Background: Polyphenol-rich fruit supplements are commonly consumed by recreationally active and athletic populations because of their proposed benefits to both exercise performance and recovery from prior exercise. While it has been proposed that 300 mg of polyphenols pre-exercise enhances performance and 1000 mg per day accelerates recovery from muscle damage, it is difficult for consumers to optimize their intake because the polyphenol content of most fruit supplements is not available. Therefore, this study aimed to profile the phenolic and anthocyanin content and in vitro antioxidant capacity of a range of polyphenol-rich fruit supplements on sale in the UK. Methods: Ten polyphenol-rich fruit supplements (six cherry, two pomegranate, one blueberry, and one New Zealand blackcurrant) commonly consumed by athletes were analyzed for total phenols (Folin-Ciocalteu method), total anthocyanins (pH differential method), and in vitro antioxidant capacity (ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC). Results: The ten tested supplements varied markedly per serving in total phenolics (range: 13.8-1007.3 mg/gallic acid equivalents), anthocyanin content (range: 0.19-40.52 mg/cyanidin-3-glucoside), ORAC (range: 150-10,072 µmol of trolox equivalents), and FRAP (range: 72-14,320 µmol of Fe2+ equivalents). Different brands of tart cherry concentrate also exhibited a marked variation in their content of total phenolics (208-591 mg/GAE), anthocyanins (1.5-23.7 mg/cyd-3-glu), and antioxidant capacity (FRAP: 1724-4489 µmol of Fe2+ equivalents; ORAC: 6015-10,072 µmol of TE per serving) per serving. Conclusion: As expected, supplements based on different fruits contained different quantities of anthocyanins and polyphenols. However, there was also a substantial variation within different brands of tart cherry supplements. Because limited compositional information is available on the labels of most fruit-based supplements, the data in this article will enable consumers to select the required volume of the ten tested supplements to meet suggested recommendations for polyphenol intake to enhance performance (300 mg pre-exercise) and accelerate recovery (1000 mg per day) from prior exercise.
Background Match analysis has evolved exponentially over the past decades in team sports resulting in a significant number of published systematic reviews and meta-analyses. An umbrella review of the available literature is needed to provide an integrated overview of current knowledge and contribute to more robust theoretical explanations of team performance. Methods The Web of Science (all databases), PubMed, Cochrane Library (Cochrane Database of Systematic Reviews), Scopus, and SPORTDiscus databases were searched for relevant publications prior to 19 February 2021. Appraisal of the methodological quality of included articles was undertaken using the tool for Assessing the Methodological Quality of Systematic Reviews (AMSTAR-2). Twenty-four studies were reviewed that met the following criteria: (1) contained relevant data from match analyses in team ball sports; (2) were defined as systematic reviews or/and meta-analyses; and (3) were written in the English language. Results The overall methodological quality of the 24 included reviews, obtained through the AMSTAR-2, revealed very low confidence ratings (Critically Low, n = 12) for the results of most systematic reviews of match analyses in team ball sports. Additionally, the results showed that research is focused mainly on four levels of analysis: (1) dyadic (microlevel); (2) individual (molecular level; predominant); (3) group (mesolevel), and (4) team dynamics (macrolevel). These levels of analysis included tactical, technical, physical, and psychosocial variables. Team performance was contextualized at two levels, with reference to: (1) match context (e.g. match status, match location, match period, quality of opposition) and (2) sociodemographic and environmental constraints (sex, age groups, competitive level, altitude, temperature, pitch surface). Conclusions The evolution of methods for match analysis in team ball sports indicates that: (1) an individual-level performance analysis was predominant; (2) the focus on intermediate levels of analysis, observing performance in dyadic and group interactions, has received less attention from researchers; (3) neglected areas of research include psychosocial aspects of team sports and women’s performance; and (4) analyses of match contexts need greater depth. Registration : The protocol was registered in the International Platform of Registered Systematic Review and Meta-Analysis Protocols with the number 202080067 and the DOI number https://doi.org/10.37766/inplasy2020.8.0067 .
What would it mean to consider research in the sport sciences as a sustainable practice? Taking a step back, in such a context, what would sustainability even mean? The time is ripe to address such questions, and what we lay out here are our initial thoughts on this most contemporary of issues. We start by exploring what is meant by the term ‘sustainability’. Rather than following mainstream thinking—the harnessing of earthly resources commodified and exploited as ‘renewables’—we situate it in the sport sciences as a continuing response-ability to the experiences of others. This view is rooted in ‘commoning’—an intransitive verb in which people conjoin varied experiences through correspondence. What makes this sustainable, is its ongoing open-endedness; meaning, it carries on as people (co) respond to one another. Central to this idea is a perceptual system attuned to the ebbs and flows of what or who one is corresponding with. Though, the current modus operandi of research in the sport sciences is located, not on the skilled perception of the scientist corresponding with the coming-into-being of phenomena, but on an unsustainable model of recognition that views phenomena as ‘objects of analysis’, fixed and final in form, waiting to be known about by means of reduction, fragmentation and classification. For research in the sport sciences to become a sustainable practice, we propose a scholarship that prioritises direct observation and participation with what holds our attention, corresponding within its natural ecology of relations, embedding the phenomenon itself. This re-conceptualisation of science views research as a response-able scholarship grounded in conversation . Like inquiring about the well-being of loved ones, what sustains such a scholarship is curiosity, care and hope —a curiosity about which captivates us, a care that sees us respond to what we observe, and a hope of carrying the correspondence on, together.
The COVID-19 pandemic forced most individuals to work from home. Simultaneously, there has been an uptake of digital platform use for personal purposes. The excessive use of technology for both work and personal activities may cause technostress. Despite the growing interest in technostress, there is a paucity of research on the effects of work and personal technology use in tandem, particularly during a crisis such as the COVID-19 pandemic. Using a sample of 306 employees, this paper addresses this research gap. The findings highlight how both work and personal digital platforms induce technostress during the enforced remote work period, which in turn increases psychological strains such as technology exhaustion and decreases subjective wellbeing. Study results also show that employees with previous remote working experience could better negotiate technostress, whereas those with high resilience experience decreased wellbeing in the presence of technostress-induced technology exhaustion in the enforced remote work context.
Aims and method Recently, the Health of the Nation Outcome Scales 65+ (HoNOS65+) were revised. Twenty-five experts from Australia and New Zealand completed an anonymous web-based survey about the content validity of the revised measure, the HoNOS Older Adults (HoNOS OA). Results All 12 HoNOS OA scales were rated by most (≥75%) experts as ‘important’ or ‘very important’ for determining overall clinical severity among older adults. Ratings of sensitivity to change, comprehensibility and comprehensiveness were more variable, but mostly positive. Experts’ comments provided possible explanations. For example, some experts suggested modifying or expanding the glossary examples for some scales (e.g. those measuring problems with relationships and problems with activities of daily living) to be more older adult-specific. Clinical implications Experts agreed that the HoNOS OA measures important constructs. Training may need to orient experienced raters to the rationale for some revisions. Further psychometric testing of the HoNOS OA is recommended.
Prior research on factors influencing the financial performance of tourism and hospitality family firms concentrated mainly on family-level traits, thus limiting our comprehension of the organizational culture mechanism by which family-level values are transformed into firm-level business processes. We bridge this void in prior literature by presenting a multi-layer organizational culture framework comprised of the organizational values and organizational climate layers. Data stemmed from eight in-depth interviews, followed by a survey with 187 tourism and hospitality family firms reveal that stewardship climate inside the firms mediates the relationship between long-term-oriented values and financial performance. Moreover, our findings show that entrepreneurial orientation moderates the organizational culture mechanism that enhance the financial performance of tourism and hospitality family firms.
Background: Falls prevention exercise programmes are evidence-based and recommended for improving physical function in older adults. However, few service evaluations exist to assess the effectiveness of community-delivered interventions in practice. Methods: We conducted a six-year, retrospective evaluation of the community-delivered Staying Steady programme (Healthworks, United Kingdom). Staying Steady is a 27-week, tailored strength and balance programme delivered in a group setting (1-h, once/week) and at home (30-40 min, 2-3 times/week). Participants were referred by healthcare professionals, or self-referred, due to a history or risk of falling. Routinely collected outcome measures (30-s chair stand, Timed Up and Go, four-stage balance test, and patient reported outcomes; including 'fear of falling' and 'ability to manage health') were analysed. Factors associated with programme completion were reported. The intervention effect on physical function was analysed in subgroups: participants used arms to chair-stand or a walking-aid at both ('aided'), neither ('unaided'), or one assessment timepoint ('aided at baseline only' or 'aided at follow-up only'). Results: There were 1,426 referrals; 835 (67.3%) participants enrolled on to the Staying Steady programme, 406 (32.7%) declined, 185 (13.0%) were inappropriately referred and excluded from analysis. After enrolling, 451 (54.0%) participants completed, and 384 (46.0%) dropped out. Chair stand performance improved in participants who were unaided (n = 264; median 2.0 [1.0, 4.0] repetitions; P < 0.001), or aided at baseline, follow-up or both (n = 170, P < 0.05). Timed Up and Go performance improved in the unaided (n = 387; median -3.1 [-5.4, -1.4] s, P < 0.001), and aided at baseline only (n = 32; median -4.9 [-10.8, -3.4] s, P < 0.001) groups. Four-stage balance performance improved (n = 295; median 1.0 [0.0, 1.0] points, P < 0.001). After programme completion, participants self-reported an improved ability to manage their health and daily activities, improved confidence, and a reduced fear of falling. Presence of chronic obstructive pulmonary disease, fear of falling, prescribed nutritional support, disability and social deprivation influenced non-completion of Staying Steady. Conclusions: Completing Staying Steady improved physical function in older adults. Methods to encourage retention of participants from groups associated with low uptake and adherence should be investigated.
Hard to decarbonize homes represent a complex problem that has historically been neglected in favour of the lower hanging fruit of easier to treat properties. To enable an equitable net zero transition, we must understand these homes in a holistic manner take into account the impacts of different routes to decarbonization on occupants.
The cancer stem cell (CSC) potency of a series of structurally analogous Group 10‐azadiphosphine metal complexes is reported. The complexes comprise of a Group 10 metal (Ni for 1, Pd for 2, or Pt for 3), an azadiphosphine ligand, and two chloride ligands. The complexes exhibit micromolar potency towards bulk breast cancer cells and breast CSCs cultured in monolayer systems. The cytotoxicity of the complexes is comparable to or better than clinically used metallopharmaceuticals, cisplatin and carboplatin, and the gold‐standard anti‐breast CSC agent, salinomycin. Notably, the breast CSC mammosphere inhibitory effect and potency of the complexes is dependent on the Group 10 metal present, increasing in the following order: 3 < 2 < 1 . This study highlights the importance of the metal within a given series of structurally related compounds to their breast CSC mammosphere activity, and reinforces the therapeutic potential of Group 10 coordination complexes as anti‐CSC agents.
The field of International Business (IB) has traditionally focused on the crossing of national boundaries. In this Perspective, we argue that organizational, knowledge domain, and language boundaries are equally important for understanding translation activities in cross-border business. We integrate three kinds of translation (organizational translation and knowledge translation from Organization Studies and interlingual translation from Translation Studies) to deepen our understanding of core IB phenomena and pose new research questions. We introduce the framework of a translation ecosystem for integrating the micro perspective of translating agents, the meso perspective of organizational units, and the macro perspective of the larger social and linguistic contexts that influence translation. This framework allows IB scholars to identify important but invisible boundaries in cross-border business. The translation ecosystem requires the kind of multi-level research that has been recognized as crucial for taking the field forward and offers the potential for making contributions both to IB and to translation research beyond the disciplinary boundaries of IB.
In this paper, we share our experience in designing and developing a mobile health (mHealth) infrastructure for non-communicable diseases (NCD) in rural areas in Indonesia called NusaHealth. The NusaHealth project builds a digital healthcare infrastructure involving universities, healthcare providers, and communities in an mHealth approach that puts patients at the center of health care. The Design Science Research Methodology (DSRM) framework was adopted in designing the mHealth application. The infrastructure to connect the mobile device network with the hospital information system was also developed. Our finding indicates that designing and developing an mHealth solution for rural areas in developing countries needs comprehensive approach and the implementation process should involve related partners and stakeholders. The NusaHealth was implemented in rural areas in Yogyakarta province in Indonesia. While Yogyakarta province successfully implemented the NusaHealth in rural areas, different activities need to be conducted to enhance community health by developing a formal mHealth system supported by local health district offices’ policies and regulations.
The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12- year data from a prospective controlled registry study The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study
2022) The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study, The Aging Male, 25:1, 185-191, ABSTRACT Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonad-ism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative , prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testoster-one undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globu-lin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (p < 0.0001), a reduction in SHBG of 10.5 nmol/L (p < 0.0001) and an increase in calculated free T of 383.04 pmol/L (p < 0.0001) over the study period. This was accompanied by an increase in estradiol levels by 14.9 pmol/L (p < 0.0001), and decreases in progesterone (0.2 ng/mL, p < 0.0001), LH (10.4 U/L, p < 0.0001) and FSH (8.4 U/L, p < 0.0001) were demonstrated at 12-years. The levels of prolactin remained unchanged. Long-term TTh altered hormonal parameters to predictably modify the endocrine system. These effects were sustained during the entire observation time of 12 years. ARTICLE HISTORY
Objective To evaluate if there was an additional benefit of combining manual therapy (MT) and exercise therapy over exercise therapy alone on pain and function in patients with hip or knee osteoarthritis Design Intervention systematic review Literature search We (i) searched 4 databases from inception to 20 June, 2021, (ii) hand searched reference list of included trials and relevant systematic reviews and (iii) contacted two researchers in the field. Study selection criteria We included randomized controlled trials that compared MT plus exercise therapy to similar exercise therapy programs alone in patients with hip or knee osteoarthritis. Data synthesis The data were combined using random-effects meta-analyses where appropriate. The certainty of evidence for each outcome was judged using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. Results We included 19 trials. There was very low to moderate certainty evidence that MT added benefit in the short-term for pain, and combined pain, function and stiffness (WOMAC global scale), but not for performance-based function and self-reported function. In the medium-term, there was low to very low certainty evidence that MT added benefit for performance-based function and WOMAC global score, but not for pain. There was high certainty evidence that MT provided no added benefit in the long-term for pain and function. Conclusion There was very low to moderate certainty evidence supporting MT as an adjunct to exercise therapy for pain and WOMAC global scale but not function in patients with knee or hip osteoarthritis in the short-term. There was high certainty evidence of no benefit for additional MT over exercise therapy alone in the long-term.
A series of gold(I) (4a-4h, 5a-5b) and silver(I) (3a-3h) complexes of 1,2,4-triazolylidene and imidazolylidene based N-heterocyclic carbene ligands were prepared and the antibacterial activities of these complexes have been evaluated. The complexes were characterised using 1H-NMR, 13C-NMR, HRMS and in the cases of 3a, 3c, 4b and 5b by X-ray crystallography. The gold(I) complexes with phenyl substituents (4a-4d) were found to have potent antibacterial activity against Gram-positive bacteria, with the complexes of the 1,2,4-triazolylidene ligands being more active (4c, MIC = 4-8 μg mL-1 against Enterococcus faecium and 2 μg mL-1 against Staphylococcus aureus) than the analogous imidazolylidene complexes 4a and 4b (4a, MIC = 64 μg mL-1 against E. faecium and 2-4 μg mL-1 against S. aureus). Two of the silver(I) complexes have promising antibacterial activity against Acinetobacter baumannii (3f, MIC = 2-4 μg mL-1 and 3g, MIC = 2 μg mL-1). Silver(I) complex 3f and gold(I) complex 4c were tested against multi-drug resistant bacterial strains and high levels of antibacterial activity were observed. The potential for antibacterial resistance to develop against these metal containing complexes was investigated and significantly, no resistance was observed upon continuous treatment, whilst resistance was developed against the widely used broad-spectrum antibiotic ciprofloxacin in the same bacterial strains, under the conditions tested. The solution and gas phase stabilities of the complexes have been investigated using a combination of 1H-NMR, HRMS and detailed computational mechanistic studies were undertaken to gain insights into the possible decomposition reactions for silver complexes in aqueous solution.
Background Guidelines aim to support evidence-informed practice but are inconsistently used without implementation strategies. Our prior scoping review revealed that guideline implementation interventions were not selected and tailored based on processes known to enhance guideline uptake and impact. The purpose of this study was to update the prior scoping review. Methods We searched MEDLINE, EMBASE, AMED, CINAHL, Scopus, and the Cochrane Database of Systematic Reviews for studies published from 2014 to January 2021 that evaluated guideline implementation interventions. We screened studies in triplicate and extracted data in duplicate. We reported study and intervention characteristics and studies that achieved impact with summary statistics. Results We included 118 studies that implemented guidelines on 16 clinical topics. With regard to implementation planning, 21% of studies referred to theories or frameworks, 50% pre-identified implementation barriers, and 36% engaged stakeholders in selecting or tailoring interventions. Studies that employed frameworks ( n =25) most often used the theoretical domains framework (28%) or social cognitive theory (28%). Those that pre-identified barriers ( n =59) most often consulted literature (60%). Those that engaged stakeholders ( n =42) most often consulted healthcare professionals (79%). Common interventions included educating professionals about guidelines (44%) and information systems/technology (41%). Most studies employed multi-faceted interventions (75%). A total of 97 (82%) studies achieved impact (improvements in one or more reported outcomes) including 10 (40% of 25) studies that employed frameworks, 28 (47.45% of 59) studies that pre-identified barriers, 22 (52.38% of 42) studies that engaged stakeholders, and 21 (70% of 30) studies that employed single interventions. Conclusions Compared to our prior review, this review found that more studies used processes to select and tailor interventions, and a wider array of types of interventions across the Mazza taxonomy. Given that most studies achieved impact, this might reinforce the need for implementation planning. However, even studies that did not plan implementation achieved impact. Similarly, even single interventions achieved impact. Thus, a future systematic review based on this data is warranted to establish if the use of frameworks, barrier identification, stakeholder engagement, and multi-faceted interventions are associated with impact. Trial registration The protocol was registered with Open Science Framework ( https://osf.io/4nxpr ) and published in JBI Evidence Synthesis.
Institution pages aggregate content on ResearchGate related to an institution. The members listed on this page have self-identified as being affiliated with this institution. Publications listed on this page were identified by our algorithms as relating to this institution. This page was not created or approved by the institution. If you represent an institution and have questions about these pages or wish to report inaccurate content, you can contact us here.