Senac University Center
  • São Paulo, Brazil
Recent publications
Fused deposition modeling (FDM) has emerged as one of the most accessible and versatile additive manufacturing processes. However, non-uniform thermal distribution on the printing bed remains a critical challenge, as it can lead to warping, dimensional inaccuracies, and compromised mechanical properties in printed parts. These issues highlight the need for more effective thermal management strategies to ensure improved part quality and process reliability. This study addresses these limitations by developing and implementing a segmented thermal bed composed of a matrix of individually controlled resistive elements. A closed-loop control circuit was designed to deliver precise thermal regulation, minimizing temperature gradients across the bed surface. The research was conducted in three stages: (1) design and fabrication of the segmented resistive-element bed, (2) development and optimization of an AC-based control circuit, and (3) integration of the system with an FDM 3D printer. Electrical, thermographic, and mechanical evaluations demonstrated a more uniform temperature distribution, a modest (approximately 3%) improvement in tensile strength of printed specimens compared to those produced on a conventional bed, and potential energy savings of up to 20% for fully heated areas and 95% when only a single segment is activated. Furthermore, cross-sectional optical microscopy revealed enhanced interlayer adhesion, more uniform layer thickness, and improved surface quality. While these findings are promising, future work will focus on automating element selection, applying statistical analyses to reinforce mechanical property improvements, and conducting long-term stability and cost–benefit studies. Such advancements aim to facilitate industrial-scale adoption of this technology, ultimately leading to higher-quality, more energy-efficient FDM printing processes.
Deepening of the nasolabial fold (NLF), drooping of the nasal tip, and facial expressions perceived as angry face, are common esthetic concerns. However, no studies have correlated this set of signs and symptoms with common anatomical causes. We review anatomical considerations of the region and propose a combined treatment modality. We performed a retrospective analysis of cases treated with combined botulinum toxin (abobotulinumtoxinA) using an injection pattern encompassing the nasal muscles and hyaluronic acid (HA) fillers in the deep pyriform space. Photographs were taken at rest and during motion (frontal and oblique views), before and after treatment. Results demonstrated effacement of the NLF, improved nasal tip positioning during smiling, and generally more favorable facial expressions. Combined treatment with HA in the deep pyriform space and abobotulinumtoxinA in the nasal muscles can improve angry expression and aging stigma in patients with deep empty pyriform space, both in the static and dynamic conditions of facial mimic. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Background Cardiovascular risk factors (CVRF) are among the main modifiable risk factors for dementia in Latin America (LA). Therefore, improving cardiovascular health (CVH) is one of the main objectives of the LatAm‐FINGERS trial, the largest non‐pharmacological (lifestyle improvement) randomized trial in LA. But, to fully comprehend CVH it is necessary to explore its relation with the social determinants of health (SDH), that are closely associated with lifestyle. Methods LatAm‐FINGERS is an initiative to develop a joint regional intervention protocol to prevent cognitive deterioration in 12 LA countries. Participants (between 60‐77 years old) should have high dementia risk (CAIDE >6), were evaluated clinically and cognitively at baseline and every 6 months for 2 years. At baseline, we measured the CVRF according to the Framingham risk score and the CVH with the “Life’s Essential 8 cardiovascular health index” (CVHI), a composed score that includes lifestyle’s (diet, physical activity, nicotine exposure, sleep health) and metabolic variables (body mass index (BMI), blood lipids, blood glucose, and blood pressure). Each score ranges from 0 to 100, with higher values meaning a healthier profile. SDH was characterized by years of education, race, and occupation. Occupation categorical data was transformed into an ordinal scale using the Hollingshead score. Partial correlations (controlled by age and sex) between CVHI and SDH measures were done. Results Preliminary data from 1,024 participants were analyzed, age = 67±5 years, education = 13±4 years, 72% women, 87% had high CVRF. The CVHI (60 ± 16) was obtained with 7 of the 8 variables, excluding sleep health (Figure 1). Diet (39±13) and physical activity (37±39) were the unhealthiest scores, while blood glucose (75±26) was the healthiest one (Figure 2). There were significant correlations between CVHI with years of education (r = 0.179, p<0.001) and occupation score (r = 0.169, p<0.001). Moreover, CVH individual components correlated with this SDH, except for blood lipids (Figure 3). Conclusions In the LatAm‐FINGERS cohort, better socioeconomic position is associated with a healthier cardiovascular index at baseline, being important to explore the role of SDH in CVH modification across the trial. Funded by Alzheimer Association
Background: Glioblastoma multiforme (GBM) is the most common and aggressive adult glioma (16-month median survival). Its immunosuppressive microenvironment limits the efficacy of immune checkpoint inhibitors (ICIs). Objectives: To assess the effects of the ICIs antibodies anti-programmed cell death 1 (anti-PD-1) and anti-programmed cell death ligand 1 (anti-PD-L1) in treating adults with diffuse glioma. Search methods: We searched CENTRAL, MEDLINE, Embase, and clinical trials registers on 8 March 2024. Selection criteria: We included randomised controlled trials (RCTs) evaluating adults with diffuse glioma treated with anti-PD-1/PD-L1 compared to placebo or other therapies used alone or with other ICIs. Primary outcomes were overall survival (OS), progression-free survival (PFS), and serious adverse events (SAE). Secondary outcomes were overall response rate (ORR), quality of life (QoL), and less serious AEs. Data collection and analysis: We followed standard Cochrane methods. Main results: We included seven RCTs evaluating anti-PD-1 treatment in recurrent (N = 4) and newly diagnosed (N = 3) grade 4 glioma participants. The analysis encompassed 1953 participants; sample sizes ranged from 35 to 716. Meta-analyses were not possible due to heterogeneity and the small number of studies. Most trials had high risk of bias. Nivolumab versus bevacizumab in people with recurrent GBM (1 trial, 369 participants) Nivolumab probably does not increase OS (hazard ratio (HR) 1.04, 95% confidence interval (CI) 0.83 to 1.30; 1.3% more, 95% CI 6.30 fewer to 7.80 more; 369 participants; moderate-certainty evidence) or PFS (HR 1.97, 95% CI 1.57 to 2.48; 16.40% more, 95% CI 12.40 more to 19.00 more; 369 participants; moderate-certainty evidence). The evidence for SAE is very uncertain (risk ratio (RR) 1.20, 95% CI 0.74 to 1.92; 347 participants). Nivolumab probably does not increase ORR (RR 0.34, 95% CI 0.18 to 0.63; 309 participants; moderate-certainty evidence), but may not increase less serious AEs (RR 1.03, 95% CI 0.96 to 1.10; 347 participants; low-certainty evidence). Nivolumab plus bevacizumab 10 mg/kg versus nivolumab plus bevacizumab 3 mg/kg in people with recurrent GBM (1 trial, 90 participants) Nivolumab plus bevacizumab 10 mg/kg may not increase OS (HR 1.39, 95% CI 0.86 to 2.25; 9.90% more, 95% CI 5.20 fewer to 18.80 more; 90 participants; low-certainty evidence). The evidence for PFS (HR 1.23, 95% CI 0.78 to 1.93; 5.80% more, 95% CI 8.20 fewer to 14.20 more; 90 participants) and SAE (RR 1.19, 95% CI 0.79 to 1.79; 90 participants) is very uncertain. Nivolumab may not increase less serious AEs (RR 1.02, 95% CI 0.96 to 1.09; low-certainty evidence; 90 participants). Pembrolizumab plus bevacizumab versus pembrolizumab in people with recurrent GBM (1 trial, 80 participants) The evidence for OS (HR 1.03, 95% CI 0.65 to 1.63; 0.30% more, 95% CI 7.60 fewer to 2.90 more; 80 participants), PFS (HR 0.97, 95% CI 0.61 to 1.54: 0.40% fewer, 95% CI 9.20 fewer to 2.80 more; 80 participants), SAE (RR 1.32, 95% CI 0.75 to 2.42; 80 participants), and ORR (RR 12.76, 95% CI 0.77 to 210.27; 80 participants) is very uncertain. Pembrolizumab plus bevacizumab may not increase less serious AEs (RR 1.04, 95% CI 0.96 to 1.13; 80 participants; low-certainty evidence). Neoadjuvant (before surgical resection) and adjuvant (after surgical resection) pembrolizumab versus adjuvant-only pembrolizumab in people with recurrent GBM (1 trial, 35 participants) The evidence for OS (HR 0.39, 95% CI 0.17 to 0.92; 25.20% fewer, 95% CI 37.10 fewer to 2.10 fewer; 35 participants), PFS (HR 0.43, 95% CI 0.20 to 0.91; 30.10% fewer, 95% CI 52.20 fewer to 3.60 fewer; 35 participants), and SAE (RR 1.00, 95% CI 0.31 to 3.28; 32 participants) is very uncertain. Nivolumab plus radiotherapy versus temozolomide plus radiotherapy in people with newly diagnosed unmethylated GBM (1 trial, 560 participants) Nivolumab plus radiotherapy probably does not increase OS (HR 1.31, 95% CI 1.09 to 1.58 months; 8.30% more, 95% CI 2.80 more to 12.90 more; 560 participants) and PFS (HR 1.38, 95% CI 1.15 to 1.65 months; 7.50% more, 95% CI 3.60 more to 10.30 more; 560 participants; moderate-certainty evidence). The evidence for SAE is very uncertain (RR 0.87, 95% CI 0.65 to 1.18; 553 participants). It may not increase ORR (RR 1.08, 95% CI 0.43 to 2.69; 560 participants; low-certainty evidence) and probably does not increase less serious AEs (RR 1.00, 95% CI 0.96 to 1.04; 560 participants; moderate-certainty evidence). The evidence for time to deterioration of QoL is very uncertain (HR 0.76, 95% CI 0.59 to 0.99; 560 participants). Nivolumab plus temozolomide plus radiotherapy versus placebo plus temozolomide plus radiotherapy in people with newly diagnosed methylated GBM (1 trial, 716 participants) Nivolumab plus temozolomide plus radiotherapy probably does not increase OS (HR 1.10, 95% CI 0.92 to 1.32; 3.50 more, 95% CI 3.80 fewer to 9.60 more; 716 participants) and PFS (HR 1.10, 95% CI 0.92 to 1.32; 3.00 more, 95% CI 3.50 fewer to 7.90 more; 716 participants), and probably increases SAE (RR 2.91, 95% CI 2.05 to 4.12; 709 participants; moderate-certainty evidence). It does not increase less serious AEs (RR 1.02, 95% CI 1.00 to 1.04; 709 participants; high-certainty evidence). Adjuvant nivolumab plus temozolomide versus temozolomide in older people with GBM (1 trial, 103 participants) Nivolumab plus temozolomide probably does not increase OS (HR 0.85, 95% CI 0.54 to 1.33; 3.10 fewer, 95% CI 15.80 fewer to 3.60 more; 103 participants; moderate-certainty evidence) and PFS (HR 0.77, 95% CI 0.49 to 1.19; 5.40 fewer, 95% CI 19.10 fewer to 2.40 more; 103 participants; moderate-certainty evidence). The evidence for SAE is very uncertain (RR 1.58, 95% CI 0.88 to 2.81; 103 participants). The evidence for QoL is very uncertain (results only reported graphically; 103 participants). Authors' conclusions: In recurrent GBM, nivolumab alone probably has no benefit. Anti-PD1 plus bevacizumab may also be ineffective based on low- to very low-certainty evidence. Neoadjuvant plus adjuvant pembrolizumab may improve OS and PFS, but this was based on only one small trial and very low-certainty evidence. In newly diagnosed GBM, nivolumab plus radiotherapy in unmethylated and plus radiotherapy plus temozolomide in methylated GBM probably has no benefit. In older participants, adjuvant nivolumab probably offers no benefit.
Background/Objectives Myosteatosis has been associated with sarcopenia, and increased mortality risk in patients on hemodialysis. We aimed to explore the associations between myosteatosis, as assessed by computed tomography (CT), with demographic parameters, body composition metrics, muscle strength, metabolic parameters and mortality in patients with chronic kidney disease (CKD). Subjects/Methods We enrolled 216 patients (age 60.3 ± 10.6 years, 63% men) with CKD stages 3–5. Abdominal CT scans at the third lumbar vertebra (L3) were used to assess body composition. Abdominal obesity was determined by abdominal adipose tissue (AT), sarcopenia by low skeletal muscle area (SMA) and low handgrip strength. Myosteatosis was evaluated by two parameters using CT scans at L3: mean muscle attenuation and percentage of intermuscular adipose tissue (%IMAT) within SMA. We evaluated the correlation between parameters of myosteatosis with demographic, clinical and metabolic variables. To determine independent predictors of myosteatosis, a multiple linear regression model was fitted. Mortality risk was evaluated with Cox-regression analysis. Results Both parameters of myosteatosis were independently associated with age, metabolic syndrome, abdominal AT and SMA in the multiple linear regression analysis (adjusted R² for multiple linear regression: muscle attenuation model 0.535, P < 0.001; %IMAT model 0.462, P < 0.001). Moreover, higher %IMAT and lower attenuation were associated with a higher mortality risk. Conclusion In patients with CKD, increased myosteatosis, as assessed by abdominal CT, was associated with old age, adiposity, metabolic dysfunction, and higher mortality risk.
BACKGROUND: The hospitals’ volume, specialization, availability of all oncological services, and experience in performing complex surgeries have a favorable impact on gastric cancer (GC) treatment. AIMS: The aim of this study was to compare the results of GC treatment according to the type of oncological hospital in the State of São Paulo. METHODS: Patients diagnosed with GC between 2000 and 2022 in qualified hospitals for cancer treatment were evaluated by data extracted from the hospital cancer registry. Patients were assessed according to the type of hospital for cancer treatment: Oncology High Complexity Assistance Unit (UNACON) and Oncology High Complexity Care Center (CACON), which has greater complexity. RESULTS: Among the 33,774 patients, 23,387 (69.2%) were treated at CACONs and 10,387 (30.8%) in UNACONs. CACON patients were younger, had a higher level of education, and had a more advanced cTNM stage compared to UNACON (all p<0.001, p<0.05). The time from diagnosis to treatment was over 60 days in 49.8% of CACON’s patients and 39.4% of UNACON’s (p<0.001, p<0.05). Surgical treatment was performed in 18,314 (54.2%) patients. The frequency pN0 (40.3 vs 32.4%) and pTNM stage I (23 vs 19.5%) were higher in CACON. There was no difference in overall survival (OS) between all adenocarcinoma cases treated at CACON and UNACON (9.3 vs 10.3 months, p=0.462, p>0.05). However, considering only patients who underwent curative surgery, the OS of patients treated at CACON was better (24.4 vs 18 months, p<0.001). CONCLUSIONS: Patients with GC who underwent gastrectomy at CACONs had better survival outcomes, suggesting that the centralization of complex cancer surgery may be beneficial. HEADINGS: Centralized Hospital Services; Cancer Care Facilities; Stomach Neoplasms; Gastrectomy; Survival Analysis; Oncology Service, Hospital
Acute myeloid leukemia (AML) with FLT3-ITD mutation represents a quarter of AML patients and is associated with high relapse rate and dismal prognosis. FLT3 tyrosine kinase inhibitors (TKIs) were developed in order to target this genetic alteration and among these TKIs, AC220 (quizartinib) combined with chemotherapy has already shown an increased overall survival for patients with AML with FLT3-ITD mutation. Even though this increase in overall survival was significant, it remains discrete, and relapse rate is still high, so there is an unmet medical need. All-trans retinoic acid (ATRA) is well known for its effectiveness in acute promyelocytic leukemia (APL) treatment and has already been shown to have synergistic effects combined with another TKI, sorafenib. In this study, quizartinib, a more potent FLT3-TKI, was tested in combination with ATRA in the AML FLT3-ITD positive cell lines MOLM-13 and MV4-11. ATRA has effectively improved AC220 induced cell death via caspase activation. In addition, ATRA in combination with AC220 treatment notably enhanced BECN1 cleavage compared to AC220 treatment alone. Finally, in a xenotransplantation model ATRA plus AC220 was more efficient to reduce the leukemic burden than monotherapy with ATRA or AC220. Taken together, our results are a proof of the concept that ATRA and AC220 have synergistic anti-leukemic effects.
Introduction: This article looks at the academic work surrounding the Car-Wash Case (CWC), which began in 2014 with the homonymous Federal Police investigation. Using a bibliometric approach, the study seeks to explore several questions: How is this intellectual output structured? Who is producing it? How is it distributed geographically and institutionally? What are its main themes and prominent authors? Materials and methods: To explore these research questions, we analyzed a corpus of 119 academic articles published on the Car-Wash Case, selected from five bibliographic databases: Scielo, Scopus, CAPES Journal Portal, Google Scholar, and ProQuest. Our analytical methods included frequency statistics, which used variables to characterize the articles and their authors, as well as co-occurrence and co-citation analyses to identify the main debates and references driving these researches. Results: Academic production on the Car-Wash Case is primarily concentrated in the Southeast and South regions of Brazil. Although institutions and journals publishing on this topic vary, there is a noticeable convergence around several academic fields, particularly Law, Business, Interdisciplinary Studies, and Political Science. We found a trend toward co-authorship, with a slight predominance of male authors. The number of articles on the Car-Wash Case increased until 2018, after which it began to decline. The academic production is multidisciplinary and fragmented, with academic fields/disciplines organizing both the dominant themes and approaches as well as the key reference authors. Discussion: We present an innovative approach in this article by examining how academia has responded to Brazil's largest political scandal in recent history. Our findings highlight the key aspects of the case emphasized across various fields of study and identify the most frequently cited references. The contribution of this article lies in organizing the academic literature on the Car-Wash Case and providing guidance for future research to deepen existing inquiries and explore shortcoming in the current state of knowledge on the topic. Keywords Car-Wash Case (CWC); corruption; academic production; bibliometrics; co-occurrence analysis; co-citation analysis
Observational studies suggest a U-shaped association between serum potassium (K⁺) levels and mortality in patients with chronic heart failure (CHF). However, the mode of death in patients with HF and K⁺ disorders remains speculative. To investigate the association between potassium disorders and the mode of death in patients with CHF. A retrospective cohort of 10,378 CHF outpatients was analyzed over an average of 3.28 ± 2.5 years. Kaplan-Meier method, Cox proportional hazards regression models, Poisson regression models adjusting for confounders, and e-value determination (e' > 1.6) were used to observe associations between potassium disorders and outcomes. Chagas etiology (p < 0.01) and triple HF therapy (p < 0.01) were associated with hyperkalemia. Atrial fibrillation was associated with hypokalemia (p < 0.01). Chronic kidney disease (CKD) (p < 0.01) and diabetes (p = 0.03) were associated with both. Hypertension was inversely related to hyperkalemia (p < 0.01); age was inversely related to hypokalemia. Associations with mortality were significant for Chagas (p < 0.01, e-value 2.16), stroke (p < 0.01, e-value 1.85), hypokalemia (p = 0.02, e-value 1.94), severe hyperkalemia (p = 0.08, e-value 1.93), and CKD (p < 0.01, e-value > 1.63). Decompensated HF or cardiogenic shock was the cause of death in 54% of patients with normokalemia, 67.8% with hypokalemia, 44.9% with mild hyperkalemia, 57.8% with moderate hyperkalemia, and 69% with severe hyperkalemia. Most patients with hypokalemia and severe hyperkalemia died from decompensated HF (p = 0.007). Data suggest hypokalemia and severe hyperkalemia, along with Chagas and CKD, are associated with death. Unexpectedly, progressive HF was the most frequent mode of death rather than arrhythmias. Further studies are needed to confirm these findings and explore the underlying mechanisms. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-74928-x.
Highlights Fish oil supplementation reduces insulin resistance in nonobese type 2 diabetes model. Fish oil supplementation increased the lymphocyte polarization towards T regulatory profile instead Th1 and Th17 profiles. Fish oil immunomodulatory effects indicate a potential effect of omega-3 to reduce inflammatory response in lean type 2 diabetic patients. Anti-inflammatory effects of fish oil can contribute for the increased insulin response in nonobese type 2 diabetic individuals. Abstract Background/Objectives: Goto-Kakizaki (GK) rats exhibit insulin resistance and type 2 diabetes mellitus (T2DM) without obesity. This study explored the effects of ω-3 fatty acid supplementation on T lymphocyte polarization in Wistar (WT) and GK rats. Methods: They were administered ω-3 fatty acid-rich fish oil (FO) containing eicosapentaenoic (540 mg/g) and docosahexaenoic acids (100 mg/g) by oral gavage at 2 g/kg, thrice a week for 8 weeks. The control groups (WT CT and GK CT) received the same volume of water. The following groups were investigated: GK CT, n = 14; GK ω-3, n = 15; Wistar CT, n = 15; and Wistar ω-3, n = 11. Glucose and insulin tolerance tests (GTT and ITT) were performed. Fasting plasma insulinemia and glycemia were measured. After euthanasia, the lymphocytes were extracted from the mesenteric lymph nodes. Results: The results showed that GK rats supplemented with FO had significantly improved glucose tolerance and insulin sensitivity (kITT). It also promoted greater polarization of lymphocytes toward T regulatory (Treg) features and a reduction in Th1 and Th17 profiles. Additionally, the GK ω-3 group exhibited lower cell proliferation, decreased pro-inflammatory cytokines, and increased IL-10 levels compared to the GK control. Conclusions: In conclusion, FO supplementation benefited GK rats by improving glucose intolerance, suppressing insulin resistance, and modulating lymphocytes toward Treg polarization.
Objectives The objective of this study was to assess the impact of the COVID-19 pandemic, after 2 years, on mammographic screening in Brazil evaluating BIRADS® results, breast cancer diagnosis rates, and breast cancer stage. Study Design This was an ecological observational study based on retrospective data from Brazil’s mammographic screening program from 2015 to 2023. Methods Data were obtained from the national screening database DATASUS – SISCAN (Cancer System Information) and retrieved in March 2024. Inclusion criteria comprised completeness of mammogram data (incomplete records were excluded), female participants aged 50 to 69 years, and mammograms exclusively performed for screening purposes. The study analyzed the number of mammograms conducted during the specified period, focusing on BIRADS® test results. Results Out of 23,851,371 mammograms performed between 2015 and 2023, 15,000,628 were included for analysis. A significant reduction of 39.6% in mammograms was observed in 2020 compared to 2019, followed by a 12.6% decrease in 2021. Notably, a substantial rise in BIRADS categories 4 and 5 examinations was seen post-pandemic. Breast cancer staging analysis revealed a shift towards more advanced stages (III and IV) diagnosed post-pandemic, suggesting potential delays in detection and diagnosis. Conclusions In conclusion, the study highlighted significant discrepancies in mammographic screenings and breast cancer diagnosis rates over 9 years. The pandemic reflected significant influence on the timing and stage at diagnosis, suggesting potential delays in detection and diagnosis that resulted in later identification of more advanced disease stages.
In this study, we evaluated the impact of yeast cell wall prebiotics and multispecies probiotics on the gut microbiota, immune response, and growth performance of weaned piglets, as alternatives to antibiotics as growth promoters (AGPs). A randomized complete block design was employed, involving 160 piglets divided into four treatment groups during the nursery phase. The treatments applied throughout the experimental period were as follows: CONT+ = basal diet with halquinol (AGP); YCW = basal diet with yeast cell wall (cell wall of Saccharomyces cerevisiae yeast); SIM+ = basal diet with yeast cell wall + multispecies probiotic (Bacillus subtilis (2.0 x 10⁹ CFU/g), Bacillus coagulans (5.0 x 10⁸ CFU/g), Clostridium butyricum (5.0 x 10⁷ CFU/g), and Bacillus licheniformis (2.0 x 10⁹ CFU/g)); SIM- = basal diet with yeast cell wall + multispecies probiotic (half dose). The parameters assessed included daily feed intake, weight gain, feed conversion ratio (FCR), diarrhea score, serum cytokine levels, and chemokine concentrations, as well as microbiota analysis. During the 21 to 63-day study period, only FCR differed significantly (p = 0.0076). CONT+ and PREB had superior FCRs of 1.543 and 1.585, while SIM- had the least favorable FCR at 1.654. At 35 days, IL-10 levels were greater in the SIM- group, showing a 271.25% increase over those in the other groups. By 49 days, the IL-8 concentration was lower in the PREB group than in the CONT+ group, with a reduction of 247%, while the IL-8 concentrations in the SIM+ and SIM- groups were not significantly different from those in the other groups. The Firmicutes/Bacteroidetes (F/B) ratio in the CONT+ group was lower than that in the PREB, SIM+, and SIM- treatment groups. The Lactobacillaceae family was more abundant in the SIM+ treatment, followed by the SIM- and PREB treatments. The CONT+ treatment had the lowest abundance. The abundance of the genus Lactobacillus differed between the CONT+ group and the PREB, SIM+, and SIM- treatment groups. Prebiotics, used either alone or combined with probiotics, serve as effective substitutes for AGPs, boosting piglets’ health and performance throughout the nursery phase.
Fishing activity has great socioeconomic importance and can be used as a tool to combat hunger and poverty, especially when considering developing countries. However, most of the fisheries' catch in these places is still unrecorded. Namibe Province, located at the South Angolan Littoral, has a 450-km-long seafront, with several communities historically relying on fishing activity. In this context, the present study sought to gather available data about fisheries exploration in Namibe, apply a SWOT (strengths, weaknesses, opportunities, and threats) analysis, and use semi-structured questionnaires to assess the status of fishing activity in the region. We acquired a 3-year catch series from the Gabinete Provincial das Pescas (Pro-vincial Fisheries Office) and interviewed 329 actors involved in the activity. We also present a sector diagnosis where we report information regarding the main landed species and their seasonality, the most commonly used fishing gear, and a characterization of the fisheries market chain. Results show an urgent need for fisheries monitoring programs to produce data that can be used in robust sustainable management policies in the region. We also report on the professionals' perceptions of the stock declines, which are mainly associated with illegal international fishing. Finally, this study provides valuable data about Namibe's regional fisheries sector and discusses possible alternatives to address the problems faced by developing public policies based on scientific data.
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174 members
Everton Crivoi Carmo
  • Health and Wellness - Physical Education
Oswaldo Scopin de Andrade
  • Faculty of Dentistry
Fernando Fogliano
  • Comunicação e Artes
Giuliano Carlo Rainatto
  • School of Business
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São Paulo, Brazil