University of Oslo

Purpose To investigate the influence of a micro-enema on diagnostic performance, submucosal width, reader confidence, and tumor conspicuity using MRI to stage early rectal cancers (ERC). Methods In this single-center study, we consecutively included 50 participants with assumed ERC who all completed MRI with (MRin) and without (MRex) a micro-enema. The diagnostic performance was recorded for two experienced radiologists using histopathology as the gold standard. In addition, the width of the submucosa in the tumor-bearing wall, reader confidence for T-staging, and tumor conspicuity were assessed. Significance levels were calculated using McNemar’s test (diagnostic performance) and Wilcoxon’s signed-rank test (reader confidence, submucosal width, and conspicuity). Interreader agreement was assessed using kappa statistics. Results Sensitivity/specificity were for Reader1 91%/87% for both MRex and MRin and for Reader2 74%/87% and 89%/87%, both readers p > 0.05. The micro-enema induced a significant widening of the submucosa, p < 0.001, with a mean increase of 2.2/2.8 mm measured by Reader1/Reader2. Reader confidence in T-staging and tumor conspicuity increased for both readers, p < 0.005. The proportion of tumors with both correct staging and high reader confidence increased from 58% (29/50) to 80% (40/50) (p = 0.04) for Reader1 and from 42% (21/50) to 72% (36/50) (p = 0.002) for Reader2. Interreader agreement increased from moderate (kappa 0.58) to good (kappa 0.68). Conclusion The micro-enema significantly increased the submucosal width in the tumor-bearing wall, reader confidence, and tumor conspicuity and improved interreader agreement from moderate to good. Sensitivity and specificity in T-staging did not improve, but there was a significant increase in the proportion of tumors staged with both high confidence and correct T-stage. Graphical Abstract

Many patients with chronic thromboembolic pulmonary disease (CTEPD) suffer from exertional dyspnea. It is unclear if CTEPD is associated with exercise pulmonary hypertension (ePH). This cross‐sectional study aimed to determine the occurrence of ePH in patients with CTEPD and to identify the haemodynamic changes during exercise. We recruited 36 patients with persistent dyspnoea and residual perfusion defects by ventilation/perfusion scintigraphy from a large cohort of patients with previous pulmonary embolism. All patients underwent exercise right heart catheterization before being classified into the following groups: (1) CTEPD without ePH; comprising patients with normal mean pulmonary artery pressure (mPAP) of ≤20 mmHg, but with mPAP/cardiac output (CO) slope of ≤3 mmHg/L/min, (2) CTEPD with ePH (CTEPD‐ePH); those with CTEPD with an mPAP/CO slope of >3 mmHg/L/min, (3) chronic thromboembolic pulmonary hypertension (CTEPH); those with mPAP >20 mmHg, pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg and pulmonary vascular resistance >2 WU. The postcapillary contribution during exercise was considered present if the PAWP/CO slope of >2 mmHg/L/min. CTEPD without resting pulmonary hypertension (PH) was present in 29 (81%) of the 36 patients, of whom six (21%) had ePH, while five (14%) had CTEPH. Two patients had unclassified PH. Two (33%) of the six patients with CTEPD‐ePH had a PAWP/CO slope of >2 mmHg/L/min, compared with two (40%) of the five of those with CTEPH. In conclusion, about 20% of patients with CTEPD and exertional dyspnoea had ePH. Exercise right heart catheterization revealed a notable proportion of patients with postcapillary contribution.

Industrial policy has regained political attention due to the challenges associated with global market integration, technological changes, and the need for sustainable transformation. However, the lack of a consistent understanding of industrial policy hampers systematic comparisons. This paper develops a novel concept of industrial policy portfolios that captures different dimensions of industrial policy outputs across countries and over time. We illustrate this approach by comparing the policy dynamics in the United States and Germany over the last four decades and show that despite similar dynamics of policy growth, the countries display pronounced variation in the areas and instruments they prioritized.

Trust in science is crucial to resolving societal problems. Americans across political ideologies have high levels of trust in science—a stable pattern observed over the past 50 years. Yet, trust in science varies by individual and group characteristics and faces several threats, from political actors, increased political polarization, or global crises. We revisit historical trends of trust in science among Americans by political orientation. We find steadily diverging trends by political views since the 1990s, and a drastically and rapidly opening gap since 2018. Recent unprecedented changes are driven not only by decreases in trust among conservatives but also by increases among liberals. Existing theoretical accounts do not fully explain these patterns. Diverging attitudes toward the institution of science can diminish capacity for collective problem-solving, eroding the shared foundation for decision-making and political discourse.

Associations between arithmetic and reading skills suggest that these important abilities may rely, at least in part, on shared neurocognitive processes. It has been argued that retrieval of arithmetic facts may rely on phonological processing; however, very few studies have explored this association using neural indices and whether it manifests similarly in children and adults. Here we examined event related potentials (ERPs) as an indirect neural correlate of arithmetic fact retrieval, and whether variability in ERP modulation is associated with individual differences in phonological processing (verbal working memory, rate of access, and phonological awareness). Arithmetic processing was examined in two samples with different levels of arithmetic expertise: (1) young adults (n = 24; Mage = 21.8 years); and (2) children (n = 25; Mage = 11.2 years). Participants were presented with simple multiplication equations that were correct or incorrect. Significant modulations of the ERPs by correctness were found at posterior electrodes in both samples, however, in different components. In adults a modulation of the P300 was observed, while for children the N400 response was modulated. For both children and adults, the size of the ERP modulation in posterior electrodes was associated with individual differences in verbal working memory. These results highlight an important distinction between behavioral outcomes and their underlying neurocognitive mechanisms. Additionally, they provide insight into how arithmetic processing evolves over the course of development.

In this study, we developed and characterised enhanced chitosan/polyethylene oxide (PEO) nanofibre scaffolds using solution blow spinning (SBS) for potential application in skin tissue engineering. SBS enabled the efficient and scalable production of fibre matrices with precise morphology control, facilitating the integration of PEO to improve spinnability, 100X the speed of electron spinning. Following fabrication, fibres were subjected to potassium carbonate neutralisation to reduce PEO content, improving chitosan stability in aqueous environments. Characterisation by scanning electron microscopy (SEM) and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) confirmed structural integrity post-neutralisation and the successful incorporation with bioactive additives. Platelet lysate (PL) was incorporated to introduce growth factors, and tannic acid (TA) was added for antibacterial properties and enhanced mechanical stability through potential crosslinking. Mechanical testing showed that the optimised PL- and TA-enriched scaffolds exhibited the highest mechanical performance, with Young’s modulus of 7.0 ± 0.6 MPa, an ultimate tensile strength of 26.4 ± 2.3 MPa, elongation at break of 16.5 ± 1.7%, and toughness of 3.0 ± 0.3 MJ m⁻³ which is within the range of human skin. At the same time, SEM and ATR-FTIR analyses confirmed the stability and distribution of these functional agents within the fibre network. Biocompatibility tests with normal human dermal fibroblasts (NHDF) indicated low cytotoxicity, appropriate cell adhesion and proliferation over 14 days in culture, suggesting these scaffolds as promising candidates for wound healing and skin regeneration applications.

This book chapter discusses Maori thinking and concepts such as Ubuntu, Vasudhaiva Kutumbakam, and Chikyu Minzokushugi. The book chapter examines the Ubuntu paradigm in Education. What was education like before colonialism? I shall go on to discuss the language situation both in Africa and in India. How have the European missionaries influenced the writing of African languages? It examines a recent Norwegian discussion on the role of universities. It deals with the question, who should decide on what to study and what to do research on? The universities should fight against the alienated scientists, the scientists who do not evaluate technology in terms of its effects on humans and the environment. The chapter is built on an invited talk given by Prof. Brock-Utne as an expert speaker at the conference of University Leaders of G20 countries at the Symbiosis International University Campus, Lavale, Pune, India on 19th–21st of June 2023.

Objective This study explores the NodeIdentifyR algorithm (NIRA) as a novel network analysis method for examining Antisocial Personality Disorder (ASPD) traits. Methods Using a sample of 2230 Brazilian adults (aged 18–73 years) who responded to ASPD‐related factors of the Personality Inventory for DSM‐5 (PID‐5), we applied NIRA to an ASPD network and compared its results with traditional network analysis methods. Results Our findings revealed that deceitfulness emerged as the most central trait across both methodologies. NIRA provided additional insights, indicating that simulated decreases in the likelihood of irresponsibility reduced the presence of other traits, while a simulated increase in deceitfulness amplified the likelihood of other ASPD pathological traits. Conclusions Our results suggest that traditional network centrality measures converge with NIRA's simulated increase results, but NIRA's simulated decrease provides additional information not captured by traditional centrality estimates. We recommend further research to validate these findings across different psychopathologies and refine NIRA use in clinical settings. The insights from this study could serve as a foundation for developing targeted interventions and enhancing our understanding of ASPD trait dynamics.

Rationale The prevalence of newborns exposed to medications for opioid use disorder (MOUD), such as methadone or buprenorphine, during pregnancy is increasing. The opioid system plays a crucial role in regulating and shaping social behavior, and children prenatally exposed to opioids face an increased risk of developing behavioral problems. However, the impact of prenatal exposure to MOUD on offspring’s social behavior during adolescence and adulthood, as well as potential intergenerational effects, remains largely unexplored. Objectives Our study employed a translationally relevant animal model to investigate how maternal (F0) exposure to MOUD during pregnancy affects social behavior in young and adult rats across the first (F1) and second (F2) generation of offspring. Methods Female Sprague–Dawley rats were implanted with an osmotic minipump delivering methadone (10 mg/kg/day), buprenorphine (1 mg/kg/day), or sterile water, prior to mating with drug-naïve males. Adult F1 females were mated with treatment-matched F1 males to generate F2 offspring. We assessed social play behavior in juvenile offspring, and social interaction behavior in a three-chamber social interaction test in young adults of the F1 and F2 generations. Results Maternal exposure to buprenorphine, but not methadone, during pregnancy reduced social play behavior in both F1 and F2 offspring, expressed by a reduced number of pounces and pins, which are the two most characteristic parameters of social play in rats. Adult social interactions were unaffected by prenatal MOUD exposure across both generations. Conclusions Maternal exposure to buprenorphine during pregnancy may have adverse effects on social play behavior across two generations of offspring.

Background Despite demands to make higher education more relevant beyond academia, and a growing body of work testifying to the benefits of work-relevance programs (e.g., work-placements, or internships) for both students and the companies that host them, there is limited information available for those aiming to optimize these programs. For example, few have explored the challenges and needs of internship supervisors. Here, we focus on the experiences of supervisors in biology and geology programs across three Norwegian institutions. Specifically, through a series of focus groups, we asked internship supervisors about their motivations for serving as student mentors, any challenges they had faced, and what higher-education institutions could do to better prepare them for hosting students at their workplaces. Results Key challenges faced by supervisors include the need to tailor placements to individual student needs and capabilities, navigating the constraints imposed by academic structures, and addressing communication gaps between students, institutions, and workplace supervisors. Internship supervisors suggest enhancing communication strategies to better define roles and expectations, increasing support and training for supervisors, and establishing clearer, more collaborative frameworks for setting learning objectives with students. Conclusions The supervisors’ suggestions aim to ensure that internships are mutually beneficial, supporting both students' educational outcomes and the workplace needs. By focusing on the supervisor's perspective, we provide valuable insights into one aspect of implementing effective and rewarding internships (i.e., supervisor preparation), thereby suggesting pathways for future improvements in these high-impact educational practices.

Purpose To explore health literacy (HL) among parents of children with Hirschsprung disease (HD). Methods Norwegian-speaking parents of children under 16 who underwent HD surgery at a tertiary center were surveyed using the Health Literacy Questionnaire-Parent, electronic Health Literacy Scale, General Self-efficacy Scale, and a study-specific questionnaire. Demographics were collected and ethical approval was obtained. Results Among 132 parents (77 mothers) of 91 children (median age 8 years), high HL scores appeared in the domains “understanding health information” and “active engagement”, with lower scores in “provider support”, “health information appraisal”, and “social support”. Higher HL correlated with parents aged over 40 and higher education. Lower scores were seen with non-exclusive Norwegian use at home and not living with the child’s other parent. High electronic HL scores were common (mean 3.6, maximum score 5). 69% had high self-efficacy scores (score > 2, maximum score 4). Self-efficacy correlated strongly with higher HL scores. Conclusion Parents of children with HD feel healthcare providers lack understanding of their child’s challenges, experience limited social support and struggle with interpreting health information. We suggest targeted HL interventions for young, lower-educated, non-cohabitating parents and those not primarily speaking the official language at home. Graphical abstract

Existing scales mainly focus on danger-based threats of death and bodily harm to assess exposure to traumatic events in war zone. However, major provocations and transgression of deeply held values and moral beliefs, as well as witnessing the suffering of others can be as traumatic as fear-inducing danger-based events. This raises the need for scales that assess both danger and nondanger-based events among soldiers operating in modern war zones. Norwegian military personnel deployed to Afghanistan between late 2001 and end of 2020 were invited to participate in a cross-sectional survey with a final sample size of 6,205 (males: n = 5,693; 91.7%; mean age = 41.93 years). We applied data reduction techniques (e.g., exploratory factor analysis, EFA, and exploratory graph analysis, EGA, through a community detection algorithm) to develop a 12-item, three-factor model (personal threat, traumatic witnessing, and moral injury) of the Warzone Stressor Exposure Index (WarZEI). Confirmatory factor analysis showed support for the factor model, with evidence of concurrent, discriminant, and incremental validity. These results indicate the WarZEI is a reliable and valid measure for assessing exposure to warzone stressors that allows for heterogeneity and the multidimensional nature of exposure to warzone stressors.

Recently intermittent negative pressure has emerged as a potential treatment in vascular disease and has similarities with established experimental interventions such as lower body negative pressure. The direct, local influences of either method upon intravascular pressure still require some clarification however, particularly in the immediate moments following onset. We investigated the acute intravascular pressure responses to intermittent cycles of negative pressure in the supine and sitting postures. Fifteen participants (6 female) received intermittent negative pressure cycles (-37 mmHg; 9.5-sec on, 7.5-sec off) upon the lower leg in both postures. Saphenous venous (n = 15), and dorsalis pedis artery pressure (n = 3) were recorded via pressure catheter, alongside beat-by-beat systemic cardiovascular parameters (heart rate and blood pressure; n = 15), from which the arteriovenous pressure gradient was ultimately derived. Negative pressure induced a transient reduction in local intravenous pressure (Supine: 14±3 mmHg to -18±6 mmHg, p<0.001; Sitting: 58±10 mmHg to 41±10 mmHg, p<0.001). Rate of venous pressure recovery during the negative pressure plateau phase was faster during sitting, than supine (1.94±0.72 vs. 1.06±0.69 mmHg·sec⁻¹; p = 0.002). Local intraarterial pressure did not change. External negative pressure readily transmits to the superficial intravenous environment of the leg and transiently augments the arteriovenous pressure gradient. The greatest and most sustained effect was during the supine position. The augmented arteriovenous gradient might briefly produce Poiseuille-dependent haemodynamics before local autoregulatory mechanisms engage. These findings benefit understanding of the immediate in-vivo effects of negative pressure upon the local vasculature, and may partly account for the positive clinical effects of intermittent negative pressure treatments in vascular disease.

Small‐angle X‐ray/neutron scattering (SAXS/SANS) techniques provide valuable nanostructural information of self‐assembling molecules. However, extracting the information from these experiments can be a challenging task, usually relying on predetermined assumptions. Conventional models for surfactant micelles consider a core–shell structure with a hydrophobic tail encapsulated by the hydrophilic part. This approach is successful in many cases but can fail even for common surfactants such as Triton X‐100 (TX‐100). SAXS and SANS combined with Metainference molecular simulations are employed to investigate TX‐100 assemblies, showing how more complex models, with diffuse core–shell boundaries, multilayering, and polydispersity, are needed to explain the aggregation. This is the first time that Metainference is employed with SAXS and SANS simultaneously to obtain the structural ensemble of assemblies. Compared to regular micelles formed by chemically similar C12EO10 molecules, the role of the hydrophobic core in micellization is discussed, finding that the relatively shorter and less hydrophobic tail of TX‐100 favors polymorphism.

Background In the CONPET study, multiple myeloma patients with abnormal 18FDG positron emission/computed tomography scan after upfront autologous stem cell transplantation were treated with four cycles of carfilzomib–lenalidomide–dexamethasone (KRd). Side effect registrations show that carfilzomib might cause dyspnea, cough, respiratory tract infections, and heart failure. The aims were to investigate patient‐reported shortness of breath and dyspnea during KRd consolidation. Methods To assess shortness of breath, patients completed the Functional Assessment of Cancer Therapy—Pulmonary Symptom Index (FACT‐PSI) and the EORTC QLQ‐C30 to assess dyspnea. Shortness of breath was defined as decrease in FACT‐PSI score or starting/increasing diuretic drugs. Mixed effect logistic regression was used for the effect analysis. Linear mixed model and clinical relevance were used to investigate dyspnea. Results A total of 50 patients were included, median age 62 years (interquartile range 54–67). 17% reported shortness of breath at Day 15 Cycles 1–4 versus 11% at Day 1 Cycles 2–4, Cycle 4 Day 29, and 1 month posttreatment (p‐value 0.048). Compared with baseline, patients reported significant, and clinically relevant worsening in dyspnea during consolidation. Conclusion Our study confirmed earlier findings of carfilzomib causing shortness of breath during KRd administration and revealed dyspnea during consolidation compared to baseline. Trial Registration Clinicaltrials.gov: NCT03314636, EudraCT: 2017–000586‐72

Objectives Videofluoroscopic swallowing studies (VFSS) remain the gold standard for the instrumental assessment of oropharyngeal swallowing disorders alongside flexible endoscopic evaluation of swallowing (FEES), requiring a high standard of quality and correct implementation. The current best practice position statements aim to guide the clinical practice of VFSS in individuals experiencing swallowing disorders. Materials and methods An international expert consensus panel with expertise in oropharyngeal dysphagia, comprised of radiologists, speech-language therapists, otolaryngologists, and other professionals in the field, convened by the European Society of Swallowing Disorders (ESSD) and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR), developed best practice position statements. They were established using an online Delphi methodology involving an online panel discussion and item preparation and three consecutive rounds. Consensus was reached when ≥ 80% of the participants agreed on a specific recommendation. Results Eighteen best practice position statements were formulated, thereby establishing standard recommendations on the technical performance of VFSS. They cover VFSS planning, correct implementation, documentation, radiation protection, equipment and maintenance, and education and training. Conclusion These position statements summarise the panel’s deliberations and recommendations in performing VFSS, representing the agreed consensus of experts from ESSD and ESGAR. They provide a structured framework for optimising and standardising the performance of VFSS in patients with swallowing disorders. Key Points Question Significant regional and national differences in clinical practice when performing VFSS highlight the need for interdisciplinary recommendations to optimise patient care . Findings Eighteen statements were developed by representatives of the ESSD and the ESGAR . Clinical relevance These best practice position statements on the technical performance of VFSS may serve as a basis for standardising the procedure and ensuring high-quality service .

In a world shaped by global crises—from pandemics to international armed conflicts to an escalating climate crisis—research into human reactions to and coping with uncertainty is becoming increasingly important. The fundamental role of identification with social groups in maintaining well‐being during times of threat has been emphasized. In this context, the aim of this study was to examine the relationship between interindividual differences— need to belong, perspective taking, need for cognitive closure—and changes in social identification. To test our hypotheses, we conducted a two‐wave online study with a sample of 1008 participants during the COVID‐19 pandemic. We examined changes in social identification in narrow social groups (i.e., family, friends, neighbors) and broader social categories (i.e., own country, Europe, humanity). We found an overall increase in social identification in times of crises across all groups. The results show that need to belong (at Time 1) was positively related to increases in social identification (at Time 2) for all groups, while the positive association between perspective taking (at Time 1) and increases in social identification (at Time 2) was observed for almost all groups except neighbors. Contrary to our expectations, however, the need for cognitive closure (at Time 1) showed no association with changes in identification with any social group (at Time 2). These findings emphasize the importance of interindividual differences for our understanding of changes in social identification over time.