# Sivas Cumhuriyet University

• Sivas, Turkey
Recent publications
In the present work we report the experimental and computational investigations of (2-aminophenyl)[4-(4-chlorophenyl)-1,3-diphenyl-1H-pyrazol-5-yl]methanone (C28H20ClN3O). X-ray diffraction (XRD) showed that the undertaken compound 3 crystallized in a monoclinic system, space group P21/n. The structure exhibited both inter- and intramolecular hydrogen bonding contacts of the type N—H···X (X= O, N, Cl) and C—H···O, which ensured the stabilization of the crystal then the molecular structure. Hirshfeld surface analysis (HSA) showed that other unconventional interactions such as H⋯H (48%) and C⋯H (28%) contributed as well in the molecular assembly. The energy of the HOMO and LUMO orbitals, the molecular electrostatic potential (MEP) and the absorption spectrum were generated using the density functional theory (DFT). The MEP map showed areas of the negative potential region around the electronegative atoms O1 and N3, while the maximum positive sites were around the hydrogen atoms of the amine group. The experimental and computed UV-Vis spectra showed the presence of π-π* and n-π* transitions. The computational results showed that the geometrical and electronic parameters were consistent and in accordance with the experimental data. The anticancer activity of the studied pyrazole was investigated in-silico via molecular docking (MD) towards EGFR tyrosine kinases (PDB ID: 1M17 and 2ITN). The outcomes suggest that the pyrazole 3 has significant interaction with the target receptors. Afterwards, drug properties were investigated by ADME/T analysis, which show that the examined pyrazole 3 has an excellent pharmacokinetic profile and no toxicity risks.
In this study, GeOx films were produced by radio frequency magnetron sputtering (RFMS) under varying oxygen percentages. The structural and optical properties of films grown have been studied experimentally and theoretical calculations have been presented using density functional theory (DFT). Considering the x-ray diffraction (XRD) analysis, Ge (111) peak was observed in the as-deposited film produced only at 2% oxygen percentage. In order to emerge crystal phases, all the amorphous films were annealed at 900 °C under atmospheric conditions. It was found that the intensity of the (101) peak increased as the oxygen percentage increased. At the same time, film grown at 2% oxygen percentage was annealed at different annealing temperatures sequentially at 850, 900, and 950 °C. As a result, the polycrystalline properties changed as the annealing temperature increased. It was found that the optical properties of the films grown are strongly dependent on the oxygen percentage. As the oxygen percentage has changed, the energy band gap has increased to the values 2.30, 2.31, 2.58, and 6.28 eV. There are Ge-O-Ge antisymmetric stretching peaks appeared at 861.51 cm⁻¹, 949.94 cm⁻¹ and symmetric stretching of hexagonal peaks at 516.34 cm⁻¹, 546.29 cm⁻¹, 581.95 cm⁻¹. The energy band gap results of the density functional theory (DFT) calculations are in good agreement with the experimental observations.
Herein, substituted-naphthol derivatives 4a-e were synthesized in two steps, namely the Diels Alder cycloaddition and Cu-catalyzed aromatization reactions, respectively. Then, pththalonitrile derivatives 7-12 have been prepared by a nucleophilic displacement reaction of 3-nitrophthalonitrile with the naphthol derivatives 4a-e, 5 and, obtained in excellent yields. Structural characterization of the compounds was identified by different spectroscopic techniques. Antimicrobial properties of the synthesized compounds were determined by the microdilution procedure against Gram-positive, Gram-negative bacteria, and yeast. Furthermore, the DNA interaction of the compounds were determined by gel electrophoresis. One of the most prominent findings is that compounds 9 and 10 have more inhibitory effects on Gram-positive bacteria than Gram-negative bacteria. These compounds especially exhibited the highest antibacterial potency against S. aureus (625 µg/mL) among Gram-positive bacteria. According to the plasmid DNA interaction results, the synthesized compounds caused changes in the structure and mobility of the plasmid DNA. Then, geometry optimizations and frequency calculations were conducted at B3LYP/6-311G(d,p) level of DFT, and optimized structures were used for further analyses. The NBO results revealed that the π→π* and n→π* interactions were greatly contributed to lowering the stabilization energy of all compounds (7-12). FMO energy analyses showed that compound 9 has the biggest electrodonating power.
Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally‐occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health‐promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants. So far there are no concrete recommendations for their use in the treatment of attention deficit‐hyperactivity disorder. This review aims to provide updated clinical evidence on the use of natural products/formulations and their derived constituents for the treatment of attention deficit hyperactivity disorder.
Background Traumatic tympanic membrane (TM) perforations usually heal spontaneously. The aim of this study was to investigate whether the topical application of Triticum Vulgare (TV) in experimentally induced traumatic TM perforations in the rats has a positive effect on wound healing process. Methods The rats were randomly assigned to four experimental groups. Drugs were introduced twice a day for 7 days. On the 7th day, specimens were sent for histological examination. Results Mean values found in group NC in terms of epithelial regeneration mean scores are as follows: fibroblast and collagen density, neovascularization, and density of inflammation cells were lower than all groups ( p < 0.05). It was found that reepithelization on the post-perforation 7th day was better in the HO group than the TV group. In terms of the subepithelial fibroblast cells, density of collagen fibers, formation of new veins, and inflammatory cell accumulation, it was observed that the group TV was better than the group HO. Conclusion This is the first study investigating the potential curative role of TV in an experimental rat model of tympanic membrane perforation. Considering these findings, it is concluded that TV can be more effective than HO on wound healing in TM perforation.
To the best of the authors’ knowledge, this study is one of its kind since it is related to the quanti- tative shape examination of particles of feed, concentrate, middling and tailing products in coarse and fine shaking table streams of a Turkish chromite concentration plant. In this study, the novel technique; Dynamic image analysis (DIA) as well as visual inspection by SEM and stereomicroscope were used for the representative samples of the plant. Analysis revealed that particle shapes of concentrate products are mostly equant or round while the most elongated particles were observed in tailing products at a 95% confidence level. This is highly linked to the rolling and slid- ing movement of round and elongated particles, respectively on the deck. This implies that par- ticle shape is one of the parameters affecting gravity separation. Using shape data with tonnages of the circuits in mass balance equations indicates that shape distributions of products in table cir- cuits are consistent. This study gives insight as better separation recovery could be obtained when a proper mill is used for producing feed particles, which have targeted shape to shaking tables since any improvements in recovery will have a big effect on the concentrate income.
Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups – (1) control group (C) administered interperitoneally with a single dose 0.9 % saline, (2) Cis group administered a single dose (7 mg/kg) of cisplatin, (3) Sun group administered 10 mg/kg sunitinib for seven days, and (4) Cis+Sun group administered 10 mg/kg sunitinib for seven days after a single dose (7 mg/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1β and TGF‐β3 expression levels when administered alone; it increased ALT, AST, and IL‐38 levels. When sunitinib was given to the cisplatin‐induced rats, it was observed that the increase in ALT, AST, and IL‐38 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.
High crystalline and optical quality aluminum nitride (AlN) films with thin thickness have been grown on Al2O3 by MOVPE (metal-organic vapor phase epitaxy) and the NH3 flow rate has been changed to improve the morphology and quality of the films. Some characterization types of equipment such as atomic force microscopy (AFM), high-resolution X-ray diffraction (HRXRD), and Raman spectroscopy have been carried out to investigate the effect of different NH3 flow rates on surface morphology, roughness, and crystal quality of AlN, respectively. Unlike in the literature, in situ optical reflectance measurements have been given depending on NH3 flow rate and optical characterization has been performed by UV–VIS–NIR spectrophotometry. The well-defined interference patterns in the optical transmittance graph report a sharp interface between AlN and Al2O3. Also, all obtained samples have a sharp absorption edge that shows the quality of the films, but Sample B with 900 sccm NH3 flow has the sharpest absorption edge because it has high optical quality and low defect. The RMS (root mean square), DS\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${D}_{S}$$\end{document} (screw-type dislocation density), and DE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${D}_{E}$$\end{document} (edge-type dislocation density) values of AlN with 900 sccm NH3 flow are 0.22 nm, 7.86 х 10⁷ , and 1.68 х 10¹⁰ cm⁻², respectively. The results obtained are comparable to the literature.
Collecting-labeled images from all possible classes related to the task at hand is highly impractical and may even be impossible. At this point, Zero-Shot Learning (ZSL) can enable the classification of new test classes for which there are no labeled images for training. The vast majority of existing ZSL methods aim to learn a projection from the feature space into the semantic space, where all classes are represented by a list of semantic attributes. To this end, they usually try to solve a complex optimization problem. Nevertheless, the semantic features (attributes) may not be suitable to represent the images because they are derived based on human knowledge and are, therefore, abstract. Alternatively, in this study, we introduce a novel ZSL method called SOMZSL, which has its roots in Self-Organizing Maps (SOM), a famous data visualization method. In particular, SOMZSL builds two SOMs of the same size and shape, one for the feature space and one for the attribute space, and then establishes a correspondence between them. Instead of considering a direct projection between the feature space and the attribute space, which is inherently different, SOMZSL connects them through comparable intermediate layers, i.e., SOMs. In terms of performance, SOMZSL can classify novel test classes as well or even better than existing ZSL methods without dealing with a complex optimization problem, thanks to the heuristic nature of SOM on which it is based. Finally, SOMZSL uses unlabeled test images in the construction of SOMs and can thus mitigate the domain shift problem inherent in ZSL.
To prevent CO2-induced climate change, the world is quickly moving toward a carbon- neutral society by using electric vehicles, renewable energy sources, and other energy sources, which demand more resources than traditional ones in terms of materials, minerals, and metals. In this regard, recycling processes of rare earth elements (REEs), metals, plastic, and glass from secondary sources with a zero-waste strategy have become more important in order to reduce environmental damage and bring them into the economy when primary mineral resources are running out. Therefore, in this Research Topic, studies on effective, non-hazardous, long-term, and ecological recycling processes of solid wastes, including by-products from industrial processes containing metals have been compiled.
We aimed to determine the relationship between the attitudes of healthcare professionals towards futile treatment and their approach to death and terminally ill patients. We collected the data from nurses-physicians working in the intensive care unit, using the Nurses' Attitudes towards Futile Treatment Scale (NAFTS) and Approach to Death and Dying Patients Attitude Scale (ADDPAS). Avoidant attitudes displayed towards death and terminally ill patients increase as futile treatment is administered more. Health workers who work in the intensive care unit and witness futile treatment more frequently in the clinic are of the opinion that futile treatment should not be performed.
Kombucha is a fermented, acidic beverage that dates back thousands of years as a remedy for various health problems in East Asia. Due to its health benefits, kombucha has gained popularity and attracted the attention of both consumers and researchers. The health benefits of kombucha are predominantly attributed to its bioactive compounds that have antioxidant, antimicrobial, probiotic, and other positive effects owing to fermentation. Many factors such as the type of the substrate used, the symbiotic culture of the bacterial yeast composition, and fermentation conditions influence the extent of these properties. This review focuses on recent developments regarding the bioactive constituents of kombucha and its potential health benefits (antimicrobial, antioxidant, antidiabetic, hepatoprotective effects) as well as its impact on multiple sclerosis, nephrotoxicity, gastric ulceration and gut microbiota. Additionally, the composition of kombucha, alternative uses of its biofilm, and potential toxicity are also discussed. Kombucha is a healthy and safe beverage with multiple health benefits that are primarily related to the presence of bacteria, yeasts, and other bioactive constituents. Moreover, kombucha has been suggested as a potential source of probiotics and eco-friendly materials (kombucha-derived bacterial cellulose) for several industries including food and textile.
In this study, for the first time, the effect of externally applied static electric, magnetic, and non-resonant THz intense laser fields on nonlinear optical properties such as the total optical absorption coefficients (TOACs) and relative refractive index changes (RRICs) in a GaAs/AlGaAs Mathieu quantum well are theoretically investigated in detail. Moreover, the influence of the adjustable physical parameters, linked to the potential shape of the structure, on the nonlinear optical properties of the system is also investigated. For this, firstly, the electronic subband energy levels of the Mathieu quantum well, and their envelope wave functions, are calculated using the diagonalization method within the framework of the effective mass and parabolic single-band approximations. Then, the outcome of the iterative solution of compact-density-matrix formalism is used to obtain the nonlinear optical properties of the structure. The obtained numerical results show that the increase in both the structure parameters and the value of the electric and magnetic field shifted the positions of the TOACs and RRICs peaks towards higher energies (blue-shift). On the other hand, the increase in the value of the intense laser field shifted the peak positions to lower energy levels (red-shift). The determination of the functional range for the optical properties of the Mathieu quantum well, using both the structure parameters and the external fields, is an important gain in terms of providing the initial parameters for experimental studies.
Pathological angiogenesis plays a critical role in tumorigenesis and tumor progression, and anti-angiogenesis therapies have evinced promising antitumor effects in solid tumors. Chalcone skeleton has been regarded as a potential antitumor agent that also targets angiogenesis. In this study, we designed twenty-one non-fluoro-substituted chalcones (13–18, 24–27) and saturated chalcone derivatives (19–23, 28–33) as anti-angiogenic compounds. During the initial stage, these compounds were assessed for their anti-cancer activities against MCF-7 cancer cell lines according to the MTT assay. The compounds revealed satisfactory anti-proliferative capability. An ex vivo fertilized hens’ egg-chorioallantoic membrane (HET-CAM) angiogenic study was conducted for the compounds to gauge their mortality and toxicity, which, in turn, revealed a potent anti-angiogenic effect. Eight compounds (16, 17, 21, 24, 26, 27, 29, and 31) significantly reduced densities of capillaries on CAM, whereas compounds 27 and 29 were the most effective anti-angiogenic agents, when compared with Suramin. Moreover, RT-qPCR analysis demonstrated that the anti-angiogenic activity was associated with the fold changes of VEGFR2. Molecular docking studies were conducted for compounds to investigate their mode of interaction within the binding site of VEGFR-2 kinases. This work provided a basis for further design, structural modification, and development of chalcone derivatives as new anti-angiogenic agents.
Five new nickel(II) complexes have been synthesised with an NNO donor tridentate aroylhydrazone (HFPB) employing the chloride, nitrate, acetate and perchlorate salts, and all the complexes are physiochemically characterized. Elemental analyses suggested stoichiometries as Ni(FPB)(NO3)]·2H2O (1), [Ni(HFPB)(FPB)]Cl (2), [Ni(FPB)(OAc)(DMF)] (3), [Ni(FPB)(ClO4)]·DMF (4), [Ni(FPB)2] (5). Aroylhydrazone is found coordinating in deprotonated iminolate form in four of the complexes (1, 3, 4, 5) however in one case (complex 2), two aroylhydrazone moieties are binding to the metal centre in the neutral and anionic forms. The structure of the bisligated complex 5, found using single crystal X ray diffraction studies confirmed that the metal has a distorted octahedral N4O2 coordination environment, with each of the two deprotonated ligands coordinating through the pyridine nitrogen, imino-hydrazone nitrogen and the enolate oxygen of the hydrazone moiety. To compare and study, the electronic interactions and stabilities of the metal complexes, various quantum chemical parameters were calculated. Moreover, Hirshfeld surface analysis was carried out for complex 5 to determine the intermolecular interactions. The biophysical attributes of the ligand and complex 5 have been investigated with CT-DNA and experimental outcomes show that the Ni(II) complex exhibited higher binding propensity towards DNA as compared to ligand. Furthermore, to specifically understand the type of interactions of the metal complexes with DNA, molecular docking studies were effectuated. In addition, the electronic and related reactivity behaviors of the ligand and five Ni(II) complexes were studied using B3LYP/6–31 + + G**/LANL2DZ level. As expected, the obtained results from Natural Bond Orbital (NBO) computations displayed that the resonance interactions (n → π* and π → π*) play a determinant role in evaluating the chemical attributes of the reported compounds. Graphical abstract
This study was aimed to evaluate the effects of Er:YAG and Er,Cr:YSGG laser irradiation and adhesive systems on the microtensile bond strength of Fusio Liquid Dentin (FLD) which is a self-adhering composite (SAC). Twenty-four freshly extracted human molar teeth were collected, and the enamel was removed from the occlusal surface to obtain a flat dentin surface. Twenty-four teeth were randomly divided into eight groups: Group 1: only Fusio Liquid Dentin (FLD) (Petron Clinical, Orange, California, USA) was applied to the dentin surface; Group 2: 37% Phosphoricacid (i-GEL, Medicinos Linija UAB, Lithuania) + FLD; Group 3: Single Bond Universal (SBU) (3 M ESPE, Germany) + FLD; Group 4: Adper Easy One (AEO) (3 M ESPE, Germany) + FLD; Group 5: Er:YAG laser + AEO + FLD; Group 6: Er:YAG laser + SBU + FLD; Group 7: Er,Cr:YSGG laser + AEO + FLD; and Group 8: Er,Cr:YSGG laser + SBU + FLD. After thermocycling, 1 × 1 mm2 sticks were used for the μTBS test (n = 10). Two sticks per group were used for SEM analysis. Fractured sample surfaces were evaluated using a stereomicroscope. Group 8 showed the highest μTBS value (13.70 MPa), whereas Group 1 showed the lowest μTBS value (5.60 MPa). There were no significant differences between Groups 2, 3, and 4 (P = 0.324), but Groups 5–8 showed statistically significant results that were higher than Groups 1–4 (P = 0.012). Adhesive failure mode was predominant followed by mixed failure. The evaluation of bonding of the FLD to dentin showed that the combined use of Er:YAG and Er,Cr:YSGG lasers with SBU and AEO on dentin surfaces improved the dentinal bond strength of the FLD.
To avoid the potential risks associated with all hazardous wastes, it is important that containment methods are intended to prevent the migration of liquid hazardous wastes or leaks containing hazardous components. Therefore, impermeable barriers were used to prevent contamination. In this study, geotechnical tests were performed on samples by mixing rubber and bentonite with silica fume at certain percentages. The aim of the experimental studies is to evaluate the applicability of certain proportions of silica fume, rubber, and bentonite mixtures as impermeable liner material. Possible cracks in bentonite during drying are reduced by the use of silica fume. Absorption of dynamic effects that may occur on the impermeable barrier layer is achieved by adding waste rubber in a uniform size. Several geotechnical tests were performed to examine the mixed rubber and bentonite with silica fumes. Looking at the results of the whole that mixed rubber and bentonite with silica fume yielded usable results and a blend for construction of a liner.
The current study aimed to investigate the biosorption of rhodamine B from aqueous solution using an almond shell as an agricultural solid waste biosorbent. The almond shell biosorbent was characterized via Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) with energy dispersive X-ray (EDX), and point of zero charge (pHPZC) analyses. The parameters that influence the biosorption process such as contact time, initial dye concentration, biosorbent dose, temperature, and pH were investigated. According to the correlation coefficient, the data were best outlined by the Langmuir isotherm with adsorption capacity of 14.70 mg g⁻¹. The adsorption energy found from the D-R model showed that the adsorption process is chemical. The kinetic data were described by the pseudo-second-order kinetic and intraparticle diffusion kinetic models. Thermodynamic parameters were calculated; it was seen that the biosorption process is spontaneous and endothermic. The density functional theory (DFT) calculation results are well-matched with those discovered through experimentation. The results indicate that almond shells could be interesting alternative material used for dye removal from aqueous solutions.
In this study, we consider the discontinuous Dirac equations system with eigenparameter dependent boundary and finite number of transmission conditions. First, the space that corresponds to problem is introduced, the norm on this space is defined and the operator model that corresponds to the given problem is constructed on this space. Then the integral equations and asymptotics of eigenfunctions of the problem are obtained. The characteristic function is defined and the asymptotic formula of the characteristic function is given by using obtained asymptotics of eigenfunctions. After the Weyl solution and the Weyl function of the problem are formed. Finally, some uniqueness theorems are proved by using Weyl function and some spectral data.
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• Health Science Faculty,Nursing Department
• Internal Disease Nursing
• Histology Embryology
• Health Sciences Faculty
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