Recent publications
Novel four MBTOB-bridged ball-type metallophthalocyanines were obtained from 4,4′-((methylenebis(6-(2H-benzo[d][1, 2, 3]triazol-2-yl)−4-(2,4,4-trimethylpentan-2-yl)−2, 1-phenylene))bis(oxy))diphthalonitrile by means of transition metal (II) acetate salts in 2-dimethylaminoethanol. The new starting bisphthalonitrile compound was accomplished from 2,2′-methylenebis[6-(benzotriazol-2-yl)−4-tert-octylphenol] and 4-nitrophthalonitrile in dimethylformamide under the catalysis of potassium carbonate at 50 °C. The structural characterization of the compounds was accomplished by infrared, proton-nuclear magnetic resonance, matrix-assisted laser desorption/ionisation time-of-flight mass, and ultraviolet–visible spectroscopic methods. The supercapacitor performances of the electrodes were examined by cyclic voltammetry, galvanostatic charge discharge, and electrochemical impedance spectroscopy analyses. The specific capacitances obtained from the GCD measurements were calculated as 320.4 ± 15.1 F g⁻¹ for ball-type zinc (II) phthalocyanine in three electrode systems. The highest specific capacitance value was found in the electrode containing ball-type nickel (II) phthalocyanine as 929.8 ± 32.8 F g⁻¹ at a scan rate of 100 mV s⁻¹. In symmetric supercapacitor measurements, the capacitance retention value was 100.7% after 5000 cycles.
There is growing interest in the association between COVID-19-related stressors and quality of life. This study aimed to extend current knowledge by investigating the potential mediating roles of COVID-19 anxiety and COVID-19 burnout in the association between fear of COVID-19 and COVID-19 quality of life in nurses. A total of 300 nurses were selected by convenience sampling approach from a training and research hospital serving as a pandemic hospital in Turkey. COVID-19 anxiety, COVID-19 burnout, and COVID-19 quality of life data were collected using the self-reported questionnaires using both online and paper-and-pencil versions of the questionnaires. Structural equation modeling was used to conduct serial multiple mediation analysis. We found statistically significant associations among fear of COVID-19, COVID-19 anxiety, COVID-19 burnout, and COVID-19 quality of life. Serial multiple mediation analysis revealed that the association of fear of COVID-19 with COVID-19 quality of life was partially mediated by COVID-19 anxiety and COVID-19 burnout. These results indicate that the association of fear of COVID-19 with COVID-19 quality of life in nurses may be changed through COVID-19 anxiety and COVID-19 burnout, which appear to play serial multiple mediating roles in this association. These findings enrich our understanding of the associations among these psychological factors and suggest that focusing solely on fear of COVID-19 without considering the mediating effects of COVID-19 anxiety and COVID-19 burnout might not be adequate for reducing the COVID-19–impact on the quality of life among nurses.
In this perspective, we present and discuss four major causes of the worldwide nature conservation failure: 1) ideologies based on nature–culture dualism, 2) the bias prioritising forests in conservation, 3) the illusory objectiveness of selected biological indicators, and 4) the mismanagement of rural agricultural landscapes. All of these relate to ignorance of historical ecology and neglect of the role past plays in shaping landscapes and fostering biodiversity. These led to a false anthropology focussed on the broader human economy (including agriculture) as the absolute culprit of biodiversity loss. It is believed, therefore, that biodiversity preservation depends on conservation policies and actions providing protection against human activities, such as farming. In this way, nature conservation has been detached from the rich experiences of long and fruitful coexistence of people with other elements of nature. The bio-cultural legacy includes biodiversity-rich rural landscapes, whose habitats are often either neglected or wrongly interpreted as “remnants of natural ecosystems”. Consequently, conservation efforts are frequently ineffective or worse still, counter-effective. In the face of policies favouring subsidised intensive agribusiness at the cost of destroying smallholder family farming, even expensive conservation projects are usually nothing more than a “fig leaf” to cover failure. We advocate re-focussing of conservation planning to put more emphasis on landscapes’ historical ecology responsible for their bio-cultural diversity. It implies the need for new principles in policies necessary to secure the economic and cultural sovereignty of local socio-ecological systems responsible for the world’s bio-cultural diversity.
Background
The need for predictive factors regarding the response to immune checkpoint inhibitors (ICIs) is increasing. Recent research indicates that an enhanced response to ICIs is associated with a higher body mass index (BMI). This study aims to evaluate the relationship between response to ICIs and BMI in solid tumors.
Methods
We retrospectively analyzed patients with advanced cancer treated with ICIs at one academic center. We compared the treatment responses of patients classified as underweight/normal weight (BMI <25) and overweight/obese (BMI ⩾ 25) according to their BMI at the initiation of ICI treatment. After excluding underweight patients, we also compared the progression-free survival (PFS) and overall survival (OS) of normal-weight, overweight, and obese patients.
Results
Overall, 113 patients were evaluated. Forty-seven (41.6%) patients had BMI <25 and 66 (58.4%) patients had a BMI ⩾ 25. In underweight/normal patients, median PFS was 7.7 months (95% CI: 4.7-10.6) while it was 8.0 months (95% CI: 4.1–11.9) in overweight/obese patients (HR 1.16, 95% CI: (0.76-1.75), p=0.477). In underweight/normal patients, the median OS was 21.7 months (95% CI: 11.6-31.7) compared to 18.7 months (95% CI: 12.7-24.6) in overweight/obese patients (HR 1.06, 95% CI: (0.69-1.64), p=0.774). The objective response rate (ORR) was 38.3% in underweight/normal patients and 34.8% in overweight/obese patients (p = 0.707). After excluding underweight patients, there were also no significant differences in PFS (p = 0.914), OS (p = 0.642), and ORR (p = 0.909) between patients of normal weight, overweight, and obesity.
Conclusion
Our research found no correlation between BMI and response to ICIs. Additional prospective studies are necessary to assess the effect of BMI on the response to ICIs.
Current treatment strategy for managing Weber B ankle fractures is mainly governed by mortise congruency, malleolar alignment, deltoid ligament competence and fracture stability. While nonoperative treatment has yielded good functional outcomes in satisfactorily aligned stable injuries, a biomechanical rationale is not firmly established. Furthermore, current radiographic analysis is obscured by observer inaccuracy and beam rotation. This study aimed to utilize weightbearing CT and computational biomechanics to analyse 3D mortise displacement and contact mechanics in Weber-B ankle fractures and compare them with the uninjured contralateral side. 32 patients were included who sustained a Weber-B ankle fracture and underwent bilateral weightbearing CT imaging at injury. Segmentation into 3D models of bone was performed semi-automatically, and individualized cartilage layers were modeled based on a previously validated methodology. The 3D mortise congruency was evaluated by use of following parameters: alpha angle, fibular length, talocrural angle, medial gutter- and tibiofibular clear space- distance mapping. Contact mechanics were evaluated by the mean and maximum contact stress of the tibiotalar articulation. Statistical analysis revealed that there were no significant differences for all anatomical parameters. There was also no significant difference between the mean contact stress of the injured (2.10 ± 0.42 MPa) and uninjured side (2.10 ± 0.41 MPa), nor the maximum contact stress of the injured (7.67 ± 1.55 MPa) and uninjured (7.47 ± 1.67), respectively. Contact mechanics were unaffected in congruent Weber-B fractures. These findings support consideration of nonoperative management in such cases, given their presumably low risk for posttraumatic arthritic development in the long term.
Level of Evidence: Level III; retrospective case-control study.
Background
This study was designed to investigate the effects of different housing systems on production performance, egg quality and welfare in laying hens.
Methods
One hundred and twenty 42‐week‐old “Atak S” laying hens, purchased from a manufacturing company, were randomly assigned to 4 housing systems: conventional cages, furnished cages, deep‐litter system and free‐range. Each system housed 30 hens, which were kept in these systems for 6 weeks. Parameters regarding production performance, egg quality, plumage condition scores and tonic immobility were assessed at the end of the housing period.
Results
Egg production and egg mass were lower in cage‐free rearing systems than in caged systems. Mean egg weight in free‐range hens, and albumen height and Haugh unit in deep‐litter hens, were lower than in other housing systems. Eggshell weight in hens housed in furnished cages was greater than in free‐range hens, while eggshell strength was better compared to that of hens in conventional cages. The housing system did not impact fearfulness; however, the deep‐litter housing increased the sensitivity to touch or capture. Whole body and regional plumage condition scores of free‐range hens elicited more favourable results than those kept in conventional cages. Because the plumage condition indicates welfare, the results proved the superiority of free‐range over conventional rearing regarding welfare.
Conclusions
Concerning the parameters, such as egg production, animal welfare and fear level, overall data revealed the pros and cons of all housing systems investigated. We consider that this study's findings might contribute to the researchers and breeders seeking alternative housing for laying hens.
Aim
To examine the relationship between perceived social support level and depression, anxiety and stress in pregnant women diagnosed with foetal anomaly.
Design/Methods
This descriptive and correlational study was conducted in an advanced prenatal evaluation unit of a university hospital between December 2021 and May 2022. The study data collected from 131 pregnant women through a personal information form, depression, anxiety and stress scale (DASS‐42) and multidimensional scale of perceived social support (MSPSS).
Results
Most of the pregnant women were in the second trimester of pregnancy, and more than half had been advised by a healthcare professional to terminate their pregnancy. Overall, the pregnant women reported moderate levels of social support, while their depression, anxiety and stress levels varied. There was a weak negative correlation between perceived social support from family, friends and multidimensional sources with stress, but the effect rate was low.
Conclusion
Most pregnant women diagnosed with foetal anomaly have normal levels of depression, stress and anxiety. There is a weak negative correlation between perceived social support and stress, with family and friend support affecting stress levels at a low rate. Professional support should be provided, and both the woman's mental health and social support mechanisms must be evaluated.
Impact
This study highlights the importance of social support in managing stress among pregnant women with foetal anomalies. While most women had normal levels of depression, anxiety and stress, increased social support from family and friends was shown to reduce stress. The findings underscore the need for healthcare professionals to assess and strengthen mental health and social support systems in this vulnerable population, informing interventions to improve psychosocial outcomes.
Reporting Method
This descriptive and correlational study adhered to the CONSORT guidelines for reporting non‐randomised trials.
Patient or Public Contribution
No patient or public contribution.
As the world still vividly recalls the previous monkeypox (mpox) outbreak that impacted over 120 countries worldwide with more than 99,000 cases in 2022, we are now facing a second wave of infections from the monkeypox virus (MPXV), characterized by an exponential increase in cases. The current 2024 outbreak has already recorded more than 20,000 cases in Africa, marking a dramatic escalation compared to previous outbreaks. The predominance of the newly identified clade Ib variant, first detected in the Democratic Republic of the Congo (DRC) and now identified across multiple African nations and beyond, underscores its enhanced transmissibility and potential for international spread, evidenced by cases in Sweden and Thailand. The World Health Organization (WHO) declared on August 14, 2024, the current mpox outbreak a Public Health Emergency of International Concern (PHEIC), calling for heightened global public health measures. The ongoing pattern of unusual, frequent, and extensive outbreaks of mpox with potential global implications poses significant questions. This review addresses, in the format of 50 questions and answers, the 2024 mpox outbreak, detailing its characteristics, epidemiological data, and impact compared to previous outbreaks. It comprehensively explores critical questions related to MPXV virological characteristics, immunological response, clinical manifestations, epidemiology, diagnostics, and available treatments. The review also documents the significant and evolving challenges posed by the current mpox outbreak, highlighting its scale, spread, and public health response.
In the past decade, there have been substantial changes in diagnostic nomenclature. This study investigated sex differences in attention-deficit/hyperactivity disorder (ADHD) symptom severity based on Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV, DSM-IV(TR), and DSM-5 criteria, separating rating scale and clinical interview data in children and adults with ADHD. PubMed, PsycINFO, and Scopus were searched for published studies (1996–2021) reporting severity of attention, and hyperactivity/impulsivity in males and females. We compared data: (1) across the entire lifespan aggregating rating scale and clinical interview data (51 studies), (2) drawing solely on rating scale data (18 studies), and (3) drawing solely on clinical interview data (33 studies). Fifty-two studies met inclusion criteria comparing data for females ( n = 8423) and males ( n = 9985) with ADHD across childhood and/or adulthood. In total, 15 meta-analyses were conducted. Pooled data across the lifespan aggregating both rating scale and clinical diagnostic interview data, showed males had significantly more severe hyperactivity/impulsivity symptoms than females. Rating scale data were similar; boys had significantly more severe hyperactivity/impulsivity than girls. In adulthood, men were rated to have significantly more severe inattention than women with no difference in the hyperactivity/impulsivity dimension. All significant differences were of small effect size. No significant sex differences in the severity of symptoms emerged for clinical interview data for children or adults, in contrast. Possible reasons for the discrepancy in findings between rating scales and clinical diagnostic interviews are discussed.
Restless legs syndrome is usually associated with periodic limb movements during sleep, which are defined as repetitive, stereotyped movements in sleep. Changes in spectral analysis of electroencephalography and heart rate were shown to be associated with periodic limb movements during sleep and non‐periodic leg movements in sleep. Considering the circadian distribution of symptoms of restless legs syndrome, we investigated spectral electroencephalography and heart rate accompanying periodic limb movements, isolated leg movements and short‐interval leg movements during suggested immobilization test. The mean age of 53 patients was 51.9 ± 13 years, 54.7% were females. Prominent increases in electroencephalography activation were associated with periodic limb movements, isolated leg movements and short‐interval leg movements during the suggested immobilization test, which were significant in all spectral bands ( p < 0.001). An increase in all electroencephalography bands started ~10 s before periodic limb movements, isolated leg movements and short‐interval leg movements; increases in delta and theta band activities ended ~10 s after the movements, while increases in alpha and beta band activities lasted for about ~20 s. Maximum increases in delta, theta, alpha and beta bands were all observed after periodic limb movements and short‐interval leg movements, but before isolated leg movements in theta and alpha bands, and after isolated leg movements in delta and beta bands. A notably longer increase in alpha and beta bands was evident for periodic limb movements and short‐interval leg movements. An increase in heart rate was prominent at 4–12 s after movement onset in short‐interval leg movements, being significantly higher than those associated with periodic limb movements and isolated leg movements. Our study shows that, in patients with restless legs syndrome, periodic limb movements, isolated leg movements and short‐interval leg movements during suggested immobilization test are associated with prominent cortical and cardiac activation, which warrants confirmation in larger restless legs syndrome cohorts and requires long‐term follow‐up studies to delineate its possible clinical consequences.
This paper presents a new voltage-mode instrumentation amplifier circuit that employs two current-feedback operational amplifiers (CFOAs) and three grounded resistors. The ideal and non-ideal analyses of the proposed circuit are presented. SPICE simulations with 0.18 µm TSMC CMOS process parameters are conducted to validate the theoretical analyses. The proposed circuit provides a high differential-mode gain (40 dB) and high bandwidth (23.13 MHz). Moreover, the common-mode rejection ratio (CMRR) is also high (60.23 dB), with a CMRR bandwidth of 1.07 MHz. The supply voltage is ± 1.25 V, and the total power consumption is found to be low at 0.954 mW. The robustness of the circuit is confirmed through simulations, and its performance against Process-Voltage-Temperature (PVT) variations is also examined. A key advantage of the proposed circuit is its ability to be easily implemented using commercially available integrated circuits, such as the AD844, which underscores its practical superiority over current-mode designs in terms of simplicity and accessibility. Additionally, the proposed circuit has been experimentally tested using these commercially available ICs.
Purpose
Non-selective closed kinetic chain exercises (NSKCE) and or selective closed kinetic chain exercises (SCKCE) has been shown to increase Vastus medialis obliquus (VMO) muscle power in patellofemoral pain syndrome (PFPS). However, the superiority of the exercises to each other has not been shown. This study aimed to evaluating the effects of different exercises on the stiffness of the VMO and vastus lateralis (VL) muscles, pain management, functional scores, and thigh circumferences.
Methods
One hundred 60 knees of 80 patients followed up in our outpatient clinic between December 2016 and February 2018 were included in the study. Patients were divided into two groups as 40 patients with single-sided PFPS (20 male and 20 female patients) and 40 healthy controls (20 male and 20 female patients). The patients in each group were divided into subgroups according to NSCKCE or SCKCE. VMO and VL muscles were measured by shear wave elastography (SWE) before and after a 6-weeks therapy.
Results
There was a significant decrease in Visual Analog Scale (VAS) score while a significant increase was found in Lysholm Knee Scale (LKS), however, no statistically difference was found between the two exercise groups in PFPS patients. The effect of both exercises on pain and functional improvement was similar.
Conclusion
Decrease in VAS scores, increase in LKS scores, increase in thigh circumference measurements, and increase in the stiffness of VMO and VL muscles were observed in both groups who received SCKCE and NSCKCE on PFPS patients.
Trial Registration
Study registered at ClinicalTrials.gov (registration number: NCT05427357).
Design
Randomized controlled trial.
Purpose: Despite dramatic medical advances over the last few decades, cardiovascular disease remains a leading cause of death globally. High BP is clearly established, but modifiable, risk factor for early disability and death. Although most of the adverse outcomes occur in adulthood it has become clear that high BP is a life course problem that can become evident in early life however, relatively little attention has been paid to the problem of high BP in children and adolescents. Materials and methods: Being aware of the problem and the needs, the Task Force of the ESH Guidelines in children and adolescents took the initiative to move forward in the field, identifying the COST Action program. A proposal, HyperChildNET, was submitted, approved and funded for 4 years starting in October 2020. Results: The aim of the Action has been to establish a European sustainable and multidisciplinary network of researchers, clinicians, early career investigators, health economists, decision-makers, regulatory bodies, and medical devices manufacturers under the umbrella of the European Commission in order to acquire a holistic understanding of those factors affecting high BP in children and adolescents in order to propose and implement preventive and corrective actions. All the activities carried out during the 4 years are described. Conclusions: HyperChildNET offers a European perspective of the issue giving us the opportunity to develop new strategies and objectives moving forward in the field.
Pulmonary embolism is a complication of COVID-19 infection. The aim of this study is to assess prognosis and treatment response, including incidences of chronicity, relapse, and mortality among outpatients diagnosed with COVID-19-related pulmonary embolism between 2020 and 2022. A total of 101 patients with pulmonary embolism, started on anticoagulation during or within a month of COVID-19 infection, were included after testing positive by PCR. Data about comorbidities, Pulmonary Embolism Severity Index scores, PE diagnostic modalities, biochemical parameters, and transthoracic echocardiographic findings at diagnosis and at 24-month follow-up were collected. Cardiac catheterization parameters were recorded and compared between groups at diagnosis and at the 24-month follow-up. Groups were comparable with respect to gender, age, body mass index, and comorbidity score. Use of Q-SPECT for diagnosis was found significantly higher in patients with COVID-19-related pulmonary embolism ( P < .001). The incidence of deep vein thrombosis was similar. In the study group, 43.6% of patients received anticoagulants for 3 months, with 49.1% using low molecular weight heparin and 50.9% using direct oral anticoagulants. At 24 months, rate of patients continuing treatment was comparable between groups. Specific pulmonary artery blockage value was found to be higher in patients with chronic thromboembolic pulmonary hypertension compared to those who demonstrated a response to pulmonary embolism treatment ( P = .009). No adverse effects of anticoagulant therapy were observed during course of treatment. Over 24-month follow-up period, mortality, relapse, chronic thromboembolic hypertension and thromboembolic disease was observed in 2%, 2.2%, 4.9%, and 9.9% of patients, respectively.
Background
In the multicohort phase 2 KEYVIBE-005 study (NCT05007106), the antitumor activity of vibostolimab (anti-T-cell immunoreceptor with Ig and ITIM domains [TIGIT]) coformulated with pembrolizumab (anti–PD-1; vibostolimab/pembrolizumab) was demonstrated in patients with previously treated advanced mismatch repair–deficient (dMMR) endometrial cancer (cohort B1; n = 40; ORR, 64%) and in patients with previously untreated advanced esophageal cancer treated with vibostolimab/pembrolizumab plus 5-fluorouracil and cisplatin (cohort E; n = 40; ORR, 53%). In this exploratory analysis, we evaluated the association between biomarkers and response to study treatment.
Methods
Evaluable pretreatment tumor samples from patients enrolled in cohorts B1 and E were analyzed. Immunohistochemistry was used to measure TIGIT (clone SP410, formulation locked assay) and PD-L1 (per combined positive score using PD-L1 IHC 22C3 pharmDx) expression. RNA NanoString was used to assess T-cell–inflamed gene expression profile (TcellinfGEP), TIGIT, and poliovirus receptor (PVR) expression. A Spearman correlation was used to assess the relationship between the proportion of total immune cells (ICs) and TIGIT-positive ICs, and association was evaluated using a box plot of each biomarker by responder status. Area under the receiver operating characteristics curve (AUROC) was also estimated when sample size was sufficient. Clinical data cutoff was May 8, 2023.
Results
In cohort B1, TIGIT IHC was evaluable in 35 patients (88%), PD-L1 in 39 patients (98%), TcellinfGEP in 20 patients (50%), and TIGIT RNA and PVR in 19 patients (48%). There was a correlation between total ICs and TIGIT-positive ICs (ρ = 0.62). The AUROC for discriminating TIGIT IHC, PD-L1, and TcellinfGEP as predictors of response were 0.51 (95% CI, 0.27–0.76), 0.65 (0.44–0.85), and 0.38 (0.08–0.69), respectively. No clear relationships between TIGIT RNA and PVR and response were observed. In cohort E, TIGIT IHC was evaluable in 34 patients (85%), PD-L1 in 35 patients (88%), and TcellinfGEP, TIGIT RNA, and PVR in 11 patients (28%). A correlation was observed between total ICs and TIGIT-positive ICs (ρ = 0.64). The AUROCs for discriminating TIGIT IHC and PD-L1 as predictors of response were 0.49 (95% CI, 0.27–0.70) and 0.62 (0.41–0.82), respectively. No relationships between TcellinfGEP, TIGIT RNA, and PVR and response were observed.
Conclusions
We observed a trend between PD-L1 expression and response in patients with advanced dMMR endometrial cancer treated with vibostolimab/pembrolizumab as well as patients with advanced esophageal cancer treated with vibostolimab/pembrolizumab plus 5-fluorouracil and cisplatin. TIGIT IHC, TcellinfGEP, TIGIT RNA, and PVR were not associated with response.
Acknowledgements
Medical writing and/or editorial assistance was provided by Mehak Aggarwal, PharmD, and Holly C. Cappelli, PhD, CMPP, of ApotheCom (Yardley, PA, USA). This assistance was funded by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.
Trial Registration
clinicaltrials.gov, NCT05007106.
Ethics Approval
The study protocol and all amendments were approved by the institutional review board or ethics committee at each institution.
Consent
All patients provided written informed consent.
Background:
Acute appendicitis is a common surgical emergency that causes acute abdominal pain and affects approximately 7-8% of the population during their lifetime. The closure of the appendix stump during laparoscopic appendectomy is one of the most critical steps of the surgery to prevent life-threatening complications such as postoperative fistula, peritonitis, and sepsis. The mate-rial chosen for appendix stump closure must be effective, safe, and economical. However, there is still no consensus on the optimal method for stump closure. In this study, we aimed to compare the advantages and reliability of three different methods used for appendix stump closure.
Methods:
At Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Department of General Surgery, cases that underwent laparoscopic appendectomy for acute appendicitis between January 2022 and April 2024 were retrospectively analyzed using the hospital's data system. The patients' demographic data, laboratory values, pathology reports, surgical notes, duration of hospital stay, duration of surgery, total hospital costs, complications related to the surgery within 30 days postoperatively, and the management of these complications were examined.
Results:
The study included a total of 150 individuals, with 83 (55.33%) males and 67 (44.67%) females. The average age of the participants was 38.45±14.48 years. In terms of the materials used for stump closure, endoloop was used in 82 (54.67%) cases, Hem-o-lok clip in 30 (20.00%) cases, and endostapler in 38 (25.33%) cases. In 144 (96%) cases, no Clavien-Dindo (CD) complications were observed, while complications occurred in six (4%) cases. These six complications included two intra-abdominal abscesses (CD Grade 3), two wound infections (CD Grade 1), one case of bleeding (CD Grade 2), and one pulmonary embolism (CD Grade 4).
Conclusion:
The use of endoloop, polymeric clips, and endostapler in laparoscopic appendectomy is safe and effective for appendectomy. All three methods can be successfully applied without an increase in intraoperative or postoperative complications. However, due to the higher treatment costs associated with endostapler, its use should be reserved for situations where securing the appendix stump cannot be achieved with endoloop or Hem-o-lok clip.
Dynamic impacts such as wind and earthquakes cause loss of life and economic damage. To ensure safety against these effects, various measures have been taken from past to present and solutions have been developed using different technologies. Tall buildings are more susceptible to vibrations such as wind and earthquakes. Therefore, vibration control has become an important issue in civil engineering. This study optimizes tuned mass damper inerter (TMDI) using far-fault ground motion records. This study derives the optimum parameters of TMDI using the Adaptive Harmony Search algorithm. Structure displacement and total acceleration against earthquake load are analyzed to assess the performance of the TMDI system. The effect of the inerter when connected to different floors is observed, and the results are compared to the conventional tuned mass damper (TMD). It is indicated that the case of connecting the inerter force to the 5th floor gives better results. As a result, TMD and TMDI systems reduce the displacement by 21.87% and 25.45%, respectively, and the total acceleration by 25.45% and 19.59%, respectively. These percentage reductions indicated that the structure resilience against dynamic loads can be increased using control systems.
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