Journal of Neurology Neurosurgery & Psychiatry (J NEUROL NEUROSUR PS)

Publisher: British Medical Association, BMJ Publishing Group

Journal description

Journal of Neurology, Neurosurgery, & Psychiatry (JNNP) publishes important papers covering the whole field of clinical neurological practice. Emphasis is given to common disorders such as cerebrovascular disease, multiple sclerosis, Parkinson's disease, peripheral neuropathy, epilepsy, subarachnoid haemorrhage, including papers concerning pathogenesis and treatment. Only high priority articles are published in the journal.

Current impact factor: 6.81

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 6.807
2013 Impact Factor 5.58
2012 Impact Factor 4.924
2011 Impact Factor 4.764
2010 Impact Factor 4.791
2009 Impact Factor 4.869
2008 Impact Factor 4.622
2007 Impact Factor 3.857
2006 Impact Factor 3.63
2005 Impact Factor 3.122
2004 Impact Factor 3.11
2003 Impact Factor 3.035
2002 Impact Factor 2.939
2001 Impact Factor 3.024
2000 Impact Factor 2.846
1999 Impact Factor 2.735
1998 Impact Factor 2.938
1997 Impact Factor 3.041
1996 Impact Factor 2.93
1995 Impact Factor 2.504
1994 Impact Factor 2.534
1993 Impact Factor 2.261
1992 Impact Factor 2.696

Impact factor over time

Impact factor
Year

Additional details

5-year impact 5.55
Cited half-life >10.0
Immediacy index 2.13
Eigenfactor 0.03
Article influence 1.97
Website Journal of Neurology, Neurosurgery & Psychiatry website
Other titles Journal of neurology, neurosurgery and psychiatry, Journal of neurology, neurosurgery & psychiatry
ISSN 0022-3050
OCLC 1695236
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

BMJ Publishing Group

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's personal website, institutional website or institutional repository
    • Publisher copyright and source must be acknowledged
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • Authors retain copyright
    • If funding agency rules apply, authors may post articles in PubMed Central and mirror sites, website, institutional website or institutional repository
    • On PubMed Central after 12 months embargo from print publication, or as required by funding agency
    • On social networks such as ResearchGate and Mendeley after 6 months embargo from print publication
    • Publisher last contacted on 08/12/2014
    • Publisher last reviewed on 29/06/2015
  • Classification
    green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective: Chromosome 1p/19q deletion is an established prognostic and predictive marker in the WHO grade III oligodendroglial tumours (OT). To estimate the genetic status preoperatively, the authors investigated the correlation between the uptake of (11)C-methionine in positron emission tomography (PET) and the 1p/19q status in grades II and III OT. Methods: We retrospectively reviewed 144 patients with gliomas who received (11)C-methionine PET. 66 cases with grades II-III oligodendrogliomas or oligoastrocytomas underwent fluorescence in situ hybridisation to determine the 1p/19q status. The tissue uptake of (11)C-methionine was expressed as the ratio of the maximum standardised uptake value (SUVmax) in tumour areas to the mean SUV (SUVmean) in the contralateral normal brain (tumour-to-normal tissue (T/N) ratio). Results: The T/N ratio in (11)C-methionine PET was significantly higher in grade III OT than in grade II tumours. The mean T/N ratio of the grade II tumours without 1p/19q deletion was significantly higher than that of the grade II tumours with 1p/19q deletion (mean 2.67 vs 1.94, respectively; p=0.0457). In grade III tumours, the mean T/N ratio of the tumours without 1p/19q deletion was also significantly higher than that of the tumours with 1p/19q deletion (mean 4.83 vs 3.49, respectively; p=0.0261). The rate of IDH1 mutation was lower and the rate of contrast enhancement on MRIs was higher in the 1p/19q non-deleted OT than those with 1p/19q deletion, which may contribute to the high T/N ratio. Conclusions: Among suspected OT, (11)C-methionine PET may help us preoperatively discriminate tumours with and without 1p/19q deletion.
    No preview · Article · Feb 2016 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: Background: The pathophysiology underlying different types of dystonia is not yet understood. We report microelectrode data from the globus pallidus interna (GPi) and globus pallidus externa (GPe) in children undergoing deep brain stimulation (DBS) for dystonia and investigate whether GPi and GPe firing rates differ between dystonia types. Methods: Single pass microelectrode data were obtained to guide electrode position in 44 children (3.3-18.1 years, median 10.7) with the following dystonia types: 14 primary, 22 secondary Static and 8 progressive secondary to neuronal brain iron accumulation (NBIA). Preoperative stereotactic MRI determined coordinates for the GPi target. Digitised spike trains were analysed offline, blind to clinical data. Electrode placement was confirmed by a postoperative stereotactic CT scan. Findings: We identified 263 GPi and 87 GPe cells. Both GPi and GPe firing frequencies differed significantly with dystonia aetiology. The median GPi firing frequency was higher in the primary group than in the secondary static group (13.5 Hz vs 9.6 Hz; p=0.002) and higher in the NBIA group than in either the primary (25 Hz vs 13.5 Hz; p=0.006) or the secondary static group (25 Hz vs 9.6 Hz; p=0.00004). The median GPe firing frequency was higher in the NBIA group than in the secondary static group (15.9 Hz vs 7 Hz; p=0.013). The NBIA group also showed a higher proportion of regularly firing GPi cells compared with the other groups (p<0.001). A higher proportion of regular GPi cells was also seen in patients with fixed/tonic dystonia compared with a phasic/dynamic dystonia phenotype (p<0.001). The GPi firing frequency showed a positive correlation with 1-year outcome from DBS measured by improvement in the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-m) score (p=0.030). This association was stronger for the non-progressive patients (p=0.006). Interpretation: Pallidal firing rates and patterns differ significantly with dystonia aetiology and phenotype. Identification of specific firing patterns may help determine targets and patient-specific protocols for neuromodulation therapy. Funding: National Institute of Health Research, Guy's and St. Thomas' Charity, Dystonia Society UK, Action Medical Research, German National Academic Foundation.
    No preview · Article · Feb 2016 · Journal of Neurology Neurosurgery & Psychiatry

  • No preview · Article · Feb 2016 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used as a human disease model for Parkinson's disease (PD). iPSCs can be also utilised to probe the mechanism, and serve as an ‘in vivo’ platform for drug screening and for cell-replacement therapies. However, any clinical trial approaches should be extensively supported by validated robust biological evidence (based on previous experience with fetal mesencephalic transplantation), in particular, the production and selection of the ‘ideal’ neurons (functional units with no oncological risk), together with the careful screening of appropriate candidates (such as genetic carriers), with inbuilt safeguards (safety studies) in the evaluation and monitoring (functional neuroimaging of both DA and non-DA system) of trial subjects. While iPSCs hold great promise for PD, there are still numerous scientific and clinical challenges that need to be surmounted before any clinical application can be safely introduced.
    Full-text · Article · Feb 2016 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: Accurate and timely diagnosis of intracranial vasculopathies is important due to significant risk of morbidity with delayed and/or incorrect diagnosis both from the disease process as well as inappropriate therapies. Conventional vascular imaging techniques for analysis of intracranial vascular disease provide limited information since they only identify changes to the vessel lumen. New advanced MR intracranial vessel wall imaging (IVW) techniques can allow direct characterisation of the vessel wall. These techniques can advance diagnostic accuracy and may potentially improve patient outcomes by better guided treatment decisions in comparison to previously available invasive and non-invasive techniques. While neuroradiological expertise is invaluable in accurate examination interpretation, clinician familiarity with the application and findings of the various vasculopathies on IVW can help guide diagnostic and therapeutic decision-making. This review article provides a brief overview of the technical aspects of IVW and discusses the IVW findings of various intracranial vasculopathies, differentiating characteristics and indications for when this technique can be beneficial in patient management.
    No preview · Article · Jan 2016 · Journal of Neurology Neurosurgery & Psychiatry

  • No preview · Article · Jan 2016 · Journal of Neurology Neurosurgery & Psychiatry

  • No preview · Article · Dec 2015 · Journal of Neurology Neurosurgery & Psychiatry

  • No preview · Article · Nov 2015 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: A limited literature suggests that people with Parkinson's disease have reduced religious beliefs, practices and experiences, compared to normal healthy controls. But we reasoned these results may be confounded by reduced mobility and social isolation associated with Parkinson's disease. So, we recruited a cohort of 42 Parkinson's patients and 39 controls with chronic respiratory disease, non-neurological autoimmune disease or rheumatological problems. Each subject was examined twice, 12 months apart and assessed on validated scales of handicap and impairment, with spirituality measured by the modified Brief Multidimensional Measure of Religiousness/Spirituality (BMMRS), an abbreviated Hood Mysticism Scale, and the Cloninger Transcendance Inventory. As expected, the Parkinson's group showed a greater decline in mobility and cognitive function over 12 months, compared to controls yet their religiosity scores were undiminished. Quantitative analysis showed significantly increased positive spiritual experiences in the Parkinson's group (p=0.04) relative to controls. “Religious support”, a proxy for involvement in a religious community, was maintained despite decreasing mobility. Qualitative accounts indicated that faith and spirituality were maintained in those patients with PD for whom it was important at baseline. We identified no aspect of faith that was reduced by degeneration of basal ganglia pathways.
    No preview · Article · Nov 2015 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: Recovery of language function after aphasic stroke is the product of activity in domain-general and domain-specific distributed brain networks. These may include left and right fronto-temporo-parietal, cingulo-opercular, and default mode networks. This functional MRI study investigated the effects of a previous left hemisphere stroke on brain activity during speech production in fifty-three patients. The results were related to twenty-four healthy participants. The analyses investigated not only local activity, but also functional connectivity both within and between distributed networks. Although activity within individual networks was not predictive of speech production, the relative activity between networks was a predictor of both within-scanner and out-of-scanner performance, over and above that predicted from lesion volume and various demographic factors. The specific imaging predictors were the differential activity between the default mode network and both the left and right fronto-temporo-parietal networks, respectively activated and deactivated during speech. These networks also showed altered between-network functional connectivity in patients. Therefore the systems neuroscience of recovery of function after focal lesions is not adequately captured by notions of brain regions ‘taking over’ lost domain specific functions, but is best considered as the interaction between what remains of domain-specific networks and the domain-general systems that regulate behaviour.
    No preview · Article · Nov 2015 · Journal of Neurology Neurosurgery & Psychiatry
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    ABSTRACT: Aim To determine how suspected encephalitis is managed in a regional DGH against standard of ABN/BIA (Association of British Neurologists/British Infection Association) Guidelines (2012). Methodology A retrospective audit of notes for 21 cases with suspected encephalitis (June to December 2013). Sampling utilised case coding, records of referrals to neurology and CSF analyses. Latency from time of admission to suspicion of encephalitis, CT, LP, MRI, aciclovir administration and neurological input were determined. Results 12/21 patients received aciclovir within 6 hours (average 11.5h), 18/21 patients had a CT head scan before LP and in 14/21 cases aciclovir was started before LP. 18/21 cases underwent LP (6 on MAU, 11 by medical teams and 1 by neurology), 17/18 had CSF constituents requested, 9/18 had a paired serum glucose. 5 cases had repeat HSV PCR, 5 had HIV testing and 12/21 had an EEG. The average latency to MRI was 2.34 days and time to be seen by a neurologist was 2 days. Treatment was discontinued in 7 cases after negative HSV PCR and 5 after alternative diagnosis were made. Conclusions Management of suspected encephalitis varied, we need to increase awareness ABN/BIA guidance and address the delay in neurology services seeing these patients.
    No preview · Article · Nov 2015 · Journal of Neurology Neurosurgery & Psychiatry