Okayama University

Estimation of the return level of daily rainfall commonly employs the "annual maximum series" (AMS) method. However, the sample size of annual maxima is usually very small. Moreover, if the sample includes extremely large annual maxima values, then these few extreme data affect the accurate estimation of the return level and return period. The meta-statistical approach proposed in recent years enables more robust estimates than the AMS method because estimation is done with a large sample. For this study, we evaluated the accuracy of quantile estimation of observed rainfall data and rainfall data simulated using the Compound Poisson Model by application of the Meta statistical Extreme Value (MEV) distribution and the Simplified Meta statistical Extreme Value (SMEV) distribution. Additionally, we estimated the relation between the fitness of the probability distribution to daily rainfall and the accuracy of quantile estimation by adopting multiple daily rainfall probability distributions. Results indicated that the different sample sizes of daily rainfall in both distributions affect the accuracy of quantile estimates at high non-exceedance probabilities because of the sample size of daily rainfall used for parameter estimation. That sample size affects the number of extreme value samples. Furthermore, the relation between the sample dispersion, depending on the sample size of daily rainfall and the goodness of fit of daily probability distributions, affected the quantile estimation accuracy.

This study examined the possibility that a principal's leadership is related to different levels of teachers' group identity. The results of a web-based survey of school teachers revealed that the transformational and empowering leadership of principals were positively related to teachers' group identity at the relational as well as the collective level of group identity. The transformational leadership, "providing intellectual stimulation," was positively associated with "identification with the administration" and "identification with the organization" at the relationship level of group identity and at the group level, while "providing individualized support" was positively associated with "identification with the administration" at the relationship level of teachers. A principal empowering leadership was positively associated with teachers' total group identification scores. Based on these results, we discuss principals' leadership that contributes to reducing teachers' sense of busyness and promoting team schools.

We herein report the first case of dyspnea with hemidiaphragm elevation in a 68-year-old woman with active giant cell arteritis (GCA), including successful treatment. Contrast-enhanced computed tomography showed a reduced density of the left ophthalmic artery and the left superficial temporal artery with increased soft tissue compared to the other side, indicating that the GCA had flared up and suggesting that the hemidiaphragm elevation might be caused by vasculitis-associated ischemia of the right phrenic nerve. Hemidiaphragm paralysis due to vasculitis-associated ischemia in patients with GCA needs to be distinguished from local infection, tumors, and hepatomegaly, which are the major causes of hemidiaphragm elevation.

Identifying deposits of modern/historical and prehistorical tsunamis in Taiwan has been successful in the past two decades and has substantially increased the extant tsunami catalogs, which have been limited in the past four centuries due to scarce and ambiguous historical accounts. In this review, the initiation of the investigation is briefly discussed, partly in response to the latest catastrophic tsunamis in the Indo-Pacific and the stimulated public concern in Taiwan. Major developments and results of the investigation include the onset of the first stage before 2010, with findings in Keelung, the eastern coast, and Lanyu Island, and the second/ongoing stage after 2013, with findings in the northern and eastern coasts and Penghu Islands. These findings contributed to validating the debated historical events, expanding the event number and time span of the tsunami catalog, and elaborating on tsunami processes, which collectively enabled the delineation of the recurrence time intervals between events. Limitations, uncertainty, further contributions, and feedback are discussed including insights into the regional western Pacific hazards of tsunamis, earthquakes, and volcanic eruptions; the principles of recognizing tsunami deposits and processes; and the propositions of future studies and hazard mitigations in Taiwan.

Brain metastasis (BM) is a poor prognostic factor in cancer patients. Despite showing efficacy in many extracranial tumors, immunotherapy with anti-PD-1 monoclonal antibody (mAb) or anti-CTLA-4 mAb appears to be less effective against intracranial tumors. Promisingly, recent clinical studies have reported that combination therapy with anti-PD-1 and anti-CTLA-4 mAbs has a potent antitumor effect on BM, highlighting the need to elucidate the detailed mechanisms controlling the intracranial tumor microenvironment (TME) to develop effective immunotherapeutic strategies. Here, we analyzed the tumor-infiltrating lymphocytes in murine models of BM that responded to anti-CTLA-4 mAb to anti-PD-1 mAb. Activated CD4+ T follicular helper (TFH) cells with high CTLA-4 expression characteristically infiltrated the intracranial TME, which were activated by the combination anti-CTLA-4 and anti-PD-1 treatment. Loss of TFH cells suppressed the additive effect of CTLA-4 blockade on anti-PD-1 mAb. B cell-activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) produced by abundant myeloid cells, particularly CD80hiCD206lo pro-inflammatory M1-like macrophages, in the intracranial TME, induced B cell and TFH cell infiltration and activation. Furthermore, the intracranial TME of patients with non-small cell lung cancer featured TFH and B cell infiltration as tertiary lymphoid structures. Together, these findings provide insights into the immune cell crosstalk in the intracranial TME that facilitates an additive anti-tumor effect of CTLA-4 blockade with anti-PD-1 treatment, supporting the potential of a combination immunotherapeutic strategy for BM.

Elastofibromatous changes of the oral mucosa, such as an elastofibroma (EF) or an elastofibromatous lesion (EFL), are not well recognized, and the second such case in Japan is reported. A 72-year-old man wearing a complete maxillary denture presented with a small nodule on the hard palate. Histopathological examination showed abundant fibrous tissue with numerous elastic fibers on Elastica van Gieson (EvG) staining. The diagnosis of an oral EFL was made. In the review of oral EF and EFL, no cases with recurrence were identified, but such lesions may resemble neoplastic lesions macroscopically. Accurate diagnosis using EvG stain is needed to recognize oral EFs and EFLs.

DNA methylation is a crucial epigenetic modification used as a biomarker for early cancer progression. However, existing methods for DNA methylation analysis are complex, time-consuming, and prone to DNA degradation. This work demonstrates selective capture of unmethylated DNAs using ZnO nanowires without chemical or biological modifications, thereby concentrating methylated DNA, particularly those with high methylation levels that can predict cancer risk. We observe varying affinities between methylated and unmethylated DNA on ZnO nanowires, which may be influenced by differences in hydrogen bonding strength, potentially related to the effects of methylation on DNA strand behavior, including self-aggregation and stretching inhibition. As a result, the nanowire-based microfluidic device effectively collects unmethylated DNA, leading to a significantly increased ratio of methylated to unmethylated DNA, particularly for collecting low-concentration methylated DNA. This simplified microfluidic device, composed of ZnO nanowires, enables direct separation of specific methylated DNA, offering a potential approach for DNA methylation mapping in clinical disease diagnostics.

Silicon (Si), the most abundant mineral element in soil, functions as a beneficial element for plant growth. Higher Si accumulation in the shoots is required for high and stable production of rice, a typical Si-accumulating plant species. During the last two decades, great progresses has been made in the identification of Si transporters involved in uptake, xylem loading and unloading as well as preferential distribution and deposition of Si in rice. In addition to these transporters, simulation by mathematical models revealed several other key factors required for efficient uptake and distribution of Si. The expression of Lsi1 , Lsi2 and Lsi3 genes is down-regulated by Si deposition in the shoots rather than in the roots, but the exact mechanisms underlying this down-regulation are still unknown. In this short review, we focus on Si transporters identified in rice and discuss how rice optimizes Si accumulation (“homeostasis”) through regulating Si transporters in response to the fluctuations of this element in the soil solution.

The present randomized controlled trial aimed to investigate the effects of home-based telemedicine with wearable devices and usual care on pain-related outcomes in patients with chronic musculoskeletal pain, compared to usual care alone. The patients with chronic musculoskeletal pain were randomly allocated to the usual care group or the telemedicine group, which participated in telemedicine with wearable devices, the objective data from which were recorded, in conjunction with usual care for six months. The primary outcome measure was the Numeric Rating Scale (NRS) for pain. The secondary outcome measures were the Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS), Pain Disability Assessment Scale (PDAS), and EuroQol-five dimensions-three level (EQ-5D-3L). Seventy-one participants were analyzed. At 1 and 3 months, there were no significant differences in the NRS scores between the groups; however, the telemedicine group had a significantly superior effect on all of the outcome measures at 6 months compared to the usual care group. The number of steps and distance were significantly increased at 6 months compared to baseline in the telemedicine group. Home-based telemedicine with wearable devices and usual care has a modest effect on pain-related outcomes compared to usual care in patients with chronic musculoskeletal pain. This study was registered (UMIN000052994 - 04/12/2023).

Background Enhancing students’ empathy is critical in medical school education. The COVID-19 pandemic necessitated a shift from in-person to online classes. However, the effectiveness of online classes for enhancing medical students’ empathy has not been investigated sufficiently and the evidence is limited. This study compared the effectiveness of enhancing empathy between pre-pandemic in-person classes and during-pandemic online classes among medical students in Japan using pre-pandemic and during-pandemic data. Methods This is a retrospective observational study. This study measured students’ empathy using the Japanese translation of the Jefferson Scale of Empathy-Student Version (JSE-S) before and after the special programs for professional identity formation and clinical communication among first- and second-year students who matriculated from 2015–2021. This study categorized the matriculation year groups as “pre-pandemic” and “during-pandemic” groups for the first- and second-year students. This study estimated the adjusted mean score differences of the JSE-S and 95% confidence intervals (CIs) from the pre- to post-program between the pre-pandemic and during-pandemic groups in the first and second years using linear regression analysis. Results This study’s participants included 653 first-year students and 562 second-year students. In the first year, the during-pandemic group had a significantly higher mean score difference from the pre- to post-program compared to the pre-pandemic group. The adjusted regression coefficient (95% CI) was 7.6 (5.7 – 9.5), with the pre-pandemic group as the reference. In the second year, there were no significant differences between the two groups. Conclusions The results suggest that online classes are not inferior to in-person classes or even slightly better in enhancing medical students’ empathy, which should be clarified by further studies. This study’s findings have important implications for medical education and implementing hybrid class formats to enhance students’ empathy.

The advancement of an effective hydrogen liberation technology from liquid organic hydrogen carriers, particularly cycloalkanes such as cyclohexane and methylcyclohexane, holds significance in realizing a hydrogen-centric society. However, the attainment of homogeneous catalytic acceptorless dehydrogenation characterized by elevated selectivity for thorough aromatization under mild conditions remains unrealized. In this study, a catalyst system, facilitated by a double hydrogen atom transfer processes, has been devised for the catalytic acceptorless dehydrogenation of inert cycloalkanes at ambient temperature under visible light irradiation. Through the synergistic utilization of tetrabutylammonium chloride and thiophosphoric acid hydrogen atom transfer catalysts, successful catalytic acceptorless dehydrogenation with comprehensive aromatization has been accomplished with potential liquid organic hydrogen carrier candidates and showcased high functional group tolerance.

Flotation methods are widely used to detect oocysts/cysts of protozoans and eggs of helminths, except trematodes. However, details regarding the concentration and recovery rates of these parasites are poorly understood. Using Eimeria tenella oocysts as a model parasite, the present study evaluated three check points: (1) the proportion of parasites that remain floating in flotation solution (sucrose or saturated saline) during centrifugation, (2) the proportion of oocysts that naturally float after addition of flotation solution after centrifugation, and (3) the rate of recovery on cover slips after completion of the flotation protocol. After centrifugation in sucrose solution and saturated saline solution, 82.4% and 60.3% of oocysts floated, respectively. After addition of flotation solution after the final centrifugation step, the recovery rates for oocysts that naturally floated again for 30 min in sucrose and saturated saline were 39.2% and 38.2%, respectively. The recovery rate on cover slips as the final step after performing a commonly used flotation method was 36.4% in sucrose solution (the rate for saturated saline solution could not be assessed due to rapid crystallization). Our results suggest that floating oocysts could have become dispersed by the addition of flotation solution, and not all of these oocysts remained floating after an additional 30 min of settling time although collection on cover slips could be effective for accurate recovery.

Accurate prediction of tool life is crucial for reducing production costs and enhancing quality in the machining process. However, such predictions often rely on empirical knowledge, which may limit inexperienced engineers to reliably obtain accurate predictions. This study explores a method to predict the tool life of a cutting machine using servo motor current data collected during the initial stages of tool wear, which is a cost-effective approach. The LightGBM model was identified as suitable for predicting tool life from current data, given the challenges associated with predicting from the average variation of current values. By identifying and utilizing the top 50 features from the current data for prediction, the accuracy of tool life prediction in the early wear stage improved. As this prediction method was developed based on current data obtained during the very early wear stage in experiments with square end-mills, it was tested on extrapolated data using different end-mill diameters. The findings revealed average accuracy rates of 71.2% and 69.4% when using maximum machining time and maximum removal volume as thresholds, respectively.

Visual attention is intrinsically rhythmic and oscillates based on the discrete sampling of either single or multiple objects. Recently, studies have found that the early visual cortex (V1/V2) modulates attentional rhythms. Both monocular and binocular cells are present in the early visual cortex, which acts as a transfer station for transformation of the monocular visual pathway into the binocular visual pathway. However, whether the neural site of attentional rhythms is in the monocular or binocular visual pathway needs further study. In the current study, we leveraged the anatomical features of the monocular and binocular pathway to design a paradigm with same‐eye and different‐eye presentations of cues and targets. By combining this approach with EEG recordings and analysis the impulse response function (TRF), we aimed to address this question. In Experiment 1, we reset the phase of attentional rhythms in one monocular channel (left eye or right eye) by a dichoptic cue and tracked the impulse response function (TRF) of the monocular channel in the left and right eye separately. We found no significant differences in the respective TRFs and their spectra for each eye, suggesting that attention rarely switched between the two eyes, indicating that the binocular visual pathway, not the monocular visual pathway, is the neural site of attentional rhythms. These results were verified when resetting the phases of attentional rhythms by a binocular cue in Experiment 2. These results suggest that attentional rhythms may be sensitive to activities in the binocular visual pathway.

Intramolecular aromatic oxidative coupling of 3,6‐bis(m‐terphenyl‐2’‐yl)carbazole provided a bis(m‐terphenyl)‐fused carbazole, while that of 3,6‐bis(m‐terphenyl‐2’‐yl)‐1,8‐diphenylcarbazole afforded a bis(quaterphenyl)‐fused carbazole. Borylation of the latter furnished a B,N‐embedded helical nanographene binding a fluoride anion via a structural change from the three‐coordinate boron to the four‐coordinate boron. The anionic charge derived from the fluoride anion is stabilized over the expanded p‐framework, which leads to the high binding constant (Ka) of 1 × 105 M–1. The four‐coordinate boron species was converted back to the parent three‐coordinate boron species with Ag+, and the chiroptical switch between the three‐coordinate boron and four‐coordinate boron species has been achieved via the ion recognition with the change in the color and glum values.