Tanta University
  • Al Gharbiyah Governorate, Egypt
Recent publications
With the advantages of fast response, good stability, and strong robustness to filter parameter variations as well as load perturbations, the application of passivity-based control (PBC) in the single-phase voltage source inverter (SPVSI) has received extensive attention. However, as a non-linear control strategy, PBC control has a complex coupling structure containing feed-forward, negative feedback, etc., which poses many difficulties for multi-damping design. In addition, ensuring the passivity of the islanded system under various load conditions or filter parameter drift is still an unresolved issue in the damping coefficient design of the PBC controller. Therefore, for SPVSI systems with LC filters, this paper proposes a multi-damping coefficient design method for PBC controllers based on stability domain analysis. The designed PBC controller can ensure system stability under several load conditions or certain deviations of LC filter parameters. Moreover, the design order from the inner to the outer control loop is adopted according to the distribution of individual damping coefficients in the control loop. As a result, each control loop has a good dynamic performance and distinct control bandwidth. Finally, robustness analysis, simulation, and experimental results verify the correctness and effectiveness of the proposed multi-damping coefficients design method for the PBC controller.
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared to 54.00 nM for sorafenib. Compounds 15a, 15b, and 15d showed IC50 from 17.39 to 47.10 µM against human cancer cell lines; hepatocellular carcinoma (HepG2), prostate cancer (PC3), and breast cancer (MCF-7). Meanwhile, the first in terms of VEGFR-2 inhibition was compound 15d which came second with regard to antitumor assay with IC50 = 24.10, 40.90, and 33.40 µM against aforementioned cell lines, respectively. Furthermore, Compound 15d increased apoptosis rate of HepG2 from 1.20 to 12.46% as it significantly increased levels of Caspase-3, BAX, and P53 from 49.6274, 40.62, and 42.84 to 561.427, 395.04, and 415.027 pg/mL, respectively. Moreover, 15d showed IC50 of 253 and 381 nM against HER2 and FGFR, respectively.
Objectives: Evaluation of outcome of women undergoing laparoscopic hysterectomy under general anesthesia with intraoperative (IO) multimodal analgesia. Patients & Methods: 129 women were allocated into three groups: Group F received fentanyl loading dose and IO infusion; Group D received loading doses of dexmedetomidine (DEX) and lidocaine (LID) and infusions; Group M included patients received parecoxib sodium infusion (80 µg/ml), 30 minutes prior to induction of anesthesia and loading doses and IO infusions as group D in addition to parecoxib infusion. Heart rate (HR) and mean arterial pressure (MAP) were continuously non-invasively monitored. Blood samples were obtained for ELISA estimation of serum levels of inflammatory cytokines. Outcomes included adequacy of IO analgesia to control intraoperative MAP changes and postoperative (PO) pain scores and its relation to change in serum cytokines’ levels. Results: Fentanyl infusion induced significantly higher incidence and extent of decreased MAP in relation to preoperative MAP, while IO analgesia used for groups M and D allowed more hemodynamic stability. Patients of groups D and M had significantly shorter duration of PACU stay, longer duration of PO analgesia and lower number requests of rescue analgesia with significantly lower 24-hr pain score. Serum cytokines’ levels were significantly lower in patients of group M than in groups D and F with significantly lower levels in patients of group D compared to group F. Conclusion: Multimodal IO analgesia was efficient to provide IO hemodynamic stability, reduce PO pain, consumption of rescue analgesia and serum cytokines’ levels. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Background: Evaluation of the impact of at-admission hyperglycemia and its management on the outcome of non-diabetic COVID-19 patients concerning development of critical illness. Methods: In total, 364 patients were categorized according to at-admission random blood glucose (RBG) as persistent hyperglycemic (PHG) if at-admission and 6-hr RBG was >140 mg/dl or as stress hyperglycemic (SHG) if at-admission RBG was >140 mg/dl but decreased 6 hr later. Only PHG patients received intensive insulin therapy (IIT) using dose titration schedule according to Leuven titration protocol. All patients were evaluated for critical illness risk using the COVID-GRAM Critical Illness Risk (CG-CIR) score. Study outcomes are the incidence of critical illness and mortality rate (MR) and its relation with the levels of at-admission RBG and inflammatory markers. Results: One hundred and twenty-three patients had PHG and received IIT, and 241 had SHG. Unfortunately, 138 patients developed critical illness and 58 of them deceased with significantly lower incidences among patients who received IIT. Progress to critical disease and mortality were significantly correlated with high CG-CIS scores, RBG and serum levels of CRP and IL-6 but showed negative significant correlation with the application of IIT. The automatic linear modeling analysis defined high at-admission RBG as the most important predictor for progress to critical illness (57%) and mortality (60%), and the Mentel-Haenszel statistic defined IIT as a significant independent predictor for survival of critical COVID patients with at-admission hyperglycemia. Conclusion: Admission hyperglycemia worsens the outcomes of non-diabetic COVID patients, and this effect is positively correlated with RBG. IIT is a safe and effective management and improves outcomes. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
With the growing concern about climate change, businesses have been under increasing pressure from regulatory agencies and customers to implement proactive environmental practices such as eco-innovation. While environmental pressures have been extensively discussed in the literature as drivers of eco-innovation, empirical evidence on the influence of these pressures on eco-innovation behaviour remains inconsistent. Therefore, the current study essentially aims to investigate the direct effect of institutional pressures, namely, regulation, eco-friendly product demand, and competitive pressure on eco-innovation, coupled with the indirect effect of these pressures by mediating internal drivers of eco-innovation including green absorptive capacity and strategically environmental orientation among manufacturing SMEs in Egypt. Based on a sample of 176 managers and owners of these enterprises, a cross-sectional survey is conducted to collect data related to research constructs. The results of data analysis using Smart-PLS show that all external pressures are not directly associated with eco-innovation. Of the six indirect hypothesized effects, only four indirect effects are supported. The results illustrate that green absorptive capacity mediates the relationship between institutional pressure (eco-friendly product demand and competitive pressure) and eco-innovation. The results also show that strategically environmental orientation mediates the relationship between institutional pressure (regulation and competitive pressure) and eco-innovation. This study provides an in-depth understanding of firms’ responses to institutional pressures as well as the notable implications for SMEs managers, policymakers and future researchers.
Tomato is one of the major economically domesticated crops, and it is extensively used in different ways and purposes worldwide. Cell metabolism is the central core of all the biological processes to sustain life including cell growth, differentiation, maintenance, and response to environmental stress. To evaluate how genetic engineering can improve tomato fruit metabolome, the transcriptomic and metabolomic dataset of two transgenic tomato (SlMX1 overexpression and RNAi lines) have been compared with wild type. The combined results demonstrated that the constitutive expression of SlMX1 not only increased trichome formation, carotenoids, and terpenoids as has been stated in several studies, but has also up and down regulate expression of multiple gene related to cell growth (cell wall turnover), primary (carbohydrates, vitamins and phytohormones) and secondary (phenylpropanoids, carotenoids and terpenoids) metabolism, cell signaling, and stress responses. These changes in gene expression due to the constitutive expression of SlMX1 promote the most important agroeconomic traits such as fruit yield and quality, biosynthesis of health-promoting phytochemicals (including phenolic acids, flavonoids, and anthocyanins), and finally, activate resistance to Botrytis cinerea and repress of over-ripening related genes, extending fruit shelf life. In conclusion, the traits improvement achieved by SlMX1 overexpression can be harnessed in molecular breeding programs to engineer increase fruit size and yield, induce health-promoting secondary metabolites , promote fungal resistance and to extend fruit shelf-life.
Epigallocatechin-3-gallate (EGCG) was isolated from Cycas thouarsii leaves for the first time and encapsulated in aqueous core poly(lactide-co-glycolide) (PLGA) nanocapsules (NCs). This work investigates antimicrobial activity and in vivo reno-protective effects of EGCG-PLGA NCs in cisplatin-induced nephrotoxicity. A double emulsion solvent evaporation process was adopted to prepare PLGA NCs loaded with EGCG. Particle size, polydispersity index (PDI), zeta potential, percent entrapment efficiency (%EE), structural morphology, and in vitro release platform were all studied in vitro. The optimum formula (F2) with particle size (61.37 ± 5.90 nm), PDI (0.125 ± 0.027), zeta potential (–11.83 ± 3.22 mV), %EE (85.79 ± 5.89%w/w), initial burst (36.85 ± 4.79), and percent cumulative release (87.79 ± 9.84) was selected for further in vitro/in vivo studies. F2 exhibited an enhanced antimicrobial activity against uropathogens as it had lower minimum inhibitory concentration (MIC) values and a more significant impact on bacterial growth than free EGCG. Forty male adult mice were randomly allocated into five groups: control vehicle, untreated methotrexate, MTX groups treated with a daily oral dose of free EGCG, placebo PLGA NCs, and EGCG PLGA NCs (F2) for 10 days. Results showed that EGCG PLGA NCs (F2) exerted promising renoprotective effects compared to free EGCG. EGCG PLGA NCs group induced a significant decrease in kidney index, serum creatinine, kidney injury molecule-1 (KIM-1), NGAL serum levels, and pronounced inhibition of NLPR-3/caspase-1/IL/1β inflammasome pathway. It also significantly ameliorated oxidative stress and decreased NFκB, Bax expression levels. Aqueous core PLGA NCs are a promising formulation strategy that provides high polymeric protection and sustained release pattern for hydrophilic therapeutic agents. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Objectives Evaluation of the effect and safety of intravenous and local application of tranexamic acid (TXA) on outcomes of transurethral resection of the prostate (TURP). Patients & Methods 138 patients were divided into three groups according to the mode of TXA delivery (Groups I and II) or placebo. Hemoglobin concentration (HBC) and hematocrit value (HTC) were determined before and immediately after surgery to calculate hemoglobin deficit and estimated intraoperative blood loss (IO-BL). All surgeries were performed under bupivacaine spinal anesthesia with the preoperative saline co-load infusion. Results: Patients who received combined IV and local delivery of TXA showed significantly shorter operative time and duration of PO catheterization and hospital stay than patients of other groups. The IO-BL was significantly lower in patients received TXA than placebo. Hemoglobin deficit after surgery was significantly lower in patients received both IV and local delivery of TXA than patients of other groups. No adverse effects of TXA s were reported. Conclusion The applied policy for antifibrinolysis during TURP was safe and effectively improved operative and immediate PO outcomes.
Plant diversity is undoubtedly influenced by spatial and climatic factors, as well as others as architecture, human effects, and population percentage. This research demonstrates how site characteristics influence crop species diversity. One hundred eighty-five cultivated centers of 20 governorates forming the Egyptian Nile Region were examined regarding to their crop diversity from February 2020 to February 2022, including170 crop species, sub-species and varieties. These cultivated centers were classified using two-way cluster analysis (TWCA) into 62 groups according to their floristic composition; and ordinated along the first and second axes of Principal Coordinates Analysis (PCOA) with type of irrigation supply. Group 51 had the uppermost species richness (333.5 species group⁻¹), while group 44 had the uppermost species turnover (9). Eighteen least cultivated species were recorded: 12 species in 2 centers e.g., Actinidia chinensis and Carica papaya and 6 in 3 e.g., Carya illinoinensis and Cyperus papyrus, while 60 species are common in > 50 cultivated centers. Significant correlations were depicted between the species richness and X and Y coordinates, while insignificant correlation with area (m²) of each cultivated centre. Precipitation (mm yr⁻¹), relative humidity (%) and temperature (oC) were depicted an insignificant correlation. Species density (Species m⁻²) was depicted an insignificant correlation, while population percentage had an insignificant correlation. Descriptively, a regular relationship between species diversity and type of irrigation supply and main human activities in each centre was observed.
The growing world population, rapid industrialization, and intensive agriculture have increased environmental impacts such as wastewater discharge and global warming. These threats coupled the deficiency of fossil fuel and the rise in crude oil prices globally cause serious social, environmental and economic problems. Microalgae strains can withstand the harsh environments of modern industrial and municipal wastes. The shift toward a circular bio-economy that relies on resource diversification has also prompted the reorganization of traditional wastewater treatment (WWT) processes into a low-carbon, integrated biorefinery model that can accommodate multiple waste streams. Therefore, microalgae-based WWT is now a serious competitor to conventional WWT since the major bottlenecks of nutrient assimilation and high microalgae population have been partially mitigated. This review paper aims to collate advances and new knowledge emerged in recent years for microalgae-based WWT and related biofuel technologies.
Abstract Background The recent pandemic of COVID‐19 has thrown the world into chaos due to its high rate of transmissions. This study aimed to highlight the encountered CT findings in 910 patients with COVID-19 pneumonia in Egypt including the mean severity score and also correlation between the initial CT finding and the short-term prognosis in 320 patients. Results All patients had confirmed COVID-19 infection. Non-contrast CT chest was performed for all cases; in addition, the correlation between each CT finding and disease severity or the short-term prognosis was reported. The mean age was higher for patients with unfavorable prognosis (P
Background Damage occurs in the brain tissue in MS which appears normal on standard conventional imaging (normal appearing brain tissue). This slow, evolving damage can be monitored by nonconventional advanced MR imaging techniques. New techniques for the measurement of cortical thickness have been validated against histological analysis and manual measurements. The aim of our study was to study the role of MRI surface-based analysis and cortical thickness measurement in the evaluation of patients with Relapsing Remitting Multiple Sclerosis and to detect if there is localized rather than generalized cortical atrophy in Multiple Sclerosis patients and correlating these findings with clinical data. Results 30 patients and 30 healthy control were included in this study and they were subjected to cortical thickness analysis using MRI. The patients in our study showed decreased thickness of the precentral, paracentral, postcentral, posterior cingulate cortices and mean cortical thickness in both hemispheres when compared with the normal control group. Statistical analysis was significant ( P value < 0.05) for the precentral, paracentral, postcentral, posterior cingulate cortices and mean cortical thickness in both hemispheres. On the other hand, statistical analysis was not significant ( P value > 0.05) for other cortices. There was a significant negative correlation between the precentral, paracentral, postcentral, posterior cingulate cortices and mean cortical thickness in both hemispheres and EDSS scores with correlation coefficients ranging from − 0.9878 to − 0.7977. Conclusions MRI and post-processing segmentation analysis for cortical thickness is non-invasive imaging techniques that can increase the level of diagnostic confidence in diagnosis of MS patients and should be included as routine modality when evaluating patients with MS.
Background The presented evidence-based clinical practice guideline (CPG) is proposed as a National CPG using an evidence-based and formal CPG adaptation methodology. The purpose of this study was to adapt the international CPGs’ recommendations for children with bronchiolitis to suit the healthcare system in the Egyptian context. This CPG, ‘diagnosis, treatment, and prevention of Bronchiolitis’, applies to children from 1 through 23 months of age. Other exclusions are noted. The quality of evidence, benefit-harm relationship, and strength of recommendations are indicated. This study is part of a larger collaborative initiative with the faculty staff of pediatric departments of 15 Egyptian universities and a national research center to formulate a national Committee (EPG) that aims to define the topics of, assign authors to, and assist in the adaptation of pediatric evidence-based CPGs according to a national strategic plan. The committee is guided by a formal CPG adaptation methodology: the ‘Adapted ADAPTE’. Results The Bronchiolitis Guideline Adaptation Group (BGAG) reviewed the results of the AGREE II assessment and decided to adapt mainly the Australasian (PREDICT) CPG and for the questions not answered in PREDICT we adapted the relevant recommendations from the American Academy of Pediatrics (AAP) CPG. Seven implementation tools were included: a care pathway for assessment of severity, a clinical algorithm for treatment of acute bronchiolitis in the emergency room, a separate flowchart for assessing babies with bronchiolitis, a power point slide presentation lecture for treatment of acute bronchiolitis, patient information in Arabic, a clinical score (Modified Tal Score) for prediction of bronchiolitis severity, and the criteria for admission and discharge in the hospital. A comprehensive set of multifaceted CPG implementation strategies was provided for the clinicians, patients, nurses, and other relevant stakeholders contextualized to the national settings Conclusion Our experience with this adaptation methodology provides useful insight into its utilization on a national level in Egypt. The BGAG recommended the next review of this adapted CPG to be after 3 years from its publication (i.e., 2022) after checking for updates in the original CPG.
Background Thrombotic consequences have been reported in COVID-19-infected patients, especially those who are critically ill. Multiple studies have tested antiphospholipid antibodies (aPLs) among COVID-19 patients, but to date, the actual frequency of aPLs is still uncharted. In this cohort study, we analyzed the outcomes of 173 consecutive patients with confirmed COVID-19 infection. Anti-phospholipid antibodies, which include anti-cardiolipin antibodies [aCL (IgM), aCL (IgG)], and B2-glycoprotein I antibodies [aβ2GPI (IgM), aβ2GPI (IgG)] were detected by using immunoassays. In contrast, lupus anti-coagulant (LAC) antibodies are identified through a coagulation-based assay. Results The study demonstrated a high incidence of thrombotic consequences in severe COVID pneumonia cases and supported an increased risk of developing aPLs following COVID-19 infection. Pulmonary embolism had the most common prevalence of all thrombotic events. Among the various aPLs tested in thrombotic patients, lupus anti-coagulant (LAC) had the highest positivity (46.2%). Most patients with arterial thromboembolism (stroke, myocardial infarction, limb ischemia, bowel ischemia, and renal artery thrombosis) had triple positivity of anti-phospholipid antibodies. Testing aPLs antibodies after 12 weeks of recovery for survived patients only 2 out of 23 patients had aPLs positivity compared to 35 out of 65 tested during hospital admission. Furthermore, we found no significant changes in aPLs positivity between survived and non-survived patients with thrombotic event. Conclusions aPLs increased transiently as an inflammatory-mediated condition. Individuals with aPLs triple positivity (positive LAC, aCL, and aB2GPI) had a considerable risk of arterial thromboembolism (ATE).
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7,602 members
Mohammed Elhendawy
  • Hepatology and Gastroenterology. (Tropical Medicine and Infectious Diseases)
Ashraf Emara
  • Department of Forensic Medicine and Clinical Toxicology
Ghada Esheba
  • Department of Clinical Pathology
Ahmed Said Elgebaly
  • Faculty of Medicine
Information
Address
El Geish Street, 31111, Al Gharbiyah Governorate, Egypt
Head of institution
Prof. Dr. Mahmoud A.Zaki
Website
http://tanta.edu.eg
Phone
+20403317928, +20403317929
Fax
+2040 3286114