Journal of the American Chemical Society (J AM CHEM SOC)

Publisher: American Chemical Society; American Chemical Society; Marian S. Carson Collection (Library of Congress), American Chemical Society

Journal description

The Journal of the American Chemical Society, founded in 1879, is the flagship journal of the American Chemical Society and a highly esteemed journal in the field. This periodical is devoted to the publication of research papers in all fields of chemistry and publishes approximately 13,000 pages of new chemistry a year. Published weekly, JACS provides research crucial to the field of chemistry. The Journal of the American Chemical Society publishes articles, communications to the Editor, book reviews, and computer software reviews.

Current impact factor: 12.11

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 12.113
2013 Impact Factor 11.444
2012 Impact Factor 10.677
2011 Impact Factor 9.907
2010 Impact Factor 9.019
2009 Impact Factor 8.58
2008 Impact Factor 8.091
2007 Impact Factor 7.885
2006 Impact Factor 7.696
2005 Impact Factor 7.419
2004 Impact Factor 6.903
2003 Impact Factor 6.516
2002 Impact Factor 6.201
2001 Impact Factor 6.079
2000 Impact Factor 6.025
1999 Impact Factor 5.537
1998 Impact Factor 5.725
1997 Impact Factor 5.65
1996 Impact Factor 5.948
1995 Impact Factor 5.263
1994 Impact Factor 5.039
1993 Impact Factor 5.365
1992 Impact Factor 5.298

Impact factor over time

Impact factor
Year

Additional details

5-year impact 11.73
Cited half-life 8.00
Immediacy index 2.61
Eigenfactor 0.82
Article influence 3.29
Website Journal of the American Chemical Society website
Other titles Journal of the American Chemical Society, Review of American chemical research
ISSN 0002-7863
OCLC 1226990
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details

American Chemical Society

  • Pre-print
    • Author cannot archive a pre-print version
  • Restrictions
    • Must obtain written permission from Editor
    • Must not violate ACS ethical Guidelines
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • If mandated by funding agency or employer/ institution
    • If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
    • 12 months embargo
  • Conditions
    • On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
    • Non-Commercial
    • Must be accompanied by set statement (see policy)
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • If mandated sooner than 12 months, must obtain waiver from Editors or use AuthorChoice
    • Reviewed on 07/08/2014
  • Classification
    white

Publications in this journal

  • Xiaoxi Wei · Guoqing Zhang · Yi Shen · Yulong Zhong · Rui Liu · Na Yang · Fayez Y. Al-mkhaizim · Mark Kline · Lan He · Minfeng Li · Zhong-Lin Lu · Zhifeng Shao · Bing Gong

    No preview · Article · Feb 2016 · Journal of the American Chemical Society
  • Guillaume Passard · Andrew M. Ullman · Casey N Brodsky · Daniel G. Nocera

    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: 2-(o-Amidophenyl)-oxa- and thiazolines undergo excited state in-tramolecular proton transfer (ESIPT), generating aza-o-xylylenes capable of intramolecular [4+2] and [4+4] cycloadditions with tethered unsaturated pendants. Facile hydrolysis of the primary photoproducts, spiro-oxazolidines and thiazolidines, under mild conditions unmasks a phenone functionality. Variations in linkers allows for access to diverse core scaffolds in the primary photo-products, rendering the approach compatible with the philosophy of diversity-oriented synthesis. Chiral oxazolines, readily available from the corresponding amino alcohols, yield enantioenriched keto-polyheterocycles of complex topologies with ee's up to 90%.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Herein, we synthesized a series of ten core-shell silver-silica nanoparticles with a photosensitizer, Rose Bengal, tethered to their surface. Each nanoparticle possesses an identical silver core of about 67 nm, but presents a different silica shell thickness ranging from 5 nm to 100 nm. These hybrid plasmonic nanoparticles thus afford a plasmonic nanostructure platform with a source of singlet oxygen (1O2) at a well-defined distance from the metallic core. Via time-resolved and steady state spectroscopic techniques, we demonstrate the silver core exerts a dual role of enhancing both the production of 1O2, through enhanced absorption of light, and its radiative decay, which in turn boosts 1O2 phos-phorescence emission to a greater extend. Furthermore, we show both the production and emission of 1O2 in vitro to be dependent on proximity to the plasmonic nanostructure. Our results clearly exhibit three distinct regimes as the plas-monic nanostructure moves apart from the 1O2 source, with a greater enhancement for silica shell thicknesses ranging be-tween 10 nm and 20 nm. Moreover, these hybrid plasmonic nanoparticles can be delivered to both Gram-positive and Gram-negative bacteria boosting both photo-antibacterial activity and detection limit of 1O2 in cells.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Covalent organic nanosheets (CONs) have emerged as functional two dimensional materials for versatile applications. Although π-π stacking between layers, hydrolytic instability, possible restacking prevents their exfoliation on to few thin lay-ered CONs from crystalline porous polymers. We anticipated rational designing of a structure by intrinsic ionic linker could be the solution to produce self-exfoliated CONs without external stimuli. In an attempt to address this issue, we have synthesized three self-exfoliated guanidinium halide based ionic covalent organic nanosheets (iCONs) with antimicrobial property. Self-exfoliation phenomenon has been supported by molecular dynamics (MD) simulation as well. Intrinsic ionic guanidinium unit plays the pivotal role for both self-exfoliation and antibacterial property against both gram-positive and gram-negative bacteria. Using such iCONs we have devised mixed matrix membrane which could be useful for antimicrobial coatings with plausible medical benefits.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Strain is known to greatly influence low temperature oxygen electrocatalysis on noble metal films, leading to significant enhancements in bifunctional activity essential for fuel cells and metal-air batteries. However, its catalytic impact on transition metal oxide thin films, such as perovskites, is not widely understood. Here, we epitaxially strain the conducting perovskite LaNiO3 to systematically determine its influence on both the oxygen reduction and oxygen evolution reaction. Uniquely, we found that compressive strain could significantly enhance both reactions, yielding a bifunctional catalyst that surpasses the performance of noble metals such as Pt. We attribute the improved bifunctionality to strain-induced splitting of the eg orbitals, which can customize orbital asymmetry at the surface. Analogous to strain-induced shifts in the d-band center of noble metals relative to Fermi level, such splitting can dramatically affect catalytic activity in this perovskite and other potentially more active oxides.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Bioorthogonal chemistry enables a specific moiety in a complex biomolecule to be selectively modified in the presence of many reactive functional groups and other cellular entities. Such selectivity has become indispensable in biology, enabling biomolecules to be derivatized, conjugated, labelled or immobilized for imaging, biochemical assays or therapeutic applications. Methyltransferase enzymes (MTase) that accept analogs of the cofactor S adenosyl methionine have been widely deployed for al-kyl-diversification and bioorthogonal labelling. However, MTases typically possess tight substrate specificity. Here we introduce a more flexible methodology for selective derivatization of phenolic moieties in complex biomolecules. Our approach relies on the tandem enzymatic reaction of a fungal tyrosinase and the mammalian catechol-O-methyltransferase (COMT), which can effect the sequential hydroxylation of the phenolic group to give an intermediate catechol moiety that is subsequently O-alkylated. When used in this combination, the alkoxylation is highly selective for tyrosine residues in peptides and proteins, yet remarkably tolerant to changes in the peptide sequence. Tyrosinase-COMT are shown to provide highly versatile and regioselective modification of a di-verse range of substrates including peptide antitumor agents, hormones, cyclic peptide antibiotics and model proteins.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: A series of p-terphenyl-based macrocycles, containing highly distorted para-phenylene units, have been synthesized. The biaryl bonds of the nonplanar p-terphenyl nuclei were constructed in the absence of Pd-catalyzed or Ni-mediated cross-coupling reactions, using 1,4-diketones as surrogates to strained arene units. A streamlined synthetic protocol for the synthesis of 1,4-diketo macrocycles has been developed, using only 2.5 mol% of the Hoveyda-Grubbs second-generation catalyst in both metathesis and transfer hydrogenation reactions. Under protic acid-mediated dehydrative aromatization conditions, the central and most strained benzene ring of the p-terphenyl systems was susceptible to rearrangement reactions. To overcome this, a dehydrative aromatization protocol using the Burgess reagent was developed. Under these conditions, no strain-induced rearrangement reactions occur, delivering para-phenylene units with up to 28.4 kcal/mol of SE and deformation angles that sum up to 40°.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: We report the design of a phosphorescence/fluorescence dual-emissive nanoscale metal organic framework (NMOF), R-UiO, as an intracellular oxygen (O2) sensor. R-UiO con-tains a Pt(II)-porphyrin ligand as an O2-sensitive probe and a Rhodamine-B isothiocyanate (RITC) ligand as an O2-insensitive reference probe, and exhibits good crystallinity, high stability, and excellent ratiometric luminescence re-sponse to O2 partial pressure. In vitro experiments con-firmed the applicability of R-UiO as an intracellular O2 bio-sensor. This work is the first report of a NMOF-based intra-cellular oxygen sensor and should inspire the design of rati-ometric NMOF sensors for other important analytes in bio-logical systems.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: New and active earth-abundant metal catalysts are critically needed to replace precious metal-based catalysts for sustaina-ble production of commodity and fine chemicals. We report here the design of highly robust, active, and reusable cobalt-bipyridine and cobalt-phenanthroline based metal-organic framework (MOF) catalysts for alkene hydrogenation and hydroboration, aldehyde/ketone hydroboration, and arene C-H borylation. In alkene hydrogenation, the MOF catalysts dis-played unprecedentedly high turnover numbers of ~2.5×106 and turnover frequencies of ~1.1×105 h-1. Structural, computational, and spectroscopic studies show that site isolation of the highly reactive (bpy)Co(THF)2 species in the MOFs prevents intermolecular deactivation and stabilizes solution-inaccessible catalysts for broad-scope organic transformations. Compu-tational, spectroscopic, and kinetic evidences further support a hitherto unknown (bpy∙ )CoI(THF)2 ground state that coordi-nates to alkene and dihydrogen, then undergoing sigma-complex assisted metathesis to form (bpy)Co(alkyl)(H). Reductive elimination of alkane followed by alkene binding completes the catalytic cycle. MOFs thus provide a novel platform for discovering new base-metal molecular catalysts and exhibit enormous potential in sustainable chemical catalysis.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Two- and multi-steps spin transitions are frequently observed in switchable cooperative molecular solids. They present the advantage to open the way for three or several-bits electronics. Despite of extensive experimental studies, their theoretical description was to date only phenomenological, based on Ising models including competing ferro- and antiferro-magnetic interactions, even though it is recognized, that the elastic interactions are at the hearth of the spin transition phenomenon, due to the volume change between the low- and high-temperature phases. To remedy this shortcoming, we designed the first consistent elastic model, taking into account both volume change upon spin transition and elastic frustration. This ingredient revealed to be powerful, since it enabled to obtain all observed experimental configurations in the consistent way. Thus, according to the strength of the elastic frustration, the system may undergo: first-order transition with hysteresis, gradual, hysteretic two-step or multi-step transitions, and incomplete transitions. Furthermore, the analysis of the spatial organization of the HS and LS species in the plateau regions revealed the emergence of complex antiferroelastic patterns going from simple antiferromagnetic-like order to long-range spatial modulations of the high-spin fraction. These results enable to identify the elastic frustration as the fundamental mechanism at the origin of the very recent experimental observations showing the existence of organized spatial modulations of the high-spin fraction inside the plateau of two-step spin transitions.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Cancer cells, and in particular those found circulating in blood, can have widely varying phenotypes and molecular profiles despite a common origin. New methods are needed that can deconvolute the heterogeneity of cancer cells and sort small numbers of cells to aid in the characterization of cancer cell subpopulations. Here, we describe a new molecular approach to capturing cancer cells that isolates subpopulations using two-dimensional sorting. Using aptamer-mediated capture and antisense-triggered release, the new strategy sorts cells according to levels of two different markers and thereby separates them into their corresponding subpopulations. Using a phenotypic assay, we demonstrate that the subpopulations isolated have markedly different properties. This system provides an important new tool for identifying CTC subtypes exhibiting the greatest clinical relevance.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Knowledge of the transfer free energy of amino acids from aqueous solution to a lipid bilayer is essential for understanding membrane protein folding and for predicting membrane protein structure. Here we report a computational approach that can calculate the folding free energy of the transmembrane region of outer membrane β-barrel proteins (OMPs) by combining an empirical energy function with a reduced discrete state space model. We quantitatively analyzed the transfer free energies of 20 amino acid residues at the center of the lipid bilayer of OmpLA. Our results are in excellent agreement with the experimentally derived hydrophobicity scales. We further exhaustively calculated the transfer free energies of 20 amino acids at all positions in the TM region of OmpLA. We found that the asymmetry of the gram-negative bacterial outer membrane as well as the TM residues of an OMP determine its functional fold in vivo. Our results suggest that the folding process of an OMP is driven by the lipid-facing residues in its hydrophobic core, and its NC-IN topology is determined by the differential stabilities of OMPs in the asymmetrical outer membrane. The folding free energy is further reduced by lipid A and assisted by general depth-dependent cooperativities that exist between polar and ionizable residues. Moreover, context-dependency of transfer free energies at specific positions in OmpLA predict regions important for protein function as well as structural anomalies. Our computational approach is fast, efficient and applicable to any OMP.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: One of the most charming and challenging topics in organic chemistry is the selective C-H bond activation. The difficulty arises not only from the relatively large bond-dissociation enthalpy, but also from the poor reaction selectivity. In this work, Au(111) and Ag(111) surfaces were used to address ortho C-H functionalization and ortho-ortho couplings of phenol derivatives. More importantly, the competition between dehydrogenation and deoxygenation drove the diversity of reaction pathways of phenols on surfaces, that is, di-selective ortho C-H bond activation on Au(111) surfaces and mono-selective ortho C-H bond activation on Ag(111) surfaces. The mechanism of this unprecedented phenomenon was extensively explored by scanning tunneling microscopy, density function theory and X-ray photoelectron spectroscopy. Our findings provide new pathways for surface-assisted organic synthesis via the mono-/di-selective C-H bond activation.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: The ability to drive reactivity using visible light is of importance for many disciplines of chemistry and has significant implications for sustainable chemistry. Identifying photochemically active compounds and understanding photochemical mechanisms is important for the development of useful materials for synthesis and catalysis. Here we report a series of photoactive diphenyltellurophene compounds bearing electron-withdrawing and electron-donating substituents synthesized by alkyne coupling/ring-closing or palladium-catalyzed ipso-arylation chemistry. The redox chemistry of these compounds was studied with respect to oxidative addition and photoelimination of bromine, which is of importance for energy storage reactions involving X2. The oxidative addition reaction mechanism was studied using density functional theory (DFT), the results of which support a 3-step mechanism involving the formation of an initial η1 association complex, a monobrominated intermediate, and finally, the dibrominated product. All of the tellurophene derivatives undergo photoreduction using 430 nm, 447 nm or 617 nm light depending on the absorption properties of the compound. Compounds bearing electron-withdrawing substituents have the highest photochemical quantum efficiencies in the presence of an alkene trap, with efficiencies up to 42.4% for a pentafluorophenyl-functionalized tellurophene. The photoelimination reaction was studied in detail through bromine trapping experiments and laser flash photolysis and a mechanism is proposed. The photoreaction, which occurs by release of bromine radicals, is competitive with intersystem crossing to the triplet of the brominated species as evidenced by the formation of singlet oxygen. These findings should be useful for the design of new photochemically active compounds supported by main group elements.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Despite the remarkable rise in efficiencies of solar cells containing the lead-halide perovskite absorbers RPbX3 (R = organic cation; X = Br(-) or I(-)), the toxicity of lead remains a concern for the large-scale implementation of this technology. This has spurred the search for lead-free materials with similar optoelectronic properties. Here, we use the double-perovskite structure to incorporate nontoxic Bi(3+) into the perovskite lattice in Cs2AgBiBr6 (1). The solid shows a long room-temperature fundamental photoluminescence (PL) lifetime of ca. 660 ns, which is very encouraging for photovoltaic applications. Comparison between single-crystal and powder PL decay curves of 1 suggests inherently high defect tolerance. The material has an indirect bandgap of 1.95 eV, suited for a tandem solar cell. Furthermore, 1 is significantly more heat and moisture stable compared to (MA)PbI3. The extremely promising optical and physical properties of 1 shown here motivate further exploration of both inorganic and hybrid halide double perovskites for photovoltaics and other optoelectronics.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: We report the first nitrogen-containing iron-pnictide superconductor ThFeAsN, which is synthesized by a solid-state reaction in an evacuated container. The compound crystallizes in a ZrCuSiAs-type structure with the space group P4/nmm and lattice parameters a=4.0367(1) Å and c=8.5262(2) Å at 300 K. The electrical resistivity and dc magnetic susceptibility measurements indicate superconductivity at 30 K for the nominally undoped ThFeAsN.
    No preview · Article · Feb 2016 · Journal of the American Chemical Society
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    ABSTRACT: Ultraviolet and infrared-ultraviolet (IR-UV) double resonance photofragment spectroscopy has been carried out in a tandem mass spectrometer to determine the three-dimensional structure of cryogenically-cooled protonated C-terminally methyl esterified leucine enkephalin [YGGFL-OMe+H]+. By comparing the experimental IR spectrum of the dominant conformer with the predictions of DFT M05-2X/6-31+G(d) calculations, a backbone structure was assigned that is analogous to that previously assigned by our group for the un-modified peptide [Burke, N.L. et al. Int. J. Mass Spectrom. 2015, 378, 196], despite the loss of a C-terminal OH binding site that was thought to play an important role in its stabilization. Both structures are characterized by a type II' β-turn around Gly3-Phe4 and a γ-turn around Gly2, providing spectroscopic evidence for the formation of a β-hairpin hydrogen bonding pattern. Rather than disrupting peptide backbone structure, the protonated N-terminus serves to stabilize the -hairpin by positioning itself in a pocket above the turn where it can form H-bonds to the Gly3 and C-terminus C=O groups. This β-hairpin type structure has been previously proposed as the biologically active conformation of leucine enkephalin and its methyl ester in the non-polar cell membrane environment [Naito, A.; Nishimura, K. Curr. Top. Med. Chem. 2004, 4, 135-143].
    No preview · Article · Feb 2016 · Journal of the American Chemical Society