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    ABSTRACT: The use of Internet services is part of the daily life of people and should be easy to understand, presenting no technological barriers regardless of the type of user or of the equipment being used. Elderly users play a prominent role in the increased use of online tools, not only on personal computers but also in the use of new technologies such as tablets. This exploratory study, with ten participants, aims at analyzing interactions made by elderly and young users when accessing Gmail on the web version of the iPad and comparing it to that of young users in order to assess similarities and differences. Focus was placed on academic issues related to interfacing by elderly users, whereby some points were still relevant and others criticized for not being aligned with the technology of tablets and the form of gestural interaction. As a result, a list of recommendations was compiled for the development of web interfaces for tablets/iPads with emphasis on elderly users.
    No preview · Article · Dec 2015 · Procedia Computer Science
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    ABSTRACT: The lack of reading skills affects the way users search on the Web or interact with computer interfaces. Developers and designers must comprehend these users’ limitations in order to provide features that meet their needs and help them to have a better experience on the Web when using search features. In this work we analyzed the interaction of users with low reading skills with a limited set of search features. Their behavior and preferences were compared to general users’ behavior on search interfaces retrieved from literature. These comparison permitted to identify related issues and create a set of common recommendations.
    Full-text · Article · Dec 2014 · Procedia Computer Science
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    ABSTRACT: Unlabelled: Retinoblastoma (RB) is a malignant neoplasia that occurs mostly in children under 5 years. Recently, CDKN1A gene has been shown to be up-regulated in a context of loss of function of pRb. This gene encodes the p21 protein, which is the bona fide effector of p53. We hypothesized whether two putatively functional single nucleotide polymorphisms (SNPs) of CDKN1A (rs1801270 C>A and rs1059234 C>T) may influence the risk and/or survival of RB patients. We genotyped both SNPs in 141 RB patients and 120 unrelated healthy individuals. Statistical analyses consisted of chi-square (χ(2)), odds ratio (OR) and survival curves by Kaplan-Meier method. We found that patients who carry the genotype CA for rs1801270 and CT for rs1059234 were associated to an increased risk of RB [OR = 2.5, 95% confidence interval (CI) = 1.38-4.53], whereas patients with CC for both polymorphisms were associated to a lower risk of developing RB (OR = 0.43, 95% CI = 0.25-0.74). On the other hand, Kaplan-Meier curves did not show statistically significant differences in survival among the studied polymorphisms. We conclude that the minor alleles of rs1801270 and rs1059234 polymorphisms may act as risk factors for the development of RB in our sample. Summary: The minor alleles of polymorphisms rs1801270 C>A and rs1059234 C>T in CDKN1A (p21) gene may act as risk factors for the development of RB; however, they do not seem to influence overall survival.
    Full-text · Article · Sep 2013 · Carcinogenesis

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