Valencia College
  • Orlando, United States
Recent publications
Brain is an oxyregulator organ, however extremely vulnerable to oxygen. Both high and low oxygen concentrations generate free radicals and may cause oxidative stress and damage because of an insufficient response of the antioxidant system. Hypoxic preconditioning exerts neuroprotective effects and may be a protecting tool against oxygen fluctuations thus preventing neuronal damage in events such as ischemia, acute hypoxia, stroke, or traumatic brain injury, among others. This review aims to discuss the molecular mechanisms involved in the neuroprotective action of HP against oxidative stress and subsequently upon the brain under pro-oxidant conditions. Activation of the antioxidant defences represents the first line to neutralize oxidative stress and is characterized by low reactive oxygen species (ROS), reduced oxidative damage biomarkers, and increased level of reduced glutathione (GSH). These protective mechanisms decrease cell death activating anti-apoptotic signalling pathways and reducing neuroinflammation by the inactivation of microglia and astroglia cells. HP could be considered a new approach to reduce oxidative stress derived damage caused by a great variety of brain pathologies. Despite our intriguing findings, further experiments are needed for a better understanding of the molecular mechanisms involved in the neuroprotective actions of HP.
An optimal labeling of a graph with n vertices and m edges is an injective assignment of the first n nonnegative integers to the vertices‎, ‎that induces‎, ‎for each edge‎, ‎a weight given by the sum of the labels of its end-vertices with the property that the set of all induced weights consists of the first m positive integers‎. ‎We explore the connection of this labeling with other well-known functions such as super edge-magic and α-labelings‎. ‎A graph with n vertices is maximal when the number of edges is 2n−3; all the results included in this work are about maximal graphs‎. ‎We determine the number of optimally labeled graphs using the adjacency matrix‎. ‎Several techniques to construct maximal graphs that admit an optimal labeling are introduced as well as a family of outerplanar graphs that can be labeled in this form.
This paper analyzes the political, philosophical, societal, legal, educational, biological, psychological and technological reasons why there is an urgent need for basic intercultural and interfaith ethics in the world and whether it is possible to formulate a valid code of such ethics. It is shown that universal ethics could be founded on natural law, which can be understood in both religious and secular ways. Alternatively, universal ethics could be based on a single supreme principle that is independent of worldview and culture: human dignity. In accordance with these concepts, a minimalist and normative code of essential, self-evident universal ethical principles and norms is proposed. The implementation of universal ethics in society is a long-term political task that could be achieved by including universal ethics in the compulsory school curriculum of all countries and in the UNESCO agenda of Global Citizen Education.
Funding Acknowledgements Type of funding sources: None. Microvascular damage is a poor prognostic factor after STEMI and is a goal to improve its diagnosis and treatment. The aim of this work is to analyze the value of cardiac magnetic resonance (CMR) functional parameters to predict the presence of microvascular damage in the setting of reperfusion injury. Methods A cohort of patients with acute STEMI was prospectively included and systolic and diastolic blood pressure at catheterization laboratory during reperfusion procedures were assessed . All patients underwent cardiac MRI during the first week post reperfusion with a standardized protocol including functional evaluation with b-SSFP sequences and also 8-10 short axis slices in IR-FGRE sequences assessing the area of necrosis as area of signal hyper intensity> 5 Sds relative to the remote myocardium and microvascular obstruction (MVO) as signal hypointensity in the infarct core . Functional derived parameters as left ventricle (LV) and right ventricle (RV) volumes, mass and ejection fraction (LVEF, RVE ) , biventricular stroke volumes (SV), systolic and diastolic relative LV parietal mass ) and end systolic and diastolic pressure /volume (P/V) ratio were calculated and assessed in this clinical setting. Results 94 patients with reperfused STEMI were included. Forty nine of them (51%) have microvascular obstruction detected by CMR. Univariate analysis was performed showing that presence of MVO was significantly related to LV and RV ejection fraction, LVSV, end systolic biventricular volumes , systolic P / V ratio and systolic relative parietal mass. Area under ROC curve and statistic significance of analyzed data was shown in the picture. A multivariate regression model adjusted by LV ejection fraction was performed showing that LVSV (CI: 0.6-0.8 p=0.02) and systolic P / V ratio (p=0.01 CI: 0.8-0.9) as the most powerful functional predictors improving diagnostic accuracy of MVO in this clinical setting. Conclusions In addition to LV ejection fraction, LV stroke volume and systolic P / V ratio were the most powerful functional predictors associated to presence of microvascular damage in the setting of reperfused STEMI.
This correlational study examined the relationship between self‐care, burnout, compassion satisfaction, and secondary traumatic stress among higher education faculty members during the COVID‐19 pandemic. The results inform higher education faculty members about the effects of self‐care and suggest strategies to reduce burnout, compassion satisfaction and secondary traumatic stress.
Living in a social group increases the risks of parasitism, especially in highly-related groups. In homogenous groups, with no reproductive division of labour, the impact of parasitism is unlikely to vary with host identity. Many social systems, however, do exhibit division of reproductive labour, most famously in social insects with their reproductive queens and generally infertile workers. In such systems, the impact of parasitism will differ for each group. Consequently, we predict that susceptibility to parasites will vary to reflect such differential impact. We tested this prediction using a trypanosome-bumble bee system, where Crithidia bombi infects both gynes and workers of Bombus terrestris . We studied both susceptibility to the parasite and relevant measures of the immune function. As predicted, gynes were significantly less susceptible to the parasite than workers, but while gynes and workers expressed different immune profiles, how these link to differential susceptibility remains unclear. In conclusion, our results suggest that differential selection pressures exerted by parasites may produce multiple phenotypes from a single genotype in order to maximise fitness in a social group context. Significance statement Social insect colonies dominate terrestrial ecology, and as such are targets for parasites. How they defend themselves against such threats is a key question. Here, we show that bumble bee gynes — the reproductive individuals that overwinter and found colonies in this annual social system — are more resistant to a parasite that disproportionately affects reproductive fitness than their sister workers. Differential patterns of susceptibility may help to explain the success of these social insects.
Editors' introductory chapter delineates common threads among the volume's cross-disciplinary contributions and connects these to the history of research on modernity as well as the most compelling issues confronting us today. The introduction discusses how the pandemic carries on the possibility (threat?) of a tabula rasa condition, a civilizational detour based on a foundation of global awareness of nature and society. The authors support the need for global problem-solving strategies, new global ethics, and a global resource management paradigm solidly cognizant of the commons and redistribution. The introduction explores the main hiatuses in today's modernity and provides an update to the necessary assertion of a global modernity in the midst of political, ecological, and health crises. The use terms and concepts like modernity, modernism, and modernization is a leitmotif and common denominator of various disciplines. However, modernity, modernism, and modernization are also controversial concepts that range from the theoretical to the empirical. Resurging in the last decades in the light of globalization, the climate crisis, technological advancement, and populism, the questioning of modernity begins to couple with questions of our present time and plans for the future. When and how did we start being modern? One may note that the attribution of specifijic characteristics of modernity traces back to a fundamental switch from one epoch to another: the dissociation with tradition; the Akil, H.N. and S. Maddanu (eds.), Global Modernity from Coloniality to Pandemic: A Cross-disciplinary Perspective.
Yet the daydream, because it is common property, extends both into the broad and into the deep expanse, into the non-sublimated, but in fact concentrated expanse, into that of the utopian dimensions. And this automatically posits the better world also as the more beautiful, in the sense of completed images, the like of which have not yet been seen on earth. Through planning or forming, windows are hewn in deprivation, hardness, rawness, banality, with distant prospects, full of light. The daydream as a stepping-stone to art so very obviously intends world-improvement, has this as its robustly real character. (Bloch 1995 [1959], 94) Abstract This chapter unifijies cross-disciplinary references, analysis, and conceptu-alizations of modernity and modernization, highlighting a clear distinction between the spirit of both modernization and modernity. As we saw from diffferent perspectives and criticisms, although modernization operates as a levelling process, modernity still appears to be worth a potential update. From coloniality to pandemic, by connecting modernities and histories, modernity can now represent a global necessity, where awareness of injustice, inequality, and human and environmental crises would create the possibility of a modernity-to-come. A cross-disciplinary volume is an invitation and a challenge to discover and appreciate the diverse disciplinary approaches and methodologies used in dealing with a single general subject. The book lays out an intellectual landscape that can lead to concord and harmony through the very disciplinary discords it avails its readers. In a way, we, as editors, follow a humanist tradition of representing all perspectives, approaches, and Akil, H.N. and S. Maddanu (eds.), Global Modernity from Coloniality to Pandemic: A Cross-disciplinary Perspective.
This book poses questions about viewing modernity today from the vantage point of traditionally disparate disciplines engaging scholars from sociology to science, philosophy to robotics, medicine to visual culture, mathematics to cultural theory, etc., including a contribution by Alain Touraine. From coloniality to pandemic, modernity can now represent a global necessity in which awareness of human and environmental crises, injustices, and inequality would create the possibility of a modernity-to-come.
Introduction: Preoperative progressive pneumoperitoneum (PPP) is a technique that has been used since 1947 to expand the abdominal cavity volume, for presurgical preparation of patients with large hernias. This systematic review attempts to answer some unresolved questions about PPP, while using the evidence to clarify the different forms that the procedure has taken over time. Purpose: The purpose of the paper was to analyze the literature about PPP and gather information about the procedure and its indications, advantages, and disadvantages. Methods: A systematic review was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. The database searches, in English and Spanish, were made using the terms "preoperative pneumoperitoneum," "progressive pneumoperitoneum," "preoperative pneumoperitoneum," and "progressive pneumoperitoneum," for the period between 1 January 1940 and 31 May 2019. Indications, techniques, results, and complications were registered. The statistical analysis was based on means, standard deviations, medians, mode, and interquartile ranges for quantitative variables, and frequencies and percentages for categories. Results: The qualitative synthesis was made on the basis of 53 articles that reported the treatment of a total of 1216 patients. The most frequent indication for PPP was a large incisional hernia with loss of domain. The most common technique employed a spinal needle or multipurpose catheter by the anatomical method in the left hypochondrium. In spite of the heterogeneity of the data and the management of different volumes of air and daily insufflations, 99.6% of visceral reintroduction and 86% of primary fascial closure was achieved. Complications had an incidence of 12%, mostly minor, and there were five mortalities. Conclusion: Preoperative progressive pneumoperitoneum (PPP) is a beneficial and safe technique to use in preparing patients with large hernias, but the procedure is not free of complications. The technique has evolved through the years and, although many variations exist, it is possible to establish an algorithm for its application.
Domestication of horses fundamentally transformed long-range mobility and warfare¹. However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling2–4 at Botai, Central Asia around 3500 bc³. Other longstanding candidate regions for horse domestication, such as Iberia⁵ and Anatolia⁶, have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 bc, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association⁷ between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 bc8,9 driving the spread of Indo-European languages¹⁰. This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium bc Sintashta culture11,12.
Two of the most studied graph labelings are the types of harmonious and graceful. A harmonious labeling of a graph of size m and order n, is an injective assignment of nonnegative integers smaller than m, such that the weights of the edges, which are defined as the sum of the labels of the end-vertices, are distinct consecutive integers after reducing modulo m. When n = m + 1, exactly two vertices of the graph have the same label. An α-labeling of a tree of size m is a bijective assignment of nonnegative integers, not larger than m, such that the labels on one stable set are smaller than the labels on the other stable set, and the weights of the edges, which are defined as the absolute difference of the labels of the end-vertices, are all distinct; this is the most restrictive type of graceful labeling. Even when these labelings are significantly different in their definitions of the weight, for certain kinds of graphs, there is a deep connection between harmonious and α-labelings. We present new families of harmoniously labeled graphs built on α-labeled trees. Among these new results there are three families of trees, the kth power of the path Pn, the join of a graph G and tK1 where G is a graph that admits a more restrictive type of harmonious labeling and its order is different of its size by at most one unit. We also prove the existence of two families of disconnected harmonius graphs: Kn, m ∪ K1, m − 1 and G ∪ T, where G is a unicyclic graph and T is a tree built with α-trees. In addition, we show that almost all trees admit a harmonious labeling.
A series of experiments is described which were conducted to measure the absolute spectral irradiances of laser plasmas created from metal targets over the wavelength region of 123–164 nm by two separate 1.0 μm lasers, i.e., using 100 Hz, 10 ns, 2–20 kHz, 60–100 ns full-width-at-half-maximum pulses. A maximum radiation conversion efficiency of ≈ 3%/2πsr is measured over a wavelength region from ≈ 125 to 160 nm. A developed collisional-radiative solver and radiation-hydrodynamics simulations in comparison to the spectra detected by the Seya–Namioka-type monochromator reveal the strong broadband experimental radiations which mainly originate from bound–bound transitions of low-ionized charges superimposed on a strong continuum from a dense plasma with an electron temperature of less than 10 eV.
Objective: Physical education (PE) courses may provide young adults with opportunities to become active, however, enrollment in college PE courses remains low. Participants: This study examined psychosocial factors related to PE enrollment in a sample of 177 college students (29.4% completed a PE course). Methods: Participants completed an online survey that inquired about demographic information, college PE enrollment, exercise self-efficacy, and several open-ended questions regarding their enrollment decisions. Results: There were no differences in self-efficacy scores between PE completers and non-completers. PE completers had more positive previous experiences with PE (43.7% vs 19.3%, p < .01) while non-completers had more negative PE experiences (33% vs 12.5%, p = .03). PE completers felt that self-improvement (51.5% vs 21.3%, p < .01) was most important regarding decisions to enroll in a PE course, while non-completers were concerned with PE courses counting toward their degree (29.2% vs 9.1%, p = .02). Conclusions: These findings can help inform those involved in teaching and administration of PE courses at the state college level. Future research should further investigate how past PE experiences shape students' feelings toward PE.
A direct sp3 C-H amination of cyclic amines (dihydroquinoxalinones and dihydrobenzoxazinones) with dialkyl azo dicarboxylates accelerated by visible-light irradiation under metal and photocatalyst-free conditions is described. This protocol features very mild reaction conditions for the synthesis of aminal quinoxaline and benzoxazine derivatives with good to high yields (up to 99%). These aminal derivatives respresent versatile building blocks for the divergent synthesis of quinoxalin-2-one derivatives.
Three Hofmann-like metal-organic frameworks {Fe(bpac)[Pt(CN)4]}·G (bpac = 1,2-bis(4-pyridyl)acetylene) were synthesized with photoisomerizable guest molecules (G = trans-azobenzene, trans-stilbene or cis-stilbene) and were characterized by elemental analysis, thermogravimetry and powder X-ray diffraction. The insertion of guest molecules and their conformation were inferred from Raman and FTIR spectra and from single-crystal X-ray diffraction and confronted with computational simulation. The magnetic and photomagnetic behaviors of the framework are significantly altered by the different guest molecules and different conformations. On the other hand, photoisomerization of the guest molecules becomes strongly hindered by the framework.
In this work, a bioactive persimmon extract was produced from discarded fruits. A central composite design was used to evaluate the effect of different extraction parameters and ripeness stages of persimmon fruits on the total phenolic content and antioxidant activity of the resulting extracts. Significantly greater phenolic contents were obtained from immature persimmon (IP) fruits. The optimum IP extract with the conditions set by the experimental design was industrially up-scaled and its composition and functional properties were evaluated and compared with those obtained under lab-scale conditions. Both extracts contained significant protein (>20%) and phenolic contents (∼11-27 mg GA/g dry extract) and displayed significant antiviral activity against murine norovirus and hepatitis A virus. Moreover, the extract showed no toxicity and significantly reduced the fat content and the cellular ageing of Caenorhabditis elegans (C. elegans) without affecting the worm development. These effects were mediated by down-regulation of fat-7, suggesting an anti-lipogenic activity of this extract.
We present a robust, fresh-frozen approach to immunohistochemistry (IHC), without committing the tissue to IHC via fixation and cryopreservation while maintaining long-term storage, using LiCor-based infrared (IR) quantification for sensitive assessment of TH in immunoreacted midbrain sections for quantitative comparison across studies. In fresh-frozen tissue stored up to 1 year prior to IHC reaction, we found our method to be highly sensitive to rotenone treatment in 3-month-old Sprague-Dawley rats, and correlated with a significant decline in rotarod latency-to-fall measurement by approximately 2.5 fold. The measured midbrain region revealed a 31 % lower TH signal when compared to control (p < 0.01 by t test, n = 5). Bivariate analysis of integrated TH counts versus rotarod latency-to-fall indicates a positive slope and modest but significant correlation of R² = 0.68 (p < 0.05, n = 10). These results indicate this rapid, instrument-based quantification method by IR detection successfully quantifies TH levels in rat brain tissue, while taking only 5 days from euthanasia to data output. This approach also allows for the identification of multiple targets by IHC with the simultaneous performance of downstream molecular analysis within the same animal tissue, allowing for the use of fewer animals per study.
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Maria Puerta Riera
  • Department of Political Science
Bijay Shrestha
  • east college
Marie Trone
  • Department of Physical Sciences
Orlando, United States