University of Tours
  • Tours, France
Recent publications
A growing number of studies show that anthropization can alter the behaviour, survival, physiology, cognition and reproduction of many animal species. However, its impact on parental care, a common behaviour where even subtle changes can have dramatic effects on the viability of future generations and thereby jeopardize population dynamics, remains surprisingly unclear. Here, we studied the effects of exposure to cadmium, a highly toxic chemical pollutant widely distributed in the trophic chain, on egg production and maternal egg care in the European earwig, Forficula auricularia. We fed 200 females with food containing cadmium at five different concentrations for several weeks, and then quantified the number of eggs produced, the expression of six forms of egg care and three forms of noncare behaviours, as well as maternal survival and egg development. In contrast to most results reported in other animal species, we found no evidence that ingestion of even substantial doses of cadmium affects egg production or maternal egg care in the form of grooming, antennation, displacement, gathering, defence or retrieval. Moreover, it neither affected maternal exploration, inactivity or self-grooming behaviours, nor egg development time, hatching rate or juvenile weight. Overall, these results reveal that egg care is resilient to environmental cadmium pollution in earwigs and suggest that females possess efficient and fast-acting physiological processes that help them reduce their sensitivity to heavy metal contamination. More generally, our findings may suggest that selection pressures associated with the necessity to express egg care has directly or indirectly selected for higher resistance/tolerance against certain chemical pollution, and thus that species with parental care could be more resilient in the face of increasing levels of anthropogenic pollution.
This article aims to explain how innovations in urban governance contribute to economic resilience of post-socialist regional metropoles, by retracing the path development process of the local governance systems in two Romanian cities - Timișoara and Cluj-Napoca. Firstly, the paper brings analytical cross-fertilization between urban governance studies and the emerging field of path development, by proposing a combined framework based on four dimensions: structural features, actors, timing and spatiality of resources employed in the process of governance innovation. Secondly, it contributes to the path development literature with evidences from post-socialist regional metropoles, defined by a mix of central and peripheral attributes and therefore constituting a new category of spaces which has not been approached by this strand of literature to date. The methodology includes a comparative case study protocol based on the process tracing method, according to the proposed analytical framework and applied on various sources (interviews, planning documents, reports, newspaper articles). The results reveal an important role of structural inherited features in driving governance innovations, while the public actors and the external resources complement the process in different degrees. However, these tendencies diminish across time, as new actors and roles appear in the city landscape and new challenges arise.
Background: Identification of underlying diseases is crucial for secondary hyperhidrosis management, but data are lacking to guide appropriate investigation. Objective: To describe aetiologies of recurrent sweating in a hospital setting and the diagnostic performance parameters of their respective clinical/biological features. Patients and Methods: We performed a monocentric evaluative study in a tertiary care centre. Patients with recurrent generalised sweating were selected via the Clinical Data Warehouse (CDW) by screening all electronic hospital documents from the year 2018 using a keyword-based algorithm. All in and out-patients aged ≥ 18 years having reported recurrent sweating for at least 2 weeks in 2018 were included, with a minimum one-year follow-up after symptoms’ onset. Results: A total of 420 patients were included. Over 130 different aetiologies were identified; 70 patients (16.7%) remained without diagnosis. Solid organ cancers (14.3% with 13 lung cancers), haematologic malignancies (14.0% with 35 non-Hodgkin’s lymphomas) and Infectious Diseases (10.5% including 13 tuberculosis) were the most frequent diagnoses. Other aetiologies were gathered into inflammatory (16.9%) and non-inflammatory (27.6%) conditions. To distinguish non-inflammatory and undiagnosed hyperhidrosis from other causes, fever had a specificity of 94%, impaired general condition a sensitivity of 78%, and C-reactive protein (CRP) > 5.6 mg/l a positive predictive value of 0.86. Symptoms’ duration over 1 year was in favour of non-infectious and non-malignant causes (94% specificity). Conclusions: We identified fever, impaired general condition, duration, and CRP as helpful orientation parameters to assess the need for complementary explorations for hyperhidrosis. The study provides a diagnostic algorithm for the investigation of recurrent sweating. • KEY MESSAGES • In a hospital setting, malignancies and infections are the most frequently associated diseases, but 1/5 remain without diagnosis. • Fever is a specific but not sensitive sign to distinguish inflammatory conditions. • Over 1 year duration of symptoms significantly reduce the probability of malignancy or infection as the underlying diagnosis.
Background Salmonella Enteritidis (SE) is one of the major causes of human foodborne intoxication resulting from consumption of contaminated poultry products. Genetic selection of animals that are more resistant to Salmonella carriage and modulation of the gut microbiota are two promising ways to decrease individual Salmonella carriage. The aims of this study were to identify the main genetic and microbial factors that control the level of Salmonella carriage in chickens ( Gallus gallus ) under controlled experimental conditions. Two-hundred and forty animals from the White Leghorn inbred lines N and 6 1 were infected by SE at 7 days of age. After infection, animals were kept in isolators to reduce recontamination of birds by Salmonella . Caecal contents were sampled at 12 days post-infection and used for DNA extraction. Microbiota DNA was used to measure individual counts of SE by digital PCR and to determine the bacterial taxonomic composition, using a 16S rRNA gene high-throughput sequencing approach. Results Our results confirmed that the N line is more resistant to Salmonella carriage than the 6 1 line, and that intra-line variability is higher for the 6 1 line. Furthermore, the 16S analysis showed strong significant differences in microbiota taxonomic composition between the two lines. Among the 617 operational taxonomic units (OTU) observed, more than 390 were differentially abundant between the two lines. Furthermore, within the 6 1 line, we found a difference in the microbiota taxonomic composition between the high and low Salmonella carriers, with 39 differentially abundant OTU. Using metagenome functional prediction based on 16S data, several metabolic pathways that are potentially associated to microbiota taxonomic differences (e.g. short chain fatty acids pathways) were identified between high and low carriers. Conclusions Overall, our findings demonstrate that the caecal microbiota composition differs between genetic lines of chickens. This could be one of the reasons why the investigated lines differed in Salmonella carriage levels under experimental infection conditions.
Background Transition from childhood to adulthood (TCA) is usually difficult in rare, progressive and multisystemic diseases. New treatments and modalities of care for many lysosomal diseases (LD) can increase life expectancy, and a successful TCA can help patient who reach adulthood to avoid disruption to health care. In France, some TCA initiatives have been taken by referral centers but in view of the problems encountered by Vaincre les Maladies Lysosomales (VML), the LD patient association, they seem to be insufficient. The aim of this study is to determine the current state of the TCA process and to identify actions to improve it through interviews with patient families and physicians in LD referral centers. The study is based upon an observational, non-interventional, cross-sectional, national survey which used two anonymous questionnaires. These questionnaires, developed by a scientific committee including representatives from VML and medical specialists in LD, were sent to patients who were receiving care in pediatric departments at age 15 years or older. Questionnaires were also sent to their referral pediatricians. Results Fifty-four patients were included. Forty-two questionnaires were completed by patients and their corresponding physicians and 12 were completed by physicians only. The majority of the patients (80%) were informed that transfer to adult healthcare would occur, but 52% were informed after their eighteenth birthday. Forty-eight percent indicated that they were informed that a TCA coordinator would be appointed; for 39% the time frame for the transfer was communicated, and 31% were informed of the composition of the adult medical team. Among the actions that patients rated as “important/very important”, and considered to be a priority in their comments, the most frequently cited were the provision of explanatory documents on the TCA (94%), the transmission of the medical file from the pediatric sector to the adult sector (94%) and a joint consultation with both pediatrician and adult unit physician (91%). Physicians were in agreement concerning the primary importance of the last two actions. Conclusion This study provides a basis for the deployment, on the national level, of transition programs which include specific actions that patients view as priorities.
Purpose Despite the benefits of mechanical ventilation, its use in critically ill patients is associated with complications and had led to the growth of noninvasive techniques. We assessed the effect of early intubation (first 8 h after vasopressor start) in septic shock patients, as compared to non-early intubated subjects (unexposed), regarding in-hospital mortality, intensive care and hospital length of stay. Methods This study involves secondary analysis of a multicenter prospective study. To adjust for baseline differences in potential confounders, propensity score matching was carried out. In-hospital mortality was analyzed in a time-to-event fashion, while length of stay was assessed as a median difference using bootstrapping. Results A total of 735 patients (137 intubated in the first 8 h) were evaluated. Propensity score matching identified 78 pairs with similar severity and characteristics on admission. Intubation was used in all patients in the early intubation group and in 27 (35%) subjects beyond 8 h in the unexposed group. Mortality occurred in 35 (45%) and in 26 (33%) subjects in the early intubation and unexposed groups (hazard ratio 1.44 95% CI 0.86–2.39, p = 0.16). ICU and hospital length of stay were not different among groups [9 vs. 5 (95% CI 1 to 7) and 14 vs. 16 (95% CI − 7 to 8) days]. All sensitivity analyses confirmed the robustness of our findings. Conclusions An early approach to invasive mechanical ventilation did not improve outcomes in this matched cohort of patients. The limited number of patients included in these analyses out the total number included in the study may limit generalizability of these findings. Trial registration NCT02780466. Registered on May 19, 2016.
Objectif : Ce travail propose l’investigation des répercussions émotionnelles immédiates des annonces du troisième confinement en France. Afin de répondre à cet objectif, nous nous intéressons aux réactions émotionnelles exprimées sur le réseau social Twitter entre le 11 mars 2021 et le 08 avril 2021. Méthode : 481 601 tweets ont été récupérés via la bibliothèque rtweet du logiciel R. Une analyse automatisée du lexique émotionnel a été conduite en étudiant sur le contenu des tweets jours après jours. Les données ont donc été traitées selon deux approches : (i) l’une transversale et (ii) l’autre considérant longitudinalement l’aspect dynamique des émotions. Résultats : L’impact des annonces de confinement n’est pas anodin. Si des émotions positives peuvent être observées, l’impact reste majoritairement négatif et global. Sur l’ensemble de la période considérée, le mal-être est le ressenti dominant. Il s’illustre par un vécu de solitude, des sensations de tensions, de la souffrance et/ou de la frustration. Les affects dépressifs et la souffrance apparaissent également de manière prépondérante sur l’ensemble des tweets. Les analyses temporelles montrent que les émotions varient dans leur nature et dans leur diversité selon la date à laquelle les tweets ont été publiés. Les annonces de reconfinement sont ainsi principalement associées à la haine, mais n’apparaissent que de façons transitoires. Discussion : Les résultats sont discutés au regard des fonctions adaptatives que procurent des émotions. Conclusion : L'analyse des messages postés sur ce réseau social nous apporte une compréhension en temps réel des réactions émotionnelles en lien avec les annonces de reconfinement. Outre l’examen du type d’émotions mobilisées, une lecture dynamique de celles-ci a contribuera à faire émerger la signification personnelle que le confinement a pu avoir.
In this study, the effectiveness of bioaugmentation approach using zeolite supported biofilms as inoculants was evaluated in microcosm experiments. For this, selected MCPA-degrading microbial consortium was grown as biofilm on natural and Fe-modified zeolite grains (0.2–1.25 mm in size) and the obtained biocomposites (4 × 10¹⁰ cells/g of biocomposite) were amended to soil or sand microcosms (130 g biocomposites/m²; 4 × 10⁷ cells/g of dry weight soil or sand) supplemented with herbicide MCPA (2-methyl-4-chlorophenoxyacetic acid, 0.166 mg/kg dw soil or 0.309 mg/kg of dw sand, respectively). The major part of the identified bacterial sequences (51–59 %) in both biocomposites was attributed to the bacterial genera related to biodegradation of pesticides, including phenoxy-herbicides (Cupriavidus, Novosphingobium, Pseudomonas, Rhodococcus, Sphingobium, Sphingopyxis). The present study showed that the MCPA biodegradation ability of the studied biocomposites was very close to each other and characterised with similar kinetics: biodegradation of 80 % MCPA within 2 days in soil and 5 days in sand. Thus, the zeolite-supported biofilms could be effective inoculants for pesticide biodegradation at polluted agricultural sites. The biocomposites can be effectively used not only for treatment of soil but also sand, however its activity may change with variation of the matrix. Surface modifications of a given support material is an interesting approach to select different microbial communities, which can provide significant advantages according to the site to be treated.
Introduction: Several studies have shown that emotional competence (EC) impacts cancer adjustment via anxiety and depression symptoms. The objective was to test this model for the quality of life (QoL) of partners: first, the direct effect of partners' EC on their QoL, anxiety and depression symptoms after cancer diagnosis (T1), after chemotherapy (T2) and after radiotherapy (T3); Second, the indirect effects of partners' EC at T1 on their QoL at T2 and T3 through anxiety and depression symptoms. Methods: 192 partners of women with breast cancer completed a questionnaire at T1, T2 and T3 to assess their EC (PEC), anxiety and depression symptoms (HADS) and QoL (Partner-YW-BCI). Partial correlations and regression analyses were performed to test direct and indirect effects of EC on issues. Results: EC at T1 predicted fewer anxiety and depression symptoms at each time and all dimensions of QoL, except for career management and financial difficulties. EC showed different significant indirect effects (i.e. via anxiety or depression symptoms) on all sub-dimensions of QoL, except for financial difficulties, according to the step of care pathway (T2 and T3). Anxiety and depression played a different role in the psychological processes that influence QoL. Conclusion: Findings confirm the importance of taking emotional processes into account in the adjustment of partners, especially regarding their QoL and the support they may provide to patients. It, thus, seems important to integrate EC in future health models and psychosocial interventions focused on partners or caregivers.
Background A functioning vascular access (VA) is crucial to providing adequate hemodialysis (HD) and considered a critically important outcome by patients and healthcare professionals. A validated, patient-important outcome measure for VA function that can be easily measured in research and practice to harvest reliable and relevant evidence for informing patient-centered HD care is lacking. Vascular Access outcome measure for function: a vaLidation study In hemoDialysis (VALID) aims to assess the accuracy and feasibility of measuring a core outcome for VA function established by the international Standardized Outcomes in Nephrology (SONG) initiative. Methods VALID is a prospective, multi-center, multinational validation study that will assess the accuracy and feasibility of measuring VA function, defined as the need for interventions to enable and maintain the use of a VA for HD. The primary objective is to determine whether VA function can be measured accurately by clinical staff as part of routine clinical practice (Assessor 1) compared to the reference standard of documented VA procedures collected by a VA expert (Assessor 2) during a 6-month follow-up period. Secondary outcomes include feasibility and acceptability of measuring VA function and the time to, rate of, and type of VA interventions. An estimated 612 participants will be recruited from approximately 10 dialysis units of different size, type (home-, in-center and satellite), governance (private versus public), and location (rural versus urban) across Australia, Canada, Europe, and Malaysia. Validity will be measured by the sensitivity and specificity of the data acquisition process. The sensitivity corresponds to the proportion of correctly identified interventions by Assessor 1, among the interventions identified by Assessor 2 (reference standard). The feasibility of measuring VA function will be assessed by the average data collection time, data completeness, feasibility questionnaires and semi-structured interviews on key feasibility aspects with the assessors. Discussion Accuracy, acceptability, and feasibility of measuring VA function as part of routine clinical practice are required to facilitate global implementation of this core outcome across all HD trials. Global use of a standardized, patient-centered outcome measure for VA function in HD research will enhance the consistency and relevance of trial evidence to guide patient-centered care. Trial registration NCT03969225. Registered on 31st May 2019.
Background Tracheobronchopathia osteochondroplastica (TO) is a rare condition of unknown etiology. TO is characterized by submucosal nodules, with or without calcifications, protruding in the anterolateral walls of the trachea and proximal bronchi. The objective of this study was to describe TO features and associated comorbidities in a series of patients. Methods Patients suffering from TO were retrospectively included by investigators from the Groupe d’Endoscopie Thoracique et Interventionnelle Francophone (GETIF). Demographic, clinical, comorbidities, bronchoscopic, functional, and radiological characteristics, and outcomes were recorded and analyzed. Results Thirty-six patients were included (69% male with a mean of 65 ± 12 years). Chronic symptoms were described by 81% of patients including cough (74%) and dyspnea on exertion (74%). TO was associated with COPD in 19% of the cases and gastroesophageal reflux disease in 6%. A mild to severe airflow obstruction was present in 55% of the cases. CT scan showed tracheal submucosal nodules in 93% of patients and tracheal stenosis in 17%. Bronchoscopy identified TO lesions in the trachea in 65% of the cases, and 66% of them were scattered. A bronchoscopic reevaluation was performed in 7 cases, 9 ± 14 months [1–56] after initial diagnosis, and showed the stability of lesions in all cases. Three patients underwent interventional bronchoscopic treatment. Conclusion The diagnosis of TO relies on typical bronchoscopic findings and can be evoked on a CT scan. Histologic diagnosis can be useful in atypical cases for differential diagnosis. Given its low consequences in terms of symptoms, lung functions, and evolution, no treatment is usually required.
BACKGROUND Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with acute basilar occlusion due to underlying ICAD to patients with other causes of occlusion. METHODS The Trevo Registry ( Identifier: NCT02040259) was a prospective open‐label mechanical thrombectomy registry that included 2008 patients from 76 sites across 12 countries. For a secondary analysis, we selected patients with isolated acute basilar occlusion. We then classified patients into 2 groups: patients with acute basilar artery occlusion due to ICAD (ICAD group) and patients with acute basilar occlusion due to another cause (non‐ICAD group). RESULTS We identified 90 subjects with acute basilar occlusion. According to stroke mechanism, there were 9 (10.0%) patients in the ICAD group and 81 (90.0%) in the non‐ICAD group. There was a significant difference ( P =0.001) in the lesion location between the 2 groups, with 60.5% of non‐ICAD occlusions located in the distal region and no ICAD occlusions there. The 2 groups showed a significant difference ( P =0.003) for rescue therapy with balloon angioplasty, with 33.3% in the ICAD group and 1.2% in the non‐ICAD group, respectively. In a multivariable model adjusted for age, baseline National Institutes of Health Stroke Scale, and intravenous tissue‐type plasminogen activator (tPA), the odds of 90‐day death (odds ratio=4.6; P =0.10) were higher for atherosclerotic subjects. CONCLUSION Acute basilar occlusions related to ICAD showed a similar good clinical outcome (modified Rankin scale (mRS) 0–2) and a tendency for a higher rate of 90‐day mortality compared with non‐ICAD occlusions.
Background The COVID-19 pandemic has not only impacted intensive care units, but all healthcare services generally. This PsyGipo2C project specifically investigates how psychiatry and mental health professionals have been affected by the reorganizations and constraints imposed, which have reshaped their often already difficult working conditions. Methods Our research combined quantitative and qualitative methods, surveying and interviewing health professionals of all occupations working in psychiatric and mental health services. A questionnaire was completed by 1241 professionals from 10 European countries, and 13 group interviews were conducted across 5 countries. In addition to this, 31 individual interviews were conducted in Belgium and France. Results Among the questionnaire respondents, 70.2% felt that their workload had increased, particularly due to their tasks being diversified and due to increased complexity in the provision of care. 48.9% felt that finding a work-life balance had become more difficult, and 59.5% felt their health had been affected by the crisis. The impact of the health crisis nevertheless varied across professions: our data provides insight into how the health measures have had a differential impact on professional tasks and roles across the various categories of occupations, obliging professionals to make various adaptations. The distress incurred has been linked not only to these new constraints in their work, but also to the combination of these with other pressures in their personal lives, which has consequently compromised their well-being and their ability to cope with multiple demands. Discussion The COVID-19 health crisis has had varying impacts depending on the profession and access to remote work, sometimes leading to conflicts within the teams. The suffering expressed by the professionals was tied to their values and patterns of investment in work. Our research also highlights how these professionals made little use of the psychological supports offered, probably due to a reluctance to acknowledge that their mental health was affected.
Multi-model DBMSs, which support different data models with a fully integrated backend, have been shown to be beneficial to data warehouses and OLAP systems. Indeed, they can store data according to the multidimensional model and, at the same time, let each of its elements be represented through the most appropriate model. An open challenge in this context is the lack of methods for logical design. Indeed, in a multi-model context, several alternatives emerge for the logical representation of dimensions and facts. The goal of this paper is to devise a set of guidelines for the logical design of multi-model data warehouses so that the designer can achieve the best trade-off between features such as querying, storage, and ETL. To this end, for each model considered (relational, document-based, and graph-based) and for each type of multidimensional element (e.g., non-strict hierarchy) we propose some solutions and carry out a set of intra-model and inter-model comparisons. The resulting guidelines are then tested on a case study that shows all types of multidimensional elements.
Several randomized controlled trials have demonstrated the benefits of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on ischemic stroke in patients with diabetes. In this review, we summarize and discuss the potential mechanisms of stroke protection by GLP-1RAs. GLP-1RAs exert multiple anti-atherosclerotic effects contributing to stroke prevention such as enhanced plaque stability, reduced vascular smooth muscle proliferation, increased nitric oxide, and improved endothelial function. GLP-1RAs also lower the risk of stroke by reducing traditional stroke risk factors including hyperglycemia, hypertension, and dyslipidemia. Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, blood–brain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion. Despite these encouraging findings, further research is still needed to understand more thoroughly the mechanisms by which GLP-1RAs may mediate stroke protection specifically in the human diabetic brain.
Bactrocera oleae is the key pest of olive production. Several attempts have been carried out over time to control it using biological solutions but with results rarely comparable to those obtained with chemical applications. The purpose of this work was to identify and test new compounds from samples of various Smoke Waters (SWs) for their effect on the fly, and given their low impact on the environment. SWs obtained from different feedstocks were used in in vitro and open field applications. SWs were shown to alter B. oleae fitness, acting on its microbiome, particularly on the presence and activity of the primary endosymbiont “Ca. Erwinia dacicola”, and also to affect the behavior of the adult flies, altering the attractiveness of the drupes susceptible to attack. The effects recorded were concentration-dependent and varied among repulsion, up to 87% towards females, indecision, up to 70% towards males, and attraction, comparable to fresh green olives, based on the starting materials. These responses were confirmed in electroantennography trials and during two-years of field trials carried out in South and Central Italy. Gas Chromatography–Mass Spectrometry highlighted the presence of compounds such as guaiacol and hydroquinone as potentially important for the observed activity. Principal Component Analyses confirmed the proximity among SWs obtained from similar feedstocks. In controlled conditions, females appear to be more sensitive to the SW treatments. Field trials have shown how the effects of SWs can lead depression of infestation levels obtainable with other well-known compounds, such as kaolin clay and isopropyl-myristate (repulsive), or pheromones (attractive).
Background: The Schizophrenia Coping Oral Health Profile and Index (SCOOHPI) scale studies the coping strategies of schizophrenic patients with regard to oral health. The structural validity of this scale is studied has been studied using factor analyses. In this article, we study the unidimensionality of the SCOOHPI scale to use it as an index. Methods: We studied the internal consistency of the items of the SCOOHPI scale. Then, we studied the construct validity. The unidimensionality of the SCOOHPI scale was studied by the partial credit model. Results: The data used in this study come from five hospitals, and the total number of individuals participating in this study is 96, of which 72% are men and 59% are smokers. The SCOOHPI scale has good internal consistency (α = 0.84). The validity of divergence was checked by the absence of correlation between the SCOOHPI scale and the GOHAI (General Oral Health Assessment Index) scale. The unidimensionality of the SCOOHPI scale with data smoothing was demonstrated by the partial credit model. Conclusion: In this study, we completed the study of the psychometric validation of the SCOOHPI. The SCOOHPI scale can then contribute to improving evaluation of the coping strategies of schizophrenic patients with regard to oral health.
Introduction : Childhood immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by isolated thrombocytopenia. Prolonged ITP (persistent and chronic) leads to a reduced quality of life for children in many domains. To provide optimal support for children, with ITP, it is important to be able to predict those who will develop prolonged ITP. This study aimed to develop a mathematical model based on platelet recovery that allows the early prediction of prolonged ITP. Methods : In this retrospective study, we used platelet counts from the six months following the diagnosis of ITP to model the kinetics of platelet evolution using a pharmacokinetic-pharmacodynamic model. Results : In a learning set (n=103), platelet counts were satisfactorily described by our kinetic model. The K parameter, which describes spontaneous platelet recovery, allowed a distinction between acute and prolonged ITP with an AUC of 0.74. In a validation set (n=58), spontaneous platelet recovery was robustly predicted using platelet counts from 15 (AUC=0.76) or 30 (AUC=0.82) days after ITP diagnosis. Discussion : In our model, platelet recovery quantified using the k parameter allowed prediction of the clinical course of ITP. Future prospective studies are needed to improve the predictivity of this model, in particular, by combining it with the predictive scores previously reported in the literature.
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4,688 members
Guylaine Poulin-Vittrant
  • UMR CNRS 7347 Matériaux, microélectronique, acoustique, nanotechnologies (GREMAN)
Fouquereau Evelyne
  • Département de psychologie
Claudio R. Lazzari
  • Insect Biology Research Institute
Fabien Espitalier
  • Anaesthesiology and Critical Care
Igor Lima Maldonado
  • INSERM U1253 iBrain
Tours, France