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    ABSTRACT: To correlate the prevalence of TORCH (Toxoplasma gondii, Rubella, Cytomegalovirus and Herpes simplex) infections with incidence of abortion in pregnant women in the Malabar area of Kerala, in order to establish basic knowledge for future pregnancy care. Patients attending the Institute of Maternity and Child Health, Calicut Medical College, Kerala were subjected for the study. Seventy one miscarriage cases and thirty normal pregnant women were studied through their medical, clinical, and serological data. Results were analyzed using person's chi-square test. This study showed that general population of Malabar area has an infection susceptibility of 32.3% to Toxoplasma gondii, 9.6% to Rubella, 3.2% to CMV (Cytomegalovirus) and 61.3% to HSV (Herpes simplex virus) infections. This was revealed through the estimation of TORCH specific IgG. IgM specific to TORCH agents was also studied in abortion cases and was observed as T. gondii-50.7% (p<0.03), Rubella-11.3% (p<0.597), CMV-28.2% (p<0.231) and HSV-59.2% (p<0.022). When 40.8% of the miscarriage cases were showing IgM specific to one or the other TORCH agents, only 20% of the control cases possessed IgM to TORCH agents. Cross infections with more than one of the TORCH agents was observed and 5.6% of the aborted mothers were infected with all the four pathogens. The significant role of T. gondii and HSV infection on spontaneous abortion, compared to CMV and Rubella, is provided here. The increased susceptibility of the general population of Malabar to these two pathogens, substantiates this observation further. Various abortion categories are also influenced by these pathogens differently. We also observed cross infections with two or more of the pathogens in the TORCH group, with a statistical significance of p<0.003.
    Full-text · Article · Apr 2008 · African journal of microbiology research
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    ABSTRACT: Stress has negative effect on health and type 2 diabetes patients may be at an increased risk. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can increase lipid peroxidation and insulin resistance. The objective of the present study was to demonstrate the efficacy of yogic practice in geriatric patients with type 2 diabetes mellitus and also to compare the efficacy with the state of glycaemic control. Seventy three (73) healthy elderly patients of type 2 diabetes mellitus in the age group of 60 to 70 years with a history of diabetes for 5 to 10 years and with poor glycaemic control (HbA(1c) >8 %) residing in Kozhikode district were recruited for the study. The subjects were divided into three groups according to their glycaemic control. Group I with HbA(1c) 8.6-9.7 %, group II with HbA(1c) 9.8-10.7 % and group III with HbA(1c) 10.8-12.7 %. Participants did yogic practice under the supervision of experienced trainer, daily 90 minutes and for three months. Biochemical estimation of HbA(1c), glucose, lipid profile, cortisol, ferritin, malondialdehyde (MDA) and catalase activity were carried out on 0 day and 90(th) day. Seventy patients participated in a comparable control session. The participants in the test group showed statistically significant (P < 0.001) decrease in glucose, HbA(1c), lipids, cortisol, ferritin, MDA and significant increase in catalase activity after yogic practice. Yoga may improve risk profiles induced by stress in geriatric patients with type 2 diabetes and may have promise for the prevention or delay in diabetes complications. And at all stages of the disease a significant improvement can be achieved by yogic practice in geriatric diabetes.
    Full-text · Article · Mar 2013 · International Journal of Yoga
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    ABSTRACT: The objective of this study was to identify the presence of non-alcoholic fatty liver disease (NAFLD) in patients with coronary artery disease (CAD). 149 patients were selected, who had been referred to the Institute of Cardiology, Banglore, India, between January 2007 and June 2009 and diagnosed with CAD. Four patients did not participate in the study. Venous blood samples were taken from these cases, and agematched healthy controls who came for a master health check-up (N = 100). All were subjected to routine liver function tests including serum transaminases, enzyme immunoassays for plasminogen activator inhibitor I (PAI-I), C reactive protein (CRP), and tumour necrosis factor-alpha (TNF-α). Using ultrasonography and serum alanine aminotransferase (ALT) levels, the presence of NAFLD in CAD patients was reported. CAD patients with NAFLD had significantly higher liver enzymes and marginally higher A1C levels compared to control subjects. Levels of TNF-α and PAI-I were higher in CAD patients with NAFLD compared to both female and male controls (P <0.1 and P <0.05). Levels of CRP (P <0.01 in both groups) and uric acid were increased in both group of patients (P <0.05 and P <0.01 in male and female patients, respectively). Levels of adiponectin were significantly reduced in the patients compared to the controls (P <0.05 and P <0.001) in male and female patients respectively. The increased serum levels of PAI-I and TNF-α reflected the proinflammatory status in these CAD patients which may be due to the presence of NAFLD. This could contribute additively to the development of cardiovascular events (CVD).
    Full-text · Article · Aug 2010 · Sultan Qaboos University medical journal
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African journal of microbiology research 04/2008; 2(3):56-59.
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Proceedings of the International Conference on Biodiversity and Evaluation: Perspectives and Paradigm shifts. Organized by Sree Sankara College, Kalady in association with the depa...
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