University of Mount Olive

Background Although control of chemotherapy‐induced nausea and vomiting (CINV) is substantially improved with guideline‐directed antiemetic prophylaxis, breakthrough CINV remains a significant clinical patient problem. In subsequent cycles after breakthrough occurs, antiemetic guidelines recommend adding agents not used in the initial cycle. This study was designed to evaluate the use of NEPA (netupitant/palonosetron) plus dexamethasone with or without olanzapine for the prevention of CINV in the second cycle of chemotherapy for patients receiving highly (HEC) or moderately emetogenic chemotherapy (MEC) who developed breakthrough CINV in their first cycle despite guideline‐directed prophylactic antiemetics. Methods This was a Phase 2, single center, open‐label study. Patients received guideline‐recommended prophylactic antiemetics in Cycle 1 based on the chemotherapy emetogenicity. Patients who experienced breakthrough CINV in Cycle 1 received intravenous (IV) NEPA (Day 1) plus dexamethasone (Days 1–4) and olanzapine (Days 1–4) for HEC or IV NEPA (Day 1) plus dexamethasone (Days 1–4) for MEC in Cycle 2. Results Of the 227 patients enrolled in Cycle 1, 100 patients (n = 37 HEC, 63 MEC) experienced breakthrough CINV and received the NEPA‐based treatments in Cycle 2. The complete response (no emesis/no rescue use) rates [95% confidence intervals] during the overall (0–120 h) phase were 76% [59%, 88%] and 79% [67%, 89%] in the HEC and MEC groups, respectively. Conclusion These results show that NEPA with or without olanzapine is an effective approach for CINV prevention for patients receiving HEC or MEC who develop breakthrough CINV after their first course of chemotherapy. The results support the antiemetic guideline recommendations. Trial Registration clinicaltrials.gov identifier: NCT06065722

Plain Language Summary Patients with cancer who are treated with chemotherapy often have nausea and vomiting as side effects. These symptoms can be very uncomfortable, negatively impact the quality of life, and may cause patients to stop treatment. Using the right antinausea and vomiting medications can help to reduce symptoms and enable patients to stay on therapy. Many studies have looked at how effective different combinations and doses of these medications are in reducing or preventing nausea and vomiting in the 5 days after chemotherapy treatment. However, it is now clear that nausea and vomiting can last longer than this time period. Newer treatments called antibody-drug conjugates (ADCs) are being used to treat patients with cancer but may also cause nausea and vomiting after 5 days (known as long-delayed nausea and vomiting). To make sure patients receive the best possible care to prevent these symptoms, it is important to understand how well antinausea and vomiting medications work over longer periods of time. This paper discusses how often this long-delayed nausea and vomiting occurs in patients after they have received chemotherapy or ADCs. We also look at different medications that are being used to prevent nausea and vomiting, including a drug called NEPA (netupitant and palonosetron). NEPA is a combination of two antinausea and vomiting medications. It may be a good option for preventing long-delayed nausea and vomiting, as it is effective over longer time periods than other similar medications. NEPA has shown very promising results in studies so far.

Background: Every minute is crucial in treating acute ischemic stroke (AIS), as the effectiveness of intravenous thrombolysis and endovascular therapy is highly time-dependent. AHA/ASA guidelines recommend door-to-needle (DTN) times of less than 60 minutes for at least 85% of AIS patients treated with IV thrombolytics, with further goals of achieving DTN times within 45 minutes for 75% of patients, and within 30 minutes for 50% of patients. However, less than a third of patients meet these time frames, prompting the implementation of a Launchpad protocol to hasten patient triage and intervention. This quality improvement initiative evaluates the Launchpad protocol's effectiveness at reducing DTN times in AIS treatment at an academic hospital, aiming to meet AHA/ASA guidelines and improve outcomes through a nurse-driven code stroke activation process. Fig.1. Updated Code Stroke Algorithm. Methods: A multidisciplinary team was assembled to address DTN delays by pinpointing treatment barriers. While the nurse-driven code stroke activation process has been a crucial development, it still requires enhancements to optimize the rapid identification and management of AIS patients. The Code Stroke Launchpad, located adjacent to the CT suite, was launched on 7.18.2023. Previously, AIS patients were triaged to the next open ED room resulting in AIS patients broadly distributed over a 60 room ED. The Launch Pad allowed the centralization of care to a defined area in close proximity to the CT scanner as well as helped expedite the intervention and evaluation of the multidisciplinary care team. The effectiveness of this new protocol is evaluated by comparing time differences before and after the Launchpad's implementation. Results: Post-Launchpad, door-to-needle times improved significantly: 84% of patients achieved the 60-minute target (up from 61%), 65% reached the 45-minute target (up from 39%), and 26% met the 30-minute target (up from 19%). Fig.2. Pre and Post DTN Averages Conclusion: The Launchpad implementation significantly reduced DTN times. Ongoing enhancements in nurse training, communication, and support are needed. Introducing Stroke Champions could further boost compliance and response times by ensuring regular updates and better coordination.

Elementary school curricular standards in the United States emphasize mathematics and literacy, while social studies and science are often left behind. Integrating science instruction with either mathematics or literacy is a strategy some teachers use to teach skills and concepts in both disciplines. Understanding science at a young age is reliant on grasping vocabulary that is new to the learner. Integrating visual imagery into reading instruction improves students’ comprehension, enhances retrieval, and increases retention. The media-based reading enhancement of text through spatial computing has begun to show promise for the integration of science vocabulary and reading comprehension, especially for low-proficiency readers. This paper provides a literary rationale for technology-enhanced intervention, provides examples of a study conducted to test the efficacy of such an intervention, presents the implications of the study’s findings, and discusses future avenues for how spatial computing might be used in science and literacy instruction in the future.

Plain Language Summary Corn (Zea mays L.), cotton (Gossypium hirsutum L.), and peanut (Arachis hypogaea L.) are traditional crops grown in the southeast region of the United States. Row crop producers have adopted many strategies to reduce the presence of disease and parasitic nematodes among peanut. One management strategy that has not been considered is the potential use of twin‐row planting patterns compared to single‐row cropping systems under various tillage practices. The objective of this study is to determine if corn yield differs when comparing twin‐row and single‐row planting patterns when planted in various rotation sequences following corn, cotton, and peanut in continuous strip tillage or conventional tillage. Results indicated that corn yield increased as the length of rotation increased relative to peanut. Furthermore, the increase in the planting of cotton within the rotation also increased corn yield. The use of strip tillage increased corn yield compared to conventional. No significant yield increase was seen when comparing twin‐row to single‐row.

During the nineteenth century in Ireland, agents of the colonial state like the police, along with the administrators that they served, forged an association between political motivations and Irish agrarian violence. They did so not only through the policing of Irish violence, but through the methods used by the colonial state to categorize, process, record, and archive it. Central to this endeavor was the category of “outrage.” Using this category, the Irish Constabulary created a record that impressed an association between Irish violence or criminality and political resistance. Because the British colonial state had control over the production of the archive, it also dictated the metanarratives present in this “archive of outrages” that gave form and function to the colonial state's fears that Irish violence represented a budding insurrection or a desire to fracture the Union. By perpetuating this logic in document and archival form, Dublin Castle (the seat of the British government's administration of Ireland) helped create the very demon that it sought to exorcise—that of Irish nationalist action and sentiment.

Isothiocyanates are biologically active products resulting from the hydrolysis of glucosinolates predominantly present in cruciferous vegetables belonging to the Brassicaceae family. Numerous studies have demonstrated the diverse bioactivities of various isothiocyanates, encompassing anticarcinogenic, anti-inflammatory, and antioxidative properties. Nature harbors distinct isothiocyanate precursors, glucosinolates such as glucoraphanin and gluconastrin, each characterized by unique structures, physical properties, and pharmacological potentials. This comprehensive review aims to consolidate the current understanding of Moringa isothiocyanates, mainly 4-[(α-L-rhamnosyloxy) benzyl] isothiocyanate), comparing this compound with other well-studied isothiocyanates such as sulforaphane and phenyl ethyl isothiocyanates. The focus is directed toward elucidating differences and similarities in the efficacy of these compounds as agents with anticancer, anti-inflammatory, and antioxidative properties.

In 2013, Engelhardt (2013) calculated that the combined power of the top five hundred supercomputers would take approximately 10.5 quintillion years to compute the distribution of eighty thousand heterogeneous goods among six billion consumers, posing a serious practical challenge to the implementation of computerized central planning. Allin Cottrell (2021) calls into question Engelhardt’s assertion, noting that the algorithm used by Engelhardt not only scales poorly but is not even valid for the problem Engelhardt posed. Cottrell offers an iterative algorithm that a one-petaflop machine could use to solve the distribution problem in about five minutes. We correct errors in both Engelhardt and Cottrell, and we offer a way to incorporate production into the problem. The result: modern supercomputers are still not powerful enough to solve central planning’s computation problem.

Ternary glassy electrolytes containing K2S as a glass modifier and P2S5 as a network former are synthesized by introducing a new type of complex and asymmetric salt, potassium triflate (KOTf), to obtain unprecedented K⁺ ion conductivity at ambient temperature. The glasses are synthesized using a conventional quenching technique at a low temperature. In general, alkali ionic glassy electrolytes of ternary systems, specifically for Li⁺ and Na⁺ ion conductivity, have been studied with the addition of halide salts or oxysalts such as M2SO4, M2SiO4, M3PO4 (M = Li or Na), etc. We introduce a distinct and complex salt, potassium triflate (KOTf) with asymmetric anion, to the conventional glass modifier and former to synthesize K⁺-ion-conducting glassy electrolytes. Two series of glassy electrolytes with a ternary system of (0.9–x)K2S-xP2S5-0.1KOTf (x = 0.15, 0.30, 0.45, 0.60, and 0.75) and z(K2S-2P2S5)-yKOTf (y = 0.05, 0.10, 0.15, 0.20, and 0.25) on a straight line of z(K2S-2P2S5) are studied for their K⁺ ionic conductivities by using electrochemical impedance spectroscopy (EIS). The composition 0.3K2S-0.6P2S5-0.1KOTf is found to have the highest conductivity among the studied glassy electrolytes at ambient temperature with the value of 1.06 × 10⁻⁷ S cm⁻¹, which is the highest of all pure K⁺-ion-conducting glasses reported to date. Since the glass transition temperatures of the glasses are near 100 °C, as demonstrated by DSC, temperature-dependent conductivities are studied within the range of 25 to 100 °C to determine the activation energies. A Raman spectroscopic study shows the variation in the structural units PS43−, P2S74−, and P2S64− of the network former for different glassy electrolytes. It seems that there is a role of P2S74− and P2S64− in K⁺-ion conductivity in the glassy electrolytes because the spectroscopic results are compatible with the composition-dependent, room-temperature conductivity trend.

Core Ideas Under a moderate to high pricing structure, a subsurface irrigation system can pay for itself when growing corn. A twin‐row planter does not increase yield or increase financial returns regardless of irrigation system. Financial returns will likely be higher under sub‐surface irrigation when compared with dryland corn production.

During the past few years, Americans have experienced a wide variety of stressors, including political tensions, racial/civil unrest, and the coronavirus disease 2019 (COVID-19) pandemic. All of these have led to uncertainty within society. Chronic feelings of helplessness can lead to depression or feelings of hopelessness in those who perceive their situation as unchanging. The purpose of this study was to evaluate the impacts of gardening and outdoor activities during the COVID-19 pandemic on perceptions of hope, hopelessness, and levels of depression, stress, and anxiety. Participants of this study were recruited through online social media platforms such as Facebook and Instagram; 458 participants completed the 21-item Depression Anxiety and Stress Scale inventory as well as the Hope Scale. Our data indicated that individuals who self-reported themselves as gardeners had significantly more positive scores related to levels of stress, anxiety, and depression and a sense of hope. Furthermore, gardeners had lower levels of self-reported depression, anxiety, and stress when compared with those who did not identify themselves as gardeners. The gardeners also had a more positive outlook regarding hope for the future. Additionally, a significant positive correlation was found between the number of hours spent participating in gardening and a sense of hope, and a negative correlation was found between the number of hours gardening and stress levels. Similarly, there was a significant negative correlation between the number of hours spent participating in any outdoor activity and self-reported levels of stress, anxiety, or depression; however, there was a positive correlation between the number of hours spent participating in any outdoor activity and a sense of hope. Our data suggested that more hours spent outside gardening or participating in recreational activities led to less perceived stress, anxiety, and depression and greater levels of hope for the future.

Mateusz Machaj’s book Capitalism, Socialism and Property Rights is a straightforward and useful contribution to our understanding of the problems of socialism. Translated from the original Polish by Kacper Potocki, the book flowed smoothly. In it, Machaj makes three important points. The first centers on the discussion on how the socialist economists, who thought that a market could be mimicked or limited to only consumer goods, were wrong. The second is that the neoclassical economists, who used the model of perfect competition and thought solving the right set of equations could produce equilibrium, were also wrong. And the third, and most important, point is Machaj’s claim that Mises’s approach was too narrowly focused on economics and not broad enough for the legal and ethical implications of property rights. By broadening the perspective beyond the economic and into the legal and moral realms, one sets the foundations for policies of nations transitioning away from socialism in any of its forms.

A non‐experimental, correlational survey design was used to explore relationships between counselor recovery status, training, and counselor demographic variables on multicultural counseling self‐efficacy in addiction counselors (N = 283) using the Multicultural Counseling Self‐Efficacy – Racial Diversity Form. A multiple‐indicators and multiple‐causes model analysis indicated significant differences based on race, multicultural education, and CACREP program attendance on multicultural counseling self‐efficacy. Implications from this study and recommendations for future research are discussed.

This fascinating book examines the complex history of the people of the Indian Territory (modern-day Oklahoma) in the 1830s period of Native American displacements known as the Trail of Tears to statehood in 1907. It chronicles the author's own family, and her passion to get at the heart of the story is captivating. The book is complex because it focuses on how new “settler colonialists”— consisting of the Five Tribes (Creek, Cherokee, Choctaw, Chickasaw, and Seminole peoples forced on the Trail of Tears), Indian freedpeople (Black people who had been owned as slaves by the Five Tribes and freed after the Civil War), newly freed African Americans from the former Confederacy, and white Americans mostly from the South—interacted with one another and the original Native Americans already there as each group sought to establish identity and ideas of race, citizenship, and land ownership (p. 97). The result is an excellent book that is personal and informative.

Introduction Administrators and faculty at associate-level nursing programs face challenges retaining qualified faculty members. Job satisfaction and effective mentoring programs may increase retention. The framework for this study was Herzberg's motivation-hygiene theory. The aim was to determine if job satisfaction and mentoring satisfaction levels could predict retention. Method Full-time nursing faculty employed at state-approved associate-level nursing programs in the Mountain, Pacific, West North Central, and West South Central regions of the United States received an invitation to participate in this cross-sectional quantitative online survey. Multiple regression analysis was used to answer the research question. Results There was a weak relationship between mentoring satisfaction and retention. There was a moderate, significant relationship between job satisfaction and retention. Job satisfaction predicted retention. Discussion Administrators and faculty can improve job satisfaction among nursing faculty by addressing motivators (like recognition, advancement, and achievement) and hygiene factors (like salary and workload). Evidence-based mentoring programs may help improve nursing faculty job satisfaction and retention.

This study evaluated preservatives to stabilize sodium chloride (NaCl)–free‐cucumber fermentations. The brining of air‐purged laboratory cucumber fermentations with 100.0 mM calcium chloride (CaCl2) and 25.0 mM acetic acid resulted in immediate rises in pH, the chemical reduction of the medium, and malodors. Supplementation with 3.0 mM sodium benzoate or 3.0 mM potassium sorbate enabled a decline in pH, a continuous oxidative state of the medium, and delayed rising pH spoilage. However, lactic and acetic acids eventually disappeared in fermentations supplemented with preservatives. The amount of preservatives needed to suppress growth of brined‐cucumber‐spoilage microbes was determined in Fermented Cucumber Juice Medium (FCJM). Supplementation of FCJM with 10.0 mM sodium benzoate was inhibitory for the spoilage yeasts, Issatchenkia occidentalis and Pichia manshurica, and the lactobacilli, Lentilactobacillus buchneri and Lentilactobacillus parafarraginis, but not of Zygosaccharomyces globiformis. Potassium sorbate inhibited the spoilage yeasts at 15.0 mM in FCJM but not the lactobacilli. Supplementation of FCJM with 20.0 mM fumaric acid had a bactericidal effect on the spoilage‐associated lactobacilli. As expected, NaCl‐free‐commercial cucumber fermentations brined with 100 mM CaCl2, no acetic acid, and 6 mM potassium sorbate resulted in complete fermentations, but supported rising pH, microbially induced spoilage during long‐term storage. Post‐fermentation supplementation with 12 mM sodium benzoate, 10 mM fumaric acid, a combination of the two, or 10 mM fumaric acid and 2 mM AITC prevented microbial activity during long‐term bulk storage. Practical Application Several preservative‐based strategies for stabilizing NaCl‐free cucumber fermentation in a commercial production setting were developed, enabling the implementation of a processing technology that reduces wastewater volumes and environmental impact.

The economics profession, in general, has been failing to educate the general public on basic economic principles. It has been failing for at least a century, as the ascendancy of the administrative state clearly shows. Progressive President Woodrow Wilson believed that an administrative state was better than a representative republic. Dwight Waldo took the Progressive vision a step further and argued that not only is it impossible for the experts to be value neutral, but that the experts should never be value neutral. The consequences of this authoritarian, constructivist-rationalist solution are visibly manifested in the form of wokeism: the adoption of diversity, equity, inclusion (DEI) with social justice (JEDI); what is referred to as environmental, social, and governance “values” (ESG values); and the rejection of the free market. CEOs sign on to this belief system because wokeism provides the CEO, management team, and board of directors an excuse to loosen the profit leash that constrains them. Yet for all the woke victories in academia, media, and the corporate world, those who support individual liberty and the free market can hope for victory. This lecture offers suggestions for reversing the tide.

The study tries to investigate the obesity and obesity related health implications of Colorado and Mississippi States to see the significant factors affecting obesity in each state to propose effective and doable policy suggestions to the states, especially to Mississippi state. The study follows logit analysis using Behavior Risk Factor Surveillance Systems (BRFSS) survey data of 2018. The individual data reported for the states were used for the analysis. The statistical package of STATA was used for the analysis. The analytical results show that physical exercise (EXER), number of sleeping hours (SLEP), and education (EDUC) play a major role in combatting obesity. Also, the impact of smoking (SMOK), alcohol consumption (DRNK), and obesity -related diseases ((DISE). The large differences in value between Colorado and Mississippi indicate the significance of these variables and how they could be used in Mississippi. Thus, Mississippi needs to go for efficient and effective policy implications to facilitate more for physical exercises, and education. Both states report that obesity-related illnesses have a significant impact on obesity. Thus, health programs on these diseases would be required to reduce obesity.

A magnetic compass sense has been demonstrated in all major classes of vertebrates, as well as in many invertebrates. In mammals, controlled laboratory studies of mice have provided evidence for a robust magnetic compass that is comparable to, or exceeds, the performance of that in other animals. Nevertheless, the vast majority of laboratory studies of spatial behavior and cognition in murine rodents have failed to produce evidence of sensitivity to magnetic cues. Given the central role that a magnetic compass sense plays in the spatial ecology and cognition of non-mammalian vertebrates, and the potential utility that a global/universal reference frame derived from the magnetic field would have in mammals, the question of why responses to magnetic cues have been so difficult to demonstrate reliably is of considerable importance. In this paper, we review evidence that the magnetic compass of murine rodents shares a number of properties with light-dependent compasses in a wide variety of other animals generally believed to be mediated by a radical pair mechanism (RPM) or related quantum process. Consistent with the RPM, we summarize both published and previously unpublished findings suggesting that the murine rodent compass is sensitive to low-level radio frequency (RF) fields. Finally, we argue that the presence of anthropogenic RF fields in laboratory settings, may be an important source of variability in responses of murine rodents to magnetic cues.