TECENTRIQ, in combination with Avastin (bevacizumab) and carboplatin/paclitaxel (carbo/pac) is a new regimen indicated for 1L treatment of mNSCLC. TECENTRIQ combination* is the first cancer immunotherapy to demonstrate meaningful OS advantage in EGFR/ALK+ who have previously progressed on tyrosine kinase inhibitors (TKIs) as well as in patients with liver metastases (mets). The efficacy and safety of TECENTRIQ combination* was established in the IMpower150 clinical trial.
IMpower150
A phase III multicentre, international, randomised, open-label, 3-arm trial in mNSCLC (N=1,202) comparing TECENTRIQ+Avastin+carbo/pac vs Avastin+carbo/pac alone.
TECENTRIQ combination*: delivered a statistically significant OS benefit vs Avastin + carbo/pac alone
HR= Hazard ratio
CI = Confidence interval
PFS at 12 months was nearly doubled in TECENTRIQ combination* vs Avastin+carbo/pac alone (38% vs 20%, HR= 0.59; 95% CI, 0.50, 0.69; P<0.0001).
TECENTRIQ combination* is the first cancer immunotherapy combination to demonstrate clinically meaningful survival in EGFR/ALK+ who have progressed on TKIs as well as in patients with liver mets.
Median OS (95% CI, 0.29, 1.03) was NR in TECENTRIQ combination* vs 17.5 months in Avastin + carbo/pac. Median OS (95% CI, 0.33, 0.82) in liver mets was 13.3 months versus 9.4 months in Avastin + carbo/pac.
HR= Hazard ratio
A majority of patients responded to TECENTRIQ combination* vs Avastin+carbo/pac alone
HR= Hazard ratio
CI = Confidence interval
ORR was 56.4% (95% CI, 51.4, 61.4) with TECENTRIQ combination* vs 40.2% (95% CI, 35.3, 45.2) with Avastin+carbo/pac.
TECENTRIQ combination* delivered a manageable and familiar safety profile.
- Low incidence of immune-related ARs was observed with TECENTRIQ+Avastin+carbo/pac
- Low incidence of ≥ grade 3 bleeding events.
- A safety profile supported by patient-reported outcomes
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- TECENTRIQ Summary of Product Characteristics. Roche. March 2019.
* TECENTRIQ combination = TECENTRIQ + Avastin (bevacizumab) + carboplatin/paclitaxel
▼ This medicinal product is subject to additional monitoring in EMA-approved countries. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse events or reactions.
Full prescribing information available. Download the EU TECENTRIQ SmPC here.
@ 2019 F. Hoffmann-La Roche Ltd.
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