Kitakyushu, Fukuoka-ken, Japan

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    ABSTRACT: Rutile titania (TiO2) is an efficient photocatalyst for oxidizing water to O-2. The photocatalytic activity of particulate rutile for water oxidation was significantly improved by H-2 reduction at 700 degrees C, after calcination at 1100 degrees C. The improved activity was due to an increase in crystalline size during calcination, and an increase in conduction band electron concentration by the creation of oxygen vacancies. In contrast to the consideration that oxygen vacancy increases the recombination of electron and holes, the hydrogenated TiO2 exhibited high apparent quantum efficiency for O-2 evolution, 41% under irradiation at 365 nm. It was found that H-2 treatment improved the photocatalytic activity per unit of surface area not only for O-2 evolution but also for H-2 evolution and acetic acid decomposition. The effect of H-2 reduction treatment was obtained only if the rutile particle was previously calcined at temperatures higher than 1000 degrees C. This suggests that space charge layer in large crystalline particles is involved in the activation mechanism of hydrogenated rutile TiO2 particles.
    No preview · Article · Oct 2014 · Applied Catalysis B Environmental
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    ABSTRACT: Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively expressed on hepatocyte and hepatoma. In this study, we synthesized a galactose-modified lipid with aromatic ring with click chemistry. To make a complex with DNA, termed 'lipoplex', we prepared a binary micelle composed of cationic lipid; dioleoyltrimethylammoniumpropane (DOTAP) and galactose-modified lipid (D/Gal). We prepared lipoplex from plasmid DNA (pDNA) and D/Gal and examined the cell specificity and transfection efficiency. The lipoplex was able to interact with ASGPR immobilized on gold substrate in the quartz-crystal microbalance (QCM) sensor cell. The lipoplex induced high gene expression to HepG2 cells, a human hepatocellular carcinoma cell line, but not to A549 cells, a human alveolar adenocarcinoma cell line. The treatment with asialofetuin, which is a ligand for ASGPR and would work as a competitive inhibitor, before addition of the lipoplexes decreased the expression to HepG2 cells. These results indicate that D/Gal lipoplex was incorporated into HepG2 cells preferentially through ASGPR and the uptake was caused by galactose specific receptor. This delivery system to hepatocytes may overcome the problems for gene therapy and be used for treatment of hepatitis and hepatic cirrhosis.
    No preview · Article · Oct 2014 · Bioorganic & Medicinal Chemistry
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    ABSTRACT: When plants are threaten by microbial attacks or treated with elicitors, alkalization of extracellular space is often induced and thus pH-dependent extracellular peroxidase-mediated oxidative burst reportedly takes place, especially at the site of microbial challenge. However, direct stimulus involved in activation of peroxidase-catalyzed oxidative burst has not been identified to date. Here, we would like to propose a likely role for free ferrous ion in reduction of ferric native peroxidase into ferrous enzyme intermediate which readily produces superoxide anion via mechanism involving Compound III, especially under alkaline condition, thus, possibly contributing to the plant defense mechanism. Through spectroscopic and chemiluminescence (CL) analyses of reactions catalyzed by horseradish peroxidase (HRP), the present study proposed that plant peroxidase-catalyzed production of superoxide anion can be stimulated in the absence of conventional peroxidase substrates but in the presence of free ferrous ion.
    Full-text · Article · Jul 2014 · Frontiers in Plant Science


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    4-2-1 Kitagata, Kokuraminami Ward, 802-0841, Kitakyushu, Fukuoka-ken, Japan
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Top publications last week by reads

Environmental Control in Biology 01/2016; 54(1):7-16. DOI:10.2525/ecb.54.7
16 Reads
Journal of Water and Environment Technology 01/2015; 13(3):263-278. DOI:10.2965/jwet.2015.263
13 Reads

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