Selcuk University
  • Konya, Turkey
Recent publications
Background The domestication of goat ( Capra hircus ) started 11,000 years ago in the fertile crescent. Breed formation in the nineteenth century, establishment of herd books, and selection for specific traits resulted in 10 modern goat breeds in Switzerland. We analyzed whole-genome sequencing (WGS) data from 217 modern goats and nine wild Bezoar goats ( Capra aegagrus ). After quality control, 27,728,288 biallelic single nucleotide variants (SNVs) were used for the identification of runs of homozygosity (ROH) and the detection of ROH islands. Results Across the 226 caprine genomes from 11 populations, we detected 344 ROH islands that harbor 1220 annotated genes. We compared the ROH islands between the modern breeds and the Bezoar goats. As a proof of principle, we confirmed a signature of selection, which contains the ASIP gene that controls several breed-specific coat color patterns. In two other ROH islands, we identified two missense variants, STC1: p.Lys139Arg and TSHR :p.Ala239Thr, which might represent causative functional variants for domestication signatures. Conclusions We have shown that the information from ROH islands using WGS data is suitable for the analysis of signatures of selection and allowed the detection of protein coding variants that may have conferred beneficial phenotypes during goat domestication. We hypothesize that the TSHR :p.Ala239Thr variant may have played a role in changing the seasonality of reproduction in modern domesticated goats. The exact functional significance of the STC1 :p.Lys139Arg variant remains unclear and requires further investigation. Nonetheless, STC1 might represent a new domestication gene affecting relevant traits such as body size and/or milk yield in goats.
Background Aortic arch and vertebral artery anomalies are vascular variations that occur as a result of embryological developmental defects. Bicarotid trunk anomaly is a rare aortic arch anomaly and refers to a common single trunk origin of common carotid arteries. VA origin anomalies are mostly unilateral and the most common is the LVA originating from the aortic arch. Abnormal origin of the RVA from the RCCA is a rare vascular anomaly. In this case, we presented ARSA and bicarotid trunk anomaly with abnormal origin of the vertebral arteries. Case presentation A 64-year-old male was admitted to our center with complaints of chronic headache and dizziness. In addition to ARSA and bicarotid trunk anomaly, RVA originating from RCCA and LVA originating from aortic arch were observed in CT angiography. The origin of LVA was between the bicarotid trunk and LSCA. Both VA were entering the transverse foramen at the level of the C6 vertebra. These anomalies were also revealed in detail by MR angiography of head/neck. Conclusion Aortic arch anomalies are a group with different subtypes. Awareness of VA origin anomalies is important for planning surgical and endovascular interventional procedures.
Shalgam is a fermented beverage obtained by lactic acid fermentation and its quality depends on flora. Therefore, it is essential to be able to characterize yeasts, in order to improve the quality and safety controls of final products. This study aimed to identify endogenous yeasts found during the fermentation of shalgam and to determine their technological properties. 172 yeast isolates were obtained and the DNA fingerprints were constituted by iPBS-PCR method. Sequencing of ITS regions of different groups revealed the species of Pichia kudriavzevii, P. fermentans, Saccharomyces cerevisiae, Candida oleophila, Kazachstania bulderi, and Geotrichum candidum. Interestingly, the prevalence of P. kudriavzevii in the flora increased during the fermentation, while the other species decreased. To determine the preliminary technological properties of yeasts, their development at different conditions was examined and 31 technologically superior strains were determined by Principal Component Analysis (PCA). Among these, 17 P. kudriavzevii strains had a vigorous fermentation rate and selected to assess their enzymatic activity. The isolates had diverse enzyme activities, including esterase, esterase lipase, and leucine arylamidase, which may have crucial roles for aroma formation. According to the results, P. kudriavzevii 3-3S9, 3-3S2, and 3-3Y1 strains were selected to be candidate starters for shalgam production.
This study aims to find the optimal switching angles in a cascaded H-bridge multilevel inverter (CHB-MLI) fed by photovoltaic (PV) panels, keeping the output voltage constant regardless of the panel voltage change and eliminating low-order harmonics. For this purpose, Red Deer Algorithm (RDA), a newly developed algorithm, has been applied to solve selective harmonic elimination (SHE) equations. Calculated switching angles are simulated by applying three-phase 7-level CHB-MLI in Matlab/Simulink environment. RDA optimization has been compared in performance to evolutionary algorithms such as particle swarm optimization (PSO), genetic algorithm (GA) and pigeon inspired optimization (PIO). The results show that in the case of unequal DC voltage, RDA can suppress selected harmonics accurately and quickly while controlling the fundamental voltage with a 0.02% error. The proposed RDA optimization can be used for multilevel inverters fed by any number of variable input voltages to eliminate selected harmonics and reduce total harmonic distortion (THD) without complex analytical calculations.
Self-excited induction generator (SEIG)-based wind energy conversion systems (WECS) are very popular for feeding stand-alone loads in remote areas where there is no grid. SEIG needs adjustable reactive power to regulate terminal voltage and frequency. Usually, a combination of a distributed static compensator (DSTATCOM) and a fixed capacitor bank is used to meet this reactive power demand. DSTATCOM is the most suitable option for power quality compensation. The performance of DSTATCOM depends on its control algorithm that generates the proper switching signals for voltage source inverter (VSI). Many control algorithms have been proposed for DSTATCOM in the literature. Among them, the most frequently used algorithms are synchronous reference frame (SRF), instantaneous reactive power (IRP), and current synchronous detection (CSD) algorithms. An effective control algorithm must accurately estimate the amplitude of the terminal voltage without being affected by harmonics, DC-offset, and frequency variation. For this purpose, an enhanced phase locked loop (EPLL)-based CSD control algorithm is proposed to estimate the amplitudes of individual phase voltages, and to filter SEIG voltages in case of harmonics, DC offset, and frequency variation. The proposed algorithm has been tested under linear and nonlinear load conditions. The obtained results clearly demonstrate the effectiveness of the proposed EPLL-based CSD control algorithm.
Culicoides biting midges are well known biological vectors of several arboviruses causing more than 100 veterinary and medical diseases worldwide. In Algeria, bluetongue virus, which is transmitted by Culicoides midges, is responsible for one of the most critical insect-borne diseases of sheep. For example, this disease caused clinically severe morbidity of about 2,661 confirmed cases out of 21,175 susceptible sheep in Algeria. This study compared the abundance, richness, and diversity of Culicoides species in rural and suburban environments of semi-arid regions in North Africa. It examined the potential influence of the bio-climatic factors on the variation of population sizes and the elevation distribution of biting midges. Specimen collection was carried out from June to September during two successive years (2018 and 2019) using CDC light traps installed at 15 sites in different environments. Culicoides specimens were dissected, slide-mounted, and morphologically identified using the interactive identification key IIKC and various standard morphological criteria. A total of 1,046 Culicoides specimens (1,024 females and 22 males) were trapped and classified into 22 species, belonged to nine distinct subgenera. Two new species records for Algeria and and even North Africa are reported: Culicoides albicans (Winnertz, 1852) and Culicoides nubeculosus (Meigen, 1830). Culicoides newsteadi Austen, 1921 (51.6%) was the dominant species, and it was followed by Culicoides punctatus (Meigen, 1804) (16.3%) and Culicoides odiatus Austen, 1921 (11.5%). These three species, comprising 80% of the collected Culicoides, were the most abundant both outside and inside livestock stables in rural and suburban environments. Species diversity was similar in the two settings, with a slight increase in suburban environments. None of the Culicoides species encountered correlated significantly with the climatic factors (mean temperature, precipitation, and relative humidity). Elevation was the most determinant environmental parameter that affected the abundance and distribution of Culicoides midges in the semi-arid and sub-humid areas studied. The maximum distribution of Culicoides species was detected at mid elevations (400‒800 m). Using a modeling approach, we explored for the first time the variation of composition and diversity in Culicoides communities within different climatic regions, environments and livestock settings in Algeria. This survey deepens our understanding of the relationships among environmental factors, abundance, diversity, and geographic distribution of Culicoides. This is a crucial step to assess the epidemiological situation of the diseases transmitted by these biting midges and to allow mitigation of the associated risks.
The seeds of Aframomum melegueta K. Schum (grains of paradise, Zingiberaceae) are used as a common spice in African countries and a fine condiment in the European cuisine. In this study, we evaluated the phytochemical profile of various seed extracts of A. melegueta as well as their antimicrobial, antioxidant and enzyme inhibitory effects. In total, 25 diarylheptanoids, five gingerol derivatives and nine phenolic/organic acids were tentatively annotated in A. melegueta by liquid chromatography hyphenated with high resolution tandem mass spectrometry (LC-HRMS/MS). A. melegueta showed a moderate inhibitory activity against different human pathogenic microbial strains, with H. pylori the most sensitive microorganism. A strong antioxidant and enzyme inhibitory potential was shown in various radical scavenging, reducing and chelating assays as well as in cholinesterase, tyrosinase and glucosidase assays. Several specialized metabolites from A. melegueta (diarylheptanoids, gingerols) were shown to be directly linked with the investigated antioxidant and enzyme inhibitory activities, as evaluated through the correlation analysis. In addition, two diarylheptanoids (one heptan-3-ol and one heptan-3,5-diol) displayed the strongest binding to acetylcholinesterase (AChE) via multiple H-bonds, a couple of π-π interactions and van der Waals interactions all over the catalytic channel of the enzyme, as evidenced by the molecular docking study. Overall, our work brings new contributions to the phyto-complexity and poly-pharmacology of spices from genus Aframomum than can find future applications in pharmaceutical, nutraceutical or cosmeceutical industry.
Alzheimer's disease (AD), especially its sporadic form (sAD), is of multifactorial nature. Brain insulin resistance and disrupted zinc homeostasis are two key aspects of AD that remain to be elucidated. Here, we investigated the effects of dietary zinc deficiency and supplementation on memory, hippocampal synaptic plasticity, and insulin signaling in intracerebroven-tricular streptozotocin (icv-STZ)-induced sAD in rats. The memory performance was evaluated by Morris water maze. The expression of hippocampal protein and mRNA levels of targets related to synaptic plasticity and insulin pathway was assessed by Western blot and real-time quantitative PCR. We found memory deficits in icv-STZ rats, which were fully recovered by zinc supplementation. Western blot analysis revealed that icv-STZ treatment significantly reduced hippocampal PSD95 and p-GSK3β, and zinc supplementation restored the normal protein levels. mRNA levels of BDNF, PSD95, SIRT1, GLUT4, insulin receptor, and ZnT3 were found to be reduced by icv-STZ and reestablished by zinc supplementation. Our data suggest that zinc supplementation improves cognitive deficits and rescues the decline in key molecular targets of synaptic plasticity and insulin signaling in hippocampus caused by icv-STZ induced sAD in rats.
Background Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013–2017, and 2017–current. Results A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (× 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (× 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.
Pandemic diseases have caused dramatic changes in people's lives throughout history. Today, the COVID-19 virus spreads rapidly and affects human beings around the globe. This study aimed to discover the coping strategies and post-traumatic growth (PTG) experiences of persons who were infected by the COVID-19 virus using the qualitative research method. The research involved 17 individuals, nine of whom were female. All had been diagnosed with COVID-19. Face-to-face and online interviews were conducted with participants. In the analysis of the data, the thematic analysis method was performed by developing themes and sub-themes. The created themes include coping strategies, existential growth, lessons learned from disease, new opportunities, and social growth. These themes indicated positive changes in the lives of persons who were infected by the COVID-19 virus after the COVID-19 disease. Findings and implications for the practice were discussed.
Social voles of the genus Microtus consist of at least eight nominal species occurring in the Western Palearctic. Despite the significant influence of Middle Eastern Geo-climatic heterogeneity on small mammal diversification, this area remains largely unexplored. In this study, we considered mitochondrial cytochrome b phylogeny and chromosomal data to assess taxonomy and intraspecific variability within two closely related social voles, Microtus irani and Microtus schidlovskii in the Middle East. We also performed univariate and multivariate analyses to elucidate the craniodental variations between the studied voles. We confirmed the close relationship of the “irani-schidlovskii” complex while providing pieces of evidence for their distinct species’ status. In addition, our new material from Iran outlines a novel view on the distribution of the taxonomically obscure Iranian vole M. irani with an undescribed subspecies from Chahar-Mahal & Bakhtiari Province in southwestern Iran.
The element found at the highest amount in onion samples was sulfur, and followed by K, Ca, P, Na, and Mg in decreasing order. While K contents of white onion parts are determined between 1406.31 (outer most edible) and 1758.72 mg/kg (inner most edible), K contents of the parts of brown onions were measured between 1779.79 (head) and 2495.89 mg/kg (inner most edible). Also, K amounts of purple onions were detected between 2248.73 (shell) and 3064.64 mg/kg (middle edible). In addition, in general, the highest P, S, and K were detected in the middle edible and inner most edible parts of the edible onion samples. While the highest Ca content was localized in brown and purple onion roots, it was most localized in the shell part of white onions. In edible white and brown onions, the highest Na content was found in the inner most edible part. Fe amounts of white and brown onion samples were identified between 7.94 (head) and 20.41 mg/kg (root) to 9.56 (middle edible) and 23.67 mg/kg (head), respectively. Also, Fe contents of the parts of purple onions varied between 13.04 (shell) and 20.61 mg/kg (inner most edible). While the highest Fe and Zn are determined in the middle edible part in edible white onions, the highest Fe and Zn were determined in the outer most edible part in brown onions. In general, the most heavy metals were localized in the bark, head, and root parts of the onions. This had a positive effect on the safe edibility of onions. The heavy metal detected in the highest amount in onion samples was arsenic, followed by Cr, Al, Ni, Se, Ba, Pb, Mo, Co, and Cd in descending order. Generally, purple onion type showed maximum values. Therefore, results of the present study seen to be beneficial in the way that it allowed us to selected some varieties with nutrition value that could be interesting to introduce in gastronomy.
Lattice structures are vital for biological applications because of its numerous benefits (for example, faster and stronger binding to bone tissue). Consequently, processing of lattice structure is a particularly popular area of study currently. In this study, additive manufacturing technologies utilized in several engineering disciplines were collated and their merits and shortcomings were examined. Numerous sectors and disciplines view lattice structured additive manufacturing as a prototyping technique. In recent years, additive manufacturing technology has also progressed toward the fabrication of useable final goods. The objective of this review is to classify the produced systems under the headings of aviation, automotive, and military technologies within the context of engineering and to compare them by examining the research and technology firms in this sector. In this categorization, lattice-structured additive manufacturing techniques are categorized as an engineering production technology, and examples of this field are investigated. Technologies, which are examples of diverse engineering applications, are categorized under four primary headings: additive manufacturing knowledge, selective laser melting (SLM), lattice structure, and changeable porosity cellular structures.
Nitrate (NO3ˉ) toxicity is a serious problem that threatens the health of living organisms and especially agricultural production. The presence of NO3ˉ leads to biomass loss by causing the imbalance of biochemical metabolism and inhibiting photosynthetic activity. A new critical approach to cope with nitrate toxicity is the use of polyamines (PAs) as an antioxidant defence system enhancer in plants. However, there is no information about the impacts of cadaverine, is one of PAs, on chloroplasts of plants exposed to NO3ˉ toxicity. For this purpose, this study focused on the photosynthetic and biochemical process taking place in chloroplasts of Triticum aestivum under nitrate stress (100 mM and 200 mM NO3ˉ) and/or cadaverine (100 µM and 1 mM Cad). Gas exchange, chlorophyll fluorescence (Fv/Fm and Fv/Fo), the efficiency of the light reaction (ΦPo/(1- ΦPo)), the performance index (PItotal) and relative water content (RWC) levels were suppressed under NO3ˉ stress. Stress did not improve the antioxidant activities in chloroplasts such as superoxide dismutase (SOD), glutathione reductase (GR). After 100 mM NO3ˉ exposure, Cad increased chloroplastic SOD, peroxidase (POX), ascorbate peroxidase (APX), GR, monodehydroascorbate reductase (MDHAR) and glutathione S-transferase (GST) activities. In the presence of 200 mM NO3ˉ, Cads decreased SOD and GST activity. In NO3ˉ+Cad-applied wheat, the high contents of hydrogen peroxide (H2O2) and lipid peroxidation (TBARS) were effectively removed through ascorbate (AsA) regeneration. Cads promoted the maintenance of cellular redox state by regulating antioxidant pathways included in the ascorbate-glutathione (AsA-GSH) cycle. Our results showed that Cad has great potential to confer tolerance to wheat by reducing oxidative damage and protecting the biochemical reactions of photosynthesis against NO3ˉ toxicity.
The proper design and management of trickle irrigation systems are important factors in ensuring the efficient water use in agriculture. In this study, the effects of different irrigation strategies were determined on the yield, net income, and water use productivity of trickle-irrigated sunflower (Helianthus annuus L. cv. Sirena) in a two-year open-field experiment (2013–14) in a semi-arid climate. Two different lateral spacings (L) of 70 cm (one lateral line per one plant row) and 140 cm (one lateral line per two plant rows) were designed, and three different wetting factors (W) were applied for each lateral spacing. Wetting factors of 1.00 and 0.60 were used as fixed values for both 70 and 140 cm lateral spacings. Moreover, two different wetting factors, 0.85 and 0.42, were used for the lateral spacings of 70 and 140 cm, respectively, using the measured wet diameter values in the experiment area. Thus, six treatments were designated as L70W1.00, L70W0.60, L70W0.85, L140W1.00, L140W0.60, and L140W0.42. The study was designed as randomized complete block design with three replications. When the trial years and treatments were evaluated together, the irrigation depth applied per treatment varied between 333.2 and 666.0 mm, while the plant water consumption (ETc) varied between 473.8 and 751.6 mm, and the highest ETc was found in L70W1.00. The highest seed yield (5.70 t ha⁻¹) was obtained in the L70W1.00, and the seed yield generally decreased with the decrease in water consumption. In L140W1.00, in which the same amount of irrigation water was used as in the L70W1.00, there was an 8% decrease in yield due to the design of one lateral per two plant rows. The yield response factor (ky) of sunflower was found to be 0.97, indicating that a certain level of water restriction can be applied to sunflower. However, there was a 17% reduction in seed yield in the L70W0.60 treatment compared to that in the L70W1.00 treatment, which resulted in a significant water saving of 34%. On the other hand, the lateral spacing of 1.40 m led to a significant decrease in yield under deficit irrigation conditions. The highest net income (1358 US $ ha⁻¹) was obtained in the L70W1.00 treatment, and the net income in the L140W1.00 treatment was found to be 1160 US $ ha⁻¹ with an approximate decrease of 15%. Therefore, to achieve high yield and net income in sunflower production, one lateral design should be used for each plant row with the wetting factor of 1.00. Moreover, to save the irrigation water in semi-arid areas, it is suggested to design a trickle lateral pipe for each plant row in sunflower production and use the wetting factor of 0.60.
Corn has great importance in terms of production in the field of agriculture and animal feed. Obtaining pure corn seeds in corn production is quite significant for seed quality. For this reason, the distinction of corn seeds that have numerous varieties plays an essential role in marketing. This study was conducted with 14,469 images of BT6470, Calipso, Es_Armandi, and Hiva types of corn licensed by BIOTEK. The classification of images was carried out in three stages. At the first stage, deep feature extraction of the four types of corn images was performed with the pretrained CNN model SqueezeNet 1000 deep features were obtained for each image. In the second stage, in order to reduce these features obtained from deep feature extraction with SqueezeNet, separate feature selection processes were performed with the Bat Optimization (BA), Whale Optimization (WOA), and Gray Wolf Optimization (GWO) algorithms among optimization algorithms. Finally, in the last stage, the features obtained from the first and second stages were classified by using the machine learning methods Decision Tree (DT), Naive Bayes (NB), multi-class Support Vector Machine (mSVM), k-Nearest Neighbor (KNN), and Neural Network (NN). In the classification processes of the features obtained in the first stage, the mSVM model has achieved the highest classification success with 89.40%. In the second stage, as a result of the classifications performed through the active features selected by using three types of feature selection algorithms (BA, WOA, GWO), the classification success obtained with the mSVM model was 88.82%, 88.72%, and 88.95%, respectively. The classification accuracies of the tested methods and the classification accuracies obtained in the first stage are close to each other in terms of classification success. However, with the algorithms used in feature selection, successful classification processes have been carried out with fewer features and in a shorter time. The results of the study, in which classification was carried out in the inexpensive, the objective, and the shorter time of processing for the corn types, present a different perspective in terms of classification performance.
The oil contents of outer and iner parts of blue cheese were 0.90% (outer part) and 2.05% (iner part), respectively. Total phenol and flavonoid values of outer and iner parts of blue cheese samples were 120.30 (outer part) and 101.96 mg GAE/100g (iner part) to 16.55 (outer part) and 8.45 mg quercetin equivalent (QE)/100g (iner part), respectively. The predominant phenolic compounds of outer and iner parts of blue moldy cheese were gallic acid, 3,4‐dihydroxybenzoic acid, catechin and rutin. In addition, catechin contents of outer and iner parts of blue cheese were detected as 4.28 (outer part) and 4.09 mg/100g (iner part), while rutin values of blue cheese are determined as 4.93 (outer part) and 3.06 mg/100g (iner part), respectively. Lauric, myristic, palmitic, stearic, oleic and linoleic acids were the most abundant fatty acids in moldy chese oils. Also, palmitic and stearic acid contents of outer and iner parts of blue moldy cheese were identified as 41.99 (outer part) and 39.87% (iner part) to 14.95 (outer part) and 12.85% (iner part), respectively. In addition, oleic acid contents of outer and iner parts of blue moldy cheese were 19.31% (outer part) and 22.58% (iner part), respectively.
Sickle cell disease (SCD) is an inherited hemoglobin disorder characterized by the occlusion of small blood vessels by sickle-shaped red blood cells. SCD is associated with a number of complications, including ischemic priapism. While SCD accounts for at least one-third of all priapism cases, no definitive treatment strategy has been established to specifically treat patients with SC priapism. The aim of this systematic review was to assess the efficacy and safety of contemporary treatment modalities for acute and stuttering ischemic priapism associated with SCD. The primary outcome measures were defined as resolution of acute priapism (detumescence) and complete response of stuttering priapism, while the primary harm outcome was as sexual dysfunction. The protocol for the review has been registered (PROSPERO Nr: CRD42020182001), and a systematic search of Medline, Embase, and Cochrane controlled trials databases was performed. Three trials with 41 observational studies met the criteria for inclusion in this review. None of the trials assessed detumescence, as a primary outcome. All of the trials reported a complete response of stuttering priapism; however, the certainty of the evidence was low. It is clear that assessing the effectiveness of specific interventions for priapism in SCD, well-designed, adequately-powered, multicenter trials are strongly required.
In this study, eleven new compounds with a series of benzimidazole-1,3,4-oxadiazole derivatives structures were synthesized and evaluated for their human (h) carbonic anhydrase inhibitory activities against two isoforms hCA I, hCA II, and antioxidant activity. The synthesized compounds were fully characterized by spectral analysis methods such as ¹H-NMR, ¹³C-NMR, and HRMS. Compared to acetazolamide (IC50 = 2.26 µM) for hCA I, the most potent compound 4a was with the IC50 value of 1.322 µM and compound 4d is the other molecule with a greater IC50 value (IC50 = 1.989 µM) than that of acetazolamide in these series. Among all the compounds, 4a (1.826 µM), 4d (1.502 µM), and 4g (1.886 µM) are the most active hybrids against carbonic hCA II. Considering that compound 4a containing 4-bromophenyl structure is effective on both hCA I and hCA II, it can be considered as a promising structure for the development of effective candidates with potent CA inhibitory activities. TAS assay was used to evaluate the antioxidant activities of synthesized compounds. The synthesized compound was analyzed for their in vitro cytotoxic activity on the L929 cell line by using MTT assay. In the last step of this study, molecular docking studies were performed in order to compare the biological activities of the most active molecules against the enzymes of hCAI and hCA II.
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3,709 members
Aynur Keskin Kaymakci
  • Department of Mathematics
Ali Aygun
  • Department of Animal Science
Kamil Hakan Dogan
  • Department of Forensic Medicine
Humar Kahramanli
  • Department of Computer Engineering (Faculty of Technology)
Dursun Ali Dinc
  • Department of Obstetrics and Gynecology
Alaaddin Keykubat Kampusu, 42075, Konya, Turkey
Head of institution
Prof. Dr. Metin Aksoy
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