Temple University

Madagascar's celebrated land-vertebrate assemblage has long been studied and discussed. How the ancestors of the 30 different lineages arrived on the island, which has existed since 85 Mya and is separated from neighboring Africa by 430 km of water, is a deeply important question. Did the colonizations take place when the landmass formed part of Gondwana, or did they occur later and involve either now-drowned causeways or overwater dispersal (on vegetation rafts or by floating/swimming)? Following a historical review, we appraise the geological–geophysical evidence and the faunal-suite colonization record. Twenty-six of the clades are explained by temporally stochastic overwater dispersals, spanning 69–0 Mya, while two others are considered Gondwanan vicariant relicts. Due to a lack of information, the remaining two groups cannot be evaluated. The findings thus appear to resolve a debate that has rumbled along, with sporadic eruptions, since the mid-1800s.

Although childhood maltreatment is associated with externalizing symptoms, not all individuals with these experiences develop externalizing behaviors and some exhibit positive adjustment. To address this multifinality, we used latent growth curve modeling to identify trajectories of (a) externalizing symptoms and (b) subjective wellbeing from late adolescence through young adulthood, determine whether types of childhood maltreatment and domains of executive functioning (EF) are associated with initial levels and growth (slopes) of externalizing symptoms or subjective wellbeing, and investigate whether EF moderates these relations. Participants were youth recruited at ages 10–12 ( N = 775; 69% male, 31% female; 76% White, 21% Black/African American, 3% multiracial). We examined EF at ages 10–12, childhood maltreatment reported retrospectively at age 25, and externalizing symptoms and subjective wellbeing at multiple points between ages 16 and 28. Experience of childhood maltreatment and certain EF domains were associated with externalizing symptoms and subjective wellbeing at age 16. EF domains were associated with rate of change in externalizing problems, though not in expected directions. EF variables moderated the relation between maltreatment and initial levels of both outcomes and change in externalizing symptoms. Findings have implications for intervention efforts to mitigate externalizing problems and bolster positive adjustment.

The Global initiative for chronic Obstructive Lung Disease (GOLD) report states that the diagnosis of chronic obstructive pulmonary disease (COPD) should be considered in individuals with chronic respiratory symptoms and / or exposure to risk factors. Forced spirometry demonstrating airflow obstruction after bronchodilation is required to confirm the diagnosis using a threshold of forced expiratory volume in 1 s (FEV 1 ) / forced vital capacity (FVC) ratio<0.7. This GOLD Science Committee review weighs the evidence for using pre- or post-bronchodilator (BD) spirometry to diagnose COPD. Cohort studies have shown that pre- and post-BD spirometry give concordant diagnostic results in most cases, although the prevalence of COPD is up to 36% lower with post-BD values. Discordant results may occur in “volume” or “flow” responders. Volume responders have reduced FVC due to gas trapping causing FEV 1 / FVC ratio >0.7 pre-BD, but a volume response occurs post-BD with a greater improvement in FVC relative to FEV 1 decreasing the ratio to <0.7. Flow responders show a greater FEV 1 improvement relative to FVC which may increase FEV 1 / FVC from <0.7 pre-BD to >0.7 post-BD; these individuals have an increased likelihood of developing post-BD obstruction during follow up and require monitoring longitudinally. GOLD 2025 recommends using pre-BD spirometry to rule out COPD and post-BD measurements to confirm the diagnosis. This will reduce clinical workload. Post-BD results close to the threshold should be repeated to ensure a correct diagnosis is made. Post-BD measurements ensure that volume responders are not overlooked and limit COPD overdiagnosis.

Objectives To determine whether history of traumatic brain injury (TBI) is associated with psychopathology, and, in particular, substance use disorder (SUD) in young adults with a history of athletic participation. Design Observational study. Setting University in the northeastern United States. Participants A large (n = 534) and mixed sex (57% female) sample of varsity and club sport athletes older than 18 years. Interventions None. Main Outcome Measure The Ohio State University Traumatic Brain Injury ID assessment and the Structured Clinical Interview for the diagnostic and statistical manual of mental disorders, fifth edition. Results Twenty-five percent of participants reported no history of head injuries, 32% reported 1 head injury, and 43% reported more than 1 head injury. Thirty-eight percent of participants had been diagnosed with 1 or more concussions. Twenty-eight percent of participants had a current psychiatric diagnosis and 49% had at least 1 lifetime diagnosis. Head injuries and concussions were significantly associated with the presence of lifetime psychiatric diagnosis and symptoms or diagnosis of alcohol or SUD. More head injuries were associated with symptoms of post-traumatic stress disorder. Conclusions Higher number of self-reported head injuries and diagnosed concussions were associated with a lifetime history of psychopathology, and specifically, with alcohol and substance use disorders. These relationships are similar to those seen in the general population of adults. The relationships also raise several interesting questions about recovery from head injuries in young adult athletes.

Printed electrochemical strips are increasingly used in nucleic acid diagnostics due to their affordability portability, compactness, and ease of use. To respond to traditional electrochemical methods that require complex immobilization protocols, in this study, we introduce a simplified platform that combines a cost-effective electrode printed on a polyester substrate with a hybridization chain reaction (HCR) for DNA signal amplification. Unlike prior approaches that rely on nanomaterials or intricate modifications, our method places the target sequence and hairpins directly on the electrode surface, reducing both cost and preparation time while maintaining efficient signal amplification. Using DNA modified with methylene blue (MB) as a redox mediator, the system generates a "signal-off" response by suppressing electron transfer when MB intercalates into the DNA polymers formed by HCR. This approach eliminates the need for complex surface functionalization, enhancing ease of fabrication and consistency. Targeting miRNA-21, a known cancer biomarker, the sensor achieves picomolar sensitivity in both buffer and diluted human serum. This platform offers a cost-effective, sensitive, and portable solution for point-of-care diagnostics and real-time miRNA monitoring in clinical settings.

This review examines the integration of traditional pharmacological methods with alternative and complementary therapies in chronic pain management. It delves into neurostimulation techniques, highlighting their clinical outcomes and biological bases. Acupuncture's role in modulating pain pathways is explored, illustrating its balance of tradition and clinical application. The paper also covers the pain-relieving potential of herbal medicine, emphasizing natural products' significance in pain relief. Additionally, it discusses the psychological and rehabilitative dimensions of pain through psychosocial therapy and counseling. The conclusion underscores the importance of a multidisciplinary approach, integrating diverse therapies into conventional pain management to effectively treat chronic pain. This synthesis highlights the synergistic potential of combining traditional and innovative therapeutic modalities, offering a comprehensive guide for healthcare professionals in enhancing pain management practices.

Purpose of Review To summarize selected late-breaking science on cardiovascular disease (CVD) prevention presented at the 2024 European Society of Cardiology (ESC) Congress. Recent Findings Key studies from the 2024 ESC Congress highlight advances in (CVD) management. Apolipoprotein A-1 infusions reduced risk in acute myocardial infarction patients with high LDL cholesterol. Plozasiran cut triglycerides and apolipoprotein C-III levels, lowering pancreatitis risk. A 14-year study linked smoking among youth to cardiac abnormalities. Baseline hsCRP, LDL-C, and Lp(a) were strong predictors of 30-year outcomes in women. Alternative LDL-lowering strategies matched high-intensity statins in effectiveness of LDL-C lowering and reduced diabetes risk. Early combination lipid lowering therapy improved outcomes post-myocardial infarction. Nordic and Mediterranean diets were linked to lower atherosclerotic CVD risk. Summary The findings from the 2024 ESC Congress highlight significant advancements in CVD prevention, including novel lipid-lowering therapies, biomarker-based risk prediction, and lifestyle interventions. These studies underscore the importance of early and personalized treatment strategies to mitigate long-term cardiovascular risk.

Radiation-induced fibrosis (RIF) is a common side effect of cancer treatment, but can manifest into a devastating syndrome for which there is no preventive measure or cure. In rats who perform a repetitive work task, who left untreated develop signs and symptoms that resemble repetitive motion disorders in humans, we have shown that manual therapy prevents the development of fibrosis and other key biomarkers. The fibrosis of RIF and repetitive motion disorders has similar biomarkers. In rats, we sought to determine if manual therapy would alter key biomarkers of post-irradiation fibrosis following X-ray irradiation given to the rat forelimb. One limb of rats was given a damaging dose of X-ray irradiation. Some limbs were massaged using a protocol previously described and characterized. Serum inflammatory markers, histological assays of tissue fibrosis and nerve pathology, and electrophysiology for neuropathic discharge were assayed after 8 weeks. We also tested if an experienced therapist could identify the irradiated limb using blinded palpation at the 8 week end-point. While preliminary assays showed robust changes compared to control limbs, the other assays did not show similar pathology. Our therapist could detect each irradiated limb. Serum inflammatory markers were reduced by massage to the irradiated limb. We conclude that blinded palpation is sensitive to detect subtle changes in tissue following irradiation. In contrast to the preliminary studies, the dose of irradiation used was insufficient to induce long-lasting deep fibrosis or nerve degeneration. We suspect that a difference in housing, and thus physical activity, was the plausible reason for this difference.

Background The positive impact of physical activity on health is widely known. A comparison between activPAL objective measures and International Physical Activity Questionnaire short form (IPAQ‐SF) self‐reported activity levels was completed with older adults with intellectual disability. Understanding differences between the two methodologies will better support the interpretations of findings and recommendations. Methods ActivPAL measures including intensity, time and type were considered for 72 participants. Similarly, the IPAQ‐determined measures were investigated. Implications of different numbers of activPAL valid days were considered. Comparisons between the activPAL and IPAQ‐SF scores were examined using multiple correlation coefficients. Results Low to moderate agreement was found between the activPAL and IPAQ‐SF using Spearman's Rho and Pearson's correlation coefficients. Conclusions The IPAQ‐SF may not be the optimal tool for the accurate determination of activity levels in this population.

Introduction The relationship between food insecurity and access to healthcare in low-resource settings remains unclear. Some studies find that food insecurity is a barrier to accessing care, while others report that food insecurity is associated with a greater need for care, leading to more care utilisation. We use data from the Harambee study in western Kenya to assess the association between food insecurity and difficulty accessing care among people living with HIV (PLWH) with or without comorbid non-communicable diseases (NCDs). Methods The Harambee study is a cluster randomised trial that tested the effectiveness of delivering integrated HIV and NCD care for PLWH. In this cross-sectional analysis, we examined baseline data from Harambee participants to investigate the relationship between household food insecurity and difficulty accessing care, using multivariable logistic regression models, controlling for sociodemographic factors and care satisfaction. We tested for effect measure modification by gender and household wealth and stratified analyses by NCD status. Results Among 1039 participants, 11.1% reported difficulty accessing care, and 18.9% and 51.9% of participants had moderate and severe food insecurity, respectively. Among those with difficulty accessing care, 73.9% cited transportation issues as the major barrier. Difficulty accessing care was greater with higher levels of food insecurity: among participants with low, moderate and severe food insecurity, 5.9%, 9.7% and 14.4% reported difficulty accessing care, respectively. After adjusting for confounders, severe food insecurity was independently associated with difficulty accessing care (adjusted OR=2.5, 95% CI 1.4 to 4.4). There was no statistical evidence for effect measure modification by gender or wealth. Conclusions We found that greater food insecurity was associated with greater difficulty accessing care among PLWH with or without NCDs in rural western Kenya. These findings suggest that addressing social determinants of health may be necessary when implementing integrated HIV and NCD care programmes.

Deep learning (DL) has recently become a key technology supporting radio frequency (RF) signal classification applications. Given the heavy DL training requirement, adopting outsourced training is a practical option for RF application developers. However, the outsourcing process exposes a security vulnerability that enables a backdoor attack. While backdoor attacks have been explored in the vision domain, it is rarely explored in the RF domain. In this work, we present a stealthy backdoor attack that targets DL-based RF signal classification. To realize such an attack, we extensively explore the characteristics of the RF data in different applications, which include RF modulation classification and RF fingerprint-based device identification. Then, we design a training-based backdoor trigger generation approach with different optimization procedures for two backdoor attack scenarios (i.e., poison-label and clean-label). Extensive experiments on two RF signal classification datasets show that the attack success rate is over 99.2%, while its classification accuracy for the clean data remains high (i.e., less than a 0.6% drop compared to the clean model). The low NMSE (less than 0.091) indicates the stealthiness of the attack. Additionally, we demonstrate that our attack can bypass existing defense strategies, such as Neural Cleanse and STRIP.

Mobile CrowdSensing (MCS) is a promising sensing paradigm that leverages users' mobile devices to collect and share data for various applications. A key challenge in MCS is task allocation, which aims to assign sensing tasks to suitable users efficiently and effectively. Existing task allocation approaches are mostly centralized, requiring users to disclose their private information and facing high computational complexity. Moreover, centralized approaches may not satisfy users' preferences or incentives. To address these issues, we propose a novel distributed task allocation scheme based on route navigation systems. We consider two scenarios: time-tolerant tasks and time-sensitive tasks, and formulate them as potential games. We design distributed algorithms to achieve Nash equilibria while considering users' individual preferences and the platform's task allocation objectives. We also analyze the convergence and performance of our algorithm theoretically. In the time-sensitive task scenario, the problem becomes even more intricate due to temporal conflicts among tasks. We prove the task selection problem is NP-hard and propose a distributed task selection algorithm. In contrast to existing distributed approaches that require users to deviate from their regular routes, our method ensures task completion while minimizing disruption to users. Trace-based simulation results validate that the proposed algorithm attains a Nash equilibrium and offers a total user profit performance closely aligned with that of the optimal solution.

Federated Learning (FL) has recently attracted a lot of attention due to its ability to train a machine learning model using data from multiple clients without divulging their privacy. However, the training data across clients can be very heterogeneous in terms of quality, amount, occurrences of specific features, etc. In this paper, we demonstrate how the server can observe data heterogeneity by mining gradient trajectories that the clients compute from a two-dimensional mapping of high-dimensional gradients computed by each client from its bottom layer. Based on these ideas, we propose a new clustered federated learning with gradient trajectory method, called CFLGT, which dynamically clusters clients together based on the gradient trajectories. We analyze CFLGT both theoretically and experimentally to show that it overcomes several drawbacks of mainstream Clustered Federated Learning (CFL) methods and outperforms other baselines.

Background Previous researches on the effect of low-fat diet (LF) on insulin-like growth factor-1 (IGF-1), and its binding proteins (IGFBPs) did not reach a consensus result, and there is no study summarizing these findings. Thus, this systematic review and meta-analysis of randomized control trials (RCTs) was performed to pool available evidence and answer the question whether dietary fat can affect IGF-1 and IGFBPs or not. Methods PubMed, Scopus, ISI Web of Science, Google, Google scholar, ProQuest, and the Cochrane Library were searched without language restrictions until July 2, 2024 to retrieve related studies. Weighted mean difference and the corresponding variance were considered as the effect size. Standard tools were applied to assess the quality of the studies and evidence. Results Pooling data of the eligible studies showed no significant effect of LF diet on IGF-1 (six studies; participants = 1029.; pooled mean = 1.63 ng/ml, 95% CI= [-1.34, 4.59], P = 0.28, I² = 0.00%), and IGFBP-3 (five studies; participants = 969; pooled mean = 65.24 ng/ml, 95% CI= [-169.53, 300.00], P = 0.59, I² = 0.0%). The results of subgroup analysis for IGF-1 and IGFBP-3 also demonstrated no significant findings. For IGFBP-1, available evidence is insufficient since only two studies have been performed yet and their results are contradictory. Conclusions This study indicated no significant effect of LF diet on IGF-1, and IGFBP-3 concentrations. Low certainty of evidence indicates that available evidence cannot support to draw a firm conclusion and future researches may change the estimates.

Converging findings have established that the endocannabinoid (eCB) system serves as a possible target for the development of new treatments as a complement to opioid-based treatments. Here, we show in male and female mice that enhancing levels of the eCB, 2-arachidonoylglycerol (2-AG), through pharmacological inhibition of its catabolic enzyme, monoacylglycerol lipase (MAGL), either systemically or in the ventral tegmental area (VTA) with JZL184, leads to a substantial attenuation of the rewarding effects of opioids in mice using conditioned place preference and self-administration paradigms, without altering their analgesic properties. These effects are driven by cannabinoid receptor 1 (CB1R) within the VTA, as VTA CB1R conditional knockout counteracts JZL184’s effects. Using fiber photometry with fluorescent sensors for calcium and dopamine (DA), we find that enhancing 2-AG levels diminishes opioid reward–related nucleus accumbens (NAc) activity and DA neurotransmission. Together, these findings reveal that 2-AG diminishes the rewarding properties of opioids and provides a potential adjunctive therapeutic strategy for opioid-related analgesic treatments.

This study examined news sources and formats in relation to cultural competence indicators in 140 obesity articles in mainstream and ethnic urban newspapers. Through semantic network analysis, the research found that community and non-government sources and personalized news formats were most strongly associated with cultural competence. Ethnic newspapers pursued a culturally competent approach across all news formats and with their community sources, providing important health news to audiences who need it most.

On January 30, 2022, Northern Ireland observed the 50th anniversary of Bloody Sunday. On that day in 1972, the British Army opened fire on a group of unarmed protesters in Derry, killing 13 and wounding an additional 15. Bloody Sunday was a pivotal moment during the 30 years of conflict in Northern Ireland known as the Troubles, a day widely considered a ‘watershed in British-Irish history’. And while 50 years have passed since this dark day, Bloody Sunday remains vivid in the collective memory of the small country. Considering the cultural and social significance of Bloody Sunday, I sought to answer a simple yet deceptively complicated question: does this still matter? In pursuing this answer, I aimed to understand how journalists and news outlets chose to mark and remember the anniversary in their January and February 2022 coverage. First, I present an overview of Bloody Sunday and its historical role as a catalyst for the three decades of the Troubles. Then, I review relevant memory studies literature in order to understand the role that commemorative news media play in the process of remembering in conflict and post-conflict environments. I then introduce my three research questions and methods before finally discussing the results of my analysis. I found that Bloody Sunday continues to be invoked against British colonialism, that key details of the day remain contested even now, and that the press presented Bloody Sunday as part of a globalised narrative of war-time atrocities.