University of Ilorin
  • Ilorin, Kwara State, Nigeria
Recent publications
Escherichia coli (E. coli) is a common cause of poor milk microbial quality, often resulting from unhygienic milk handling. Here, a cross-sectional study was performed to determine the prevalence and antibiotic susceptibility profile of E. coli O157 in raw cow milk sold in Kwara State. Raw cow milk (n=1225) samples from 11 selected markets within the agro-ecological zones of Kwara State (known for vending milk) were collected across rainy (n=548) and dry (n=677) seasons. Isolation and identification of E. coli were done using standard procedures. The Polymerase Chain Reaction was utilized to detect E. coli O157 targeting 16S RNA and its virulence (eaeAO157) and toxigenic (Shiga-toxin 1 (stx1)) genes. The antimicrobial susceptibility profile of E. coli O157 isolates was determined by multi-disc diffusion. The total prevalence of E. coli was 48.9% (n=599), of which 2.3% (n=28) were E. coli O157. The prevalence of E. coli was significantly higher during the dry (58.8%) than during the rainy (36.7%) season. Twenty-six E. coli O157 isolates possessed the eaeAO157 gene, while all the 28 isolates carried the stx1. E. coli O157 were susceptible to nitrofurantoin (50.0%) and ciprofloxacin (46.5%), but resistant to cefotaxime (96.4%), ampicillin (89.3%), gentamicin (89.3%) and chloramphenicol (71.4%). This study established the presence of E. coli O157 with virulence, toxigenic genes, and antimicrobial resistance in raw cow milk in Kwara State. Improved hygienic practices during milk handling are recommended.
Foliar application of nanoparticles (NPs) as an application for abiotic stress is increasingly employed in crop production. In this study, the potential of CeO2-NPs as stress suppressants was investigated on cadmium (Cd)-stressed okra (Abelmoschus esculentus) plants using two cycles of foliar application of CeO2-NPs at 200, 400, and 600 mg/l. Compared to untreated stressed plants, Cd-stressed treated-plants with CeO2-NPs presented higher pigments (chlorophyll. a and carotenoids). In contrast, foliar applications did not alter Cd’s root uptake and leaf bioaccumulation. Foliar CeO2-NPs application modulated stress enzymes (APX, SOD, and GPx) in both roots and leaves of Cd-stressed plants, and led to decreases in Cd toxicity in plant’s tissues. Foliar application of CeO2-NPs in Cd-stressed okra plants decreased fruit Cd contents, and improved fruit mineral elements and bioactive compounds. The infrared spectroscopic analysis of fruit tissues showed that foliar-applied CeO2-NPs treatments did not induce chemical changes but induced conformational changes in fruit macromolecules. Additionally, CeO2-NPs applications did not alter the eating quality indicator (Mg/K ratio) of okra fruits. Conclusively, the present study demonstrated that foliar application of CeO2-NPs has the potential to ameliorate Cd toxicity in tissues and improve fruits of okra plants.
In this paper, a new four-parameter lifetime model tilted the exponentiated power Gompertz (EXPGO) model is proposed. The explicit expressions of the density, distribution and quantile functions of the EXPGO are provided. Its density function can be expressed as a linear mixture of the generalized Gompertz densities, and can be unimodal and left skewed. The failure rate of the new model can be concave decreasing and reversed J-shaped. Likewise, the structural properties of the new model like the moments, moments generating function, probability weighted moments and entropies expressed in Laplace transform are provided. The maximum likelihood estimator for the new model is discussed and the performance of the estimator evaluated using Monte Carlo simulations. Three real-data applications indicate that the EXPGO model provides a better fit and can be utilized in fitting skewed datasets with unimodal features and concave decreasing failure rates.
The COVID‐19 vaccination program is the most extensive vaccination program held in Nigeria to date. As of September 21, 2022, more than 31 million people have been fully vaccinated which made up 15% of the entire population. Following the global COVID‐19 vaccination goal, Nigeria was expected to vaccinate 40% of its population in 2021 and reach the 70% vaccination threshold before the end of 2022. Currently, Nigeria is nowhere near the global vaccination goal due to various challenges encountered by the program. Challenges such as distrust in government, poor cold‐chain management, and poor communication during the onset of the program all contributed to the inability to attain the set goal. With the pledge of Global Alliance for Vaccines and Immunizations to extend the malaria vaccination program to other Sub‐Saharan African countries after the success of the first dose vaccination in Ghana, Kenya, and Malawi and the recent reemergence of monkeypox virus in Africa which also requires vaccination to curtail its spread, it is important that Nigeria, in preparation for these vaccination programs, learn from some of the challenges that the COVID‐19 vaccination program encountered and take actions to ensure greater success in future vaccination programs in the country. This paper aims to give an overview of the COVID‐19 vaccination program in Nigeria, highlight the challenges encountered, and provide recommendations for better future vaccination initiatives in the country.
The low constitutive activation of Liver X receptor, an endogenous nuclear receptor with two subtypes (α and β), is a condition lying at the crossroad of cancer and cardiovascular disease. Both natural and synthetic Liver X receptor agonists have reportedly shown remarkable antiproliferative and atheroprotective effects but the repeated doses of its synthetic ones are also paradoxically associated with hyperlipidaemic effects and neurotoxicity, though attributed to the alpha subtype. This highlights the need for novel, safe, and potent LXR-beta-selective agonists. Hypocholesterolaemic effects of black theaflavins have been widely reported, but data on the exact theaflavin compound (s) responsible for these effects is currently lacking. Neither is information on the possible modulatory effects of the compound (s) on LXR-beta nor its possible implications in the context of drug development for cardiovascular diseases and cancers is explored. On this account, we investigated the potential interaction of four main theaflavin monomers (TF1, TF2A, TF2B & TF3) with human LXR-beta through robust computational modelling that entails molecular docking, free energy calculations and molecular dynamics simulations. The ligands were further profiled (in silico) for absorption, distribution, metabolism, excretion, and toxicological properties. Our result revealed theaflavin TF2B as a putative LXR-beta agonist, possibly responsible for the widely observed hypocholesterolaemic effect in black tea. This finding, while encouraging, needs to be experimentally verified in wet studies. Communicated by Ramaswamy H. Sarma
Abstarct Setbacks in engineering systems amid thermal variation and temperature common-cause effects led to disorderliness in working systems. For adequate heat and mass transfer process, minimization of energy loss, improvement of technological development, et cetera, the present work contributes to the existing literature with the investigation of entropy generation for the combined response of Joule heating, thermal radiation, variable thermal conductivity, quadratic thermal and solutal convection in Carreau fluid motion over an inclined non-linear stretching sheet. An induced flow due to non-uniform stretching characteristics and dissipative heat is assumed. The mathematical systems are formulated, and the numerical solution to the model distributions is approximated via Galerkin weighted residual approach, while the narrow results benchmark the existing studies. This report predicts a reduction of flow and heat mechanism due to convection and magnetization effect. The higher impact of the magneto-hydrodynamic field and radiation phenomenon optimized the entropy generation rate on the flow surface. More disorderliness is recorded for the shear-thickening fluid compared to the shear-thinning fluid type. The dissipation effect also contributes significantly to more entropy generation.
In this comparative examination, the paradox of mass diffusion and heat conduction on the improved surface of weakly hydromagnetic and unsteady fluid flow is examined. Material relaxation time is believed to be one of the contributing factors militating against an effective heat and mass transfer. This flow process is estimated to predict accurately the fluids enhancement and condensation/evaporation properties. With a workable similarity variable, the formulated model of modified Fick's and Fourier's laws assumed in the Riga surface-induced flow conveying Casson-Williamson fluids with variable transport properties are transformed to the systems of ordinary differential equations. The spectral iterative technique (SLLM in particular), thus employed to analyze the flow distributions and ascertain the validity of the obtained results. However, cohesion force between the fluid particle establishes abnormalities of both Fick's and Fourier's laws indicating that extra time will be required for effective mass and heat convection to the immediate environment. Generalized heat flux parameter minimizes the fluid temperature and accelerated the nanoparticle concentration, relative minimization of the fluid temperature resulted to much more nanoparticle concentration. Moreover, Williamson fluid demonstrated a higher conductivity/diffusivity capacity in contrast to the Casson fluid. When compared to Casson fluid, the modified Hartman number has a stronger influence on Williamson fluid.
The Tinto River is known globally for having a reddish color due to the high concentration of dissolved metals in its waters. The general objective of this study is to analyze the dispersion of nanoparticles (NPs) and ultra-fine particles in terrestrial and geospatial suspended sediments (SSs) using Sentinel-3B OLCI (Ocean Land Color Instrument) satellite images; by examining water turbidity levels (TSM_NN), suspended pollution potential (ADG_443_NN) and presence of chlorophyll-a (CHL_NN). The images were collected in the estuary of the Tinto River, in the city of Nerva, Spanish province of Huelva, between 2019 and 2021. The following hazardous elements were identified in nanoparticles and ultra-fine particles by FE-SEM/EDS: As, Cd, Ni, V, Se, Mo, Pb, Sb and Sn. Sentinel-3B OLCI satellite images detected a 2019 TSM_NN of 23.47 g − 3 , and a 2021 reading of 16.38 g − 3 .
Dogs are the most cosmopolitan pets of humans and as such a means of transmitting zoonotic parasites to their owners. This study was designed to investigate the diversity, prevalence, pattern of infection, intensity of infections, and the risk factors associated with gastrointestinal parasites of dogs in Kwara Central, North Central, Nigeria. Three hundred and five clinically healthy dogs were sampled. Faecal samples were subjected to the direct smear, simple faecal centrifugation flotation, formol-ether concentration, and the Modified Ziehl-Neelsen staining techniques. Oocysts/eggs per gram of faeces were counted using the modified McMaster technique. Data were analysed using univariate logistic regression, multivariate logistic regression, and the one-way analysis of variance (ANOVA). p -value of < 0.05 was considered significant for all analyses. One hundred and sixty-six dogs were positive for at least one species of gastrointestinal parasite, representing 54.43% (95% CI: 44.81 - 59.96) of the sampled population. The study identified Cystoisospora species (15.41%), Cryptosporidium species (25.25%), Ancylostoma species (25.25%), Toxocara canis (19.02%), Strongyloides stercoralis (7.54%), Uncinaria stenocephala (6.89%), and Dipylidium caninum (2.30%) as the gastrointestinal parasites infecting dogs in the study area. Coinfection with more than one species of gastrointestinal parasites was a common finding in dogs. The intensity of Cystoisospora spp. among infected dogs ranged between 40 and 980 oocysts per gram of faeces, while that of helminth parasites was 40 - 1560 eggs per gram of faeces. Age, sex, breeds, body condition score, presence of ticks on dogs, the purpose of keeping dog(s), types of housing, types of feed consumed, vaccination status, and treatment with antiparasitics were predators associated with the prevalence and intensity of gastrointestinal parasites infections. Due to the zoonotic nature of most of the encountered gastrointestinal parasites, there is need for regular antiparasitic treatment, proper dog management, and adequate personal hygiene to prevent zoonosis.
The focus of this paper is based on the incidence of manifold slip on the transport and dynamics of magnetobioconvective and magnetic nanoparticles Fe 3 O 4 (magnetite) power-law flow between two parallel plates. An interaction takes place between nanoparticles and the organism by inhalation routes, oral, dermal, and distributed to different tissue through the circulatory system The equations of motion are a set of partial differential equations (PDEs). The governing equations are transformed into ordinary differential equations (ODE) by utilizing similarity transformations. The transformed equations are solved by using the Runge-Kutta Gill method alongside the shooting techniques MATLAB software implementation. The velocity of fluid decreases when the magnetic parameter increases. The outcomes of this model find usefulness in controlling the turbulent flow of fluid due to the presence of a magnetic field and also helpful in reducing the dosage of anticancer drugs in the medical field because of the presence of the magnetic nanoparticles. The correctness of the present result is ascertained by comparing it with reported data.
195 Background: It has been suggested that the intestinal microbiome plays a vital role in the development of colorectal cancer (CRC), but the changes in intestinal bacteria in healthy and CRC subjects have not yet been examined in the Nigerian population. The study sought to investigate changes in intestinal bacteria in healthy subjects and patients with CRC. Methods: Fecal samples were collected from healthy and CRC subjects at the Federal Medical Centre, Abeokuta with the study ethical approval number FMCA/47O/HREC/01/2021/23. We extracted genomic DNA with magnetic bead extraction and sequenced the whole genome using a Nanopore MinION sequencer. We performed metagenomic analysis on fecal samples from 20 healthy subjects and 20 patients with colorectal cancer (CRC) to study the bacterial community structure, relative abundance, differentially abundant bacteria, association networks, taxonomic profiling, and specialty gene expression. Results: CRC patients have significantly different bacterial community structures compared to healthy subjects. Compared to healthy subjects, CRC patients had low intestinal bacterial diversity. Only CRCs contain Gammaproteobacteria at the phylum level. Compared to CRC, Bacteroidia and Actinobacteria were significantly more abundant in healthy subjects, while Bacilli and Negativicutes were significantly less abundant. Bacteroides and Prevotella are more abundant in healthy subjects than in CRC at the genus level. There was a greater abundance of Escherichia and Pseudomonas in CRC as compared with healthy subjects. It is noteworthy that Escherichia coli, which co-occurred in both healthy and CRC subjects, was significantly elevated only in CRC, while Pseudomonas aeruginosa only occurs in CRC. Based on phylogenetic analysis, there were notable relationships between six strains of E. coli and four strains of Shigella sp. identified in CRC. There were several pathogenic-associated virulent and antimicrobial resistant genes expressed in these strains. These genes conferred resistance via antibiotic inactivation, efflux pump activity, alteration of cell wall proteins, and regulation of antibiotic permeability. Conclusions: The present study demonstrated that the taxonomic composition and functional genes of intestinal bacteria were significantly altered in CRC. Also, E. coli and P. aeruginosa are at least partially involved in the pathogenesis of CRC.
Background There are multiple stroke guidelines globally. To synthesize these and summarize what existing stroke guidelines recommend about the management of people with stroke, the World Stroke Organisation (WSO) Guideline committee, under the auspices of the WSO, reviewed available guidelines. They identified areas of strong agreement across guidelines, and their global coverage.AimsTo systematically review the literature to identify stroke guidelines (excluding primary stroke prevention and subarachnoid haemorrhage) since 1st January 2011, evaluate quality (AGREE II), tabulate strong recommendations, and judge applicability according to stroke care available (minimal, essential, advanced).Summary of reviewSearches identified 15400 titles, 911 texts were retrieved, 203 publications scrutinized by the three subgroups (acute, secondary prevention, rehabilitation), and recommendations extracted from most recent version of relevant guidelines. For acute treatment, there were more guidelines about ischaemic stroke than intracerebral haemorrhage; recommendations addressed pre-hospital, emergency, and acute hospital care. Strong recommendations were made for reperfusion therapies for acute ischaemic stroke. For secondary prevention, strong recommendations included establishing aetiological diagnosis, management of hypertension, weight, diabetes, lipids, lifestyle modification; and for ischaemic stroke: management of atrial fibrillation, valvular heart disease, left ventricular and atrial thrombi, patent foramen ovale, atherosclerotic extracranial large vessel disease, intracranial atherosclerotic disease, antithrombotics in non-cardioembolic stroke. For rehabilitation there were strong recommendations for organized stroke unit care, multidisciplinary rehabilitation, task specific training, fitness training, and specific interventions for post-stroke impairments.Most recommendations were from high income countries, and most did not consider comorbidity, resource implications and implementation. Patient and public involvement was limited.Conclusions The review identified a number of areas of stroke care in there was strong consensus. However there was extensive repetition and redundancy in guideline recommendations. Future guidelines groups should consider closer collaboration to improve efficiency, include more people with lived experience in the development process, consider comorbidity, and advise on implementation.
The metalloprotease ADAM17 is a sheddase of key molecules, including TNF and epidermal growth factor receptor ligands. ADAM17 exists within an assemblage, the “sheddase complex,” containing a rhomboid pseudoprotease (iRhom1 or iRhom2). iRhoms control multiple aspects of ADAM17 biology. The FERM domain–containing protein iTAP/Frmd8 is an iRhom-binding protein that prevents the precocious shunting of ADAM17 and iRhom2 to lysosomes and their consequent degradation. As pathophysiological role(s) of iTAP/Frmd8 have not been addressed, we characterized the impact of iTAP/Frmd8 loss on ADAM17-associated phenotypes in mice. We show that iTAP/Frmd8 KO mice exhibit defects in inflammatory and intestinal epithelial barrier repair functions, but not the collateral defects associated with global ADAM17 loss. Furthermore, we show that iTAP/Frmd8 regulates cancer cell growth in a cell-autonomous manner and by modulating the tumor microenvironment. Our work suggests that pharmacological intervention at the level of iTAP/Frmd8 may be beneficial to target ADAM17 activity in specific compartments during chronic inflammatory diseases or cancer, while avoiding the collateral impact on the vital functions associated with the widespread inhibition of ADAM17.
One of the industries with the fastest growth rates in the world is aquaculture. However, as fish meal (FM), the most expensive component of aquafeeds, is increasingly replaced with plant protein, the amount of phosphorus (P) in fish diets decreases as a result of plant proteins' high phytate content, which chelates P. Inorganic P is a dietary supplement that increases fish development and feed utilization, but its high inclusion in aquafeeds causes eutrophication due to environmental contamination. Consuming dietary phytase can make more P available, which lowers the amount of inorganic P in fish diets. The present study assessed the effects of replacing inorganic P in Nile tilapia (O. niloticus) diets with a hybrid microbial phytase (HMPhyt) derived from bacteria hybrid (Buttiauxella gaviniae, Yersinia mollaretti, and Hafnia sp.) on growth and welfare. Fish (1.50 ± 0.16 g) were divided into 18,100-L tanks with 20 fish each, and they were fed one of six low FM diets that were both isonitrogenous (300 g/kg) and isocalorific (17 kJ/g). The control diet had no P or HMPhyt supplements (0P + 0HMPhyt), the second diet contained 0.2 g/kg (1000FTU/kg) HMPhyt only (0P + HMPhyt), the third diet contained 100% P (13.0 g/kg) only (100P + 0HMPhyt), and the fourth to the six diets contained 75% (9.8 g/kg) P (75P + HMPhyt), 50% (6.5 g/kg) P (50P + HMPhyt), or 25% (3.3 g/kg) P (25P + HMPhyt). Fish were fed the experimental diets three times each day for 56 days, until they appeared satisfied. In comparison to the control diet (0P + HMPhyt), the results reveal that dietary phytase and/or inorganic P significantly increased Nile tilapia growth indices and feed intake (P < 0.05) than the control group. In contrast, there were no differences in the feed conversion ratio or the percentage of fish that survived among the various fish groups (P > 0.05). In addition, fish fed on P and/or HMPhyt containing diets had significantly greater counts of red and white blood cells, packed cell volume, and hemoglobin, as well as higher intestinal villi width/height, and absorption area compared to the control group. In contrast, higher levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde were found in fish fed the control diet (0P + HMPhyt), while higher levels of superoxide dismutase, catalase, lysozyme, and respiratory burst activity were found in fish fed the inorganic P and/or HMPhyt based diets As a result, dietary HMPhyt (1000 FTU/kg) can totally substitute inorganic P in Nile tilapia diets without having any negative impacts on the fish's welfare or growth.
ABSTRACT Purpose: Protective effect of 17β-estradiol is well-known in pulmonary hypertension. However, estrogen-based therapy may potentially increase the risk of breast cancer, necessitating a search for novel drugs. This study, therefore, investigated the ameliorative effects of a selective estrogen receptor modulator, ormeloxifene, in pulmonary hypertension. Methods: Cardiomyocytes (H9C2) and human pulmonary arterial smooth muscle cells (HPASMCs) were exposed to hypoxia (1% O2) for 42 and 96 h, respectively, with or without ormeloxifene pre-treatment (1 μM). Also, female (ovary-intact or ovariectomized) and male Sprague–Dawley rats received monocrotaline (60 mg/kg, once, subcutaneously), with or without ormeloxifene treatment (2.5 mg/kg, orally) for four weeks. Results: Hypoxia dysregulated 17β-hydroxysteroid dehydrogenase (17βHSD) 1 & 2 expressions, reducing 17βestradiol production and estrogen receptors α and β in HPASMC but increasing estrone, proliferation, inflammation, oxidative stress, and mitochondrial dysfunction. Similarly, monocrotaline decreased plasma 17β-estradiol and uterine weight in ovary-intact rats. Further, monocrotaline altered 17βHSD1 & 2 expressions and reduced estrogen receptors α and β, increasing right ventricular pressure, proliferation, inflammation, oxidative stress, endothelial dysfunction, mitochondrial dysfunction, and vascular remodeling in female and male rats, with worsened conditions in ovariectomized rats. Ormeloxifene was less uterotrophic; however, it attenuated both hypoxia and monocrotaline effects by improving pulmonary 17β-estradiol synthesis. Furthermore, ormeloxifene decreased cardiac hypertrophy and right ventricular remodeling induced by hypoxia and monocrotaline. Conclusion: This study demonstrates that ormeloxifene promoted pulmonary 17β-estradiol synthesis, alleviated inflammation, improved the NOX4/HO1/Nrf/PPARγ/PGC-1α axis, and attenuated pulmonary hypertension. It is evidently safe at tested concentrations and may be effectively repurposed for pulmonary hypertension treatment.
Herbal teas are functional foods that interest consumers as they contain bioactive compounds known to promote health. As such, five different formulations of Parquetina and Lemongrass (100:0%, 87.5:12.5%, 75:25%, 62.5:37.5% and 50:50%) were used for the development of composite herbal teas which were evaluated for their phytochemical and mineral compositions, antioxidant capacities, microbiological quality and sensory attributes. The phytochemicals present in the composite herbal teas included phenols that ranged from 0.36 to 0.90 mgGAE/100ml, flavonoids (0.25 to 0.58 mgQE/100ml), alkaloids (0.12 to 0.79 mg/100 ml), saponins (0.04 to 0.14 mg/100ml), cardiac glycosides (0.01 to 0.1 mgDT/100ml), tannins (0.03 to 0.05 mgTAE/100ml) and terpenoids (0.04 to 0.25 mg/100ml). Potassium was the mineral with the highest concentration and it ranged from 15.06 to 21.19 mg/100ml in the tea samples. The composite herbal teas showed antioxidant capacities that ranged from 17.77 to 40.96%. The total bacterial count of the composite herbal tea ranged from 8.05 × 104 to 8.95 × 104 cfu/g, total fungal count (2.55 × 104 to 3.05 × 104 cfu/g) and total coliform count (5.50 × 102 to 7.5 × 102 cfu/g). Sensory evaluation showed that the most preferred sample was P50L50 (50% parquetina and 50% lemongrass). Conclusively, parquetina and lemongrass could be utilized in the production of a composite herbal tea with good quality and sensory attributes.
Background Exercise-induced oxidative stress is a challenge in equine sports. This study aims at determining the effects of ergothioneine on heat shock protein-70 (HSP-70) following the stress of an endurance exercise of 30 km by Arabian stallions. Molecular docking was also done to investigate the interaction between the ligand ergothioneine and heat shock protein-70 using sulfogalactosylceramide and sulfogalactoglycerolipid as standards. The study involved a total of 18 clinically healthy stallions, with an average age of 6.7 ± 2.4 years and an average weight of 411.54 ± 12.46 kg. Only clinically healthy stallions were selected as subjects. The stallions were divided into two groups of nine stallions each. Group I (ERGX) was administered ergothioneine at a dose of 0.02 mg/kg once daily orally for four weeks while group II (ERGN) was not administered ergothioneine. The activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were determined in the two groups before and post-exercise. The concentrations of malondialdehyde and HSP-70 were also determined. Results The results obtained showed that the activities of the antioxidant enzymes and concentration of HSP-70 were higher ( P < 0.05) in the ERGX group compared to the ERGN group. The concentration of malondialdehyde was however lower in the ERGX group. Following molecular docking, ergothioneine and the selected standards have common amino acids at the site of interaction with the target protein (HSP-70) suggesting that ergothioneine may have a modulatory effect on the synthesis of HSP-70. Conclusion The results obtained indicated that ergothioneine modulated the synthesis of HSP-70 and the biomarkers of oxidative stress. It was therefore concluded that ergothioneine may be beneficial to horses subjected to endurance exercise.
Background: There are traditional barriers to accessing quality hypertension care in sub-Saharan Africa. Mobile phone technology is increasingly being used to overcome these barriers. This study assessed smartphone ownership and the willingness to receive mobile health services among patients with hypertension in Nigeria. Methods: Four hundred and twenty-seven (427) patients with hypertension were recruited from two tertiary health institutions in Ekiti State, Nigeria. Questionnaires were fed into the Open Data Kit form, which was used to take data on mobile phone ownership, the willingness to receive and the preferred type of mobile phone-based hypertension health care services. Results: Males were 37.2%. Mean age was 60.6 ± 15.3 years. Of the participants, 48.7% owned smartphones, 21.1% had regular internet subscription on their phones, 94.8% were willing to receive and pay mobile health services. Phone calls (48.0%) and text messages (31.6%) were the most preferred modes of receiving hypertension-related health education. Age category of 45-64 years was the only predictor of willingness to receive mobile health services. Conclusion: All our participants owned mobile phones, with 48.7% being smartphones and almost all the participants were willing to receive and pay for mobile health services for prevention, treatment and information on hypertension. Middle age was the only predictor of willingness to receive mobile health, and the most preferred choices were through phone calls and text messages. The above information will guide in the design of favourable mHealth interventions that will be ideal for our study population.
Opial inequality was developed to provide bounds for integral of functions and their derivatives. It has become an indispensable tool in the theory of mathematical analysis due to its usefulness. A refined Jensen inequality for multivariate functions is employed to establish new Opial-type inequalities for convex functions of several variables on time scale.
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Luqman Aribidesi Olayaki
  • Department of Physiology
Kolade Ernest
  • Department of Paediatrics
Olufemi Olumuyiwa Desalu
  • Department of Medicine
Sunday Adedeji Aderibigbe
  • Department of Epidemiology and Community Health
Oluwole Akinola
  • Department of Anatomy
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P.M.B.1515, 240003, Ilorin, Kwara State, Nigeria
Head of institution
Professor Abdulkareem Sulyman Age
Website
www.unilorin.edu.ng
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