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    ABSTRACT: Breast cancer is the second-most prevalent cancer in the United States. Although overall outcomes are promising for early-stage (I/II) disease, prognosis is poor for those with metastatic or recurrent disease. Skeletal recurrence occurs frequently in breast cancer and is associated with significant morbidity. However, the mechanisms underlying the development of skeletal metastases in breast cancer are poorly understood. Cox et. al. recently reported their discovery that lysyl oxidase (LOX) induces skeletal metastases in estrogen receptor-negative (ER-negative) breast adenocarcinoma. They first uncovered differential expression of LOX in samples of tumoral tissue from ER-negative breast cancers. Using a murine syngeneic model of spontaneously-metastasizing ERnegative breast adenocarcinoma, they demonstrated increased formation of pre-metastatic osteolytic lesions in mice harboring tumors with high levels of LOX expression and in those treated with tumorconditioned media from tumor cell lines with high levels of LOX expression. These findings were reproducible with colorectal adenocarcinoma cell lines overexpressing LOX. Perhaps most notably, they demonstrated that the pre-metastatic lesions observed form when LOX stimulates osteoclast activity in a RANK-independent manner. Although further work is needed to elicit why LOX is associated with skeletal metastases in ER-negative breast cancer alone, this work supports a role for novel, LOX-specific inhibitors in treating skeletal recurrence of ER-negative breast adenocarcinoma.
    No preview · Article · Sep 2015
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    ABSTRACT: Nipple-areola complex reconstruction has been shown to improve breast reconstruction patients' overall satisfaction. Trilobed flap variations are some of the more commonly used flaps for nipple-areola complex reconstruction. The donor-site scar frequently extends outside the width of an ideal areolar tattoo diameter. There have been many modifications to the original flap design, but none of them addresses the length of the donor-site scar. The technique described uses a triangular stitch in the donor site to limit the length of the scar. This also creates tiny dog-ears within the future areola zone that give a natural wrinkled appearance when tattooed.
    No preview · Article · Aug 2015 · Plastic and Reconstructive Surgery
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    ABSTRACT: dictyBase is the model organism database for the social amoeba Dictyostelium discoideum and related species. The primary mission of dictyBase is to provide the biomedical research community with well-integrated high quality data, and tools that enable original research. Data presented at dictyBase is obtained from sequencing centers, groups performing high throughput experiments such as large-scale mutagenesis studies, and RNAseq data, as well as a growing number of manually added functional gene annotations from the published literature, including Gene Ontology, strain, and phenotype annotations. Through the Dicty Stock Center we provide the community with an impressive amount of annotated strains and plasmids. Recently dictyBase accomplished a major overhaul to adapt an outdated infrastructure to the current technological advances, thus facilitating the implementation of innovative tools and comparative genomics. It also provides new strategies for high quality annotations that enable bench researchers to benefit from the rapidly increasing volume of available data. dictyBase is highly responsive to its users needs, building a successful relationship that capitalizes on the vast efforts of the Dictyostelium research community. dictyBase has become the trusted data resource for Dictyostelium investigators, other investigators or organizations seeking information about Dictyostelium, as well as educators who use this model system. This article is protected by copyright. All rights reserved. © 2015 Wiley Periodicals, Inc.
    No preview · Article · Jun 2015 · genesis

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Top publications last week by reads

 
Journal of the American College of Cardiology 02/2016; 67(4):390-391. DOI:10.1016/j.jacc.2015.11.025
78 Reads
 
Therapeutic Advances in Urology 10/2015; 8(1). DOI:10.1177/1756287215607818
49 Reads

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Collaborations

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See how the RG Scores of researchers from The University of Chicago Medical Center are distributed.