytochrome P-450 and bs activities were similar in all hybrids.
- [Show abstract] [Hide abstract] ABSTRACT: This study was designed to correlated autopsy findings with the effects on cage behavior, laboratory values, and mercury clearance of long-term, low-dose exposure of primates to methylmercury. Six rhesus monkeys were given daily methylmercury hydroxide (MeHg) orally in apple juice on a preplanned dosage schedule. Three were sacrificed while receiving MeHg (group I) and the other 3 were sacrificed 2-5 mo after cessation of MeHg administration (group II). Whole-blood Hg levels (organic and inorganic) were assayed weekly, and major organ levels were assayed at autopsy. Whole-blood Hg levels were maintained between 1 and 2 micrograms/ml when the monkeys were given a MeHg dose of 80-125 micrograms/kg . d for up to 1 yr. The Hg burden of the major organs appeared to be dose- and duration-related. After periods of clearance (2.5-5 mo), intestinal wall Hg burden decreased to less than 1 microgram/g, and the hepatic Hg burden was still between 1.12 and 2.37 micrograms/g. However, the kidneys had a higher concentration of Hg, ranging from 10.34 to 29.54 micrograms/g. Whenever there was a high concentration of Hg, significant ultrastructural changes were observed. In the kidneys there were intracytoplasmic vacuoles and electron-dense inclusion bodies. In the small intestine of the animals cleared of mercury (group II), there were normal Paneth cells, as well as some degenerative cells characterized by dilation of endoplasmic reticulum and the presence of intracellular inclusion bodies. These findings suggest the long turnover time of Hg in these cell populations. During the period of study, weekly routine laboratory data including hematology, blood chemistry, and liver and kidney function tests did not reveal any significant changes.
- [Show abstract] [Hide abstract] ABSTRACT: When performing an epidemiologic study, the central trade unions should be informed. On the local (company and plant) level, the safety committee, trade unions, and shop stewards are contacted to discuss the aim and design of the study, as well as the participation of workers' and employers' representatives in collecting relevant data. When publishing the results of the epidemiologic study, as well as the results of an experimental study, open communication with the population at risk is preferable. When evaluating the risk and assessing a code of practice or an occupational standard for a carcinogen, the participation of trade union representatives is important. Scientists do not have a monopoly on decisions about future risks and actions against risks, nor can they decide better than the risk population what degree of risk should be accepted.
Article: Heredity of cancer[Show abstract] [Hide abstract] ABSTRACT: Hereditary factors are linked with cancer in four ways: by the association of specific chromosomal abnormalities with certain types of cancer, the increase of cancer incidence in some hereditary disorders, the increase of susceptibility to cancer in certain genotypes, and by direct inheritance of some rare malignant neoplasms.
- [Show abstract] [Hide abstract] ABSTRACT: A comparative study of human CYP1A1 genotypes and enzymatic activity was performed in a racially diverse population in order to determine frequencies of CYP1A1 genetic polymorphisms and the relationship between CYP1A1 genotype and function. Restriction fragment length polymorphism analyses revealed significantly higher frequencies of a variant Msp1 polymorphism in Asians versus European-Americans, while African-American CYP1A1 genotypic frequencies more closely approximated those of Asians. Comparison of CYP1A1 genotypes at the Msp1 locus to a polymorphic site in exon 7 of the gene revealed a higher frequency of variant genotypes at the Msp1 site. Measurement of lymphocyte CYP1A1 enzyme activity by the ethoxyresorufin O-deethylase assay revealed significantly elevated levels of inducible enzyme activity among variant exon 7 genotypes when compared to wild-type genotypic individuals. These results demonstrate racially distinct patterns of CYP1A1 genotypes, and suggest a functional link between genotype and catalytic activity of the cytochrome P-450 protein responsible for the metabolism of many carcinogenic polycyclic aromatic hydrocarbons.
- [Show abstract] [Hide abstract] ABSTRACT: The effect of atropine, 2-pyridine aldoxime methiodide (2-PAM), and several O,O,O-trialkylphosphorothioates on poisoning of rats by a series of O,O-dimethyl and O,O-diethyl S-alkyl phosphorothioates was investigated. Atropine and 2-PAM successfully protected rats treated with O,O-diethyl S-n-propyl and S-i-propyl phosphorothioates, while the O,O,O-trialkyl phosphorothioates were effective in protecting rats treated with O,O-dimethyl S-methyl and S-ethyl phosphorothioates. O,O-Dimethyl and O,O-diethyl S-i-propyl phosphorothioates also were examined for in vitro and in vivo inhibition of rat plasma, red blood cell, and brain cholinesterase. Overall, the results indicated that two different mechanisms, cholinergic and noncholinergic, are involved in intoxication by the O,O,S-trialkyl phosphorothioates.
- [Show abstract] [Hide abstract] ABSTRACT: Biomarkers of effect have important potential in epidemiology, since they may enable ascertainment of exposure-effect associations in relatively inexpensive cross-sectional studies, with confirmation by short follow-up after cessation of exposure. Arsenic is known to cause human skin and lung cancer, and may also cause various internal cancers including bladder, kidney, and liver cancer. The strongest epidemiological association between arsenic ingestion and an internal cancer is that with bladder cancer. Epidemiological studies of a Taiwanese population exposed to high levels of arsenic from drinking water reported relative risks for bladder cancer well above any other known environmental carcinogen. Populations at increased risk for bladder cancer from other exposures, such as smoking and schistosomiasis infection, have elevated frequencies of micronuclei in exfoliated bladder cells. We have therefore proposed that the bladder cell micronucleus assay could be an appropriate biological marker of genotoxic effect of arsenic exposure. In this paper, we present the rationale for choosing the bladder cell micronucleus assay as a potential biomarker of effect for arsenic. We also briefly describe the studies we are conducting using this biomarker in currently exposed populations.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.