Istinye Universitesi
  • Istanbul, Istanbul, Turkey
Recent publications
This paper reported a research work that investigated the compatibility of using pomegranate peel oil (PPO) as a substitute for gasoline in a spark-ignition engine. Initially, fuel characterization was performed for the PPO biofuel, and a blend was prepared by blending PPO in gasoline at a ratio of 10:90 by volume. Then, fuel properties were measured for the gasoline, PPO, and its blend. Subsequently, engine experiments were conducted for the blend at different load conditions with constant speed, and the performance, combustion, and emission results of the blend were compared with that of sole gasoline. By analyzing the results, it was found that the brake thermal efficiency of the 10% PPO blended gasoline was reduced by 1.2%, 0.6%, and 1%, at low load, mid load, and full load, respectively, when compared to sole gasoline. Whereas the HC and CO emission of the blend was higher by about 11.7% and 8.3%, respectively, at full load, when compared to that of gasoline. With an intent to improve the performance of the PPO blend, tertiary butyl alcohol (TBA) was blended with the 10% PPO blended gasoline in the volumetric proportion of 5%, 10%, and 15% to form ternary blends. The experimental study revealed that the performance of the PPO blend was enhanced significantly with increasing TBA proportion in the blend. The PPO blend with 15% TBA exhibited the highest BTE of 25.1%, which was 1.6% higher than gasoline at full load. The same blend resulted in the HC and CO emissions that were 9.2% and 9.6% lesser than gasoline, respectively, whereas NO emission was 7.6% higher than gasoline, at full load condition. The combustion analysis revealed that the start of combustion was delayed, with peak pressure and heat release rate being the maximum for ternary blends. From this investigation, it can be concluded that the sole gasoline can be replaced by the ternary blend as fuel for SI engine operation without requiring any major engine modification.
This research presents an innovative approach for optimization based on a Genetic Algorithm optimization method. The system is configured by the integration of a gas turbine cycle, a dual-pressure heat recovery steam generator, a multi-effect desalination unit, a refrigeration organic Rankine cycle with an ejector, and a proton-exchange membrane electrolyzer. The proposed system is optimized utilizing five single- and multi-objective methods and investigating each objective's effect on the optimum range of the decision variables. As a result of these optimization five best points are extracted. The base condition, and these five best points are identified as six conditions, and the performance and reliability of the optimization results are investigated in a comparative parametric study. The single-objective optimizations results show that the maximum possible exergy efficiency and freshwater production rate are 72% and 1354 m³/day, respectively, and the lowest possible total cost rate is 611 $/h. However, tri-objective optimization demonstrates for these parameters that the best point has efficiency, cost, and freshwater production rate values of 69%, 791 $/h, and 1063 m³/day, respectively. The comparative parametric study shows that the tri-objective optimization result (Condition 5) is favorable in terms of objectives and reliability.
Overall, aptamers are special classes of nucleic acid-based macromolecules that are beginning to investigate because of their capability of avidity binding to a specific target for clinical use. Taking advantage of target-specific medicine led to more effective therapeutic and limitation of side effects of drugs. Herein, we discuss several aptamers and their binding capability and capacity for selecting tumor biomarkers and usage of them as targeting ligands for the functionalization of nanomaterials. We review recent applications based on aptamers and several nanoparticles to rise efficacy and develop carrier systems such as graphene oxide, folic acid, gold, mesopores silica, and various polymers and copolymer, polyethylene glycol, cyclodextrin, chitosan. The nanocarriers have been characterized by particle size, zeta potential, aptamer conjugation, and drug encapsulation efficiency. Hydrodynamic diameter and Zeta potential can used in order to monitor aptamers' crosslinking, in-vitro drug release, intracellular delivery of nanocarriers, and cellular cytotoxicity assay. Also, they are studied for cellular uptake and internalization to types of cancer cell lines such as colorectal, breast, prostate, leukemia and etc. The results are investigated in in-vivo cytotoxicity assay and cell viability assay. Targeted cancer therapy seems a good and promising strategy to overcome the systemic toxicity of chemotherapy.
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment decisions. Patients with ZNF384 rearrangements had a distinct expression profile regardless of their diagnosis, BCP-ALL or mixed phenotype acute leukemia (MPAL) and defined as a new subtype of ALL. In this study, we screened 42 MPAL and 91 BCP-ALL patients for the most common ZNF384 fusions; ZNF384::TCF3, ZNF384::EP300 and ZNF384::TAF15 by using PCR. We identified ZNF384 fusions in 9.5% of MPAL and 7.6% of BCP-ALL. A novel breakpoint was identified in ZNF384::TCF3 fusion in one BCP-ALL patient. T-myeloid MPAL patients showed significantly lower ZNF384 expression compared to lymphoid groups. Patients with ZNF384r had intermediate survival rates based on other subtypes. Prognostic and patient-specific treatment evaluation of ZNF384 fusions in both ALL and MPAL might help to improve risk characterization of patients.
The COVID-19 pandemic negatively influenced mental health and the music industry. The present study examined the relationship of between personality traits and emotional regulation with emotional problems and compared this relationship across three groups of individuals living in Türkiye during the COVID-19 pandemic. The sample consisted of 542 participants (238 musicians, 97 artists excluding musicians, and 207 participants who engaged in no form of art). The Depression, Anxiety and Stress Scale (DASS-21), Difficulties in Emotion Regulation Scale-Brief Form (DERS-16), and Basic Personality Traits Inventory were used. Findings showed that difficulties in emotion regulation were positively associated with stress, depression, and anxiety in all groups. The pattern of the relationship between personality traits and outcome measures was similar across musicians and participants who engaged in no form of art, whereas that of difficulties in emotional regulation with personality traits was almost the same across the three groups. Except for the personality traits of extraversion and openness, group comparisons showed no differences across different measures. These findings suggest that difficulties in emotional regulation need to be a target for psychological interventions to reduce emotional problems for all three groups. Being a musician did not make any difference in terms of emotional regulation or the experience of psychological problems.
The experimental study was carried out on the port fuel injection system installed spark-ignition engine fuelled by 1.5%, 3%, and 5% higher order alcohol such as 1-hexanol and 2-heptanol blended gasoline. In this study, the endoscopic combustion visualization technique was employed to compare and analyze the changes observed in the spatial flame characteristics between the alcohol blends and sole gasoline. The Correlated Colour Temperature (CCT) method was used to predict the flame temperature distribution from the captured flame images. Also, the effect of blending alcohols on engine combustion, performance, and emission characteristics was studied. The endoscopic results revealed that the flame spread region with respect to different CA positions increases with the alcohol blending ratio in the sole gasoline at the early and middle stages of the combustion. Further, the engine characteristics study revealed that 5% hexanol and heptanol blends gave a brake thermal efficiency of 25.8% and 25.7%, respectively, which were higher than sole gasoline, having 24.8% at full load. In addition, it was observed that the early start of combustion (SoC) and a faster burn rate associated with alcohol blends raise the cylinder pressure and heat release rates (HRRs) and thereby result in higher peak pressure and HRR with slight advancement in the CA position. At 8 kW, the CO and HC emission of 5% 1-hexanol and 2-heptanol blends was decreased by about 10.3% and 13.7%, and 9.5% and 8%, respectively, and NO emission decreased slightly with a rise in alcohol concentration in the mix when compared to gasoline.
Purpose In terms of postoperative morbidity and mortality, preservation of the perforating arteries branching from the anterior communicating artery (ACoA) during clipping is particularly imperative in patients with ACoA aneurysm. In the present study, we aimed to investigate whether perforating arteries originated from ACoA were pushed away in a different location in patients with ACoA aneurysm. Furthermore, if they did so, we aimed to identify the direction in which they were dislocated and how the perforating arteries could be preserved during clipping. Methods Herein, we categorized 40 brains obtained from cadavers into two groups. The first (n = 26) and second (n = 14) groups included cases without and with ACoA aneurysms, respectively. After completing the preparation procedure, the brains were dissected using surgical microscope and the relevant anatomical region was examined and photographed. Finally, statistical analyses were performed on the data and the results were documented. Results In the aneurysms with posterior and superior projections, the perforators appeared to be pushed away inferiorly and were frequently noted at the anteroinferior part of the aneurysm neck. Most of the cases, where one of the A1s was larger at one side, the perforating arteries arose from the larger A1 side. Conclusion The mortality and morbidity associated with damage to the perforators can be reduced by approaching the patient from the dominant A1 side and pursuing the perforators primarily at the anteroinferior part of the aneurysm neck in the aneurysms with superior and posterior projections.
We herein fabricated a cancer nanotheranostics platform based on Graphene Oxide Quantum Dot-Chitosan-polyethylene glycol nanoconjugate (GOQD-CS-PEG), which were targeted with MUC-1 aptamer towards breast and colon tumors. The interaction between aptamer and MUC-1 receptor on the desired cells was investigated utilizing molecular docking. The process of curcumin release was investigated, as well as the potential of the produced nanocomposite in targeted drug delivery, specific detection, and photoluminescence imaging. The fluorescence intensity of GOQD-CS-PEG was reduced due to transferred energy between (cytosine-guanin) base pairs in the hairpin structure of the aptamer, resulting in an “on/off” photoluminescence bio-sensing. Interestingly, the integration of pH-responsive chitosan nanoparticles in the nanocomposite results in a smart nanocomposite capable of delivering more curcumin to desired tumor cells. When selectively binds to the MUC-1 receptor, the two strands of aptamer separate in acidic conditions, resulting in a sustained drug release and photoluminescence recovery. The cytotoxicity results also revealed that the nanocomposite was more toxic to MUC-1-overexpressed tumor cells than to negative control cell lines, confirming its selective targeting. As a result, the proposed nanocomposite could be used as an intelligent cancer nanotheranostic platform for tracing MUC-1-overexpressed tumor cells and targeting them with great efficiency and selectivity.
Nanocarriers have received special attention in biomedicine for the treatment of various diseases, especially cancer, as one of the leading causes of death worldwide. Nanocarriers can improve the potential of contemporary strategies in cancer therapy and also provide new methods for diagnosis and biosensing. The present review focuses on the biomedical application of nanocarriers in the treatment of prostate cancer (PCa), one of the most common urological cancers in men. The chemotherapeutic and radiotherapeutic potentials in PCa may be improved using nanocarriers by providing targeted drug delivery and inducing PCa cells' sensitivity via induction of cell death. Delivery of nucleic acid drugs such as siRNA, shRNA and CRISPR/Cas9 system by nanocarriers in PCa therapy enhances the intracellular accumulation of these therapeutics and increases their efficacy in gene expression regulation. The high proliferation rate and metastasis of PCa cells result in poor prognosis. They may be dually suppressed by nanocarriers, as nanoplatforms facilitate co-delivery of drugs and gene therapeutics in PCa suppression. Selectivity toward PCa cells may be enhanced via surface modification of the nanocarriers to facilitate internalization via endocytosis. In addition to their applications for PCa treatment, nanocarriers mediate the detection of biomarkers for PCa diagnosis.
The synthesis and extensive characterization of newly developed boron nitride nanosheet (BNNSs)-reinforced WNiCoFeCr high-entropy alloys (HEAs) are presented. The influence of B4C on the structural, physical, mechanical, and nuclear shielding characteristics of synthesized HEAs has been widely examined in terms of its monotonic effects on the behavior changes. The internal morphology and structural characteristics of the fabricated composites are first investigated using X-ray diffraction, scanning electron microscopy, and energy-dispersive spectroscopy. Wear testing is used to determine the coefficient of friction as a function of sliding distance. Experimental gamma ray and neutron setups are created to determine their shielding characteristics against nuclear radiation. Finally, the shielding characteristics of nuclear radiation for gamma ray and fast neutrons are compared extensively to those of many existing and new-generation shielding materials. Among the examined samples, the S2 sample with B4C and BNNSs reinforcement had the greatest mechanical characteristics. Our findings imply that increasing B4C directly contributes to the shielding qualities of nuclear radiation. The B4C created in the structure of BNNSs contributes to the overall properties of HEAs, which are crucial for nuclear applications, since HEAs are being examined as a component of future nuclear reactors. Additionally, B4C is a very versatile material that may be used in circumstances where mechanical and nuclear shielding properties need to be enhanced for a variety of radiation energies.
Genetic heterogeneity, reduced penetrance and variable expressivity, the latter including asymmetric body axis plane presentations, have all been described in families with congenital limb malformations (CLM). Both interfamilial and intrafamilial heterogeneity highlight the complexity of the underlying genetic pathogenesis of these developmental anomalies. Family-based genomics by exome sequencing (ES) and rare variant analyses combined with whole-genome array-based comparative genomic hybridization, were implemented to investigate 18 families with limb birth defects. Eleven of 18 (61%) families revealed explanatory variants including 7 single nucleotide variant alleles and 3 copy number variants (CNVs), at previously reported ‘disease trait associated loci’: BHLHA9, GLI3, HOXD cluster, HOXD13, NPR2 and WNT10B. Breakpoint junction analyses for all three CNV alleles revealed mutational signatures consistent with microhomology-mediated break-induced replication (MMBIR); a mechanism facilitated by Alu/Alu-mediated rearrangement. Of note, homozygous duplication of BHLHA9 was observed in one Turkish kindred and represents a novel contributory genetic mechanism to Gollop-Wolfgang Complex (MIM %228250); wherein triplication of the locus has been reported in one family from Japan [i.e., 4n = 2n + 2n versus 4n = 3n + 1n allelic configurations]. In conclusion, genes acting on limb patterning are sensitive to a gene dosage effect and are often associated with an allelic series. We extend an allele-specific gene dosage model to potentially assist, in an adjuvant way, interpretations of interconnections among an allelic series, clinical severity, and reduced penetrance of the BHLHA9-related CLM spectrum.
Objective Dexpanthenol (DXP) reportedly protects tissues against oxidative damage in various inflammation models. This study aimed to evaluate its effects on oxidative stress, inflammation, apoptosis, and neurological recovery in an experimental rabbit spinal cord ischemia/reperfusion injury (SCIRI) model. Methods Rabbits were randomized into five groups of eight animals each: group 1 (control), group 2 (ischemia), group 3 (vehicle), group 4 (methylprednisolone, 30 mg/kg), and group 5 (DXP, 500 mg/kg). The control group underwent laparotomy only, whereas other groups were subjected to spinal cord ischemia by aortic occlusion (just caudal to the two renal arteries) for 20 min. After 24 h, a modified Tarlov scale was employed to record neurological examination results. Malondialdehyde and caspase-3 levels and catalase and myeloperoxidase activities were analyzed in tissue and serum samples. Xanthine oxidase activity was measured in the serum. Histopathological and ultrastructural evaluations were also performed on the spinal cord. Results After SCIRI, serum and tissue malondialdehyde and caspase-3 levels and myeloperoxidase activity and serum xanthine oxidase activity were increased (p <0.05–0.001). However, serum and tissue catalase activity decreased significantly (p <0.001). DXP treatment was associated with lower malondialdehyde and caspase-3 levels and reduced myeloperoxidase and xanthine oxidase activities but increased catalase activity (p <0.05–0.001). Furthermore, DXP was associated with better histopathological, ultrastructural, and neurological outcome scores. Conclusion This study was the first to evaluate antioxidant, anti-inflammatory, antiapoptotic, and neuroprotective effects of DXP on SCIRI. Further experimental and clinical investigations are warranted to confirm that DXP can be administered to treat SCIRI.
Ellagic acid (EA) is one of the bioactive polyphenolic flavonoids found in many fruits. Over the years, various extraction methods have been developed to isolate pure EA from plant samples. These methods, however, have some disadvantages, such as low specificity and selectivity, not easy incorporation into industrial processes, and low‐purification efficiency. The present study proposes an approach based on the molecular imprinting technique. We describe the nanoscale production of EA imprinted polymers for the first time. We develop a straightforward, efficient, and environmentally friendly precipitation polymerization method to synthesize molecularly imprinted polymer nanoparticles (nanoMIPs). To increase the affinity of nanoMIPs, we explore molecular interactions between EA and functional monomers before polymerization. The nanoMIPs are successfully synthesized with an excellent yield of 94.5%. The maximum binding capacity is 66.6 and 45.6 μmol/g for EA imprinted and nonimprinted polymers, respectively. Furthermore, in the presence of quercetin, an EA analog, and other compounds in the pomegranate peel extract solution, nanoMIPs selectively retain EA. NanoMIPs will be a valuable analytical tool for separation and sensing applications, especially dispersive solid‐phase extraction. We create molecularly imprinted nanoparticles for the recognition of ellagic acid (EA). We develop a straightforward, efficient, and environmentally friendly precipitation polymerization method to synthesize nanoMIPs. We employ nanoMIPs‐based dispersive solid‐phase extraction to extract EA from pomegranate peels.
Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive assessment to tailor-make chitosan cross-linkers of various types and functionalities as well as complex chitosan-based semi- and full-interpenetrating networks for drug delivery systems (DDSs). Herein, the various fabrication methods developed for chitosan hydrogels are deliberated, including chitosan crosslinking with and without diverse cross-linkers. Tripolyphosphate, genipin and multi-functional aldehydes, carboxylic acids, and epoxides are common cross-linkers used in developing biomedical chitosan for DDSs. Methods deployed for modifying the properties and performance of chitosan hydrogels, via their composite production (semi- and full-interpenetrating networks), are also cogitated here. In addition, recent advances in the fabrication of advanced chitosan hydrogels for drug delivery applications such as oral drug delivery, transdermal drug delivery, and cancer therapy are discussed. Lastly, thoughts on what is needed for the chitosan field to continue to grow is also debated in this comprehensive review article.
Hyper immunoglobulin M (HIGM) syndrome is a rare disorder of the immune system with impaired antibody functions. The clinical picture of the patients varies according to the underlying genetic variation. In this study, we identified two novel variants in AID and UNG genes, which are associated with autosomal recessive type HIGM, by targeted next-generation sequencing (NGS) panel. A biallelic 11 base pair deletion (c.278_288delATGTGGCCGAC) in the coding sequence of activation-induced cytidine deaminase (AID) gene was identified in a 36-year-old patient. Biallelic two base pair insertion in exon 7 of uracil nucleoside glycosylase (UNG) gene (c.924_925insGG) was identified in a 40-year-old patient. Both variants were confirmed by Sanger sequencing. HIGM, like many of the other primary immunodeficiencies, is a rare and difficult-to-diagnose entity with heterogeneous clinical phenotypes. It should be suspected in patients with a history of early-onset recurrent respiratory infections, enlarged lymph nodes, and autoimmune disorders. There might be a delay in diagnosis until adulthood especially in subtle cases or if HIGM is not included in the differential diagnosis due lacking of awareness. In this regard, genetic testing with NGS-based diagnostic panels provide a rapid and reasonable tool for the molecular diagnosis of patients with immunodeficiencies and hence, decrease the time to diagnose and prevent infection-related complications associated with increased morbidity and mortality.
Research on developing new methodologies on environmentally conscious manufacturing and way of reducing environmental impacts on product design was started over two decades ago. Environmentally conscious manufacturing has become a challenge to the environment and to the society itself, enforced primarily by government regulations and the customer expectation on environmental issues. In both industry and academics, there is a sizable following for environmental-related issues which are aimed at finding answers to the problems that arise in this newly emerged area. Problems are widespread including the ones related to the life cycle of products, disassembly, material recovery, and remanufacturing and pollution prevention. Only very few researchers have concentrated on ecofriendly products. This paper investigates the literature by classifying more than 200 published references into four categories, viz., design for environment checklist, environmentally conscious manufacturing, life cycle analysis, and material selection.
PurposeThis study aimed to evaluate Artificial Neural Network (ANN) modeling to estimate the significant dose length product (DLP) value during the abdominal CT examinations for quality assurance in a retrospective, cross-sectional study.Methods The structure of the ANN model was designed considering various input parameters, namely patient weight, patient size, body mass index, mean CTDI volume, scanning length, kVp, mAs, exposure time per rotation, and pitch factor. The aforementioned examination details of 551 abdominal CT scans were used as retrospective data. Different types of learning algorithms such as Levenberg-Marquardt, Bayesian and Scaled-Conjugate Gradient were checked in terms of the accuracy of the training data.ResultsThe R-value representing the correlation coefficient for the real system and system output is given as 0.925, 0.785, and 0.854 for the Levenberg-Marquardt, Bayesian, and Scaled-Conjugate Gradient algorithms, respectively. The findings showed that the Levenberg-Marquardt algorithm comprehensively detects DLP values for abdominal CT examinations. It can be a helpful approach to simplify CT quality assurance.Conclusion It can be concluded that outcomes of this novel artificial intelligence method can be used for high accuracy DLP estimations before the abdominal CT examinations, where the radiation-related risk factors are high or risk evaluation of multiple CT scans is needed for patients in terms of ALARA. Likewise, it can be concluded that artificial learning methods are powerful tools and can be used for different types of radiation-related risk assessments for quality assurance in diagnostic radiology.
The overmolding of short fiber reinforced polymer compounds onto continuous fiber reinforced composite substrates provides design flexibility and the ability to tailor stiffness, strength, and damage tolerance for structural applications. In this work, a novel molding approach that enhances the bonding strength by mechanical interlocking is presented. The effectiveness of the proposed approach was validated by characterization of the bonding strength between a short glass fiber PP (SGFPP) composite overmolded onto a continuous glass fiber reinforced PP (CGFRPP) prepreg. Enhancement of the bonding strength was achieved by judiciously drilling tapered holes on the CGFRPP substrate before molding, which facilitated better interlocking with the injection molded SGFPP composite. The overmolding of preheated composites with tapered holes yielded up to 60% improvement in bonding strength. In general, having multiple holes helped improve bonding up to certain hole diameter. Similarly, preheating of the substrate over a short time improved the interfacial adhesion, while extended preheating resulted in a reduction of bonding quality. SEM analysis of the fracture surfaces after the tensile debonding test revealed that the SGFPP filled the holes on the substrate during overmolding. Preparation of overmolded composit.
Platelets play a role in hemostasis, thrombosis, and vascular integrity. They also play a major role in the development of inflammation and the activation of immune responses. They have phagocytic activity, stimulate the secretion of immune modulators, and activate other immune cells, which results in platelet-neutrophil aggregation, platelet-induced neutrophil degranulation, and the formation of neutrophil extracellular traps. Data on 124 febrile neutropenia attacks were retrospectively examined. Patients' age, sex, diagnosis, and relapse history were obtained. The complete blood count levels on the first and last febrile day of the febrile neutropenia attacks, duration of fever, and number, type, and timing of thrombocyte suspension transfusions were recorded. The patients were divided into three groups according to the day of fever when the platelet suspension was administered (1 day, 2-3 days, and >3 days); the duration of fever was compared between the three groups. The fever duration of those who were transfused with platelet suspension on the first day of fever was found to be significantly shorter (p = 0.03 and p < 0.001, respectively). When treating a patient with febrile neutropenia, if thrombocyte suspension transfusion is indicated, transfusing thrombocytes in the first days of fever shortens the fever duration and improves the prognosis of febrile neutropenia attack, supporting the hypothesis that not only neutrophils but also platelets may play a role in fighting against microorganisms.
Objective The aim of this study was to investigate the effects of EMG-driven robotic rehabilitation on hand motor functions and daily living activities of patients with acute ischemic stroke. Materials & Method A preliminary randomized-controlled, single-blind trial rectuited twenty-four patients with acute ischemic stroke (<1 month after cerebrovascular accident) and randomly allocated to experimental group (EG) and control group (CG). Neurophysiological rehabilitation program was performed to both EG and CG for 5 days a week and totally 15 sessions. The EG also received robotic rehabilitation with the EMG-driven exoskeleton hand robot (Hand of Hope®, Rehab-Robotics Company) 15 sessions over 3 weeks. Hand motor functions (Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT)), activities of daily living (Motor Activity Log (MAL)), force and EMG activities of extensor and flexor muscles for the cup test were evaluated before treatment (pretreatment) and after the 15th session (posttreatment). Results Eleven patients (59.91 ± 14.20 yr) in the EG and 9 patients (70 ± 14.06 yr) in the CG completed the study. EG did not provide a significant advantage compared with the CG in FMA-UE, ARAT and MAL scores and cup-force and EMG activities (p > .05 for all). Conclusion In this preliminary study, improvement in motor functions, daily living activities and force were found in both groups. However, addition of the EMG-driven robotic treatment to the neurophysiological rehabilitation program did not provide an additional benefit to the clinical outcomes in 3 weeks in acute stroke patients.
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664 members
Nuri Faruk Aykan
  • Medical School
Farzad Kiani
  • Department of Computer Engineering
Sibel Ertek
  • Internal Medicine Department
Taşdemir Mehmet
  • School of Medicine Pediatric Nephrology
Serbülent Gökhan Beyaz
  • Department of Anesthesiology and Pain Medicine
Maltepe Neighbourhood, Teyyareci Sami Street, 34010, Istanbul, Istanbul, Turkey
Head of institution
Erdal Karaöz
+90850 283 6000