University College Roosevelt

Background Streptococcus pneumoniae is the most frequent causative pathogen of bacterial pneumonia in children worldwide. Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in their national immunization program for infants in 2015. We assessed its potential coverage in under-fives with community-acquired pneumonia (CAP) in the years before PCV10 was introduced. Methods A total of 1502 childhood pneumonia cases (< 5 year olds living in the urban section Kamalapur, Dhaka) were enrolled between 2011 and 2013. Acute phase and late (convalescent) serum samples were collected from 1380 cases. Serotype-specific pneumococcal antibody concentrations were measured using a 25-plex immunoassay panel. Pneumococcal CAP was diagnosed based on a serotype-specific pneumococcal antibody response. Results S. pneumoniae was serologically identified as causative pathogen in 406/1380 (29%) cases. The five most prevalent serotypes were (in descending order) 11A, 22F, 3, 2 and 19F. Based on the percentage of pneumonia cases associated with PCV10 vaccine types, the potential PCV10 coverage was 29% (116/406). Conclusions In almost a third of the studied cases S. pneumoniae was identified as a causative pathogen. Because of the characteristics of the immunoassay, this might well be a gross underestimation. Nevertheless, the potential PCV10-coverage was low. Given the high serotype diversity, the region might benefit greatly from a higher-coverage PCV or recombinant protein vaccine.

Background Clinical reasoning involves the application of knowledge and skills to collect and integrate information, typically to arrive at a diagnosis, implement appropriate interventions, solve clinical problems, and improve the quality of health care and patient outcomes. It is a vital competency that medical students must acquire, as it is considered the heart of medicine. Purpose This scoping review aimed to identify and summarize the existing literature on learning and teaching strategies for improving clinical reasoning skill in undergraduate medical education. Methods We conducted electronic searches in Scopus, PubMed/Medline (NLM), Web of Science (WOS), and ERIC to retrieve articles published between January 1, 2010, and March 23, 2024. We also performed hand searches by scanning the reference lists of included studies and similar reviews and searching three key journals. After removing duplicates, two reviewers independently extracted data from primary articles using a standard data extraction form. The authors used Arksey and O’Malley’s framework. Results Among the 46581 retrieved records, 54 full-text articles were included in the present review. We categorized the educational strategies based on their aspects, focus, and purpose. Included studies used various educational strategies for improving clinical reasoning skill in undergraduate medical education by serial cue or whole clinical cases that presented as process-oriented or knowledge-oriented. Conclusion This scoping review investigated various dimensions of educational intervention for improving clinical reasoning skill in undergraduate medical education. There is a need for more precision studies with larger sample sizes, designing studies according to randomized controlled trials standards, determining MCID, or performing meta-analyses to acquire robust and conclusive results.

The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study the direct effect of chemotherapy-induced IEC damage on T cell behavior. Exposure of intestinal organoids to busulfan, fludarabine, and clofarabine induced damage-related responses affecting both the capacity to regenerate and transcriptional reprogramming. In ex vivo co-culture assays, prior intestinal organoid damage resulted in increased T cell activation, proliferation, and migration. We identified galectin-9 (Gal-9) as a key molecule released by damaged organoids. The use of anti-Gal-9 blocking antibodies or CRISPR/Cas9-mediated Gal-9 knock-out prevented intestinal organoid damage-induced T cell proliferation, interferon-gamma release, and migration. Increased levels of Gal-9 were found early after HSCT chemotherapeutic conditioning in the plasma of patients who later developed acute GVHD. Taken together, chemotherapy-induced intestinal damage can influence T cell behavior in a Gal-9-dependent manner which may provide novel strategies for therapeutic intervention.

The current pilot study focuses on the importance of emotion regulation (ER), gender identity and sexuality for subjective well-being. It is the first large cross-cultural study to examine the difference in use of adaptive and maladaptive ER strategies while differentiating sexual and gender minorities (SGMs) from non-SGMs. An online questionnaire was distributed across 2,485 students in 13 countries using convenience sampling. Multigroup path analysis supported hypothesised model across all groups. Overall, adaptive ER strategies were positively associated with subjective well-being, while maladaptive ER strategies were negatively associated with subjective well-being. SGM participants scoed significantly lower on subjective well-being when compared to their non-SGM counterparts. Additionally, SGM participants scored significantly higher on maladaptive ER strategies, and significantly lower on adaptive ER strategies compared to non-SGMs. Further research should focus on tools and ways to increase the use of more adaptive ER strategies in SGMs to improve their well-being.

In this meta-analysis, we examined the effects on students’ motivation of student-centered, problem-driven learning methods compared to teacher-centered/lecture-based learning. Specifically, we considered problem-based (PBL), project-based (PjBL), and case-based learning (CBL). We viewed motivation as a multifaceted construct consisting of students’ beliefs (competence and control beliefs), perceptions of task value (interest and importance), and reasons for engaging in tasks (intrinsic or extrinsic). In addition, we included students’ attitudes toward school subjects (e.g., science). We included 139 subsamples from the 132 included reports (83 PBL, 37 PjBL, and 19 CBL subsamples). Overall, PBL, PjBL, and CBL had a small to moderate, heterogeneous positive effect (d = 0.498) on motivation. Moderator analyses revealed that larger effect sizes were found for students’ beliefs, values, and attitudes compared to students’ reasons for studying. No differences were found between the three instructional methods on motivation. However, effect sizes were larger when problem-driven learning was applied in a single course (when compared to a curriculum-level approach). Larger effects were also found in some academic domains (i.e., healthcare and STEM) than in others. While the impact of problem-driven learning on motivation is generally positive, the intricate interplay of factors such as academic domain and implementation level underscores the need for a nuanced approach to leveraging these instructional methods effectively with regard to increasing student motivation.

Scattering processes are a standard topic covered in introductory courses on quantum mechanics and particle physics. Unfortunately, a full mathematical treatment tends to be overwhelming for undergraduate students. This article introduces some toy models that are easy to comprehend but still contain the essential features of quantum theory. We define a Hilbert space with state vectors and use creation/annihilation operators to construct transition matrices and S-matrices. We show how perturbation theory gives rise to Feynman diagrams and Feynman rules. We also discuss how we can use symmetry and group theory to restrict what interactions are possible.

Dignification of victims is understood as the process of restoring their dignity, which is their full and equal status as human beings with autonomy and material, social and natural conditions for a good or dignified life. We discuss how civil servants’ understanding of a dignified victim affects how they implement material reparations. In turn, we explore how the implementation of material reparation affects the dignification of victims, according to victims. Using a life-story approach, we conducted 13 semi-structured interviews with civil servants and victims’ leaders. This sample allowed us to analyse a cumulation of over 20 years of dedicated work with victims in the region. We identified four themes that civil servants consider necessary for a process of victim dignification: participation, empowerment, de-stigmatisation and dignified listening. We explain how these themes can have the non-intended consequence of ignoring or denying some important elements for the recognition of victims’ dignity.

Previous studies have shown that exposure to gender stereotypes has a detrimental impact on women’s performance. In chess, it has been demonstrated that the performance level of women is negatively influenced when they are exposed to negative stereotypes about their ability to play chess. However, it is still largely unclear whether the influence of a negative stereotype of women’s ability to play chess is only limited to their level of performance, or whether it could also affect their opponent’s performance. The present study investigated this reversed stereotype threat in online chess playing an unrated game. It was expected that a chess player’s performance would be influenced by the gender of their opponent. However, the participants’ online opponent was neither a female nor male chess player, but rather, unknown to the participants, it was a computer program that either played with a male or female nickname. The results showed that participants who played against a female nickname played less well, lost more games, and made more mistakes and blunders than participants who played against a male nickname. In sum, findings indicate that, in chess, the influence of a gender stereotype is not limited to the group the stereotype is targeted at, but also reduces the performance of the opponent’s level of play, leading to a reversed stereotype threat.

Despite advances in immunosuppressive prophylaxis and overall supportive care, gastrointestinal (GI) graft-versus-host disease (GVHD) remains a major, lethal side effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has become increasingly clear that the intestinal epithelium, in addition to being a target of transplant-related toxicity and GVHD, plays an important role in the onset of GVHD. Over the last two decades, increased understanding of the epithelial constituents and their microenvironment has led to the development of novel prophylactic and therapeutic interventions, with the potential to protect the intestinal epithelium from GVHD-associated damage and promote its recovery following insult. In this review, we will discuss intestinal epithelial injury and the role of the intestinal epithelium in GVHD pathogenesis. In addition, we will highlight possible approaches to protect the GI tract from damage posttransplant and to stimulate epithelial regeneration, in order to promote intestinal recovery. Combined treatment modalities integrating immunomodulation, epithelial protection, and induction of regeneration may hold the key to unlocking mucosal recovery and optimizing therapy for acute intestinal GVHD.

This article discusses the potential and limits of municipal solidarity with refugees to offer solutions to some of the acute problems caused by the lack of international and intra-European Union (EU) solidarity. It focuses on the Greek island of Tilos, which in contrast to the nearby hotspot islands has developed a reception model that safeguards refugees’ rights, preserves social cohesion, and contributes to local development. The article shows that spontaneous expressions of municipal solidarity can be gradually transformed into sustained commitment to refugee reception, and highlights the opportunity that municipal solidarity opens up for strengthening refugee protection in the EU. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

Aim To study the hypothesis that COPD patients who do not achieve seroprotective levels after influenza vaccination, are a less immune-competent group with a higher risk of morbidity and mortality. Methods 578 patients included in the COMIC cohort had pre- and post-vaccination stable state blood samples in which influenza-vaccine specific antibodies were measured. Post-vaccination titers of ≥40 were considered protective and indicative of being immuno-competent. Primary outcome was all-cause mortality. Morbidity was defined as time till first severe acute exacerbation in COPD (severe AECOPD) and time till first community acquired pneumonia (CAP). Results 42% of the patients achieved seroprotective levels to both H1N1 and H3N2 after vaccination. Seroprotective levels to H3N2 were markedly higher (96%) than to H1N1(43%). Having seroprotective levels to both H1N1 and H3N2 was not associated with less morbidity (severe AECOPD HR 0.91 (95% 0.66–1.25; p = 0.564) (CAP HR 1.23 (95% 0.75–2.00; p = 0.412)) or lower mortality (HR 1.10(95% 0.87–1.38; p = 0.433)). Conclusion In a large well-characterized COPD cohort only the minority of patients achieved seroprotective titers to H1N1 and H3N1 after the yearly influenza vaccination. While achieving seroprotection after vaccination can be considered a surrogate marker of being immunocompetent, this was not associated with lower morbidity and mortality. Whether this means that the immune status is not a relevant pheno/endotype in COPD patients for the course of their disease or that seroprotection is not an adequate (surrogate) marker to define the immune status in COPD needs to be further studied.

We investigated the effects of active workstations on cognitive control functions in individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). In a fully counterbalanced randomized control design, we examined the effects of cycling on a desk bike on phonological working memory (WM) in 18 adolescents with ADHD. Adolescents performed a phonological WM test across two separate sessions during which they either cycled or not. It was hypothesized that participants would perform better on the WM task while cycling as compared to seated-rest. Results showed that total WM performance was not affected by desk-bike cycling. Exploratory analyses suggested that cycling during more difficult trials (i.e., high WM demands) is beneficial for WM performance. More research is needed to shed light on how task difficulty moderates the potential compensatory effect of desk-bike cycling on WM performance in adolescent ADHD participants.

is not needed for Opinion/Commentary

In this chapter, the potential role of mindfulness training in the prevention of radicalization is discussed. After a discussion of the concept and different forms of mindfulness, the relation between mindfulness and radicalization is presented. Vulnerabilities making young people receptive to radicalization which can be addressed by mindfulness are mentioned. Next, interventions to foster mindfulness skills in school-aged children are discussed, together with empirical evidence of their effectiveness. The chapter ends with a description of the mechanisms underlying mindfulness and its effects.

In this chapter, the authors discuss the importance of young peoples’ identity development for the prevention of radicalization. After an exploration of the concept of identity, the relation between identity development and radicalization, is discussed in the context of personal, social and cultural identities. More specifically, an explanation of how identity struggles can lead to receptiveness to radical groups is offered. Then, educational interventions meant to foster positive identity development are discussed. Empirical evidence of their effectiveness is also included.

This chapter focuses on the concept of political self-efficacy. First, it describes what political self-efficacy is and how a deficit in this domain may be related to radicalization. The chapter describes how individuals perceiving a lack of acceptable effective means of addressing their collective grievances can justify violence as a valid mean. These perceptions are to a large degree synonymous to an insufficient political self-efficacy and are often coinciding with limited knowledge. The authors also describe empirical evidence for these relations. Then, educational interventions aimed at increasing political self-efficacy and thereby preventing radicalization are discussed, as well as empirical evidence for their effectiveness.

This chapter describes the relevance of perspective taking and conflict resolution skills for the prevention of radicalization. First, it describes what perspective taking is and why it is important. Then, the authors discuss the relation between perspective taking and radicalization. Afterwards, the authors describe school interventions to increase the perspective taking and conflict resolution abilities of young people, as well as empirical evidence of the effectiveness of these interventions.

Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced antibodies would not be effective). The preferential expansion of cross-reactive antibodies, or T-lymphocytes for that matter, by a related antigen has been termed the original antigenic sin and was first described by Thomas Francis Jr. in 1960. The phenomenon was initially described for influenza virus, but also has been found for dengue and rotavirus. The antibody dependent enhancement observed in feline coronavirus vaccination also may be related to the original antigenic sin. For a full interpretation of the effectivity of the immune response against SARS-CoV-2, as well as for the success of vaccination, the role of existing immunological memory against circulating corona viruses is reviewed and analyzed.

In the past decade or so, vulnerability has become a fairly prominent concept in human rights law. It has evolved from being an underlying notion to an explicit concept. This column takes stock of vulnerability's relationship to, and possible influence on human rights law, assessing the concept's potential and pitfalls. It focuses on the not altogether unrelated issues of migrants’ social rights and on the role of human rights in environmental protection. The discussion commences with a reflection on the potential of vulnerability to re-interrogate those aspects of the human rights paradigm that relate to environmental protection. The next section focuses on the potential of vulnerability to enhance migrants’ social rights within human rights law. Subsequently, it focuses on the pitfalls and the difficulties of the vulnerability concept. It concludes by offering an outlook for the future of the concept.