University of Cape Town

Roof truss systems and wall panels are two examples of popular structural components made by cold-formed steel (CFS) which is classified as a steel-based building material available in a wide range of shapes, and thicknesses. The use of CFS is increasing due to its many desirable properties, including a high strength-to-weight ratio, low weight, resistance to corrosion, and fast installation. In contrast, the thin-surfaced and opened section of CFS buckles easily when utilised as a beam or column. When the load is applied directly, the CFS section fails in modes such as web crippling, torsion, and buckling. As a result, the new I-section with top and bottom flange elements was produced by using CFS channel section, and timber board from the type of oriented strand board (OSB) as a web element. The study aimed to determine the initial structural characteristics of the built-up I-section CFS with OSB short column. A single or double web element made by yellow and dark brown OSB was used to construct the I-section for determining the initial structural characteristics. The I-section with a double web of yellow OSB showed the highest value of ultimate load and compressive strength as compared to other specimens in the range of 8.00% to 14.00%.

The main features of long-distance migration are derived from landbirds breeding in the Northern Hemisphere. Little is known about migration within the tropics, presumably because tropical species typically move opportunistically and over shorter distances. However, such generalizations are weakened by a lack of solid data on spatial, temporal and behavioural patterns of intra-tropical migrations. To start filling the research gap, we provide comprehensive data for small-sized intra-African migrants, woodland kingfishers. We inferred stationary locations, migration timing, flight behaviour and wind experienced en route from multi-sensor loggers recording atmospheric pressure, light and acceleration. After breeding in South Africa, all tagged individuals migrated 4000 km to South Sudan, spending their non-breeding period within 100 km of each other. Thereby, woodland kingfishers tracked their climatic niche, using two rainy seasons in open woodland across the Equator. Migratory flights were strictly nocturnal, reaching 2890 m.a.s.l. Flights were unusually short, but lengthened when crossing rainforests, a behavioural adjustment similar to barrier-crossing along well-described flyways. These results suggest that long-distance intra-tropical migration displays patterns that are surprisingly similar to other flyways. Pending confirmation in other species, intra-tropical migrations might be more extensive and less flexible than assumed, underlining the importance of further research guiding conservation efforts.

This study examines how heart rate (HR) affects hemodynamics in a South African infant with Coarctation of the Aorta. Computed tomography angiography segments aortic coarctation anatomy; Doppler echocardiography derives inlet flow waveforms. Simulations occur at 100, 120, and 160 beats per minute, representing reduced, resting, and elevated HR levels. Turbulence was analyzed over time and space using turbulence-resolving and pulsatile large-eddy simulations. Specifically, a 60% reduction in HR led to a reduction in maximum velocity by 45%, and a 57% decrease in pressure drop. The reduction in turbulence-related metrics was less significant. The ratio of turbulent kinetic energy to total kinetic energy decreased by 2%, while turbulent wall shear stress decreased by 3%. These results demonstrate that HR significantly affects velocity and pressure drop, while turbulence arising from the coarctation region is relatively unaffected. The balance between turbulent kinetic energy and total kinetic energy shows minimal enhancement due to the complex interplay among HR, turbulence, and geometry. This complexity prompts discussion on how HR-slowing medications, such as beta-blockers or ivabradine, could positively influence hemodynamic stresses. In particular, the results indicate that while HR modulation can influence flow dynamics, it may not significantly reduce turbulence-induced shear stresses within the coarctation zone. Therefore, further investigation is necessary to understand the potential impact of HR modulation in the management of CoA, and whether interventions targeting the anatomical correction of the coarctation may be more effective in improving hemodynamic outcomes.

This paper presents the radiocarbon context of the megalithic monument El Amarejo 1, situated in the corridor of Almansa in the southern region of La Meseta in Spain. The monument was constructed using small and medium-sized masonry, comprising a short corridor and two separate chambers in which burials were carried out. The results of the ¹⁴ C analyses of each of the 11 individuals documented indicate that the monument was in use between approximately 1900 and 1200 cal BC. Bayesian modeling of the radiocarbon dates allows for the proposition of hypotheses regarding the construction, utilisation dynamics, and abandonment of the monument. The combination of these new data with the analysis of the ¹⁴ C dating of other burials from the Bronze Age of La Mancha reveals a complex and heterogeneous panorama. The evidence presented and analyzed in this paper suggests that burial practices associated with fortified settlements and their domestic areas shared space and time with the construction of megalithic monuments located near settlements.

Purpose Head acceleration events (HAEs) are a growing concern in contact sports, prompting two rugby governing bodies to mandate instrumented mouthguards (iMGs). This has resulted in an influx of data imposing financial and time constraints. This study presents two computational methods that leverage a dataset of video-coded match events: cross-correlation synchronisation aligns iMG data to a video recording, by providing playback timestamps for each HAE, enabling analysts to locate them in video footage; and post-synchronisation event matching identifies the coded match event (e.g. tackles and ball carries) from a video analysis dataset for each HAE, this process is important for calculating the probability of match events resulting in HAEs. Given the professional context of iMGs in rugby, utilising commercial sources of coded match event datasets may expedite iMG analysis. Methods Accuracy and validity of the methods were assessed via video verification during 60 rugby matches. The accuracy of cross-correlation synchronisation was determined by calculating synchronisation error, whilst the validity of post-synchronisation event matching was evaluated using diagnostic accuracy measures (e.g. positive predictive value [PPV] and sensitivity). Results Cross-correlation synchronisation yielded mean synchronisation errors of 0.61–0.71 s, with all matches synchronised within 3 s’ error. Post-synchronisation event matching achieved PPVs of 0.90–0.95 and sensitivity of 0.99–1.00 for identifying correct match events for SAEs. Conclusion Both methods achieved high accuracy and validity with the data sources used in this study. Implementation depends on the availability of a dataset of video-coded match events; however, integrating commercially available video-coded datasets offers the potential to expedite iMG analysis, improve feedback timeliness, and augment research analysis.

Silica exposure and silicosis are strongly associated with pulmonary tuberculosis (TB), with ex-miners from the South African gold mines carrying a large burden of both diseases. We present a case of lymph node silicosis and recurrent TB complicated by cavitation with aspergilloma requiring right upper lobectomy, in a 38-year-old ex-goldminer with only 19 months of silica exposure. While silicosis was detected histologically in the lymph nodes, radiological findings and histopathological lung parenchyma lesions were consistent with inactive TB. A worker’s compensation claim for silicotuberculosis was unsuccessful. The findings highlight the need to take into account the contribution of subradiological silicosis and/or a low silica exposure threshold to increased TB risk, and the persistence of such TB risk following exit from exposure. The case also demonstrates the need to differentiate between the radiological and pathological features of silicosis and TB, and the possible mechanistic role of lymph node silicosis in increasing TB risk. These considerations have relevance to the surveillance of silica-exposed workers in high TB settings and the potential to reduce TB risk through silica dust control.

Aim The Cape Fold Belt Mountains, underlying the Cape fynbos flora, facilitate widespread moisture collection and groundwater availability across the region, with importance for maintaining hydric habitat niches. We assessed the contribution of hydric habitat‐associated species (HH species) to the richness of this flora, and how this varies phylogenetically and spatially. Location The Cape Floristic Region (CFR), South Africa. Methods We compiled data describing habitat preference and distributions for 3114 species in 23 fynbos clades. We used published habitat descriptions to identify putative HH species and tested how hydric habitat association is structured phylogenetically using both Ornstein‐Uhlenbeck models and measures of phylogenetic signal. We used species' distribution data to identify regional hotspots of HH species and boosted regression trees (BRTs) to identify associated environmental drivers. Results Preference for hydric habitats is associated with nearly a fifth of the species in our study, being most strongly represented in monocot clades. HH species are most strongly concentrated in the southwestern CFR, where they contribute to high overall richness. BRTs indicated that hotspots of HH species are generally associated with saturating, winter precipitation and/or elevated levels of groundwater discharge. Main Conclusions Our findings indicate that the unique climate, topography and hydrology of the CFR facilitate the formation and maintenance of important hydric habitats, which play host to a large fraction of the flora despite much of the region being semi‐ or seasonally arid. These findings highlight the threat of climate change and underscore the need for extreme caution regarding activities like groundwater abstraction, which could disrupt the hydrological processes essential to sustaining these habitats and their unique flora.

Most urban community gardens in South Africa face challenges related to land tenure rights, often leading them to negotiate for land use in school gardens. This paper investigates the potential synergy between schools and school-based community gardens, exploring the mutually beneficial relationship that can be cultivated for both the community and students. The research contends that school-based community gardens can wield significant influence in enhancing food security and nutrition, catalyzing community development, and nurturing environmental sustainability. Furthermore, the research emphasizes the pivotal role of school-based community gardens in fostering well-being within communities, empowering students, and contributing to a more enduring food system. Employing a qualitative approach, through semi-structured interviews conducted across 13 school-based community gardens situated in low-income townships on the Cape Flats of Cape Town, this paper underscores the advantages and challenges associated with leveraging school land for community gardens. By fortifying food security, propelling community development, and cultivating environmental sustainability, school-based gardens stand poised to be transformative agents, particularly within distressed neighborhoods of Cape Town. The findings of this research hold the potential to shape the establishment of resilient food production and distribution networks, thereby contributing to a comprehensive strategy for addressing food security, community development, and environmental sustainability in a holistic manner.

Background Neonatal sepsis is a leading cause of death in low- and middle- income countries (LMIC). Increasing antibiotic resistance in early onset (< 72 h of life) bloodstream infection (EO-BSI) pathogens in LMIC has reduced the effectiveness of the recommended empiric antibiotic regimen (ampicillin plus gentamicin). Methods We retrospectively analysed blood culture-confirmed EO-BSI episodes at nine neonatal units from three central and six peripheral hospitals in the Western Cape Province, South Africa between 1 January 2017 and 31 December 2018. Clinical and electronic laboratory records were reviewed to determine pathogen profile, empiric antibiotic coverage rates and factors associated with EO-BSI attributable mortality, stratified by hospital type. Results Of the 8252 blood culture specimens submitted for the investigation of suspected EO-BSI, 136 EO-BSI episodes yielding 141 pathogens were identified with an EO-BSI rate of 1.3 and 0.5 episodes/1000 live births at central and peripheral hospitals respectively. Preterm (93/136; 68.3%) and low birth weight (84/136; 61.8%) neonates were most affected. The predominant pathogens were Streptococcus agalactiae (46/136; 34%), Klebsiella pneumoniae (17/136; 13%), Listeria monocytogenes (11/136; 8%), Acinetobacter baumannii (11/136; 8%) and Escherichia coli (11/136; 8%). The empiric antibiotic (ampicillin plus gentamicin) coverage rate was 64% (95% CI 51–74) at central hospitals and 84% (95% CI 74–94) at peripheral hospitals. Neonates with Gram-negative EO-BSI and discordant empiric antibiotic therapy had almost four-fold and three-fold higher odds of death respectively. Conclusion Preterm and low birth weight neonates are most vulnerable to EO-BSI and have higher odds of death with Gram-negative pathogens and discordant empiric antibiotic therapy.

Antimicrobial resistance (AMR) poses a critical public health threat, with gendered implications that are often overlooked. Key drivers of bacterial AMR include the misuse of antibiotics, inadequate water, sanitation and hygiene infrastructure and poor infection control practices. Persistent gender discrimination exacerbates these issues, resulting in disparities in healthcare access and outcomes. This review explores how biological, sociocultural and behavioural factors contribute to the differential incidence of AMR in women. We present a conceptual framework to understand how gender norms influence antibiotic use and AMR. Differences in infection susceptibility, health-seeking behaviours, the ability to access and afford essential antibiotics and quality healthcare and appropriate diagnosis and management by healthcare providers across genders highlight the necessity for gender-sensitive approaches. Addressing gender dynamics within the health workforce and fostering inclusive policies is crucial for effectively mitigating AMR. Integrating intersectional and life course approaches into AMR mitigation strategies is essential to manage the changing health needs of women and other vulnerable groups.

Background Alcohol use is a well-established potentially modifiable risk factor for suicide, yet few studies have investigated the impact of alcohol restrictions on suicide rates, particularly in low- and middle-income countries. Methods We used data from nationally representative annual surveys of postmortem investigations in 2017 (n=6117) and 2020/21 (n=6586) to estimate changes in suicide rates associated with the COVID-19 pandemic and related alcohol restrictions. Findings Age standardised suicide mortality rates per 100 000 were 10.91 (10.64, 11.18) in 2017 and 10.82 (10.56, 11.08) in 2020/2021, with approximately 4.4 times more deaths among males than females in both periods. No significant differences were observed between overall suicide rates during the 2020/2021 pandemic period compared with 2017 (risk ratio=1.04 (1.00, 1.07)), but in the 15–24-year age group, suicide rates were 11% higher among males and 31% higher among females than in 2017. Partial alcohol restrictions during the pandemic were not associated with lower suicide risk. However, the shift from partial to full restriction on the sale of alcohol was associated with an 18% (95% CI 10% to 25%) reduction in suicides for both sexes combined and a 22% (95% CI 13% to 30%) reduction in suicides among men, but no significant reduction among women. Interpretation Our findings offer some support for the hypothesis that restricting access to alcohol at a population level is associated with a reduction in suicide rates and suggests that restricted access to alcohol may have been one of the reasons global suicide rates did not increase during the pandemic in some countries.

This paper critically examines how urban planning influences food security in the rapidly urbanizing landscapes of Africa, focusing on Lesotho, Zimbabwe, and South Africa. These countries, with their distinct urban challenges and developmental contexts , provide a comparative framework for understanding the pivotal role of urban planning in addressing urban food security issues. The paper presents several core aspects of urban food systems: the integration of urban agriculture, the effectiveness of food distribution networks, the impact of spatial inequalities on food access, and the potential of collaborative governance to sustain urban food systems. The analysis reveals that despite varying degrees of urban infrastructure and economic conditions , commonalities exist in the challenges faced. Key findings suggest that pro-active, innovative urban planning, tailored to the specific socioeconomic contexts of each country, can significantly enhance food security. Strategic recommendations are proposed, advocating for comprehensive urban planning reforms that prioritise food system resilience, equitable land use, and infrastructural investment. This study contributes to studies on sustainable urban development by demonstrating how integrated urban planning and targeted policy interventions can significantly enhance the resilience and equity of urban food systems.

The isotopic composition of body tissues can provide information about diet and patterns of movement or migration during life. Here, we report δ¹³C, δ¹⁵N and ⁸⁷Sr/⁸⁶Sr analyses for a small sample of fauna and for the 12 humans buried at Faraoskop, and make inferences about how these people ranged across the landscape as they hunted and foraged. δ¹³C and δ¹⁵N values for collagen from cortical and cancellous bone and (for two individuals) desiccated muscle tissue are similar, reflecting consumption of isotopically similar, mostly terrestrial foods throughout life. Not all individuals had teeth preserved but for five we were able to measure ⁸⁷Sr/⁸⁶Sr in tooth enamel in an earlier- and a later-forming tooth. Where possible, teeth were analysed near the occlusal surface, half-way up the height of the crown and near the dentine/enamel junction, to assess variation during the period of crown formation. Only one of the five (UCT 394) showed significant intra-individual variation in ⁸⁷Sr/⁸⁶Sr, between 0.6 and 3.5 years of age. Two individuals yielded enamel ⁸⁷Sr/⁸⁶Sr like the geologically recent sediments of the coastal plain to the west of Faraoskop, while three individuals had values intermediate between the coastal plain and the more ancient shales and sandstones of the Table Mountain Group to the east. As young children, people buried at Faraoskop ranged over different areas of the local landscape, probably as part of different social groups.

Purpose of Review Despite global incidence, considerable morbidity, and diverse triggers, CU is poorly characterized amongst diverse African populations. This systematic review aims to describe available African CU studies and unmet needs. Recent Findings Overall 221 publications were screened and 29 were eligible for full review. These publications represented only 12 of 54 African countries, with 38% from Nigeria. Most publications described CU within the context of dermatology out-patient clinics(21/29), with a CU prevalence of 0.03–10.4%. Two studies detailed CU demographics, with a female predominance and median age of 30–40 years. CU patients reported variable associations with infections, including T.canis(Egypt), and H.pylori(Nigeria and South Africa), with other risk factors including foods, food additives, and low vitamin D levels. UAS was reported for < 100 CU patients, and only two studies detailed and CU co-morbidities, while none addressed other patient-reported outcome or quality-of-life measures, treatment access and/or efficacy. Summary Despite considerable disease prevalence, CU is poorly detailed in African populations. Further CU studies are required to detail phenotypes, disease severity and describe treatment use and unmet needs.