New Jersey Institute of Technology

Deep learning (DL) has recently become a key technology supporting radio frequency (RF) signal classification applications. Given the heavy DL training requirement, adopting outsourced training is a practical option for RF application developers. However, the outsourcing process exposes a security vulnerability that enables a backdoor attack. While backdoor attacks have been explored in the vision domain, it is rarely explored in the RF domain. In this work, we present a stealthy backdoor attack that targets DL-based RF signal classification. To realize such an attack, we extensively explore the characteristics of the RF data in different applications, which include RF modulation classification and RF fingerprint-based device identification. Then, we design a training-based backdoor trigger generation approach with different optimization procedures for two backdoor attack scenarios (i.e., poison-label and clean-label). Extensive experiments on two RF signal classification datasets show that the attack success rate is over 99.2%, while its classification accuracy for the clean data remains high (i.e., less than a 0.6% drop compared to the clean model). The low NMSE (less than 0.091) indicates the stealthiness of the attack. Additionally, we demonstrate that our attack can bypass existing defense strategies, such as Neural Cleanse and STRIP.

This work investigates how multiple unmanned aerial vehicles (UAVs) assist the large-scale IoT devices (its count $\geq$ 100) in the edge computing system in accomplishing their tasks. The UAVs serve the latter as edge servers, and fly to footholds to collect task data from the latter, execute tasks locally and return results to the latter. The goal of this work is to minimize overall energy consumption by jointly optimizing the association between each UAV and ground-based IoT devices, deployments of UAVs, and their flight trajectories. To achieve this, this work proposes a joint optimization approach (JOA). It has three parts: 1) an improved k-means method is designed to handle the association between each UAV and ground-based IoT devices, where the number of clusters is equal to that of UAVs, which means that each UAV is responsible for the IoT devices within a cluster; 2) for the deployments of UAVs, an improved fireworks algorithm (IFWA) with variable-length encoding strategy and population size update strategy is proposed to optimize the number and locations of footholds of each UAV, where each member of the population symbolizes a UAV foothold, and each firework and its offspring are considered as the deployment of UAV. Also, the population size update strategy is employed to dynamically change the number of footholds; and 3) regarding UAV flight trajectory, a pre-computed greedy algorithm based on the footholds of UAVs obtained by IFWA is proposed to minimize the total UAV distance. The proposed approach is verified on ten large-scale instances, and the results demonstrate its effectiveness in achieving minimal energy consumption when compared to other state-of-the-art methods.

The recent advances of deep learning in various mobile and Internet-of-Things applications, coupled with the emergence of edge computing, have led to a strong trend of performing deep learning inference on the edge servers located physically close to the end devices. This trend presents the challenge of how to meet the quality-of-service requirements of inference tasks at the resource-constrained network edge, especially under variable or even bursty inference workloads. Solutions to this challenge have not yet been reported in the related literature. In the present paper, we tackle this challenge by means of workload-adaptive inference request scheduling: in different workload states, via adaptive inference request scheduling policies, different models with diverse model sizes can play different roles to maintain high-quality inference services. To implement this idea, we propose a request scheduling framework for general-purpose edge inference serving systems. Theoretically, we prove that, in our framework, the problem of optimizing the inference request scheduling policies can be formulated as a Markov decision process (MDP). To tackle such an MDP, we use reinforcement learning and propose a policy optimization approach. Through extensive experiments, we empirically demonstrate the effectiveness of our framework in the challenging practical case where the MDP is partially observable.

Differential evolution (DE) has been developed as a state-of-the-art population-based stochastic optimizer for continuous nonconvex search space in recent decades. It uses difference vectors among individuals to adaptively control the balance between exploration and exploitation for achieving an excellent search performance. Specifically, one-to-one selection in DE guarantees that difference vectors vary from large for exploration to small for exploitation. However, the selection may generate inappropriate scale of difference vectors, which causes insufficient exploitation when facing complex problems with, e.g., multimodal with a huge number of local optima or plain regions. In this article, we propose a multiselection-based DE (MSDE) to address such limitation. Specifically, three different types of selection strategies are adopted to deal with the different situation during a search process. The proposed MSDE is evaluated on the 2013, 2014, and 2017 IEEE congress on evolutionary computation real parameter optimization competitions. Experimental results demonstrate that the proposed MSDE significantly outperforms the winners of those competitions. We further show that, when integrating the proposed multiselection-based strategy with the original DE or other advanced DE variants, it can also improve their search performance on most of test cases. This work makes a significant contribution to advance the state of the art in the area of population-based stochastic optimizers.

Material extrusion-based three-dimensional (3D) printing is a widely used manufacturing technology for fabricating scaffolds and devices in bone tissue engineering (BTE). This technique involves two fundamentally different extrusion approaches: solution-based and melt-based printing. In solution-based printing, a polymer solution is extruded and solidifies via solvent evaporation, whereas in melt-based printing, the polymer is melted at elevated temperatures and solidifies as it cools post-extrusion. Solution-based printing can also be enhanced to generate micro/nano-scale porosity through phase separation by printing the solution into a nonsolvent bath. The choice of the printing method directly affects scaffold properties and the biological response of stem cells. In this study, we selected polycaprolactone (PCL), a biodegradable polymer frequently used in BTE, blended with hydroxyapatite (HA) nanoparticles, a bioceramic known for promoting bone formation, to investigate the effects of the printing approach on scaffold properties and performance in vitro using human mesenchymal stem cells (hMSCs). Our results showed that while both printing methods produced scaffolds with similar strut and overall scaffold dimensions, solvent-based printing resulted in porous struts, higher surface roughness, lower stiffness, and increased crystallinity compared to melt-based printing. Although stem cell viability and proliferation were not significantly influenced by the printing approach, melt-printed scaffolds promoted a more spread morphology and exhibited pronounced vinculin staining. Furthermore, composite scaffolds outperformed their neat counterparts, with melt-printed composite scaffolds significantly enhancing bone formation. This study highlights the critical role of the printing process in determining scaffold properties and performance, providing valuable insights for optimizing scaffold design in BTE.

To provide new insights into plasma density scale‐sizes in the polar cap, irregularity spectra are developed and tracked relative to magnetic local time (MLT) and solar zenith angle (SZA). A novel Incoherent Scatter Radar (ISR) technique is applied to develop spectra between 20 and 300 km using 2016 to 2018 imaginglp mode data from Resolute Bay ISR‐North. This technique leverages: (a) volumetric plasma density measurements from Advanced Modular ISRs, (b) the slow F‐region cross‐field plasma diffusion at scales greater than 10 km, and (c) that high‐latitude geomagnetic field lines are nearly vertical. The results of this work find that the largest spectral features within periodograms that use sunlit or dayside plasma densities are predominately above 100 km, indicating that structures that are above 100 km are more common than structures below 100 km in dayside/sunlit plasma. However, the opposite is true when plasma is in the dark or on the nightside, where the largest spectral features are predominately below 100 km. This contrast between the dayside and nightside is symptomatic of photoionization generating structures larger than 100 km, highlighting the role of photoionization or E‐region shorting in removing structures less than 100 km or driving larger scale‐structures more strongly, and the role of other mechanisms (such as flows, recombination, precipitation, and instabilities) in generating small‐scale structures. This paper will discuss these findings in detail, as well as discuss forthcoming works.

Background Lung cancer brain metastases (LC-BrMs) are frequently associated with dismal mortality rates in patients with lung cancer; however, standard of care therapies for LC-BrMs are still limited in their efficacy. A deep understanding of molecular mechanisms and tumor microenvironment of LC-BrMs will provide us with new insights into developing novel therapeutics for treating patients with LC-BrMs. Methods Here, we performed integrated analyses of genomic, transcriptomic, proteomic, metabolomic, and single-cell RNA sequencing data which were derived from a total number of 154 patients with paired and unpaired primary lung cancer and LC-BrM, spanning four published and two newly generated patient cohorts on both bulk and single cell levels. Results We uncovered that LC-BrMs exhibited a significantly greater intra-tumor heterogeneity. We also observed that mutations in a subset of genes were almost always shared by both primary lung cancers and LC-BrM lesions, including TTN, TP53, MUC16, LRP1B, RYR2, and EGFR. In addition, the genome-wide landscape of somatic copy number alterations was similar between primary lung cancers and LC-BrM lesions. Nevertheless, several regions of focal amplification were significantly enriched in LC-BrMs, including 5p15.33 and 20q13.33. Intriguingly, integrated analyses of transcriptomic, proteomic, and metabolomic data revealed mitochondrial-specific metabolism was activated but tumor immune microenvironment was suppressed in LC-BrMs. Subsequently, we validated our results by conducting real-time quantitative reverse transcription PCR experiments, immunohistochemistry, and multiplexed immunofluorescence staining of patients’ paired tumor specimens. Therapeutically, targeting oxidative phosphorylation with gamitrinib in patient-derived organoids of LC-BrMs induced apoptosis and inhibited cell proliferation. The combination of gamitrinib plus anti-PD-1 immunotherapy significantly improved survival of mice bearing LC-BrMs. Patients with a higher expression of mitochondrial metabolism genes but a lower expression of immune genes in their LC-BrM lesions tended to have a worse survival outcome. Conclusions In conclusion, our findings not only provide comprehensive and integrated perspectives of molecular underpinnings of LC-BrMs but also contribute to the development of a potential, rationale-based combinatorial therapeutic strategy with the goal of translating it into clinical trials for patients with LC-BrMs.

Collective motion, that is the coordinated spatial and temporal organisation of individuals, is a core element in the study of collective animal behaviour. The self‐organised properties of how a group moves influence its various behavioural and ecological processes, such as predator–prey dynamics, social foraging and migration. However, little is known about the inter‐ and intra‐specific variation in collective motion. Despite the significant advancement in high‐resolution tracking of multiple individuals within groups, providing collective motion data for animals in the laboratory and the field, a framework to perform quantitative comparisons across species and contexts is lacking. Here, we present the swaRmverse package. Building on two existing R packages, trackdf and swaRm, swaRmverse enables the identification and analysis of collective motion ‘events’, as presented in Papadopoulou et al. (2023), creating a unit of comparison across datasets. We describe the package's structure and showcase its functionality using existing datasets from several species and simulated trajectories from an agent‐based model. From positional time‐series data for multiple individuals (x‐y‐t‐id), swaRmverse identifies events of collective motion based on the distribution of polarisation and group speed. For each event, a suite of validated biologically meaningful metrics are calculated, and events are placed into a ‘swarm space’ through dimensional reduction techniques. Our package provides the first automated pipeline enabling the analysis of data on collective behaviour. The package allows the calculation and use of complex metrics for users without a strong quantitative background and will promote communication and data‐sharing across disciplines, standardising the quantification of collective motion across species and promoting comparative investigations.

Despite almost a century of research on energetics in biological systems, we still cannot explain energy regulation in social groups, like ant colonies. How do individuals regulate their collective activity without a centralized control system? What is the role of social interactions in distributing the workload amongst group members? And how does the group save energy by avoiding being constantly active? We offer new insight into these questions by studying an intuitive compartmental model, calibrated with and compared to data on ant colonies. The model describes a previously unexplored balance between positive and negative social feedback driven by individual activity: when activity levels are low, the presence of active individuals stimulates inactive individuals to start working; when activity levels are high, however, active individuals inhibit each other, effectively capping the proportion of active individuals at any one time. Through the analysis of the system stability, we demonstrate that this balance results in energetic spending at the group level growing proportionally slower than the group size. Our finding is reminiscent of Kleiber’s law of metabolic scaling in unitary organisms and highlights the critical role of social interactions in driving the collective energetic efficiency of group-living organisms.

Emotion regulation flexibility (ERF) refers to one’s ability to respond flexibly in complex environments. Adaptiveness of ERF has been associated with cognitive flexibility, which can be improved by task-switching training. However, the impact of task-switching training on ERF and its underlying neural mechanisms remains unclear. To address this issue, we examined the effects of training on individuals’ adaptiveness of ERF by assessing altered brain network patterns. Two groups of participants completed behavioral experiments and resting-state fMRI before and after training. Behavioral results showed higher adaptiveness scores and network analysis observed a higher number of connectivity edges, in the training group compared to the control group. Moreover, we found decreased connectivity strength within the default mode network (DMN) and increased connectivity strength within the frontoparietal network (FPN) in the training group. Furthermore, the task-switch training also led to decreased DMN-FPN interconnectivity, which was significantly correlated to increased adaptiveness of ERF scores. These findings suggest that the adaptiveness of ERF can be supported by altered patterns with the brain network through task-switch training, especially the increased network segregation between the DMN and FPN.

The terahertz (THz) frequency band offers a wide range of bandwidths, from tens to hundreds of gigahertz (GHz) and also supports data speeds of several terabits per second (Tbps). Because of this, maintaining THz channel reliability and efficiency in adverse weather conditions is crucial. Rain, in particular, disrupts THz channel propagation significantly and there is still lack of comprehensive investigations due to the involved experimental difficulties. This work explores how rain affects THz channel performance by conducting experiments in a rain emulation chamber and under actual rainy conditions outdoors. We focus on variables like rain intensity, raindrop size distribution (RDSD), and the channel’s gradient height. We observe that the gradient height (for air-to-ground channel) can induce changes of the RDSD along the channel’s path, impacting the precision of modeling efforts. To address this, we propose a theoretical model, integrating Mie scattering theory with considerations of channel’s gradient height. Both our experimental and theoretical findings confirm this model’s effectiveness in predicting THz channel behavior in rainy conditions. This work underscores the necessity of incorporating the variation of RDSD when THz channel travels in scenarios involving ground-to-air or air-to-ground communications.

Recently, the growing of deep space explorations has attracted notable interests on interplanetary network (IPN), which is the key infrastructure for communications across vast distances in the solar system. However, the unique characteristics of IPN pose numerous unexplored challenges for interplanetary data transfers (IP-DTs), i.e., the challenges that existing schemes developed for Earth-based networks are ill-equipped to handle. To address these challenges, we first propose a novel distributed algorithm that leverages the Lyapunov optimization to jointly optimize the routing, scheduling and rate control of IP-DTs at each node. Specifically, our proposal adaptively optimizes the data-rate and bundle scheduling at each output port of a node, significantly improving the end-to-end (E2E) latency and delivery ratio of IP-DTs under a long-term energy constraint. Then, we further explore the heterogeneity of IPN to introduce limited state information exchange among nodes, and devise mechanisms for generating and disseminating state messages to facilitate timely adjustments of routing and scheduling schemes in response to unexpected link disruptions and traffic surges. Simulations verify the advantages of our proposal over the state-of-the-arts.

The application of machine learning to the study of coronal mass ejections (CMEs) and their impacts on Earth has seen significant growth recently. Understanding and forecasting CME geoeffectiveness are crucial for protecting infrastructure in space and ensuring the resilience of technological systems on Earth. Here we present GeoCME, a deep-learning framework designed to predict, deterministically or probabilistically, whether a CME event that arrives at Earth will cause a geomagnetic storm. A geomagnetic storm is defined as a disturbance of the Earth’s magnetosphere during which the minimum Dst index value is less than −50 nT. GeoCME is trained on observations from the instruments including LASCO C2, EIT, and MDI on board the Solar and Heliospheric Observatory (SOHO), focusing on a dataset that includes 136 halo/partial halo CMEs in Solar Cycle 23. Using ensemble and transfer learning techniques, GeoCME is capable of extracting features hidden in the SOHO observations and making predictions based on the learned features. Our experimental results demonstrate the good performance of GeoCME, achieving a Matthew’s correlation coefficient of 0.807 and a true skill statistics score of 0.714 when the tool is used as a deterministic prediction model. When the tool is used as a probabilistic forecasting model, it achieves a Brier score of 0.094 and a Brier skill score of 0.493. These results are promising, showing that the proposed GeoCME can help enhance our understanding of CME-triggered solar-terrestrial interactions.

We consider Euler flows on two-dimensional (2-D) periodic domain and are interested in the stability, both linear and nonlinear, of a simple equilibrium given by the 2-D Taylor–Green vortex. As the first main result, numerical evidence is provided for the fact that such flows possess unstable eigenvalues embedded in the band of the essential spectrum of the linearized operator. However, the unstable eigenfunction is discontinuous at the hyperbolic stagnation points of the base flow and its regularity is consistent with the prediction of Lin ( Intl Math. Res. Not. , vol. 2004, issue 41, 2004, pp. 2147–2178). This eigenfunction gives rise to an exponential transient growth with the rate given by the real part of the eigenvalue followed by passage to a nonlinear instability. As the second main result, we illustrate a fundamentally different, non-modal, growth mechanism involving a continuous family of uncorrelated functions, instead of an eigenfunction of the linearized operator. Constructed by solving a suitable partial differential equation (PDE) optimization problem, the resulting flows saturate the known estimates on the growth of the semigroup related to the essential spectrum of the linearized Euler operator as the numerical resolution is refined. These findings are contrasted with the results of earlier studies of a similar problem conducted in a slightly viscous setting where only the modal growth of instabilities was observed. This highlights the special stability properties of equilibria in inviscid flows.

Social media have enabled laypersons to disseminate, at scale, links to news and public affairs information. Many individuals share such links without first reading the linked information. Here we analysed over 35 million public Facebook posts with uniform resource locators shared between 2017 and 2020, and discovered that such ‘shares without clicks’ (SwoCs) constitute around 75% of forwarded links. Extreme and user-aligned political content received more SwoCs, with partisans engaging in it more than politically neutral users. In addition, analyses with 2,969 false uniform resource locators revealed higher shares and, hence, SwoCs by conservatives (76.94%) than liberals (14.25%), probably because, in our dataset, the vast majority (76–82%) of them originated from conservative news domains. Findings suggest that the virality of political content on social media (including misinformation) is driven by superficial processing of headlines and blurbs rather than systematic processing of core content, which has design implications for promoting deliberate discourse in the online public sphere.

Sialic acids and sialoglycans are critical actors in cancer progression and metastasis. These terminal sugar residues on glycoproteins and glycolipids modulate key cellular processes such as immune evasion, cell adhesion, and migration. Aberrant sialylation is driven by overexpression of sialyltransferases, resulting in hypersialylation on cancer cell surfaces as well as enhancing tumor aggressiveness. Sialylated glycans alter the structure of the glycocalyx, a protective barrier that fosters cancer cell detachment, migration, and invasion. This bulky glycocalyx also increases membrane tension, promoting integrin clustering and downstream signaling pathways that drive cell proliferation and metastasis. They play a critical role in immune evasion by binding to Siglecs, inhibitory receptors on immune cells, which transmit signals that protect cancer cells from immune-mediated destruction. Targeting sialylation pathways presents a promising therapeutic opportunity to understand the complex roles of sialic acids and sialoglycans in cancer mechanics and progression, which is crucial for developing novel diagnostic and therapeutic strategies that can disrupt these processes and improve cancer treatment outcomes.