Recent publications
3D-printed boluses in radiation therapy are of increasing interest for enhancing treatment precision and patient comfort. A comprehensive clinical validation of these boluses remains to be established. This study aims to confirm the effectiveness of a 3D-printed bolus through a proof-of-concept comparative validation, by implementing in a clinical setting a bolus made of PLA and designed to ensure uniform dose coverage for a case in the eye region. In this study the 3D-printed bolus was compared to two commercially available boluses (one thermoplastic and one skin type) by using a refecence where no bolus was present (with the optimal dose distribution scenario). All boluses were placed on an anthropomorphic head phantom and BeOSL detectors were used to measure dose values to determine the level of their effectiveness on delivery. During the scanning process, a thermoplastic mask was used to prevent bolus movement and to accurately reproduce clinical scenarios. Differences in dose values at Dmax and D50% revealed the performance of each bolus. The treatment planning system (TPS) and BeOSL readings for the 3D printed bolus were within 2% (the clinical tolerance), with 0.66% dose difference for the customized 3D-printed bolus. Although the thermoplastic bolus had the closest value to the detector reading, with a score of 0.30%, this result was influenced by improper shaping of the bolus on the phantom and the presence of a wide air gap, which caused lack of eye covering. Whereas, the skin bolus, due to higher volume of air between phantom surface and bolus, showed a 1.29% dose difference between the TPS values and the OSL detector readings. We provide a comparative validation for the use of 3D printed boluses and highlight that proper bolus fitting is essential in clinical settings to avoid air gaps and to maintain dose distribution over multiple treatment sessions.
The InsectAI COST action will support insect monitoring and conservation at the national and continental scale in order to understand and counteract widespread insect declines. The Action will bring together a critical mass of researchers and stakeholders in image-based insect AI technologies to direct and drive the research agenda, build research capacity across Europe and support innovation and application.
There is mounting evidence that populations of insects around the world are in sharp decline. Understanding trends in species and their drivers is key to knowing the size of the challenge, its causes and how to address it. To identify solutions that lead to sustainable biodiversity alongside economic prosperity, insect monitoring should be efficient and provide standardised and frequently updated status indicators to guide conservation actions.
The EU Biodiversity Strategy 2030 identifies the critical challenge of delivering standardised information about the state of nature and image-based insect AI can contribute to this. Specifically, the EU Nature Restoration Law will likely set binding targets for the high resolution data that cameras can provide. Thus, outputs of the Action will contribute directly to EU policies implementation, where biodiversity monitoring is considered a key component.
The InsectAI COST Action will organise workshops, conferences, short-term scientific missions, hackathons, design-sprints and much more, across four Working Groups. These groups will address how image-based insect AI technologies can best address Societal Needs, support innovation in Image Collection hardware, create standardised approaches for Image Processing and develop novel Data Analysis and Integration methods for turning data into actionable insights.
Total knee arthroplasty (TKA) is an effective procedure for pain relief and restoration of function in patients with symptomatic end-stage knee arthritis. Kinematic problems due to conventional implant design have been postulated. The objective of this study is to determine if there was any difference in postoperative ROM and outcomes between patients undergoing MP-TKA vs PS-TKA.
We prospectively colected the records of 600 consecutive patients with TKA performed by six senior orthopaedic surgeons between 2017 - 2021. We compared the ROM and patient-reported outcomes (Western Ontario McMaster Osteoarthritis Index WOMAC, Oxford Knee Score OKS, Knee Society Score KSS, Forgotten Joint Score FJS) between MP TKA and PS TKA.
There were no specific criteria for implant selection as the two groups were consecutive cohorts of patients and implant selection depended on surgeon preference. Demographics, comorbidities, diagnosis and severity of osteoarthritis were similar between MP and PS groups. The trend for OKS in our study is the same in both groups, but with higher mean values in the MP group. The trend of WOMAC pain, stiffness and disability score is the same in both groups, but with higher mean values in the PS group at one year and two years. KSS clinical and functional score is the same in both groups, but with higher mean values in the MP group. The most important score is forgetten joint score which is favourable for the MP group.
The patients who underwent the MP-TKA scored better than those who underwent the PS-TKA, particularly regarding deep knee flexion and stability of the prosthesis. This may be related to better replication of natural knee kinematics with MP-TKA.
The developmental origins of adult disease theory support the concept that undernourished fetuses are at risk of developing metabolic syndrome due to the energy-saving ‘Thrifty Phenotype’. This metabolic plasticity represents an evolutionary adaptation that allows individuals to resist the intense pressure caused by cyclically recurring periods of nutritional deprivation. A comprehensive review was conducted following an extensive literature search in the PubMed/Medline and EMBASE databases concerning reports on fetal/intrauterine growth restriction and its metabolic-related long-term outcomes. We only included articles written in English that were published before 1 July 2024. There are several underlying mechanisms and metabolic and endocrine adjustments shaped by the perinatal environment, and they all contribute to progression towards adult disease. From in utero malnutrition or other insults during the fetal period to fetal programing and postnatal catch-up growth, it is difficult to identify the exact moment when this adaptative phenomenon meant to assure fetal survival and to set children on their own physiological growth curves lose its beneficial effect, establishing the trajectory to obesity, insulin resistance, and other hallmarks of metabolic syndrome. With clinical correspondence to an altered body mass, composition, and eating behaviors, it is evident that the metabolic complications linked to FGR are intricate and arise from disturbances in several pathways and organs, but the underlying processes responsible for the long-term consequences are just starting to be understood. The lack of continuity in perinatal-to-pediatric FGR research sets the challenge of exploring new directions in future scientific opportunities. These will hopefully represent a cornerstone in the management of FGR-related metabolic disorders in children, preventing these disorders from evolving into adult disease.
Purpose Neglected acetabular fracture can be approached by different surgical methods, but the optimal treatment is represented by total hip replacement (THR), which theoretically should ensure a stable, painless hip, with almost-normal mobility and a hope of survival as long as possible. This study aims to evaluate the outcomes of THR in patients with neglected acetabular fractures. Methods By analyzing clinical and radiological outcomes, surgical challenges, and complication rates, we aim to provide insights into the efficacy and limitations of this approach. This is a retrospective study, 8 patients who underwent THR for neglected acetabular fractures between 2020 and 2024. All patients were assessed at 6 weeks, 6 months, 1 year and 2 years after surgery. Results As expected, regardless of the fracture type and the interval between initial trauma and index procedure, Harris hip score showed continuous improvement in successive examinations at 3, 6, 12, and 24 months; younger patients had the best preoperative scores and the fastest postoperative progression. The lowest preoperative score and the lowest rate of improvement was observed in elderly patients. The results of our case series suggest that THR might be an effective treatment for neglected acetabular fractures. The critical challenge is how to approach the acetabular defect to obtain a stable hip. Conclusions Neglected fractures are more difficult to repair and have poorer surgical outcomes. Successful outcomes are expected if a solid bone stock is achieved using various surgical techniques.
The state of Qatar forms a small peninsula in Arabia, with an area of 11,571 km2 that lies between 24°and 27°N and 50° and 52°E. It has a length of 186 km north from Saudi Arabia, and varies in width between 55 and 90 km. Much of the country is flat with a highest elevation of 103 m a.s.l. The soil consists of a low barren plain covered with rocks, sand, or small dunes, with arable land representing only 1.6%. Qatar’s climate is hot and arid with an average annual mean temperature of 27°C and 75 mm rainfall/year. There are no forests in Qatar and the coverage of vegetation is scarce. Qatar is one of the few countries in the world where there is no permanent natural source of surface freshwater, and the shallow rainfed aquifers that supported the population prior to the 1950s are long since depleted and salinized. Because of this there are no native amphibian species in Qatar. Since the absence of surface freshwater prevented amphibians from colonizing Qatar in the past, the rapid economic development along with its dramatically increased availability of freshwater provided greater opportunities for amphibians. Surface freshwater habitats started to be artificially created either for irrigation or for ponds used to treat wastewater. Toads were imported into the country even before the creation of wetlands, but started to spread soon after the construction of wetlands and irrigated farms. Presently, the confirmed established toad species in Qatar is the African common toad, Sclerophrys regularis. Although this introduced species has been part of the fauna of Qatar for decades; it’s persistence in Qatar is problematic. Despite their ecological values and societal services, the long-term permanence of Qatar’s artificial wetlands faces strong challenges resulting from human activities associated with sustained population growth, habitat-degradation, intensive agricultural practices, and coastal development.
The Balkan Peninsula hosts a great proportion of Europe’s biodiversity, and this is well illustrated by amphibian richness and endemism. Among them, the yellow-bellied toad Bombina variegata has been a model in ecology and evolution, but several aspects of its phylogeography and taxonomy remain surprisingly poorly understood. In this study, we combine cytochrome b DNA barcoding data (1238 individuals from 355 localities), mitogenome phylogenetics (17.2 kb), gene-based nuclear phylogenetics (3.7 kb from four gene fragments) and multilocus phylogenomics (4759 loci / ~554 kb obtained by double digest Restriction Associated DNA sequencing; ddRAD-seq) to re-assess the diversification of B. variegata, and revisit its nomenclatural history to assign scientific names to phylogeographic lineages. The analyses support four major lineages, one assigned to B. v. variegata (Carpathians and northwestern ranges), one assigned to B. v. pachypus (Apennine Peninsula), and two assigned to B. v. scabra (Dinarides, Hellenides and Balkanides vs. the Rhodope mountains). Spatiotemporal patterns of diversification suggest a role for a Late Miocene marine incursion in the Pannonian Plain (Paratethys) as the initial trigger of divergence, followed by a vicariance event in the Apennines and a “sky island” process of Pleistocene differentiation in the Balkan Peninsula. As it reached the Dinarides during the Late Pleistocene, B. v. variegata potentially hybridized with B. v. scabra and captured its mitochondrial DNA, which resulted in a massive cyto-nuclear discordance across all northwestern European populations. Finally, we show that the two lineages of B. v. scabra significantly differ in morphology and ventral coloration patterns, and describe the Rhodope lineage as a new subspecies.
Autophagy and mitophagy are critical cellular processes that maintain homeostasis by removing damaged organelles and promoting cellular survival under stress conditions. In the context of diabetic kidney disease, these mechanisms play essential roles in mitigating cellular damage. This review provides an in-depth analysis of the recent literature on the relationship between autophagy, mitophagy, and diabetic kidney disease, highlighting the current state of knowledge, existing research gaps, and potential areas for future investigations. Diabetic nephropathy (DN) is traditionally defined as a specific form of kidney disease caused by long-standing diabetes, characterized by the classic histological lesions in the kidney, including mesangial expansion, glomerular basement membrane thickening, nodular glomerulosclerosis (Kimmelstiel–Wilson nodules), and podocyte injury. Clinical markers for DN are albuminuria and the gradual decline in glomerular filtration rate (GFR). Diabetic kidney disease (DKD) is a broader and more inclusive term, for all forms of chronic kidney disease (CKD) in individuals with diabetes, regardless of the underlying pathology. This includes patients who may have diabetes-associated kidney damage without the typical histological findings of diabetic nephropathy. It also accounts for patients with other coexisting kidney diseases (e.g., hypertensive nephrosclerosis, ischemic nephropathy, tubulointerstitial nephropathies), even in the absence of albuminuria, such as a reduction in GFR.
Biological invasions are a major threat to biodiversity, ecosystem functioning and nature's contributions to people worldwide. However, the effectiveness of invasive alien species (IAS) management measures and the progress toward achieving biodiversity targets remain uncertain due to limited and nonuniform data availability. Management success is usually assessed at a local level and documented in technical reports, often written in languages other than English, which makes such data notoriously difficult to collect at large geographic scales. Here we present the first European assessment of how managers perceive trends in IAS and the effectiveness of management measures to mitigate biological invasions. We developed a structured questionnaire translated into 18 languages and disseminated it to local and regional managers of IAS in Europe. We received responses from 1928 participants from 41 European countries, including 24 European Union (EU) Member States. Our results reveal substantial efforts in IAS monitoring and control, with invasive plants being the primary focus. Yet, there is a general perception of an increase in the numbers, occupied areas, and impacts of IAS across environment and taxonomic groups, particularly plants, over time. This perceived increase is consistent across both EU and non‐EU countries, with respondents from EU countries demonstrating more certainty in their responses. Our results also indicate a lack of data on alien vertebrates and invertebrates, reflecting a need for more targeted monitoring and knowledge sharing between managers and policymakers and between countries. Overall, our study suggests that Europe's current strategies are insufficient to substantially reduce IAS by 2030 and hence to meet the Kunming‐Montreal Global Biodiversity Framework target.
Background and Objectives: Colorectal cancer is a major contributor to global cancer morbidity and mortality. Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identifying factors that influence postoperative morbidity and mortality is crucial for optimizing patient care. This study aims to evaluate the impact of preoperative, intraoperative, and postoperative factors on surgical outcomes in patients with colorectal cancer. Methods: A retrospective cohort study was conducted on 688 patients who underwent colorectal cancer surgery within a 10-year period. Data collected included demographic information, comorbidities, laboratory values, surgical details, and postoperative outcomes. Statistical analyses were performed using chi-square tests for categorical variables and t-tests for continuous variables. Multivariate logistic regression was used to identify independent predictors of postoperative complications and mortality. Results: Postoperative complications occurred in 28.5% of patients, and the 30-day mortality rate was 5.2%. Preoperative factors such as elevated C-reactive protein (CRP) levels (p < 0.001), low albumin levels (p = 0.003), a high American Society of Anesthesiologists (ASA) score (p < 0.001), and presence of comorbidities like diabetes and hypertension (p = 0.005) were significantly associated with increased postoperative complications. Intraoperative factors such as blood loss greater than 500 mL (p < 0.001) and longer operative time (p = 0.021) were also significant predictors of adverse outcomes. Multivariate analysis identified elevated CRP (OR 2.1, 95% CI 1.5–2.9), low albumin (OR 1.8, 95% CI 1.3–2.5), and blood loss > 500 mL (OR 2.4, 95% CI 1.7–3.4) as independent predictors of postoperative complications. Conclusions: Preoperative inflammatory markers, nutritional status, ASA score, comorbidities, and intraoperative factors like blood loss significantly influence postoperative outcomes in colorectal cancer surgery. Recognizing these risk factors allows for better preoperative optimization and surgical planning, potentially reducing postoperative morbidity and mortality.
Background: This is a prospective study. Atrophic vulvovaginitis (VVA), a prevalent condition resulting from estrogen deficiency after the menopause, is characterized by symptoms such as vaginal dryness, itching, burning, dyspareunia, and urinary discomfort. Standard treatment involves systemic estrogen replacement therapy (HRT) and localized estrogen treatments, such as estriol. However, many women with moderate-to-severe VVA may not fully benefit from estrogen therapy alone. Non-hormonal adjunctive treatments, such as pelvic floor exercises (e.g., Kegel exercises), are being explored to enhance clinical outcomes. Objectives: This study investigates the combined effect of local estriol therapy and Kegel exercises in improving VVA symptoms in postmenopausal women. Methods: Fifty postmenopausal women diagnosed with VVA were enrolled and divided into three severity groups: mild, moderate, and severe. All participants received estriol therapy (0.5 mg vaginal tablets daily for 10 days each month) for the first three months. Following this, Kegel exercises were introduced for an additional three-month period, alongside continued estriol therapy. Symptom improvement was evaluated after six months, with outcomes categorized as complete remission, partial remission, or no remission. Results: Significant improvements in symptom remission were observed, particularly in the moderate and severe groups. In the mild VVA group, 81.82% achieved complete remission with combined therapy compared to 68.18% with estriol alone. In the severe group, complete remission was observed in 40% of patients receiving combined therapy compared to 20% with estriol therapy alone. These findings suggest that Kegel exercises enhance the effectiveness of estriol by improving local blood circulation, which facilitates better estrogen absorption and distribution. Conclusions: The addition of Kegel exercises to local estriol therapy significantly improves symptom remission rates, especially in moderate and severe VVA cases. This approach offers a promising strategy for managing postmenopausal VVA, particularly in cases that do not fully respond to estrogen therapy alone.
Background: Breast cancer still represents the most commonly diagnosed cancer among women, accounting for 12.5% of all new annual cancer cases worldwide. In Romania in 2020, breast cancer was the most common, with a share of new cases of 26.9%, far behind the rates of colon cancer (11.8%) and cervix cancer (7.5%). The aim of this study is to reveal five years of experience in treating breast cancer at the Surgical Clinic of the Colentina Hospital in Bucharest, Romania. Methods: Retrospective analysis, including 68 patients admitted to our clinic between January 2019 and December 2023 undergoing modified radical mastectomy, sectorectomy, or subcutaneous mastectomy. Results: Madden-modified radical mastectomy with total excision of the axillary lymph nodes accounted for 77.94% of surgeries, with a complication rate of 13.2%, represented by lymphedema of the ipsilateral arm and prepectoral seroma. Conclusions: Continuous innovation regarding early diagnosis and treatment methods in our surgical clinic will, hopefully, contribute to improving the outcomes of our patients.
We find new limits of the Lie product formula type in Banach algebras with unit. Some sample results: Let X , Y , Z be Banach algebras with unit, x n , y n n ∈ N ⊂ X × Y convergent sequences with lim n → ∞ x n = x , lim n → ∞ y n = y and T : X × Y → Z a continuous bilinear operator with T 1 , 1 = 1 . Then for all sequences of natural numbers a n n ∈ N with lim n → ∞ a n = ∞ we have lim n → ∞ T ∏ k = 1 n e x k a n k + n k + 2 n , ∏ k = 1 n e y k a n k + 2 n k + 3 n a n = e ln 4 3 T x , 1 + ln 2 T 1 , y ; lim n → ∞ T ∏ k = 1 n cos x k a n n n + k , ∏ k = 1 n cos k y k n a n n 2 + k 2 n a n 2 = e - ln 2 T x 2 , 1 + 1 - π 4 T 1 , y 2 2 .
This study focuses on the investigation of the dispersive and damping characteristics of surface waves through an irregular boundary of ocean bed composed of a fluid-saturated dual porosity/dual permeability material. The nonlocal fluid-saturated dual porosity/dual permeability layer (NFSDP2L) is confined by a nonlocal viscous liquid layer (NVLL) and a nonlocal viscous sandy substrate (NVSS) having fractional viscoelastic properties. The governing equations for the proposed model are derived using Eringen’s nonlocal theory. The complex frequency relation is obtained by applying the variable separation technique and enforcing appropriate boundary conditions. By dissociating the frequency relation into real (dispersion equation) and imaginary (attenuation equation) parts, graphs are generated to illustrate the influence of several key parameters., viz.
nonlocality, porosity, sandiness, fractional-order, fluctuation, flatness, and position on the fundamental and higher modes of propagating waves. The effects of various parameters are also depicted through the graphical illustration of shear wave speed in NFSDP2L and NVSS. Furthermore, the surface response of shear stress against depth within the layered structure has been graphically illustrated. The validity of our mathematical model has been assessed by examining multiple relevant scenarios.
Cystic echinococcosis (CE) is a neglected tropical parasitic disease linked with significant social and economic burdens worldwide. The scientific community has minimal information on echinococcosis in Romanian people, and hospital medical records are the only sources that may be used to investigate its status. A 7-year retrospective clinical study on pediatric patients with CE from Southeast Romania was performed, and 39 children and adolescents were included, aged 2-15 years old. They were hospitalized with cystic echinococcosis in the. Twenty-nine (74.36%) pediatric patients came from rural zones, and 10 (25.64%) had urban residences. In total, 28 children (71.79%) had contact with four different animals (dogs, goats, pigs, and sheep); only four were from urban zones, and they had contact only with dogs. Data regarding the length of hospital stay, cyst location, and complications were collected and analyzed. According to the medical files, the diagnosis was established using imaging techniques and serological tests for CE. IgE and IgG reported appreciable variations in correlation with all parameters, and significant differences (p < 0.05) were recorded. IgE levels considerably increased in cases of no animal contact, pulmonary involvement, complications, surgical treatment, and multiple hospitalizations. Moderate IgE values were recorded in cases of urban residences, pig and sheep contact, and hepatic involvement. The IgG concentration considerably increased with sheep contact and moderately increased in cases of rural zones, hepatic involvement, complications, and Pathogens 2025, 14, 53 https://doi.org/10.3390/pathogens14010053 Pathogens 2025, 14, 53 2 of 20 surgical treatment. The results show that incidental discovery, symptoms, complications, multiple dissemination, pulmonary involvement, and dog and pig contact increase the hospitalization time. Extensive data analysis supports our results. Our findings highlight the complexity of managing E. granulosus infections in children and evidence the importance of a multidisciplinary approach, combining early diagnostic tools, tailored medical therapy, and careful surgical intervention when necessary.
Understanding the physical properties of diesel fuel blends is essential for evaluating spray characteristics, engine performance, and exhaust emissions of internal combustion engines. Moreover, higher alcohols (n-butanol, n-pentanol, and n-octanol) have recently garnered attention as promising oxygenated additives for enhancing the fuel characteristics of diesel fuel in various combustion applications. For these reasons, in this study, density (ρ), kinematic viscosity (ν), and refractive index (nD) values of pseudo-binary blends (diesel fuel + n-butanol, diesel fuel + n-pentanol, and diesel fuel + n-octanol) are measured at different temperatures (288.15 K–323.15 K with 5 K interval) and over the entire range of composition (mole fractions). Experimental results for n-butanol, n-pentanol, and n-octanol obtained in this study are consistent with literature values, showing average absolute percentage deviation less than 0.11 %, 3.94 %, and 0.14 % for density, viscosity, and refractive index, respectively. The studied blends meet density and kinematic viscosity limits imposed by the diesel fuel standard (EN 590). Derived from the experimental data, excess molar volumes, viscosity deviations, and refractive index deviations are calculated. These deviation from ideality are fitted using the Redlich–Kister polynomial equation. Refractive index data of pseudo-binary blends are predicted using different models (Lorentz–Lorenz, Gladstone–Dale, Newton, Eykman, Heller, and Edwards). These models have low average absolute percentage deviation (less than 0.67%) for all studied pseudo-binary blends and temperature ranges (293.15 K–308.15 K), which shows they give excellent fitting results between measured data and calculated values.
Objective
Wrestling is a complex sport that requires a combination of strength, endurance, and wrestling-specific technical training. Endurance activities, such as running, are commonly performed for rapid weight reduction before competition. However, these activities can severely disrupt recovery and lead to significant declines in performance. This study aimed to examine the acute effects of endurance, strength, and wrestling training sessions on hydration status and performance parameters in young wrestlers, providing insights to guide more effective hydration and recovery strategies.
Method
A total of 14 experienced young wrestlers participated in a crossover design, completing endurance, strength, and wrestling training sessions on separate days. The hydration status was assessed through urine specific gravity (USG) before and after each session. The performance measures included hand grip strength, back and leg strength tests, anaerobic power (vertical and horizontal jumps), respiratory muscle strength (maximal inspiratory pressure, MIP), and reaction time assessments.
Results
The endurance training caused the most significant acute reductions in the hydration (USG increase: 0.016 ± 0.005 g/cm³, p < 0.05) and body mass (BM; −1.89 ± 0.4%, p < 0.05), along with immediate performance decrements in the back strength (−7.02 ± 1.2%, p < 0.001), right-hand grip strength (−8.79 ± 2.1%, p < 0.001), jump height (−7.26 ± 1.8%, p < 0.001), and MIP (−9.01 ± 2.3%, p < 0.001). The hydration levels in the endurance group did not fully recover by the next day (USG post-training vs. before the next day’s training: p < 0.05). In contrast, the strength training improved the reaction time before the next day’s session (+5.6 ± 1.3%, p < 0.05), while the attention remained unaffected across all training types.
Conclusion
Endurance training—commonly used for rapid weight loss—can acutely compromise hydration and reduce key performance measures, with recovery taking more time compared to strength or wrestling sessions. Given these findings, endurance sessions should be strategically scheduled before rest days or low-intensity technical training to minimize their negative effects on subsequent performance. Implementing enhanced hydration strategies during endurance-focused sessions may also help mitigate these acute impacts and optimize recovery and performance in young wrestlers.
Taraxacum officinale (dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and is well-known for its traditional uses. The aim of this work is to provide a detailed review of scientific literature on the genus Taraxacum from the last two decades, with particular emphasis on the biological and pharmacological characteristics of dandelions. The traditional use of Taraxacum species and their potential use in medicine are assessed. In addition, individual papers describing principal pathways and molecules modulated by Taraxacum in antitumoral, anti-inflammatory, antidiabetic, hepatoprotective, immunomodulatory, antimicrobial, and antioxidant activities are presented. This review of phytochemical studies reveals that dandelions contain a wide range of bioactive compounds, such as polyphenols, phytosterols, flavonoids, carotenoids, terpene, and coumarins, whose biological activities are actively explored in various areas of human health, some constituents having synergistic activities, including antioxidant, antimicrobial, anti-inflammatory and anticancer activities. The study provides a screening of Taraxacum sp. chemical composition, an assessment of the main pharmacological properties, and a description of relevant studies supporting the use of dandelion for its particularly valuable and diversified therapeutic potential in different diseases.
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Constanţa, Romania
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Rector: Prof. univ. dr. Sorin Rugina
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