The Medical journal of Cairo University

Publisher: Jāmiʻat al-Qāhirah. Kullīyat al-Ṭibb al-Bayṭarī

Current impact factor: 0.00

Impact Factor Rankings

Additional details

5-year impact 0.00
Cited half-life 0.00
Immediacy index 0.00
Eigenfactor 0.00
Article influence 0.00
Other titles Majallah al-ṭibbīyah li-Jāmiʻat al-Qāhirah, Majallah al-ṭibbīyah li-Jāmiʻat al-Qāhirah
ISSN 0045-3803
OCLC 6403592
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background and study aim: The prevalence of antinuclear antibody (ANA) has been documented in patients with hepatitis C virus (HCV) infection. Hepatitis C virus infection plays an important role in the pathogenesis of immunological derangement, but the mechanism remains unclear. The aim of this study is to detect the significance of ANA positivity and its impact on histopathology and early virological response (EVR) to combined antiviral therapy in chronic HCV patients. Patients and methods: Two hundred Egyptian chronic HCV naïve patients were enrolled in this study. Antinuclear antibody (ANA) was detected by ELISA and it was considered positive with a titer> 1 : 14 by indirect immunofluorescence. Complete laboratory investigations and histological examination were done as a pretreatment work up for all patients. Patients were followed up during treatment and EVR was assessed in ANA positive and negative patients. Results: There was a statistically significant difference between ANA positive and negative patients regarding viral load and histopathological criteria and no significant difference was detected regarding other demographic and laboratory criteria. EVR was close in ANA positive and ANA negative patients (77 for the former Vs.80 for the later with P = 0.33). No autoimmune manifestations were detected during treatment among positive cases. Except for ALT & AST levels no statistically significant differences were detected between ANA positive and negative cases regarding haematological data, thyroid dysfunction. BMI, ALT levels, viral load and fibrosis stages were independent predictors of EVR. Conclusion: ANA postivity in chronic HCV patients was associated with advanced fibrosis but didn't affect treatment response.
    No preview · Article · Oct 2015 · The Medical journal of Cairo University
  • [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: Bleeding from placenta is a leading cause of antepartum hemorrhage and one of the most acute life threatening obstetric emergencies. The incidence of placenta previa increases with advancing age and higher parity, surgical history, especially of previous caesarean section for placenta previa, is linked to recurrent development of placenta previa and more importantly placenta accrete.Material and methods: A list of patients that had placenta previa from January 1, 2013 to December 31, 2013 admitted to Aswan university hospital will compiled from the medical records department, labour room and theatre records the case notes retrieved from the medical records department in the form of data relating to the age , parity , gestational age risk factors an history of abortion or history of caesarean section , method of termination of pregnancy fetal and maternal morbidity and mortality. Results: Rupture uterus, 1 case (1.49%), caesarean hysterectomy 3 cases (4.47%), internal iliac artery ligation 11 cases (16.41%) maternal mortality 1case (1.49%). KEY WORD: Incidence, placenta previa, Aswan University
    No preview · Article · Sep 2015 · The Medical journal of Cairo University

  • No preview · Article · Sep 2015 · The Medical journal of Cairo University
  • [Show abstract] [Hide abstract]
    ABSTRACT: Introduction: The process of ageing is accompanied with a progressive decline in skeletal muscle mass resulting in sarcopenia (1). Different studies have shown a close relationship between diabetes and sarcopenia (2). Aim of the work: This study was conducted to investigate sarcopenia in elderly people with and without type 2 diabetes mellitus and to evaluate factors that can be associated with high risk of sarcopenia. Subjects and Methods: A total number of 260 elderly aged ≥ 65years were recruited to the study and divided into two equal groups, 130 of them were non-diabetics (58 were men) and 130 were diabetics (63 were men). Muscle mass, muscle strength and physical performance were assessed in all subjects and the European Working Group on Sarcopenia in Older People (EWGSOP) recommendation was used for diagnosing sarcopenia. Results: The prevalence of sarcopenia was significantly higher in elderly diabetics compared to non-diabetics (37.7 vs. 15.4% respectively). Sarcopenia in our study showed positive correlation with age and HbA1c but negative correlation with BMI, serum albumin and hemoglobin. Conclusion: Risk of sarcopenia was higher among elderly patients with type 2 DM and increased more with aging and low BMI. Uncontrolled diabetes, hypoalbuminemia and anemia may be risk factors for sarcopenia. Key words: sarcopenia, diabetes, prevalence.
    No preview · Article · Aug 2015 · The Medical journal of Cairo University
  • [Show abstract] [Hide abstract]
    ABSTRACT: ABSTRACT Background: Pancreatic cancer is a disease with an extremely poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development, invasion and metastasis of pancreatic cancer cells. Patients & Methods: This prospective study included 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, which were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) immunohistochemical staining and soluble CEACAM6 were estimated in all cases and the pattern of expression in tissue was analyzed. Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive for CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was statistically significant (p<0.01). Patients with PDAC showed significantly elevated CEACAM6 serum expression compared to chronic pancreatitis (p<0.01). Tissue expression of CEACAM6 was also significantly correlated to presence of lymph node metastases (p<0.01). A significant correlation was found between grade of pancreatic carcinoma, nodal involvement and serum CEACAM6 level (p<0.05). Neither tumor grade nor depth of invasion were correlated to immunohistochemical CEACAM6 expression (p>0.05). Conclusion: CEACAM6 expression appears to be an early event in pancreatic carcinogenesis, and its expression may aid in the diagnosis and in detection of disease progression in patients undergoing resection for pancreatic ductal adenocarcinoma. Serum levels of CEACAM6 could be valuable in follow up of patients after surgery.
    No preview · Article · Jun 2015 · The Medical journal of Cairo University
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Pancreatic cancer is a disease with an extremely poor prognosis. The acquisition of invasion properties in pancreatic cancer is accompanied by the process of epithelial-mesenchymal transition (EMT). Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is emerging as an important determinant of the malignant phenotype in a range of cancers, including pancreatic cancer. Therefore, the aim of this study was to evaluate the potential involvement of CEACAM6 in the development,invasion and metastasis of pancreatic cancer cells. Patients & Methods: This prospective study includes 7 cases of chronic pancreatitis and 25 cases of pancreatic duct adenocarcinoma, were collected from General Surgery Department, Faculty of Medicine, Benha University and Egyptian National Cancer Institute (NCI), in the period 2010-2014. Carcinoembryonic antigen-related cell adhesion molecule -6 (CEACAM-6) immunohistoc1hemical staining were performed in all cases and the pattern of expression was analyzed. Soluble CEACAM-6was estimated for all cases. Results: Eighty eight percent of pancreatic ductal adenocarcinoma cases were positive to immunohistochemical staining with CEACAM6, while only 14.3% of chronic pancreatitis were positive, which was a statistically significant correlation (p<0.01). CEACAM6 was also significantly correlated to presence of lymph node metastases (p<0.01). Neither tumor grade nor depth of invasion were correlated to CEACAM6 expression (p>0.05). Patients with PDAC showed elevated CEACAM6 serum expression compared to chronic pancreatitis. A significant correlation was found between grade of pancreatic carcinoma, nodal involvement and serum CEACAM6 level (p<0.05), Conclusion: CEACAM6 expression appears to be an early event in pancreatic carcinogenesis, and its expression may aid in the diagnosis and in detection of disease progression in patients undergoing resection for pancreatic ductal adenocarcinoma.
    No preview · Article · Jun 2015 · The Medical journal of Cairo University

  • No preview · Article · May 2015 · The Medical journal of Cairo University