Necmettin Erbakan Üniversitesi
  • Konya, Ankara, Turkey
Recent publications
Background: We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods: This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results: A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m2 (IQR, 75.4-116.3), and median proteinuria was 6000 mg/d (IQR, 3656-9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions: Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.
Background The prognostic value of perineural invasion (PNI) in head and neck squamous cell carcinoma (HNSCC) remains controversial. This study investigated the impact of PNI on prognosis in HNSCC. A total of 49 patients with HNSCC who underwent primary surgical treatment were selected for the study. Univariate analysis of the survival curve was performed using the Kaplan-Meier method. Multivariate analysis was carried out by Cox regression. Results PNI was present in 17 of 49 (34.7%) patients. The median follow-up was 18.7 months. The median DFS and OS were 16.6 months and 41.9 months, respectively. Univariate analyses showed that PNI was associated with OS ( p : 0.02), but not with DFS ( p : 0.50). ENE was associated only with DFS in univariate analysis ( p : 0.04), but not OS (yes vs. no; 24.1 vs. 44.6 months, p : 0.21), and in multivariate analysis, ENE lost its significance for DFS ( p : 0.12). Also, PNI was the only significant independent adverse prognostic factor for OS in multivariate analysis ( p : 0.02). The median OS for patients with and without PNI was 17.1 months and 92.1 months, respectively. Conclusion PNI was an independent factor for poor prognosis in patients with HNSCC. The presence of PNI compared to ENE was associated with a greater risk of death in HNSCC. Therefore, it would be appropriate to consider adjuvant therapy in the presence of PNI alone without other adverse risk features.
Background We aimed to investigate the effect of radiological complete response on survival outcomes in patients with non-metastatic nasopharyngeal cancer. This study is conducted as a retrospective cohort. Of the 185 patients screened, 60 were metastatic, 25 patients’ data was not available, and as a result, 92 patients were included in the study. Among the complete response (CR) and incomplete response (IR) groups, overall survival (OS), distant metastasis-free survival (DMFS), and locoregional failure-free survival (LRFFS) were evaluated. Results Of the 92 patients, 54 (58.6%) were CR and 38 (41.4%) were IR patients. Of the whole study group, the 5-year OS, DMFS, and LRFFS rates were 75%, 78%, and 95%, respectively. A significant difference was found between the 5-year OS (90% vs. 60%, p = 0.001) and DMFS (87% vs. 65%, p = 0.02) rates. However, there was no significant difference in the 5-year LRFFS rate (97% vs. 92%, p = 0.16). Complete response were determined as an independent predictor for OS (HR: 0.13, 95% Cl: 0.045–0.36, p < 0.001) and DMFS (HR: 0.26, 95% CI: 0.095–0.744, p = 0.012). Conclusion As a result, the survival benefit in patients with CR after primary treatment is evident as shown in the above studies. Therefore, the aim of primary treatment should be to increase the CR rates. It is important to evaluate early tumor response to determine poor tumor regression.
In the reintegration applications of the destroyed blocks in stone monuments, the compatibility of the petrographic and engineering properties of the material selected for restoration with the original building stones provides benefits in the sustainable preservation of the structures. Infrared thermography can be an important tool in evaluating this compatibility. To this end, the restoration stones and original blocks (pyroclastic and travertine) used in Kuruçeşme Han in the city of Konya (Turkey) were examined in situ (infrared thermography, deep moisture meter, and ambient temperature meter) and in the laboratory (petrographic, index-mechanical, and thermal test) environment. To model the atmospheric events of the building stones in laboratory studies, monitoring of the capillary water rise, determination of the cooling process, and monitoring of the drying process of the saturated tests were carried out through infrared thermography. According to the results obtained from the study, it was determined that deteriorations developed due to different thermal behavior both between the pyroclastic and travertine blocks of the monument and between the restoration and the original building stones (pyroclastic and travertine). In addition, it is thought that determining the thermal behavior is very important in the selection of building stones in restoration applications.
Purpose Since dental age estimation methods' accuracy and reliability levels differ in each society, the method should be appropriate for societies. This study aims to evaluate the applicability of Nolla, Willems, and Cameriere methods to Turkish children in the Central Black Sea Region. Material and method This study was conducted based on the panoramic radiographs of 400 children between the ages of 6–14 years admitted to Tokat Gaziosmanpaşa University Faculty of Dentistry, Department of Pediatric Dentistry for examination between 2016 and 2020. Nolla, Willems, and Cameriere methods estimated dental age on the selected panoramic radiographs. While 14 teeth in the left mandible and maxilla were evaluated for Nolla method, seven teeth in the left mandible were evaluated for Willems and Cameriere methods. Data were analyzed using IBM SPSS V23. The Pearson correlation coefficient was used to analyze the relationship between the chronological age (CA) and dental age (DA), and the paired sample t-test was used to analyze the difference. Results A statistically significant difference was found between CA-Nolla dental age (p = 0.002), CA-Willems dental age (p < 0.001), and CA-Cameriere dental age (p = 0.033) in boys. The mean differences between dental age and chronological age in boys were −0.24 years in the Nolla method, +0.49 years in Willems method, and −0.17 years in the Cameriere method. A statistically significant difference was found between CA-Nolla dental age (p = 0.001) and CA-Willems dental age (p < 0.001) in girls. The mean differences between dental age and chronological age in girls were −0.27 years in the Nolla method, +0.76 years in the Willems method, and −0.1 years in the Cameriere method. Conclusion In this study method providing closest estimation for chronological age among children aged 6–14.99 that were examined in Central Black Sea Region, was the Cameriere method in both girls (79.9%) and boys (80.6%), followed by Nolla method and Willems method, respectively.
Pandemic diseases have caused dramatic changes in people's lives throughout history. Today, the COVID-19 virus spreads rapidly and affects human beings around the globe. This study aimed to discover the coping strategies and post-traumatic growth (PTG) experiences of persons who were infected by the COVID-19 virus using the qualitative research method. The research involved 17 individuals, nine of whom were female. All had been diagnosed with COVID-19. Face-to-face and online interviews were conducted with participants. In the analysis of the data, the thematic analysis method was performed by developing themes and sub-themes. The created themes include coping strategies, existential growth, lessons learned from disease, new opportunities, and social growth. These themes indicated positive changes in the lives of persons who were infected by the COVID-19 virus after the COVID-19 disease. Findings and implications for the practice were discussed.
We present the electo-optical characterization of tannic acid (TA)/n-Si heterojunction for visible and UV lights (365 nm and 395 nm). The TA was deposited on n-Si by spin coating. The morphological and structural analyses of TA film were carried out by Scanning Electron Microscopy (SEM) and Energy-dispersive X-ray (EDX) analyses, respectively. The electro-optical performance of the TA/n-Si bio-photodiode were investigated by I-V measurements for 10 mW/cm², 15 mW/cm², 20 mW/cm² and 30 mW/cm² visible light intensities in addition to UV light. Light-dependent the responsivity, ON/OFF ratio, detectivity, shunt resistance and series resistance were calculated. Maximum values of responsivity, detectivity and ON/OFF ratio were determined as ∼ 11.9 mA/W (−1.5 V), 3.2 × 10⁹ Jones (at −0.42 V) and 194 (30 mW/cm²) (AM 1.5 G), at −2 V respectively. Whereas, they were determined to be 0.1 A/W, ∼ 4 × 10⁹ Jones and 14977, respectively for UV light. Furthermore, the dielectric properties of the TA/n-Si heterostructure also were investigated from the dark Capacitance/Conductance-Voltage measurements. It was seen that both real and imaginary parts of the dielectric constants was frequency-dependent. Experimental results show that the TA/n-Si device with a high rectification ratio of 2263 is a potential candidate for detecting visible and UV lights.
In this study, propolis resin was electrosprayed (ES) without a carrier polymer in order to produce nanoparticles, and the parameters affecting the ES process were investigated. During preliminary experiments, surface tension, electrical conductivity, dielectric, and rheological properties of the feed solution and their effects on electrospraying of propolis were determined. Afterward, the propolis solution was fed to the electrospinning equipment at the different feed rates (1, 5.5, and 10 ml/h), the voltages (5, 12.5, and 20 kV), and the distances to the collector plate (5, 10, and 15 cm). According to the response surface analysis (RSA), the feed rate and the applied voltage were effective for the morphology and diameter of particles. In contrast, the antimicrobial activity of particles against Staphylococcus aureus and Escherichia coli depended on the feed rate and the distance to the collector plate. Based on these results, the optimum feed rate, applied voltage, and distance to the collector plate conditions for ES of propolis were found as 8.82 ml/h, 20 kV, and 5 cm, respectively.
In this study, four different pulps were prepared by adding 0%, 5%, 10%, and 15% carburized pine nut cone ash to a reference rubber compound based on styrene butadiene rubber (SBR). After vulcanization, the hardness, density, tensile strength, percentage elongation, tearing strength, and crosslink density of the compound were measured. In addition, the effects of the crosslink density on the mechanical properties were examined. The properties of the carburized pine nut cone ash compounds were evaluated both among themselves and comparatively with the physical and mechanical properties of the reference compound. In addition, it increased the hardness as well as the crosslink density, and it was shown to provide advantages in terms of its density, tensile strength, tearing strength, and percentage elongation properties. Furthermore, the fracture surfaces of the compounds were characterized via scanning electron microscopy and energy dispersion spectroscopy to explain the change in mechanical properties.
As educational processes are adapted to the online environment due to COVID-19 pandemic, digital citizenship and online information searching strategies came into prominence. In this context, the aim of this study is the examination of digital citizenship awareness, online information searching strategies and differentiation of the level of information literacy depending on changing state of experience in using digital technologies before and during COVID-19 pandemic. Also, it is aimed to examine the presence of relations between variables of the research. The study was conducted with the participation of 255 university students. Analyses were performed using multivariate analysis of variance (MANOVA) and partial least squares structural equation modelling (PLS-SEM). According to the results of the study, during COVID-19 pandemic, there was an increase in digital citizenship awareness of students who spend more time in social media and the ones who improved digital technology usage skills developed online information searching strategies. According to the model analysed, online information searching strategies and information literacy have an effect on digital citizenship while online information searching strategies have an effect on information literacy. The results of the study showed that the students with higher level of information literacy and online information searching strategies may help them develop digital citizenship awareness.
Purpose: This study aimed to investigate the effect of surface treatment and type of composite resin material on the color stability and surface roughness of different denture characterizing composites. Materials and methods: Two nanohybrids [Gradia Plus Gum, (GP) and SR Nexco Paste Gingiva, (SR)] and one microhybrid gingiva-colored composite resin (Amaris Gingiva, (AG)] were investigated. A total of 120 disk-shaped samples were prepared, 40 of each material. Samples were divided into two groups (n = 20) for each material according to the surface treatment applied: conventional polishing (control) and coated with a sealant in addition to the surface polishing. All groups were thermocycled. The surface roughness (Ra) was measured using a profilometer after thermal cycling. The samples were then divided into 2 subgroups (n = 10) and stored for 7 days in distilled water or coffee solution. Color differences (ΔE00 ) were calculated with a spectrophotometer. Results were evaluated with Kruskal-Wallis and Mann-Whitney U statistical analysis. Results: The type of denture characterizing composite material and surface treatment method revealed statistically significant differences for the ΔE00 (after immersion both in coffee and distilled water) and the Ra values of denture characterizing composite (p < 0.001 for both). All sealed groups showed significantly higher Ra than the all polished groups. Both in the polished groups and the sealant applied groups, the GP had the highest mean Ra values (0.29 ±0.05 μm and 0.47 ±0.09 μm, respectively). It was followed by SR (0.23 ±0.06 μm and 0.41 ±0.10 μm, respectively), and AG groups (0.20 ±0.06 μm and 0.39 ±0.09 μm, respectively). According to the mean ΔE00 results, all composite groups showed significantly higher ΔE00 values immersed in coffee solutions compared to distilled water. In coffee solutions, the highest ΔE00 was observed in the polished GP (1.90 ±0.40), and the lowest ΔE00 was observed in the polished SR (0.97 ±0.36). The sealed groups showed higher ΔE00 than the polished groups, except for GP. Conclusions: The surface roughness value of sealant applied groups were significantly higher than those of their polished groups. The surface sealant application significantly increased the staining of all composite groups compared to conventional polishing, except for GP. This article is protected by copyright. All rights reserved.
Wheat (Triticum aestivum L.) is highly rich in nutrients and is an important staple food for humankind. Mutation breeding offers a relatively quick method for crop improvement and it provides variation for selective breeding programs and functional gene studies. In vitro mutagenesis, coupled with in vitro regeneration procedure, can offer a wide variety of plant materials for mutagenesis; enable generation of large mutant populations in a relatively short period. Present experiments were conducted to investigate potential use of conventional chemical mutagenesis technique through ethyl methanesulfonate (EMS) for mature embryo culture in wheat. EMS mutagenesis was experimented with 4 treatment durations (2, 4, 6, and 8 h) and 5 treatment concentrations (0, 0.1, 0.2, 0.3, and 0.4%). Mature embryos were treated to detect optimum doses of mutagenesis and to estimate polymorphism and genomic instability. First of all, 50% reduction in number of regenerated plants as compared to the control (LD 50) was adopted as the optimum dose. Treated and untreated mature embryos were transferred to callus induction media. EMS mutagens at different duration and concentration had significant effects on callus formation rate (%), embryogenic callus formation rate (%), responded embryogenic callus rate (%), regeneration efficiency and number of plants parameters. Based on LD50 criterion, the optimum value was achieved at 8 h duration of 0.1% EMS concentration. Secondly, inter-primer binding site (iPBS) markers was applied to investigate insertion polymorphism and genomic instability in the regenerated plants. EMS mutagenic treatments had significant effects on different effects on polymorphism and genomic instability of regenerated plants. Present findings revealed that in vitro mutagenesis might be a useful approach for accelerating breeding strategies to create enough genetic variation in wheat populations. Besides, an integrated approach can be used to carry out mutation-assisted breeding and subsequent selection of desired mutants using molecular markers in wheat.
Purpose: There is growing evidence that prolonged exposure to high serum aldosterone concentrations results in target organ damage to the heart, kidney, and arterial wall, and that primary aldosteronism (PA) is associated with increased cardiovascular risk. In this study, we aimed to evaluate cardiovascular disease (CVD) risk indicators such as arterial stiffness [with pulse wave velocity (PWV) measurement] in PA patients and endocan levels, which is a biomarker of endothelial dysfunction. Methods: 28 patients with PA were included in our study. As the control group, 14 patients with essential hypertension (EHT) and 28 normotensive healthy volunteers were included. Height, weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), serum fasting glucose, insulin, hemoglobin A1c (HbA1c), C-reactive protein (CRP), lipids and endocan levels of all subjects in the PA, EHT and control groups were measured. PWV measurements were performed to assess arterial stiffness. Results: In the PA group, PWV levels were similar to the EHT group, and endocan levels were lower than the EHT group. In the PA group, PWV levels were higher than the control group, and endocan levels were lower than the control group. When we compared the PA group with new-onset HT with the PA group with long-term HT, PWV levels were higher in the PA group with long-term HT. When we compared the long-term HT group with the EHT group, PWV levels were higher in the long-term HT PA group and endocan levels were higher in the EHT group. When we compared the PA group with long-term HT with the control group, PWV levels were higher in the PA group with long-term HT, and endocan levels were similar in both groups. Conclusions: In our study, it was determined that arterial stiffness increased in PA cases with long-term HT compared to PA cases with new-onset HT, EHT cases and normotensive healthy cases. We found that endocan levels in PA patients were also lower than both EHT patients and healthy controls.
Introduction: Rituximab, which is widely used in the treatment of B-cell lymphoma, is a chimeric monoclonal antibody directed against the CD20 antigen. Rituximab has many side effects, mainly allergic and neurological. Rituximab may cause thrombocytopenia in the long term after administration. Rare cases with rituximab-induced acute thrombocytopenia have been reported in the literature. Case Report: A 51-year-old female patient who newly diagnosed splenic marginal zone lymphoma recieved rituximab as first line therapy. Petechiae occurred in the lower extremities on the day following rituximab administration. The blood test showed a severe drop in the platelet count from 112,000/μL to 5,000/μL. Blood peripheral smear evaluation confirmed severe thrombocytopenia. Management and outcome: There was no change in hemoglobin or white blood cell levels. After the diagnosis of rituximab-induced acute thrombocytopenia, thrombocyte suspension was administered due to the risk of bleeding. Close clinical and laboratory observations were made. The platelet count began to rise gradually in the following period. Before the second week of rituximab administration, the platelet count was 122,000/μL. No complications developed after premedication and slow rituximab administration, and subsequent treatments were continued in the same way. Discussion: Rituximab has a widespread use, especially in malignancies and autoimmune diseases. Like many monoclonal antibodies, rituximab has several side effects. Thrombocytopenia is a long-term side effect associated with rituximab, and rituximab-induced severe acute thrombocytopenia has been rarely reported. Therefore, it should be kept in mind that severe acute thrombocytopenia may develop after rituximab administration.
Quality function deployment (QFD) method allows reviewing of customer requirements (CRs) and design requirements (DRs) simultaneously in order to handle the correlations and relationships of CRs and DRs in calculations. It has been often combined with fuzzy numbers because it provides to gather the judgments of experts in vagueness environment more correctly and easily. This paper suggests employing q-rung orthopair fuzzy number (q-ROFN) for improving the fuzzy QFD approach. The proposed q-ROFN based QFD method uses q-ROFN to adjust the weights of CRs based the relationships between CRs and DRs with the help of the correlations and relationships of CRs and DRs. q-ROFN presents more information than numbers such as intuitionistic fuzzy number and Pythagorean fuzzy number about the correlations and relationships of CRs and DRs. VIKOR (VIsekriterijumska optimizacija i KOm-promisno Resenje) approach based on q-ROFN is also used to rank DRs. The new proposed integrated method has been applied for evaluating the anthropometry based glove design. The results show that the most important DR for anthropometry based glove design is ease of hand motion perception.
Calix[4]arene-based materials have been investigated to develop selective, sensitive, and low cost chemical sensors due to their simple, low cost synthesis, and wide range of chemical and physical properties. In this study, bisbenzothiazole-p-tert-butylcalix[4]arene-thiourea (BBTC[4]T) molecules were employed to produce thin films via Langmuir–Blodgett (LB) thin film fabrication technique. The optical properties and gas sensing abilities of these BBTC[4]T LB films were examined by Surface Plasmon Resonance (SPR) method. In order to illuminate the optical properties of calix[4]arene-based LB films the Winspall software was utilized by fitting the experimental data obtained from SPR device. The values of 1.23 ± 0.07 nm and 1.53 ± 0.05 were determined for the thickness per monolayer and the refractive index of BBTC[4]T-based LB films, respectively. The fabricated optical sensor was employed for its sensing abilities against to organic vapours (acetone, ethyl alcohol, methyl alcohol and isopropyl alcohol) via the mechanism of host–guest interaction. The current study also describes the diffusion coefficients of these organic vapours to illuminate the swelling dynamics’ BBTC[4]T-based LB thin films by performing the early-time Fick’s diffusion equation. The responses of calix[4]arene-based optical sensor in terms of the shift in reflective intensity and the values of diffusion coefficients showed that BBTC[4]T molecules can be developed as potential chemical sensor element for acetone vapour compared to alcohol vapours.
Determining the variety of wheat is important to know the physical and chemical properties which may be useful in grain processing. It also affects the price of wheat in the food industry. In this study, a Convolutional Neural Network (CNN)-based model was proposed to determine wheat varieties. Images of four different piles of wheat, two of which were the bread and the remaining durum wheat, were taken and image pre-processing techniques were applied. Small-sized images were cropped from high-resolution images, followed by data augmentation. Then, deep features were extracted from the obtained images using pre-trained seven different CNN models (AlexNet, ResNet18, ResNet50, ResNet101, Inceptionv3, DenseNet201, and Inceptionresnetv2). Support Vector Machines (SVM) classifier was used to classify deep features. The classification accuracies obtained by classification with various kernel functions such as Linear, Quadratic, Cubic and Gaussian were compared. The highest wheat classification accuracy was achieved with the deep features extracted with the Densenet201 model. In the classification made with the Cubic kernel function of SVM, the accuracy value was 98.1%.
Background Genus Adonis L. contain approximately 40 annual and perennial species, which are widely distributed in the temperate zones of Asia and Europe, and less frequently in southwestern Asia, northern Africa and the Mediterranean region. The aim of the study was to evaluate the phylogenetic relationship among Adonis taxa collected from Türkiye based on nrDNA Internal transcribed spacer (ITS) markers. Methods Samples of 64 individual genotypes from 21 populations of 10 Adonis taxa were collected from different regions of the country during vegetation period between 2014 and 2018. ITS1, ITS4, P16 and P25 primers within ITS technique was used to genotype the plant materials. Then, genotypic data was used to estimate magnitude and organization of infraspecific variation in different populations of Adonis. Results About 600 bp DNA sequences were obtained from each 64 Adonis genotypes belonging to 21 different populations. The dendrogram obtained from Adonis taxa and out-group sequences had two large main groups. While the out-group species were placed in the first large main group, the sect. Consiligo (perennial) and sect. Adonis (annuals) were placed in different sub-groups of the second large main group. Genetic similarity among Adonis taxa varied between A. microcarpa and A. dentata (98.46%). Principal component analysis indicated that two important components in Adonis taxa genotypes. The expected heterozygosity ranged from 0.0252 (sub-population A) to 0.3460 (sub-population C), with an average of 0.1154. In addition, population differentiation measurements (Fst) ranged from 0.0025 (sub-population C) to 0.9016 (sub-population A) with a relatively high average 0.6601. Conclusions Present analyses revealed that phylogenetic classification (grouping) of Adonis taxa largely depended on morphological structure and present ITS primers were quite efficient in putting forth the genetic diversity of such species. The results of this study suggested that ITS markers could be used in the identification of genetic diversity among the Adonis taxa. The results obtained from molecular data can be used to explore the genetic variation pattern, population structure, and the evolutionary history of genus Adonis in the future.
The exact immunological mechanisms of post infectious bronchiolitis obliterans (PIBO) in childhood are not fully known. It has been shown that the inflammasome and IL-18 pathway play important roles in the pathogenesis of lung fibrosis. We aimed to investigate the role of caspase-1, IL-18, and IL-18 components in PIBO. From January to May 2020, children with PIBO, children with history of influenza infection without PIBO, and healthy children were asked to participate in the study in three pediatric pulmonology centers. Serum caspase-1, IL-18, IL-18BP, IL-18R, and INF-γ levels were measured by ELISA and compared between the 3 groups. There were 21 children in the PIBO group, 16 children in the influenza group, and 39 children in the healthy control group. No differences in terms of age and gender between the 3 groups were found. IL-18 and IL-18BP levels were higher in the healthy control group (p = 0.018, p = 0.005, respectively). IL-18R was higher in the PIBO group (p = 0.001) and caspase-1 was higher in the PIBO and influenza group than the healthy control group (p = 0.002). IFN-γ levels did not differ between the 3 groups. IL-18BP/IL-18 was higher in the influenza group than the PIBO group and the healthy control group (p = 0.003). Conclusions: Caspase-1 level was increased in patients with PIBO which suggests that inflammasome activation may have a role in fibrosis; however, IL-18 level was found to be low. Mediators other than IL-18 may be involved in the inflammatory pathway in PIBO. Further immunological studies investigating inflammasome pathway are needed for PIBO with chronic inflammation. What is Known: • Post infectious bronchiolitis obliterans (PIBO) is a rare, severe chronic lung disease during childhood which is associated with inflammation and fibrosis which lead to partial or complete luminal obstruction especially in small airways. • The exact immunological mechanisms of PIBO in childhood are not fully known. What is New: • Inflammasome activation persists even years after acute infection and may play a role in fibrosis in PIBO. • Mediators other than IL-18 may be involved in these inflammatory pathway.
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1,585 members
Derya Arslan
  • Food Engineering
Serdar Toker
  • Meram Faculty of Medicine
Ahmet Uzun
  • Ahmet Keleşoğlu Faculty Of Education
Zerrin Defne Dundar
  • Meram Faculty of Medicine, Emergency Medicine Department
Gokhan Cuce
  • Histology and Embryology
Başkent University School of Medicine Biophysics Department, 06790, Konya, Ankara, Turkey
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