Sidi Mohamed Ben Abdellah University

Using the Nehari manifold and Lusternik–Schnirelmann category theory to an auxiliary problem, we study the effect of the coefficient of the critical nonlinearity on the existence and multiplicity of positive solutions for a class of singular elliptic fractional equation with critical growth in a bounded domain.

TRPV4 antagonists that could be potential drugs for pain management. This study uses advanced computational analysis techniques, including 3D-QSAR modelling, molecular docking and assessment of pharmacokinetic properties (ADMET), to identify novel ligands with potent TRPV4 antagonistic activity of on various arylsulfonamide derivatives. We developed an optimal 3D-QSAR model using partial least squares analysis (PLS) and comparative molecular similarity coefficient analysis (CoMSIA), obtaining excellent correlation and predictive power (R2 = 0.953, Q2 = 0.747 and SEE = 0.072). Our results highlight the significant roles of electrostatic and hydrophobic fields, as well as hydrogen bond acceptors and donors, in influencing variations in the observed biological activity. Molecular docking was used to validate the 3D-QSAR methods and to explain the binding site and interactions between the most active ligands and the receptor. Based on these results, a new series of compounds was predicted. The best-anchored molecules were subjected to MD simulation to confirm their dynamic behaviour and stability, and were analysed retrosynthetically to guide their synthesis.

This paper explores advanced feedforward neural networks specifically multi-layer perceptron (MLP), long short-term memory (LSTM), and convolutional neural networks (CNNs) as time-series imputation techniques to address the challenge of missing data in analytical contexts. The study evaluates their performance by introducing artificial data gaps of varying durations 3 days, 1 week, and 1 month. The results reveal that all three algorithms (MLP, LSTM, and CNN) exhibit the ability to estimate incomplete data, yet with differing accuracies. LSTM and CNN outperform in filling short-term gaps (3 days and 1 week) with R² values of 77% and 70% for LSTM, and 58.4% and 69.7% for CNN. MLP also demonstrates effectiveness, achieving accuracies of 74.9% for a 3-day gap and 67.7% for a 1-week gap. Notably, CNN proves the most accurate for monthly data gaps, attaining an R² value of 70.1%. The findings suggest that the selection of imputation techniques should consider the specific time gap, with CNN highlighted as particularly effective for monthly gaps. In conclusion, this study provides valuable insights for researchers and practitioners engaged in imputing missing data in time-series analysis.

The goal of this paper is to calculate explicitly the field index of any quintic number field K generated by a complex root α of a monic irreducible trinomial F ( x ) = x ⁵ + ax + b ∈ ℤ[ x ]. In such a way we provide a complete answer to the Problem 22 of Narkiewicz [36] for this class of number fields. Namely, for every prime integer p , we evaluate the highest power of p dividing i ( K ). In particular, we give sufficient conditions on a and b , which guarantee the non-monogenity of K .

The object of this work is to enhance the persistence sill and to reconsider the sufficient conditions leading to the extinction of the stochastic HTLV-1 infection model proposed by Shi and Jiang in [1]. As a first step, and by using some mathematical techniques, we obtain some new and better sufficient conditions for the existence of an ergodic stationary distribution. Then, by using sepectral radius analysis we identify critical condition for elimination of the diseas. After that, we demonstrate that our conditions are stronger and well justified than its homologue in [1]. Finally, we present some numerical simulation example to back up our theoretical outcomes.

In this work, we used the first principles calculations to evaluate the power conversion efficiency of thermoelectric ternary half-Heusler alloy LiMgAs using GGA and meta-GGA methods. The results confirm the structural, chemical, and mechanical stability of LiMgAs in its $\alpha$ structural configuration. Using Boltzmann transport theory, we estimate the figure of merit (zT) by examining the electronic band structure around the Fermi level ($\hbox {E}_F$) energy and the Seebeck coefficient S. Our findings demonstrate excellent thermoelectric properties within the temperature range of 200–800 K for n and p doping regions. The high figure of merit (zT $\sim$ 1 ) and the exceptional power efficiency ($\eta ^{GGA} = 13.57 \%$ and $\eta ^{meta-GGA} = 15.70 \%$) observed at the temperature difference of 600K indicate that the semiconductor LiMgAs is highly suitable for thermoelectric applications.

This paper deals with the feedback stabilisation of a class of bilinear systems with varying time delay. Firstly, we use the step-by-step method to prove the existence and uniqueness of the mild solution of the closed-loop system. Secondly, we study the weak and strong stabilisation when the usual observability estimates are not necessary verified. The main idea consists of decomposing the whole system according the observable and unobservable states. The obtained results are also exploited to prove the feedback stabilisation of linear systems. Finally, applications to partial differential equations are further provided.

BACKGROUND Psychological flourishing is a component of positive mental health that characterizes the lives of nursing and health technology students, despite the stressful situations they experience during this training. The objective of this study is to evaluate psychological flourishing and to put the thumb on its importance in the training of nursing and health technique students. MATERIALS AND METHODS A cross-sectional descriptive–analytical study was conducted at the two higher institutes of nursing and health technical professions in Fez and Rabat between 1 March and 30 March 2022, using a questionnaire containing socio-demographic characteristics, training characteristics, a perceived stress scale (PSS10) and a psychological flourishing scale. RESULTS This study allowed us to describe very correct levels of flourishing with high average scores for all items on the scale of psychological flourishing. Except that female students are more flourished compared to their male colleagues, the effect of socio-demographic data on well-being outcomes has been found to be the least important among other factors. Psychological flourishing is positively related to perceived stress, with the most flourished students displaying positive stress that stimulates students and pushes them to achieve their goals. CONCLUSION Because the most flourished students manifest a positive stress stimulating the student and pushing them to achieve their goals, training managers and decision-makers are advised to include elements that reinforce the positive mental health of students in training programs to give all students the opportunity to deal with any psychological problem that may impact their mental health.

This study utilizes montmorillonite (MMT) and ground tire rubber (GTR) particles to modify the morphology of PA6/ABS immiscible polymers by suppressing phase retraction and coalescence. MMT and GTR were incorporated at weight contents ranging from 1 to 5 wt.% and 5 to 25 wt.%, respectively, to manipulate the morphology through selective localization at the polymer interface. The morphology of the resulting composites was analyzed, and the cooperative effect between the fillers was evaluated with the structural, thermal, rheological, and mechanical properties. Scanning electron microscopy (SEM) images confirmed the formation of a finer multimicro-/nanolayer morphology in composites containing low clay content (less than 5 wt.%); additionally, the inclusion of 10 wt.% GTR effectively suppressed coalescence and promoted the formation of a compatibilized polymer blend. The stiffness of the blend matrix increased with clay content up to 4 wt.% and thermal stability to 437 °C, while the ductility of the composites improved with the addition of GTR, reaching its peak at 10 wt.% with higher thermal degradation at 412 °C. Overall, the composites exhibited synergistic properties, demonstrating the combined benefits of both fillers. The use of chemically modified nanolayered clay and GTR particles proved to be an effective strategy for achieving multimicro-/nanolayered morphologies and for compatibilizing immiscible polymer blends, paving the way for new applications of immiscible polymer blends.

Introduction Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities. Methods, results, and discussion HPLC-UV examination revealed that the leaf extract included mainly caffeine, rutin, and ferrulic acid. Spectrophometric results show that Malha leaf is rich in polyphenols (62.6 ± 1.3 mg GAE/g) and flavonoids (26.2 ± 0.1 mg QE/g). Chetoui leaf contains the highest vitamin C content (8.2 ± 0.1 mg Asc A/100 g DW), while Onk Hmam leaf has the highest condensed tannin (4.9 ± 0.1 mg CatE/g). The investigations found that all leaf extracts were antioxidant-rich, with strong Pearson bivariate correlation between bioactive polyphenol levels and antioxidant tests for DPPH, β-carotene, ABTS, and TAC (values of −0.93, −0.94, −0.85, and 0.98, respectively). The coefficients for flavonoid content were −0.89, −0.89, −0.97, and 0.80, respectively. Disk diffusion and MIC results show that the hydro-ethanol fig leaf extracts eliminate fungi and bacteria. In addition, these fig leaf extracts showed promise cytotoxicity against the breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-436 and an interesting selectivity index. In silico leaf bioactive component analysis revealed that myricitin inhibited NADPH oxidase the greatest (gscore −6.59 Kcal/mol). Trans-ferulic acid inhibits Escherichia coli beta-ketoacyl-[acyl carrier protein] synthase (−6.55 kcal/mol), whereas quercetin inhibits Staphylococcus aureus nucleoside diphosphate kinase (−8.99). CYP51 from Candida albicans is best treated with kaempferol and myricitin. Both had a glide gscore of −7.84 kcal/mol. Rutin has the most potent Sespace 3 anticancer activity, with a glide gscore of −7.09 kcal/mol. Conclusion This research indicates that fig leaf extracts from the region can be used in medicine, food, natural cosmetics, and breast cancer prevention. To maximize the value of these leaves, their use must be carefully studied. Naturally, this fortunate tree’s diversity must be preserved and enhanced.

This article shares the first author’s experiences at a high school in Fez, Morocco, while implementing education for sustainable development (ESD) in the curriculum. In this action research project, the researcher aimed to embed ESD in the current school curriculum and evaluate whether the strategies and methods used affected the students’ attitudes and behaviour towards the environment. A mixed-methods approach was used to collect data. A questionnaire was administered to 60 high school students aged between 16 and 18 immediately after the ESD training. In-depth interviews were then conducted with 44 respondents who completed the questionnaire. The results of the study suggest that formal education, class activities and extracurricular activities can contribute to reshaping students’ attitudes and behaviour towards the environment, reflecting not only academic but also personal and social growth. The findings reveal that there are multiple effective ways to embed ESD in a high school curriculum. The study also provides a pedagogical framework for teachers aiming to integrate ESD into their curriculum. While the research involved a limited sample, it could serve as a background for future studies to investigate a larger population.

Background: Food chemical antioxidants have demonstrated protective effects against reactive oxygen species and free radicals, but present in excess, harmful consequences might occur on health. Therefore, replacing these synthetic additives with nontoxic natural antioxidants is crucial. Objective: The current study examined aroma profile, antioxidant activity, and multivariate analysis of Mentha piperita, Mentha pulegium, Thymus serpyllum, and Thymus zygis essential oils from Morocco. Methods: GC-MS analysis was carried out to determine the chemical composition of the four oils, and their antioxidant activity was evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH), cation radical (ABTS⁺), hydrogen peroxide scavenging capacity (H2O2), ferric reducing antioxidant power (FRAP), and total antioxidant capacity (TAC) methods. Results: Isomintlactone (35.55%), pulegone (74.04%), borneol (37.87%), and borneol (30.99%) were the most abundant compounds of M. piperita, M. pulegium, T. serpyllum, and T. zygis EOs. The antioxidant activity of the four EOs was particularly notable, with an IC50 varying between 3.51 ± 0.22 mg/mL and 0.49 ± 0.08 mg/mL by the DPPH method, 1.02 ± 0.21 mg/mL and 0.4 ± 0.7 mg/mL by the ABTS method, and 0.063 ± 0.01 mg/mL and 0.009 ± 0.008 mg/mL by the H2O2 method. For the FRAP technique, the EC50 was between 0.42 ± 0.02 mg/mL and 0.09 ± 0.01 mg/mL. Finally, the equivalent concentration of ascorbic acid ranged between 10.42 ± 0.03 mg AAs/mL for M. piperita and 7.25 ± 0.19 mg AAs/mL for T. serpyllum. As determined by multivariate analysis, antioxidant activities through the DPPH, ABTS, TAC, and FRAP were mainly influenced the major compounds of M. pulegium and M. piperita EOs. However, the H2O2 method showed a stronger positive correlation with major compounds of T. zygis EO. Conclusion: The EOs derived from M. piperita, M. pulegium, T. serpyllum, and T. zygis species might be exploited as a natural source for antioxidant activity.

Background The timing of a breast cancer (BC) diagnosis has a significant psychological impact on patients. However, it reported that those eligible for treatment regimens based on neoadjuvant chemotherapy may experience high levels of depression, anxiety and distress. To cope with this situation, patients deploy psychological coping strategies. The aim of this study is to explore effective and ineffective psychological adjustment mobilized by Moroccan patients newly diagnosed with BC and before receiving neoadjuvant chemotherapy, as well as to identify their associations to socio-demographic and clinical determinants. Materials and methods A total of 209 patients were recruited in outpatient in oncology department in the public oncology hospital of Fez city, between 2021 and 2023. Ethics approval was obtained for this study and patients has signed an informed consent form. The questionnaire interview included socio-economic and clinical variables and the Arabic version of Mini-Mental Adjustment to Cancer (Mini-MAC) scale, which measures the strategies of mental adjustment to disease, as fighting spirit (FS), hopelessness/helplessness (HH), anxious preoccupations (AP), cognitive avoidance (CA), fatalism (FA), “maladaptive coping” and “adaptive coping”. Bivariate analysis of psychological adjustment strategies and sociodemographic and clinical variables was carried out using statistical tests according to the nature of the variables, to their normality and the homogeneity of their variances. Univariate and multivariate linear regression modelling was carried out using a forward “enter” regression procedure. Results A mean age of 47.43 ± 9.45 was found among participants. Assessment of mental adjustment to cancer using Mini-MAC scores revealed that psychological adjustment strategies with a higher mean score were FA, FS and “adaptive coping” strategies. Based mainly on multiple linear Regression, monthly family income was negatively associated with HH, and FS and positively linked to FA and “adaptive coping” strategies. Moreover, the left side as BC laterality was negatively associated with AP and “maladaptive coping” strategies. Furthermore, positive ER status was negatively associated with HH and “maladaptive coping” strategies and high Ki-67 levels were positively linked to AP. Conclusion Programs to strengthen psychological adjustment in patients with BC candidates for NACT, taking into consideration the determinants found associated in this study, are of great importance since the first oncology consultation.

Herein, a series of perovskite‐type hydride materials RMnH 3 ( R = Ca, Sr, and Ba) are investigated by density functional theory for solid‐state hydrogen storage. Their structural, mechanical, electronic, and optical properties are calculated and their thermodynamic, dynamic, and mechanical stability is assessed. All compounds crystallize in the undistorted cubic perovskite system with the Pm‐3m symmetry. The results from mechanical properties, based on parameters such as Poisson's ratio ( ν ) and the G/B ratio, indicate that CaMnH 3 and SrMnH 3 exhibit brittle behavior, primarily attributed to the dominance of ionic bonds, while BaMnH 3 is distinguished by its ductility, resulting from a prevalence of covalent bonds. Additionally, the electronic structure analysis reveals that all examined hydrides possess metallic behavior. Further calculations of the optical properties are also performed, providing supplementary insights into the physical features of the hydrides. The gravimetric hydrogen storage capacities ( C wt% ) are calculated, with values of 2.96 wt% for CaMnH 3 , 2.019 wt% for SrMnH 3 , and 1.513 wt% for BaMnH 3 , accompanied by respective desorption temperatures of 214.83, 193.42, and 145.43 K. Overall, these results highlight the potential of perovskite hydrides RMnH 3 as promising materials for hydrogen storage applications, significantly contributing to a sustainable energy future.

Assessing basin water balances is crucial for understanding hydro-climatic conditions and guiding effective water resource management. This study specifically focuses on the Inaouene watershed upstream of the Idris I dam, a significant sub-watershed within the Sebou Basin of Morocco. Covering 3608.2 km², the Inaouene watershed features a diverse topography, with vegetation primarily concentrated at the peaks in both the northern and southern parts of the basin. The region experiences a semi-arid Mediterranean climate, marked by distinct wet and cold seasons, followed by hot and dry periods. Consequently, these climatic conditions create pronounced seasonal variability in rainfall and temperature, which significantly impacts the watershed’s water balance. To analyze these dynamics, this study employs the Thornthwaite method, focusing on four main parameters: available water reserves (AWR), water storage variation (WSV), transfers, and agricultural water deficit (AWF). The performance of this method is rigorously evaluated using several key coefficients and indices, including the correlation coefficient (r), the coefficient of determination (R²), the Nash-Sutcliffe Efficiency (NSE), and the Root Mean Square Error (RMSE). Through this methodology, we reveal the spatial and temporal variations in drought and humidity, thereby allowing for precise climate classification and resource assessment, which is essential for supporting sustainable water management. The findings indicate significant water deficits during the summer, primarily due to high evapotranspiration and limited rainfall, contrasted with winter surpluses resulting from increased precipitation. The rainy season typically extends from October to April, during which mobilizable reserves play a critical role in maintaining the watershed’s water balance throughout the dry season. As a result, Thornthwaite’s application in this study demonstrates strong performance, with correlation coefficients (r) ranging from 93.07 to 98.31%, R² values from 86.63 to 96.64%, NSE values between 64.70% and 86.53%, and RMSE values from 19.16 to 28.84, further indicating satisfactory accuracy in error estimation. This study enhances understanding of hydrological dynamics in semi-arid regions, providing insights for water resource management amid climate variability and change.