University of Brighton

In May 2022, when the COVID-19 pandemic began to recede from public view, another infectious disease surprised the world—mpox (formerly monkeypox). It appeared to disproportionately affect gay, bisexual and other men who have sex with men (GBMSM). Using qualitative thematic analysis and social representations theory, we analysed a corpus of 91 items from a variety of news outlets that included GBMSM community members’ personal accounts of living through an mpox outbreak. The aim was to study the various ways in which members of a marginalised group created social representations of mpox and to ascertain whether these challenged older representations related to HIV and AIDS and newer ones related to COVID-19. Commentators anchored mpox to known, culturally accessible phenomena to render this previously unfamiliar disease familiar; objectified aspects of mpox, especially pain, through emotive language, making it ‘real’ and psychologically tangible; personified it by linking it to accounts of celebrity activists; and ontologised it through visually vivid descriptions. Challenging stigma was a cross-cutting theme in people’s accounts. In contrast to the stigmatising imagery of health issues affecting GBMSM, these accounts contribute to the development of social representations designed to challenge such stigmatisation, which, in the contexts of HIV and AIDS and COVID-19, has hindered effective medical interventions, promoted misinformation and fuelled denigration.

Net zero as a policy for reducing atmospheric carbon emissions is relatively straightforward; however, the implementation of that policy is not, particularly in difficult-to-measure sectors such as agriculture. As strategies to reduce emissions are explored, multiple uncertainties in measuring these emissions are confronted. In this paper, we use the example of a coffee supply chain in Peru to illustrate the magnitude of potential variability in emissions accounting results, which represent a necessary first step in moving towards net zero. We show that scope boundaries and emissions factors chosen for carbon calculations significantly alter emissions outcomes and can result in discrepancies of over 77 million kg CO2e when scaled to a medium-size coffee trader. Net zero targets and efforts to reduce emissions may be over- or understated depending on subjective decisions that cause significant differences in emissions results. Although framework guidance exists, it is apparent that a greater set of micro-level agreements is needed for calculating the emissions of lesser-studied sectors, such as agricultural supply chains. This process is imperative to focus efforts on reducing emissions and on moving from net zero as a mere policy to action and implementation.

Background Lesbian, gay, bisexual, trans, queer/questioning, plus young people have a higher risk of poor mental health in comparison to cisgendered heterosexual young people, and they underutilise mental health services and support. In addition, there is a paucity of research conducted in United Kingdom examining mental health early intervention provision for lesbian, gay, bisexual, trans, queer/questioning, plus young people. Objectives To produce a model of what works for early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people and increase understanding of lesbian, gay, bisexual, trans, queer/questioning, plus young people’s access to, navigation of, and engagement with mental health support. Method This was a multi-methods theory-led case study evaluation with three distinct stages: (1) a meta-narrative review of existing literature to develop a theoretical framework to explain effective mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people; (2) an online and offline service mapping exercise to locate current mental health early intervention support for lesbian, gay, bisexual, trans, queer/questioning, plus young people in the United Kingdom in order to produce a service typology; and (3) a theory-led case study evaluation of 12 case study sites selected from the service typology produced in stage 2, to establish the components of appropriate quality, early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people. Results Stage 1 produced an interdisciplinary theoretical framework indicating that early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus youth must prioritise addressing normative environments that marginalise youth, lesbian, gay, bisexual, trans, queer/questioning, plus identities and mental health problems. Stage 2 mapping found 111 services, the majority in urban settings in England. There was an absence of mainstream National Health Service support that specifically addressed the needs of lesbian, gay, bisexual, trans, queer/questioning, plus young people. The majority of lesbian, gay, bisexual, trans, queer/questioning, plus youth mental health support was provided by voluntary/community organisations. Stage 3 case study evaluation found that an intersectional, youth-rights approach is the most appropriate way to deliver early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people. Youth rights should underpin mental health support to address the multiple marginalisation, isolation and stigmatisation that lesbian, gay, bisexual, trans, queer/questioning, plus young people may experience and to enable them to make informed independent decisions about their own bodies and lives, and for the right to freedom of safe self-expression to be upheld. The model that we have produced contains 13 principles that are necessary to the provision of mental health support, and to improve access to, engagement with, and navigation of mental health services. Conclusions In the United Kingdom, a rights-based approach to mental health service provision is not prominent. In addition, at the time of writing, lesbian, gay, bisexual, trans, queer/questioning, plus young people are facing active legislative and policy attacks on their human rights. This study provides the first large-scale theory-led evaluation of early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people with common mental health problems. The resulting intersectional, youth-rights approach provides evidence on ways of improving lesbian, gay, bisexual, trans, queer/questioning, plus young people’s mental health. Further research on the implementation of an intersectional, youth-rights approach to early intervention mental health support for lesbian, gay, bisexual, trans, queer/questioning, plus young people with mental health problems is required. Study registration This study is registered as PROSPERO CRD42019135722. Funding This award was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme (NIHR award ref: 17/09/04) and is published in full in Health and Social Care Delivery Research ; Vol. 12, No. 47. See the NIHR Funding and Awards website for further award information.

Background Health inequalities are a well‐known and widespread phenomenon throughout health care settings. In particular, people of color experience higher rates of delayed and/or misdiagnosis contributing to poorer outcomes and an increased mortality risk. Research suggests that health care professionals find it more difficult to correctly diagnose dermatological conditions in the non‐White patient demographic. Although podiatrists routinely examine and assess skin lesions, there is a paucity of research exploring their accuracy or confidence in recognizing skin pathologies. This study aims to investigate podiatry student's ability, confidence, approaches, and perceptions in diagnosing dermatology pathologies in different skin tones. A mixed methods exploratory sequential design is proposed. In stage one, podiatry students from different higher education institutions will be invited to complete a pictorial survey. We have designed a survey comprising six validated images of inflammatory skin pathology (either eczema or psoriasis) in three different skin tone categories, standardized using the Fitzpatrick scale. Data from the survey in stage one will then be utilized to inform the next stage of the research. In stage two, respondents who completed the initial survey will be invited to participate in focus groups to explore their perceptions surrounding diagnostic approaches, confidence, and perceptions of skin conditions in different skin tone. A process of thematic analysis will be employed to identify emergent themes from these data. Methods A mixed methods exploratory sequential design is proposed. In stage one, podiatry students from different higher education institutions will be invited to complete a pictorial survey. We have designed a survey comprising six validated images of inflammatory skin pathology (either eczema or psoriasis) in three different skin tone categories, standardized using the Fitzpatrick scale. Data from the survey in stage one will then be utilized to inform the next stage of the research. In stage two, respondents who completed the initial survey will be invited to participate in focus groups to explore their perceptions surrounding diagnostic approaches, confidence, and perceptions of skin conditions in different skin tone. A process of thematic analysis will be employed to identify emergent themes from these data.

The present study aimed to compare peak oxygen uptake (V̇O2peak), peak heart rate (HRpeak) and peak O2 pulse during an incremental and a verification test performed on the same day in hand-cyclists with spinal cord injury (SCI). Eight competitive SCI hand-cyclists (age: 23 ± 2.7 years; V̇O2peak: 2.24 ± 0.79 l.min-1 or 36.3 ± 14.0 ml.kg-1.min-1) performed a maximal incremental handcycling test and a verification test to exhaustion at 100% of V̇O2peak speed on an oversized treadmill. The V̇O2peak, HRpeak and peak O2pulse (i.e. VO2/HR) were compared between incremental and verification tests. V̇O2peak obtained in the verification test (2.51 ± 0.96 l.min-1) was significantly higher than values obtained in the incremental test (2.24 ± 0.79 l.min-1; P = 0.018). There was no difference in HRpeak (Incremental: 169 ± 24 bpm; Verification 167 ± 25 bpm; P = 0.130). Peak O2pulse from the verification test (14.6 ± 4.7 ml.beat−1) was higher than incremental test (13.0 ± 3.8 ml.beat−1; P = 0.007). Six subjects presented variability greater than ± 4% in verification test compared with the incremental exercise. In conclusion, the verification test elicited higher V̇O2peak than the incremental test despite the similar HR, suggesting the relevance of verification phase to determine V̇O2peak of hand-cyclists with spinal cord injuries.

Microplastic contamination of river sediments has been found to be pervasive at the global scale and responsive to plastic and sediment bed properties, the flow regime and the river morphology. The physical controls governing the storage, remobilization and pathways of transfer in sand bed rivers remain unquantified. This means it is not currently possible to determine the risks posed by microplastic contamination within these globally significant river systems. Using controlled flume experiments we show that sand bed rivers can store up to 40% of their microplastic load within the sediment bed indicating that these environments can act as resilient sinks of microplastics. By linking bedform dynamics with microplastic transport characteristics we show that similarities exist between granular transport phenomena and the behavior, and hence predictability, of microplastic flux. Specifically, we demonstrate the inverse relationship between bedform celerity and microplastic retention within the bed can be used to predict microplastic flux. Further, we show that, in these environments, microplastic shape is more important than previously thought in controlling the fate of microplastics. Together, these findings are significant since they have important implications for the prediction and hence management of microplastic contamination in sand bed environments.

Background and Objectives: Evisceration and incisional hernia (IH) represent a significant morbidity following open or laparoscopic colorectal surgery where midline laparotomy or extraction incision (EI) are performed. We executed a systematic review to evaluate primary mesh closure of laparotomy or EI in colorectal resections of benign or malignant conditions. Methods: A comprehensive literature search was performed using PubMed, Science Direct, Cochrane, and Google Scholar databases for studies comparing prophylactic mesh to traditional suture techniques in closing laparotomy in open approach or EI when minimally invasive surgery was adopted in colorectal procedures, regardless of the diagnosis. Both IH and evisceration were identified as primary outcomes. Secondary outcomes included surgical site infections (SSI), postoperative seroma, and length of hospital stay (LOS). Results: Six studies were included in our analysis with a total population of 1398 patients, of whom 411 patients had prophylactic mesh augmentation when closing laparotomy or EI, and 987 underwent suture closure. The mesh closure group had a significantly lower risk of developing IH compared to the conventional closure group (OR 0.23, p = 0.00001). This result was significantly consistent in subgroup analysis of open laparotomy or EI of laparoscopic surgery subgroups. There was no statistically notable difference in evisceration incidence (OR 0.51, p = 0.25). Secondary endpoints did not significantly differ between both groups in terms of SSI (OR 1.20, p = 0.54), postoperative seroma (OR 1.80, p = 0.13), and LOS (MD −0.54, p = 0.63). Conclusions: primary mesh reinforcement of laparotomy or EI closure in colorectal resections lessens IH occurrence. No safety concerns were identified; however, further high-quality research may provide more solid conclusions.

In recent years, social media platforms have become key elements in many teachers' professional lives. In particular, teacher professional activities on X (formerly Twitter) have received attention from scholars. However, research has rarely explored X/Twitter use with attention to the diverse national contexts in which teachers work. To address this literature gap, this qualitative study collected data via individual and focus group interviews with teachers (N = 29) in three countries: England, Norway and the United States of America. Inductive analysis yielded findings related to purposes for, changes in and benefits and challenges of K‐12 teachers' X/Twitter use. Participants from all three contexts described professional learning activities that included sharing and/or acquiring knowledge and resources, and building professional networks and/or communities via X/Twitter. Multiple participants across contexts also referred to similar challenges such as avoiding negativity from other users. However, differences in X/Twitter use were also noted across teachers from the three national settings, such as only Norwegian participants speaking about using X/Twitter to find collaboration partners for teaching and learning projects. We discuss our findings in relation to literature, theory and practice around teacher professional learning in an era of widespread social media. Practitioner notes What is already known about this topic Many K‐12 teachers use X/Twitter and other social media platforms for professional learning purposes. Teachers can use X/Twitter for various purposes and in multiple ways. Contextual factors influence teachers' use of X/Twitter. Social media platform use varies to some extent across cultures and nations. What this paper adds Identification of similarities and differences in X/Twitter use among teachers. International comparative analysis based on individual and focus group interviews of participants from England, Norway and the United States of America. Evidence related to the evolving and dynamic nature of teachers' use of X/Twitter. Implications for practice and/or policy Teachers who use social media may benefit from understanding diverse potential uses of platforms. Policies and guidance regarding K‐12 teacher social media use should accommodate various contextual factors, including national context. Diversity and changes in teacher professional social media use warrant more international comparative research in relation to wider policy contexts in education.

Evidence‐based conservation has made some major steps forward in the last two decades. However, the ‘landscape’ in which evidence is generated, funded and disseminated still has some elements that will need to be further developed if the UK's conservation sector is to achieve its collective nature recovery goals. This paper articulates a shared vision of the conservation evidence landscape in 2035. It was developed by representatives of 27 organisations involved in conservation and nature recovery across the UK. Solution: the authors identified a range of issues that will need to be addressed to allow the evidence base to support and guide nature recovery efforts. These will require action in four key areas: (1) evidence creation, (2) access to evidence, (3) evidence culture, and (4) enabling evidence‐based conservation.

This chapter looks the innovations and inspirations of Caryl Churchill. I consider plays from 1970s to 2016, and her involvement with the Royal Court Theatre. I explore ways she has experimented with stylistics and language, moving between naturalism, fantasy and verse to change conceptions of what is a play and what it can do. The chapter involves close reading of three plays: Top Girls (1982) Far Away (2000) and Escaped Alone (2016) to consider ways in which her plays deal with opposing forces of authoritarian, rational and repressive power structures with the non-rational, playful and fantastical and discusses her influence on a new generation of experimental women playwrights. In the discussion of Top Girls, I consider the visceral experiential aspects of this play about the limits of sisterhood in relation to patriarchy and the rise of Mrs Thatcher. I show how Churchill resists a cathartic climax associated with the objectifying male gaze, letting us draw our own conclusions. In Faraway, I consider the influence of Blasted by Sarah Kane. In her play, Churchill uses experimental and experiential structures to reveal links between the unsafety of a child in a domestic scene, capitalist corruption and global ecocide, in just 26 pages. In my analysis of Escaped Alone I show Churchill’s enduring commitment to putting the stories and relationship between women centre stage, the pleasures women take in each other’s company. Innovation comes with a direct separate address by Mrs Jarrett in which various global catastrophes are described. Once again, the play is experiential and evades clear answers. Finally I review writers such as Winsome Pinnock, Lucy Kirkwood and Moira Buffini, who have credited Churchill as a founding influence, discussing the protean imagination of a writer who resists simple domestic interiors for bold experimentation, ‘to elicit an urgently needed political sensing that the world might be otherwise.’ (Elaine Aston)

Assessing exposure to environmental noise levels at transport corridors remains complex in conditions where no standardized noise prediction model is available. In planning and policy implementation for noise control, noise mapping is an important step. In the present study, land use regression model has been developed to predict the environmental noise levels in Delhi city, India, using previously developed approaches along with machine learning techniques, however improved using new datasets. Lday, Lnight, LAeq,24h, and Ldn were modeled at daily resolution by utilizing an annual noise levels dataset from 31 locations in Delhi city. The noise-monitored data was integrated with travel time data, nighttime light data along with common parameters including land use, road networks, and meteorological parameters. The developed LUR models showed good fit with R² of 0.72 for Lday, 0.55 for Lnight, 0.71 for LAeq,24h, and 0.61 for Ldn, which was further improved up to 0.88 for Lday, 0.79 for Lnight, 0.86 for LAeq,24h, and 0.81 for Ldn by integrating machine learning approaches. The developed models were validated through tenfold cross validation and by comparison to a separate noise level dataset. The average travel time variable was observed to be the most influential predictor of LUR models for Lday and LAeq,24h, which signifies the crucial impact of road traffic congestion on environmental noise levels. The study also analyzed the parametric sensitivity of various infrastructural factors reported in the study, which shall be helpful for planning for smart cities.

Among the known breast cancers, the subtype with HER2 receptors-overexpressing cells is associated with a poor prognosis. The adopted monoclonal antibody Trastuzumab has improved clinical outcomes, but it is associated with drug resistance and relatively high costs. The present work adopted the peptide solid-phase synthesis method to synthesise branched poly(ε-lysine) peptide dendrons with 8 branching arms integrating, at their carboxy terminal molecular root, either an arginine or the HER2 receptor-binding sequence LSYCCK or the scramble sequence CSCLYK. These dendrons were synthesised in quantities higher than 100 mg/batch and with a purity exceeding 95%. When tested with two types of breast cancer cells, the dendrons led to levels of inhibition in the HER2 receptor-overexpressing breast cancer cells (SKBR3) comparable to Trastuzumab and higher than breast cancer cells with low receptor expression (MDA-MB-231) where inhibition was more moderate. Noticeably, the presence of the amino acid sequence LSYCCK at the dendron molecular root did not appear to produce any additional inhibitory effect. This was demonstrated also when the scramble sequence CSCLYK was integrated into the dendron and by the lack of any antiproliferative effect by the control linear target sequence. The specific inhibitory effect on proliferation was finally proven by the absence of cytotoxicity and normal expression of the cell migration marker N-Cadherin. Therefore, the present study shows the potential of poly(ε-lysine) dendrons as a cost-effective alternative to Trastuzumab in the treatment of HER2-positive breast cancer.

A series of alkyl chain containing, asymmetric, homoleptic Fe( ii ) compounds with formula [Fe II (LC n ) 2 ](X) 2 where n = 4, 14 and X = BF 4 (1C4 and 1C14) or n = 6, 8, 10, 12, 16 and X = CF 3 SO 3 (1C6–1C12 and 1C16), are reported.