Corroles are deeply coloured tetrapyrrole compounds with a conjugated 18π-electron aromatic ring system carrying one direct pyrrole–pyrrole linkage. Many metal complexes of corrole ligands have been successfully synthesized in the last decades, and both their molecular as well as their electrochemical and photophysical properties have been investigated. Although several metallocorroles with group 13 elements (B, Al and Ga) are very well characterized, attempts to investigate the corresponding corrole complexes of the heavier elements of this main group are still quite rare. Especially the synthesis of a stable indium corrole molecule has been tried many times, but until today these compounds have not been obtained successfully to be characterized properly. In this work, the preparation and characterization of stable 5,10,15-tris(pentafluorophenyl)corrolatoindium(III) derivatives has been achieved. These new indium corrole complexes obtained were fully and successfully characterized by relevant analytical techniques (NMR, HR-MS, UV-Vis, Fluorescence and FTIR), and their photophysical and electrochemical features were studied and investigated for the first time.
Cognitive-behavioral group therapy is one of the most effective forms of intervention in therapy for women with breast cancer. The present study aimed to investigate the efficacy of cognitive-behavioral group therapy on depression, anxiety, and pain-coping strategies in women with breast cancer. The present study is a semiexperimental research with a pretest-posttest with the control group. For this purpose, 50 people of women with breast cancer were admitted to the medical university hospitals of Tehran to method purposive sampling and were randomly selected as experimental ( n = 25) and control ( n = 25) groups. The results showed that cognitive-behavioral group therapy significantly reduces depression and anxiety and increases the use of pain-coping strategies in women with breast cancer. Also in the field of pain-coping strategies between the experimental and control groups, there is a significant difference.
Chiral cyclopentadienyl groups and their respective metal complexes have been studied for several decades. However, it is only in the last decade that this field has gained significant momentum, primarily through the introduction of chiral C2-symmetrical 1,2-cyclopentadienes and unsymmetrically substituted chiral 1,2-cyclopentadienes and indenes as precursors for chiral complexes, especially those involving late transition metals. The utilization of chiral C2-symmetrical cyclopentadienyl (Cp) ligands allows for the circumvention of diastereomer formation upon complexation with the desired transition metal center. This is particularly advantageous for unsymmetrically substituted ligands, which often necessitate tedious racemate separation. In all cases, a multi-step synthesis is required, depending on the nature of the chiral backbone. Unsymmetrically substituted Cp rings can bypass the need for a multi-step synthetic approach but generally require the separation of racemates to obtain enantiomerically pure metal complexes. An alternative method involves conjugating achiral Cp-metal complexes to a carrier molecule, which enables the insertion of the conjugate into the active center of an enzyme protein hull. This approach establishes a chiral environment for asymmetric transformations. The resulting metal complexes find extensive applications in C-H functionalization reactions, as well as various cycloaddition reactions.
Zusammenfassung Der humanisierte monoklonale anti-α4β7-Integrin-Antikörper Vedolizumab ist eine von mehreren biologischen Therapieoptionen bei moderaten und schweren Verläufen von Colitis ulcerosa und Morbus Crohn. Im Zuge des VISIBLE-Studienprogramms wurde zusätzlich zur etablierten intravenösen Verabreichung eine subkutane Administrationsform von Vedolizumab erprobt. Die Arbeitsgruppe CED der Österreichischen Gesellschaft für Gastroenterologie und Hepatologie (ÖGGH) fasst in diesem Positionspapier die Datenlage zur subkutanen Applikation von Vedolizumab zusammen, ergänzt ein bestehendes Positionspapier zum Stellenwert von Vedolizumab als Erstlinientherapie bei chronisch entzündlichen Darmerkrankungen und bietet praxisnahe Empfehlungen zur praktischen Anwendung.
Purpose of review Management of stone disease in pregnancy poses a challenge for all healthcare professionals involved in their care. During pregnancy, there is an increase in the incidence of urolithiasis. Major technological and procedural advances have been seen in the last decade for endoscopic management of urolithiasis. The purpose of this review is to provide a comprehensive workup of available literature on use of ureteroscopy for stone treatment during pregnancy. Recent findings We identified 268 articles on screening, of which 28 were included in the final review. Overall adverse event rates were low, with no severe complications reported in the included studies. On multivariate analysis, the only significant correlation was an inverse relationship between calculated caseload and adverse obstetric events. No further correlation could be found between caseload, operation technique and adverse event rates. Data quality was low among the included studies. Summary While ureteroscopy is a relatively safe and effective option for active stone treatment during pregnancy, they should be performed in experienced endourology centres in conjunction with obstetric teams.
The electrocardiogram is a very valuable clinical tool which allows to retrieve information about the presence and location of arrhythmic foci as well as ischemic and scar tissue and disorder’s of the dedicated cardiac conduction system. In the presented study timing parameters computed by a delineating beat detector for identifying the P-Wave, QRS - complex and T-Wave are used to classify the individual beats. From a set of total 419 feature generated from these parameters 64 are used to train LDA classifier for discriminating 3 classes (Normal, Artifact, Arrhythmic) and 5 Classes (Normal, Artifact, Atrial and ventricular premature contractions and bundle branch blocks). Further it is investigated how the imbalance between normal beats and arrhythmic beats as well as the beats missed by the beat detector affect the classification results. In the case of 5 classes accuracies of 97.52 % in the imbalanced case and 96.38 r for the balanced data were obtained. For 3 classes accuracies of 97.76 % and 95.18 % were achieved. Considering in addition the beats missed by the detector the accuracies dropped to 96.68 %, and 95.54 % for 5 classes and 95.54 % and 96.92 % for 3 classes. These values are within the ranges for linear classifier reported in literature. This is quite promising for implementing a real-time classifier which exploits the parameters and values computed by the beat detector.
The SCHNAPP Spelling Test is a novel screening instrument to identify at-risk children with poor spelling abilities in German at the beginning of primary school. Although originally developed as a computerized test to be administered on tablets, in school settings paper-pencil methods are often still preferred. Therefore, the present study on N = 390 children from first grades in Austrian primary schools examined the equivalence of computer and paper-pencil versions of the test. After demonstrating unidimensional measurement models in both assessment conditions, analyses of differential response functioning on the item and test level found no substantial testing mode effects. These results indicate that the SCHNAPP Spelling Test can be comparably used as a computer- or paper-based instrument in school assessments.
Institution pages aggregate content on ResearchGate related to an institution. The members listed on this page have self-identified as being affiliated with this institution. Publications listed on this page were identified by our algorithms as relating to this institution. This page was not created or approved by the institution. If you represent an institution and have questions about these pages or wish to report inaccurate content, you can contact us here.