Roger Williams University

A key theme in Lacanian psychoanalysis is the disappearance of the subject, through aphanisis. Aphanisis was a term used in psychoanalysis to refer to the fading of the sexual desire of the subject. The term was coined by Ernest Jones in 1927, and was seen as the foundation of all neuroses. Since Jacques Lacan set desire within the realm of language, for him aphanisis meant the fading of the subject beneath the signifier, as the signifier defines a subject to another signifier, and the signifier takes precedence in the formation of the unconscious. Aphanisis defines the dialectic of the subject, and establishes its alienation and fundamental division, Lacan said in The Four Fundamental Concepts of Psycho-Analysis. Related to aphanisis and the disappearance of the subject in Lacan’s thought are the Real, the objet a, the fading of the subject in language, the fading of the subject in perception, and the gaze. Other topics related to the fading of the subject are the dream space of Sigmund Freud, the psychophysiological space of Erwin Panofsky, the heterogeneous space of Georges Bataille, and the psychasthenia of Roger Caillois. The purpose of this essay is to consider these concepts in relation to architecture, in order to consider the possibility of a subjectless architecture, and to use architecture to illustrate the concepts.

Background Cooking-related emissions contribute to air pollutants in the home and may influence children’s health outcomes. Objective In this pilot study, we investigate the effects of a cooking ventilation intervention in homes with gas stoves, including a video-based educational intervention and range hood replacement (when needed) in children’s homes. Methods This was a pilot (n = 14), before-after trial (clinicaltrials.gov #NCT04464720) in homes in the San Francisco Bay Area that had a school-aged child, a gas stove, and either a venting range hood or over-the-range microwave/hood. Cooking events, ventilation use, and indoor air pollution were measured in homes for 2–4 weeks, and children completed respiratory assessments. Midway, families received this intervention: (1) education about the hazards of cooking-related pollutants and benefits of both switching to back burners and using the range hood whenever cooking and (2) ensuring the range hood met airflow and sound performance standards. The educational intervention was delivered via a video developed in conjunction with local youth. Results We found substantially increased use of back burners and slight increases in range hood use during cooking after intervening. Even though there was no change in cooking frequency or duration, these behavior changes resulted in decreases in nitrogen dioxide (NO2), including significant decreases in the total integrated concentration of NO2 over all cooking events from 1230 ppb*min (IQR 336, 7861) to 756 (IQR 84.0, 4210; p < 0.05) and NO2 collected on samplers over the entire pre- and post-intervention intervals from 10.4 ppb (IQR 3.5, 47.5) to 9.4 (IQR 3.0, 36.1; p < 0.005). There were smaller changes in PM2.5, and no changes were seen in respiratory outcomes. Impact This pilot before-after trial evaluated the use of a four-minute educational video to improve cooking ventilation in homes with gas stoves and one or more school-aged children. Participant behavior changed after watching the video, and there were decreases in indoor air pollutant concentrations in the home, some of which were significant. This brief video is now publicly available in English and Spanish (wspehsu.ucsf.edu/projects/indoor-air-quality), and this provides suggestive evidence of the utility of this simple intervention, which could be particularly beneficial for households that have children with asthma.

Objective: In West Alabama, catfish Ictalurus spp. producers routinely face the challenge of fish that exceed market size (aka “Big Fish”) in their commercial ponds. These fish are skilled at evading seine nets during harvest and can increase in size significantly before subsequent harvests occur. This is problematic for catfish producers because processing plants prefer catfish within the 0.45–1.81-kg range and farmers are paid a premium price for catfish of this size. Due to their larger size and growth potential, hybrid catfish (female Channel Catfish Ictalurus punctatus × male Blue Catfish I. furcatus) can become a more significant issue than Channel Catfish if they evade harvest. The objective of this study was to describe and quantify the age structure and growth rate of hybrid catfish that evade capture and remain in commercial ponds following harvest and grow beyond acceptable market size as defined by catfish processing plants (i.e., Big Fish). Methods: Hybrid catfish were collected from 12 recently harvested commercial ponds in West Alabama from December 2021 to August 2022 using an electroshocking boat. Total length (mm), body weight (kg), and sex of collected fish were recorded, and lapilli otoliths were removed to estimate fish age and determine total length and total body weight at estimated ages. Result: In this study, 1005 hybrid catfish were collected with the successful age estimation for 1001 catfish, ranging from 1 to 11 years. Results of this study indicate that hybrid catfish exceeded the premium size threshold in 2.72 years ± 8 months. Additionally, from age 2 to age 3, the average hybrid catfish gained 2.90 kg, growing from 0.40 to 3.30 kg. Growth rate was significantly affected by sex; males overall were predicted to weigh more than females based on the weight-at- age model. Conclusion: Hybrid catfish should be completely harvested from commercial ponds following 1 year of harvest to receive the premium price per kilogram of live fish. If a complete harvest is unsuccessful, farmers can receive a discounted price per kilogram of leftover hybrid catfish based on current market trends.

Decolonial and decolonizing theories emerge out of different and often incommensurable genealogies of native studies on settler colonialism, decolonial theory from Latin America, and postcolonial theory that is rooted in European colonialism of Africa and Asia. A decolonizing perspective shows how contemporary psychological science and psychological theories are inextricably linked to the legacy of colonialism, coloniality, settler colonialism and created through the Eurocentric nexus between power and knowledge. From Black Lives Matter, Rhodes Must Fall in the UK and South Africa to Standing Rock, and #NoBansOn StolenLand, decolonization has been invoked from different vantage points to dismantle the legacy of colonialism and coloniality. While the decolonial turn in psychology has provided us with critical knowledge in connecting questions of race, empire, and colonialism to knowledge production and power structures, we believe there is a pressing need for more historically specific, granular and situated accounts of decolonization. This article is organized around three key themes. First, we draw on our ethnographic research on upper-, middle- and working-class communities in Pune, India to show how Euro-American psychological discourses of self, happiness, community, and diversity are being reconstituted in the social life of urban Indian youth. Second, we specifically show “coloniality of knowledge” is reflected in the way specific accents and ways of speaking the English language have become “embodied” markers of social mobility and “neoliberal subjecthood”. We analyze how EuroAmerican cross-cultural psychology, psychometric personality tests, and the language of “diversity” is being used to exhort Indian youth workers to adapt and assimilate to cultural practices that can be framed as practices of global coloniality. We focus on how these psychological discourses reflect new forms of coloniality that exploit the workforce and increase their precarity and burden of affective labor. Third, we analyze how the reworking and reframing of these EuroAmerican psychological discourses in local settings gives rise to hybrid and asymmetrical constructions of “self,” and “culture” and “community.” In conclusion, we argue that there are hardly any accounts in psychology that reflect the cultural lives and experiences of people who live in the Global South. Additionally, the idea of culture—as an analytic framework, as practice, and as representation in psychology—are largely derived from theories primarily rooted in Eurocentric understandings of self and personhood.

Background The thymus, responsible for T cell-mediated adaptive immune system, has a structural and functional complexity that is not yet fully understood. Until now, thymic anatomy has been studied using histological thin sections or confocal microscopy 3D reconstruction, necessarily for limited volumes. Methods We used Phase Contrast X-Ray Computed Tomography to address the lack of whole-organ volumetric information on the microarchitecture of its structural components. We scanned 15 human thymi (9 foetal and 6 postnatal) with synchrotron radiation, and repeated scans using a conventional laboratory x-ray system. We used histology, immunofluorescence and flow cytometry to validate the x-ray findings. Results Application to human thymi at pre- and post-natal stages allowed reliable tracking and quantification of the evolution of parameters such as size and distribution of Hassall’s Bodies and medulla-to-cortex ratio, whose changes reflect adaptation of thymic activity. We show that Hassall’s bodies can occupy 25% of the medulla volume, indicating they should be considered a third thymic compartment with possible implications on their role. Moreover, we demonstrate compatible results can be obtained with standard laboratory-based x-ray equipment, making this research tool accessible to a wider community. Conclusions Our study allows overcoming the resolution and/or volumetric limitations of existing approaches for the study of thymic disfunction in congenital and acquired disorders affecting the adaptive immune system.

Free-swimming polychaetes are common in marine habitats and exhibit a unique form of swimming whereby a metachronal wave occurs simultaneously with a bending body wave. This body wave is unusual among swimming animals because it travels in the same direction as the animal’s swimming direction. However, we currently lack a mechanistic understanding of this unusual form of locomotion. In this study we use a combination of high-speed, high-resolution video and particle image velocimetry (PIV) to quantify kinematics and fluid dynamics for three species of swimming polychaetes, spanning two orders of magnitude in size. We find that in all species, flows generated by metachronal waves of parapodia dominate while typical flows associated with body bending is absent. However, the parapodia are less flexible than propulsive structures in other metachronal swimmers. This creates a localized, but substantial upstream flow during the recovery stroke. Using body bending, the recovery stroke can occur mostly beneath the bulk flow from the power strokes, resulting in minimal inference while the subsequent power stroke can benefit from the pressure field generated during recovery. These results may have implications for future vehicle designs that incorporate metachronal locomotion.

As the global prevalence of chronic liver disease continues to rise, the need to determine which patients will develop end-stage liver disease and require liver transplantation is increasingly important. However, current prognostic models perform sub-optimally. We aim to determine microRNA profiles associated with clinical decompensation and mortality/transplantation within 1 year. We examined microRNA expression profiles in plasma samples from patients across the spectrum of cirrhosis (n = 154), acute liver failure (ALF) (n = 22), sepsis (n = 20) and healthy controls (HC) (n = 20). We demonstrated that a microRNA-based model (miR-24 and -27a) associated with systemic inflammation differentiated decompensated cirrhosis states from compensated cirrhosis and HC (AUC 0.77 (95% CI 0.69–0.85)). 6 patients within the compensated cirrhosis group decompensated the subsequent year and their exclusion improved model performance (AUC 0.81 (95% CI 0.71–0.89)). miR-191 (associated with liver injury) predicted risk of mortality across the cohort when acutely decompensated and acute-on-chronic-liver failure patients were included. When they were excluded miR-24 (associated with systemic inflammation) predicted risk of mortality. Our findings demonstrate that microRNA associated with systemic inflammation and liver injury predict adverse outcomes in cirrhosis. miR-24 and -191 require further investigation as prognostic biomarkers and therapeutic targets for patients with liver disease.

Rhizostomeae species attract our attention because of their distinctive body shape, their large size and because of blooms of some species in coastal areas around the world. The impacts of these blooms on human activities, and the interest in consumable species and those of biotechnological value have led to a significant expansion of research into the physiology and functional biology of Rhizostomeae jellyfish over the last 40 years. This review brings together information generated over these last decades on rhizostome body composition, locomotion, toxins, nutrition, respiration, growth, among other functional parameters. Rhizostomes have more than double the carbon content per unit of biomass than jellyfish of Semaeostomeae. They swim about twice as fast, and consume more oxygen than other scyphozoans of the same size. Rhizostomes also have faster initial growth in laboratory and the highest body growth rates measured in nature, when compared to other medusae groups. Parameters such as body composition, nutrition and excretion are highly influenced by the presence of symbiotic zooxanthellae in species of the Kolpophorae suborder. These physiological and functional characteristics may reveal a wide range of adaptive responses, but our conclusions are still based on studies of a limited number of species. Available data indicates that Rhizosotomeae jellyfish have a higher energy demand and higher body productivity when compared to other jellyfish groups. The information gathered here can help ecologists better understand and make more assertive predictions on the role of these jellyfish in their ecosystems.

Liver disease cases are rapidly expanding worldwide, and transplantation remains the only effective cure for end-stage disease. There is an increasing demand for developing potential drug treatments, and regenerative therapies using in-vitro culture platforms. Human decellularized extracellular matrix (dECM) is an appealing alternative to conventional animal tissues as it contains human-specific proteins and can serve as scaffolding materials. Herein we exploit this with human donor tissue from discarded liver which was not suitable for transplant using a synergistic approach to combining biological and topographical cues in electrospun materials as an in-vitro culture platform. To realise this, we developed a methodology for incorporating human liver dECM into electrospun polycaprolactone (PCL) fibres with surface nanotopographies (230–580 nm). The hybrid scaffolds were fabricated using varying concentrations of dECM; their morphology, mechanical properties, hydrophilicity and stability were analysed. The scaffolds were validated using HepG2 and primary mouse hepatocytes, with subsequent results indicating that the modified scaffolds-maintained cell growth and influenced cell attachment, proliferation and hepatic-related gene expression. This work demonstrates a novel approach to harvesting the potential from decellularized human tissues in the form of innovative in-vitro culture platforms for liver.

The aquaculture industry will be crucial in helping the world’s food supply and keep up with the demand. Aquaculture, like agriculture, must expand and develop sustainably in all the countries to keep up with the rising demand for food. To this end, the aquaculture industry has forged new scientific and technological frontiers in pursuit of long-term food security. Among these is organic aquaculture, whose distinctive protocol has great potential to advance aquaculture. Organic aquaculture is being explored for multiple reasons, encompassing the aim to minimize environmental footprints, fulfill escalating consumer appetites for seafood, and contend within the industry this paper endeavors to address the gaps in current literature by offering an exhaustive overview of various aspects of organic aquaculture. This encompasses its regulation, production methods, food quality, environmental impact, economic viability, as well as socioeconomic and marketing aspects. It is necessary to acquire more knowledge about organic farming techniques before switching over to organic aquaculture on a large scale. Organic regulation, production, food quality, economic performance, and social and marketing issues are at the top. This review found that consumers lack understanding of organic principles, and regulations are inconsistently applied. However, organic aquaculture promotes social equality by protecting producers’ rights to work without discrimination based on gender, race, or sexual orientation factors that ultimately boost the industry’s popularity. Organic aquaculture viability varies depending on factors like feed costs, fixed expenses, and the premium pricing sensitivity, making it unfeasible for certain species. However, from both societal and economic standpoints, organic aquaculture appears most suitable for implementation in developing nations.

Although there is ample research on sleep and negative work behaviors, our understanding of the link between organizational citizenship behaviors (OCB) and sleep is scarce and inconsistent. Theory-driven research on this topic is dominated by a sleep-enhances-OCB perspective, which focuses on the detrimental effects of sleep on OCB. Using an inductive research approach, this project conducted exploratory analyses to examine whether an OCB-disrupts-sleep perspective could provide a fresh new direction of research. We explored our research questions with full-time working adults in the U.S. in two daily diary studies. Study 1 (N = 86) data used surveys over five consecutive workdays with employees reporting their prior night’s sleep (quantity and quality) in the morning and OCB at the end of the workday. Study 2 (N = 136) used the same design for sleep and OCB assessment, but with additional measures of potential mechanisms at bedtime (self-regulatory depletion, work-to-family conflict, psychological detachment) and in the morning (technological tethering) explaining the sleep and OCB link. Both studies supported an alternative OCB-disrupts-sleep perspective for sleep quality but not quantity. Specifically, OCB during the workday preceded sleep quality problems, rather than the reverse. Yet none of our explored mechanisms explained the direct effect of OCB on sleep. We discuss implications for how these findings can guide future directions of research on sleep and citizenship behavior, as well as contributions to sleep-related occupational health theories and organizational practice.

This study explores how and why some individuals are resilient to radicalisation by focusing on individuals who were labelled “terror- ists” for their alleged involvement or support for an attempted coup that took place in Turkey on 15 July 2016, yet who have shown no sign of violent radicalisation since. Drawing from 15 interviews, it assesses both the potential radicalisation risk factors that the parti- cipants display, such as political persecution, imprisonment, tor- ture, social pressure and forced migration. Then, it explores participants’ explanation for why they have not become radicalised, including the role of the Hizmet doctrine, their religious adherence, individual personality traits and resources (e.g. social capital) through a socioecological framework. While terrorism studies have focused extensively on pathways towards radicalisation and countering radicalisation, this study contributes to a small body of research to explore the notion of “non-radicalisation”, informing the literature on resilience and protective factors towards larger populations.

A critical question in biology is how new traits evolve, but studying this in wild animals remains challenging. Here, we probe the genetic basis of trait gain in sea robin fish, which have evolved specialized leg-like appendages for locomotion and digging along the ocean floor. We use genome sequencing, transcriptional profiling, and interspecific hybrid analysis to explore the molecular and developmental basis of leg formation. We identified the ancient, conserved transcription factor tbx3a as a major determinant of sensory leg development. Genome editing confirms that tbx3a is required for normal leg formation in sea robins, and for formation of enlarged central nervous system lobes, sensory papillae, and adult digging behavior. Our study establishes sea robins as a model organism for studying the evolution of major trait gain and illustrates how ancient developmental control genes can underlie novel organ formation.

African catfish farmers used animal waste as feed to reduce production costs, a practice that raised concerns among consumers, causing them to avoid it. Consequently, this study aimed to explore factors that influenced the acceptance of farmed African catfish. The data survey involving 2294 participants from Egypt was analyzed using descriptive statistics and the chi-square test. The results indicated that 67% of participants abstained from consuming it, while 2.30% consumed it regularly. The chi-square test revealed significant consumption pattern variations (p < 0.05) based on most demographic factors. Entirely, 43% were uninformed about the nutritional value, market availability, and the potential impact of using aquafeeds on pricing. About 55–57% lacked information on feeding practices, had quality concerns, viewed catfish consumption as a health risk, and were unaware of its prices. Additionally, 68% were worried about pollution, and 76% found the available information insufficient. The main reasons for this challenge lie in consumers’ health, religious, and psychological concerns. To address this, we propose a targeted marketing strategy focusing on improving safety and quality through safe and cost-effective aquafeeds. This involves requiring farmers to obtain quality certifications and adhere to best management practices, adding value to the product, and transparent communication with consumers to provide them with reliable information about cultivation practices and the nutritional value of African catfish. Effective collaboration among key stakeholders in implementation, efficient sector management, establishing an activity licensing system, and prohibiting current feeding practices will enhance sustainable demand and reverse the declining production trend of this promising species.

A simple model is developed to analyze the effects of social media use by a bank’s uninsured depositors. While social media increases the likelihood of bank runs, it can be ex-ante beneficial to a bank by raising its shareholders’ equity. Social media enhances monitoring of a bank’s financial condition, thereby giving uninsured depositors a valuable option to withdraw early and avoid potential losses in states when a bank is likely to be insolvent. Recognizing this option, uninsured depositors require a lower promised interest rate that reduces the bank’s cost of funding at the expense of a greater liability for the bank’s deposit insurer.