Istanbul Medeniyet Universitesi
Recent publications
This research aimed to study consumers’ trends and the consumption of foods obtained through organic farming in two different countries, Portugal and Turkey. A questionnaire survey was used, applied through internet tools as a result of COVID-19 pandemic restrictions. For the treatment of data, we used basic statistics complemented with a tree classification, aimed at evaluating the influence of sociodemographic factors on the knowledge about this type of food. The results showed that the consumption patterns are relatively similar in both countries, with many participants consuming organic foods, especially vegetables and fruits, consuming them mostly two or three meals per week. The strongest motivations to consume organic foods include benefits for human health and lower environmental impacts, while the most substantial reason not to consume is the higher price. It was also found that in both countries, people have good knowledge about the advantages of organic foods over conventional ones. Finally, the perception of the value attributed by society to organic foods was considerably higher in Portugal. These results confirm the apparent trend of making more sustainable food choices, which is motivated by the perceived negative impact of conventional agriculture on ecosystems and health.
TPS3639 Background: Robust clinical activity has been observed with anti–PD-1 pembrolizumab (pembro) in patients (pts) with dMMR/MSI-H metastatic CRC tumors. However, given the response rate of 45% with first-line pembro demonstrated in KEYNOTE-177, there is room for improvement. Adding a second checkpoint inhibitor targeting a different pathway such as CTLA-4, LAG-3, TIGIT, or ILT4 may improve the efficacy of PD-1 inhibition. This ongoing, open-label, multicenter, multiarm, randomized, phase 2 trial (NCT04895722) will evaluate efficacy and safety of coformulated pembro and anti–CTLA-4 quavonlimab compared with pembro monotherapy in chemotherapy-refractory stage IV dMMR/MSI-H CRC in cohort A; the study will also evaluate the efficacy and safety of 4 pembro-based combinations (coformulation of pembro with either quavonlimab, anti–LAG-3 favezelimab, or anti-TIGIT vibostolimab; anti-ILT4 MK-4830 given sequentially with pembro) compared with pembro monotherapy in previously untreated stage IV dMMR/MSI-H CRC in cohort B. Methods: Pts aged ≥18 y with histologically confirmed stage IV dMMR/MSI-H CRC who have measurable disease per RECIST v1.1 by investigator and confirmed by blinded independent central review (BICR), will be enrolled. Pts in cohort A must have experienced PD after fluoropyrimidine, irinotecan, and oxaliplatin, with or without anti-VEGF antibody, and anti-EGFR antibody for pts with left-sided tumors that are RAS WT. Pts in cohort B will not have been previously treated for metastatic disease. Additional eligibility criteria include ECOG PS 0 or 1, adequate organ function, and availability of archival or newly obtained tissue sample. Pts with autoimmune disease, active CNS metastases, and those who received systemic therapy within 4 wks or radiotherapy within 2 wks before intervention will be excluded. Pts in cohort A will be randomly assigned 1:1 to receive either coformulated quavonlimab 25 mg/pembro 400 mg IV Q6W or pembro 400 mg IV Q6W. Pts in cohort B will be randomly assigned 1:1:1:1:1 to receive coformulated quavonlimab 25 mg/pembro 400 mg IV Q6W, favezelimab 800 mg/pembro 200 mg IV Q3W, vibostolimab 200 mg/pembro 200 mg IV Q3W, MK-4830 800 mg + pembro 200 mg IV Q3W (given sequentially), or pembro 400 mg IV Q6W. Pts will be stratified by RAS mutation (mutant vs WT). Treatment will continue for ≤2 y or until unacceptable toxicity, disease progression, confirmed CR (after ≥6 mo of study treatment and pts have received ≥6 wk of treatment after initial CR), or withdrawal from study. Disease assessment by CT or MRI will be performed Q9W. For both cohorts, primary end point is ORR by BICR per RECIST v1.1; secondary end points are ORR assessed by investigator, DOR and PFS assessed by BICR and by investigator per RECIST v1.1, OS, and safety and tolerability graded per NCI CTCAE v5.0. Enrollment in this trial is ongoing. Clinical trial information: NCT04895722.
In this study, we have synthesized unique Mn0.5Zn0.5ErxYxFe1.8-2xO4 (x ≤ 0.1) SFNPs via ultrasonication (sonochemical) approach. Electrical and dielectric features of Mn0.5Zn0.5ErxYxFe1.8-2xO4 SFNPs were inspected comprehensively using impedance spectroscopy up to 3.0 MHz from 20 to 120 °C for a various substitution ratio of Er³⁺ and Y³⁺ ions. The fundamental electrical and dielectric parameters which are AC/DC conductivity, activation energy, dielectric loss, dielectric constant, and tangent loss were studied in the determined frequency and temperature ranges. The experimental results showed that ac conductivity obeys the power law equation and the value of n changes considerably with the co-substitution of Er³⁺ and Y³⁺ ions in various ratios, however, exhibiting some dependencies over a given temperature range. The DC conductivity and activation energy curves show a significant variation with temperature and co-substitutional ratios of Er³⁺ and Y³⁺ ions. The conduction mechanisms can essentially be assigned to the grain–grain boundaries. Therefore, frequency-dependent dielectric properties of Mn0.5Zn0.5ErxYxFe1.8-2xO4 SFNPs can be described by means of the Koop's model. It is revealed that conductivity and dielectric properties of Mn0.5Zn0.5ErxYxFe1.8-2xO4 SFNPs are adjustable with co-substitutional ratios of Er³⁺ and Y³⁺ ions.
Shape-persistent macrocycles enable superior control on molecular self-assembly, allowing the preparation of well-defined nanostructures with new functions. Here, we report on anionic amphiphilic calixarenes of conic shape and their self-assembly behavior in aqueous media for application in intracellular delivery of peptides. Newly synthesized calixarenes bearing four phosphonate groups and two or four long alkyl chains were found to form micelles of ∼10 nm diameter, in contrast to an analogue with short alkyl chains. These amphiphilic calixarenes are able to complex model (oligo-lysine) and biologically relevant (HIV-1 nucleocapsid peptide) cationic peptides into small nanoparticles (20-40 nm). By contrast, a control anionic calixarene with short alkyl chains fails to form small nanoparticles with peptides, highlighting the importance of micellar assembly of amphiphilic calixarenes for peptide complexation. Cellular studies reveal that anionic amphiphilic calixarenes exhibit low cytotoxicity and enable internalization of fluorescently labelled peptides into live cells. These findings suggest anionic amphiphilic macrocycles as promising building blocks for the preparation of peptide delivery vehicles.
The premature ventricular contractions (PVC) have usually good prognosis in patients without structural heart disease. In case of left ventricular ejection fraction depression or symptoms, antiarrhythmic drugs or cardiac ablations could be an option for management. We present a case of a patient with high burden of PVC admitted for cardiac ablation. Preoperative assessment revealed hyperkalemia and metabolic acidosis which ended up with type‐4 renal tubular acidosis (RTA). Its’ rare cause and management may draw attention to the possibility of type 4 RTA as the cause of the PVC, and hyperkalemia. This article is protected by copyright. All rights reserved
Non-terrestrial networks have been attracting much interest from the industry and academia. Satellites and high altitude platform station (HAPS) systems are expected to be the key enablers of next-generation wireless networks. In this paper, we introduce a novel downlink satellite communication (SatCom) model where free-space optical (FSO) communication is adopted between a satellite and a HAPS node. A hybrid FSO/radio-frequency (RF) transmission model is used between the HAPS node and ground station (GS). In the first phase of transmission, the satellite selects the HAPS node that provides the highest signal-to-noise ratio (SNR). In the second phase, the selected HAPS decodes and forwards the signal to the GS. To evaluate the performance of the proposed system, outage probability expressions are derived for exponentiated Weibull (EW) and shadowed-Rician fading models while considering the atmospheric turbulence, stratospheric attenuation, and attenuation due to scattering, path loss, and pointing errors. Additionally, asymptotic analysis is carried out and diversity gain is provided. Furthermore, the impact of aperture averaging technique, temperature, and wind speed are investigated. We also provide some important guidelines that can be helpful for the design of practical HAPS-aided SatCom. Finally, the results show that the use of HAPS improves the system performance and that the proposed model performs better than all other existing models.
Die türkisch-ägyptischen Beziehungen gestalten sich aufgrund von geopolitischen, ressourcenbezogenen sowie ideologischen Gegensätzen bereits in der Vergangenheit als konfliktreich. Nach einer Zeit der Entspannung und Ansätzen der Kooperation zwischen den beiden Staaten während der Herrschaft der Muslimbrüder unter Muhammad Mursi, haben sich die Spannungen mit der Machtübernahme von Abd Al-Fattah Al-Sisi wieder verschärft und zu einer Blockbildung im arabischen Raum geführt. Die größten Konflikte sind hierbei die gegensätzlichen Positionen der Türkei und Ägypten bezüglich der Unterstützung bzw. Bekämpfung der Muslimbrüder, Konflikte um Gewässer- und Wirtschaftszonen um die Insel Zypern für eine geplante Erdgaspipeline und, damit verbunden, die Unterstützung unterschiedlicher Seiten im libyschen Bürgerkrieg, um die eigene Verhandlungsposition zu stärken.
The ability to detect DNA strands and determine their characteristics in solution plays a critical role to design a sensor in terms of its biophysical properties and receives attention in whole‐ genome sequencing. In this study, we report a simple method to detect 100‐bp DNA based on resistive‐pulse sensing and its characteristics in terms of analyte concentration, potential, tip size. and electrolyte concentration. Track‐etched polyethyleneterephtalate (PET) nanopores were used and modified (w/EDC‐NHS coupling) to decrease the negative surface charge and promote DNA translocation. We tuned up the tip diameters of nanopores by using symmetric and asymmetric chemical etching. The tip diameters ranged from 21 nm to 42 nm. To show the electrophoretic nature of translocation, we investigated the concentration and potential dependence. The current‐pulse events were observed down to 600 mV (4±1 events/min) and 0.25 nM was the minimum concentration. Both potential and concentration dependence showed linear behavior which agreed to previous studies. The effect of tip size was also studied and its effect on translocation frequency was discussed. Finally, the change in current‐pulse amplitude and duration as a function of electrolyte concentration was studied and longer duration values (13.8±11 ms) were observed. Our findings provide a guide to translocate the charged molecules more efficiently and help to understand the translocation dynamics of short DNA molecules in resistive‐pulse sensing.
In this paper, we study the secrecy performance of mixed radio-frequency (RF - free space optical (FSO systems by considering both RF and FSO eavesdropper attacks. More precisely, we shed light into the design of secure mixed RF-FSO relay networks by questioning two critical design problems: 1 What are the main parameters in the design of secure RF-FSO relay networks 2 How can we improve the confidentiality of the optical information {To do so, we derive the secrecy outage probability and the probability of positive secrecy capacity performance for mixed RF-FSO relaying schemes under RF and FSO eavesdropper attacks, respectively}. To justify the problem, we consider two general fading models, Nakagami-\emph{m} at the RF side and exponentiated Weibull distribution at the FSO side. The results, which are validated with the Monte-Carlo simulations, show that both the location and the size of the photo-aperture is very important in the design of RF-FSO relay networks to enhance the secrecy performance of the overall system.
Aort diseksiyonu nadir görülen genellikle hipertansif ve bağ doku hastalıkları ile ilişkili bir vasküler hastalık olup mortalite oranları yüksektir. Gebelik de aort diseksiyonu için bir risk faktörüdür ve tedavisi acil cerrahi müdahaledir. Gebelik sırasında aort diseksiyonuna nadiren rastlanır ve tedavisiz kalması halinde ölümle sonuçlanabilir. Ancak gebelik öncesinde aort diseksiyonu geçirip opere olan ve sonra gebe kalan hastaların gebelik takibi ile ilgili literatürde yeterli veri yoktur. Bu çalışmada Tip A aort diseksiyonu sonrasında suprakoroner ve hemiark aort sentetik greft replasman öyküsü olan ve 15 haftalık gebeliği sırasında toraks bilgisayarlı tomografisinde (BT) asendan aortta aortik, anulus düzeyinde 60x56mm fuziform anevrizmatik dilatasyon, desenden aortta proksimal kesimi 55mm, orta kesim 68 mm ve distal kesimi 45mm boyutlarında belirgin fuziform anevrizma saptanmıştır. Hastanın aynı zamanda epilepsi ve astım öyküsü mevcuttur. Mevcut medikal durumu ve komorbiditeleri sebebiyle kardiyoloji, kalp damar cerrahisi ve perinatolojinin içinde bulunduğu bir konsey kararı ile hastaya gebeliğin yüksek riskli olduğu bildirilmiştir. Hastanın terminasyon istemi olması üzerine 3 saat aralıklarla 400 mcg vajinal prostoglandin E1 uygulanmıştır. Ancak 12 saati geçmesine rağmen abortus gerçeklememesi üzerine dilatasyon amacıyla servikal balon yerleştirilmiş ve abortus sonrasında rest plasenta kalması üzerine hastaya Bumm-Küretaj yapılmıştır.
Introduction/Background* The term vaginal intraepithelial neoplasia (VaIN) refers to a premalignant lesion that has the potential to progress to invasive cancer. VaIN is a very rare disease and represents less than 1% of all female genital intraepithelial neoplastic lesions. Several studies have shown that high-risk (hr) HPV infection is an important factor in the development of VaIN. Although p16INK4A/Ki67 markers have been studied many times in cervical dysplastic lesions, they have rarely been used in vaginal dysplastic lesions. In the present study, we aimed to analyze the role of p16 and Ki67 levels on the progression or regression of VaIN together with HPV infection in vaginal epithelial cells with neoplastic changes. Methodology Cases of VaIN1, and VaIN2/3 were retrospectively identified from the surgical pathology files at the Department of Pathology, Istanbul Medical Faculty, Istanbul University from 2003 to 2020. A total of 10 cases of VAIN1, and 38 cases of VAIN2/3were identified. The primary endpoints of the study were the recurrence of VAIN and progression to vaginal carcinoma. Result(s)* Most of HPV positive cases (22 out of 36) were infected with HPV16 subtype (61.1%). One patient had HPV18 subtype (5.9%) infection. There was a significant correlation between the expression of p16INK4A and Ki67 together with the disease recurrence. Patients with strong expression of both p16INK4A and Ki67 had a significantly higher disease recurrence (p=0.010). Furthermore, we observed that the patients with strong expression of p16INK4A and Ki67 together, had the recurrence of the disease less than 12 months (p=0.041). Patients with strong expression of both p16INK4A and Ki67 had a significantly higher disease progression to invasive cancer (p=0.015). hr HPV positivity was significantly related with moderate or strong expression of p16 and ki67 (p=0.002). Conclusion* Strong expressions of p16INK4A and Ki67 together in vaginal tissue, had a significantly higher risk of recurrence. Furthermore, with strong expression of both markers together, the disease recurred more rapidly. In addition, strong expression of both markers might be associated with malignant progression. Finally, rate of infection with HPV18 subtype might be less than expected in patients with VaIN. These results need to be confirmed in future prospective studies.
The aim of the study is to determine sleep quality and related factors in people with type 2 diabetes. This descriptive and cross-sectional study was conducted with 283 people with type 2 diabetes. Data were collected The Pittsburgh Sleep Quality Index (PSQI), The Epworth Sleepiness Scale (ESS), and the World Health Organization-5 Well-Being Index (WHO-5). Data was analyzed using the SPSS 15.0 software. The mean age of the people with diabetes was 60.0±10.7. Among the participants, 60.4% were female. The mean PSQI, ESS and WHO-5 scores of the participants were 6.6±3.4, 5.1±4.2 and 11.9±5.9, respectively. Among the participants, 55.8% had sleep problems. Males, those with higher education levels, employed individuals, those with moderate economic status, those who exercised, those without sleep apnea problems, those without additional health problems, and those who did not have hypertension experienced sleep problems at a lesser degree (p [Med-Science 2021; 10(3.000): 968-75]
Amaç: COVID-19’a karşı aşı konusunda büyük ilerlemeler olmasına karşın aşının halk tarafından kabulü konusundaki belirsizlik aşılamanın önünde engel oluşturabilecek bir husustur. Bu çalışmada, Türkiye'de COVID-19’a karşı etkili bir aşının kullanıma sunulması durumunda halkın aşıya bakış açısı ve bu durumu etkileyen faktörlerin araştırılması amaçlandı. Yöntemler: Çalışma için İstanbul Medeniyet Üniversitesi Göztepe Eğitim ve Araştırma Hastanesi Etik Kurulundan izin alınarak Aralık 2020’de anket hazırlandı. Çevrimiçi olarak Türkiye'de yaşayan insanlara uygulandı. Veriler, IBM SPSS İstatistik programında ki-kare testi kullanılarak değerlendirildi. Bulgular: Anket 1293 katılımcı ile yapıldı. Katılımcıların %41,2’si COVID-19 aşısı olmaya olumlu yaklaşırken %37,9’u ise kararsızdı. Aşı yaptırmayı düşünmeyen veya kararsız olan bireylere sebebi sorulduğunda %75,9’u yeni bir aşı olduğu için yan etkilerinden korktuğunu, %34,4’ü aşı üreten firmalara güvenmediğini, %20,9’u aşının COVID-19’a karşı koruyamayacağını düşündüğünü bildirdi. %47,7’si (n=617) COVID-19’un laboratuvar ortamında yapay olarak üretildiğini, %45,9’u COVID-19’un biyolojik bir silah olduğunu düşünüyordu (n=594). %64,3’ü yerli aşıyı tercih edeceğini belirtti. Sonuç: Türkiye’de COVID-19 aşısına karşı bir tereddüt vardır. Bunun yanında olası bir aşı tercihi durumunda yerli aşıya olan güven ithal aşıya kıyasla daha fazladır.
This study aims to examine the relationship between military expenditure and environmental sustainability in developed Mediterranean countries: Greece, France, Italy, and Spain. Sustainable economic growth is strictly related to energy consumption which leads to producing a higher level of carbon emissions. Besides, there may be a nexus between military expenditures and environmental pollution. This study focuses on developed Mediterranean countries since carbon emissions and greenhouse gas emissions are relatively high in these countries. Furthermore, France and Italy are the top countries in terms of total military spending. We investigate the relationship between military expenditure and carbon emissions using the Global Vector Autoregression model proposed by Pesaran, Schuermann, and Weiner (2004) and Dees et al. (2007) between 1965 and 2019. The empirical findings indicated that the relationship between carbon emission and military expenditure should be taken into account from a global perspective for environmental sustainability, and an increase in the global military expenditure seems to be very harmful to the global environment. It can be concluded that country-based prevents cannot provide the desired solution in combating environmental pollution.
Background Atrial arrhythmias are well-known complications of atrial septal defect (ASD), and associated with substantial morbidity. After ASD closure, right atrial and ventricular enlargement regresses, however, the risk of atrial arrhythmia development continues. In this study, we aimed to investigate the relationship between the Crochetage sign, which is a possible reflection of heterogeneous ventricular depolarization due to long-term hemodynamic overload, and the development of late atrial arrhythmia after ASD closure. Methods This retrospective study included a total of 314 patients (mean age: 39.5 (30–50) years; male: 115) who underwent percutaneous device closure for secundum ASD. The study population was divided into two groups according to the presence or absence of the Crochetage sign. The Crochetage sign was defined as an M-shaped or bifid pattern notch on the R wave in one or more inferior limb leads. Cox-regression analysis was performed to determine independent predictors of late atrial arrhythmia development. Result Fifty-seven patients (18.1%) presented with late atrial arrhythmia. Of these 57 patients, 30 developed new-onset atrial fibrillation/atrial flutter (AF/AFL), and 27 patients with pre-procedure paroxysmal AF/AFL had a recurrence of AF/AFL during follow-up. History of paroxysmal AF/AFL before the procedure (HR: 4.78; 95% CI 2,52–9.05; p < 0.001), the presence of Crochetage sign (HR: 3.90; 95% CI 2.05–7.76; p < 0.001), and older age at the time of ASD closure (HR: 1.03; 95% CI 1.01–1.06; p = 0.002) were found as independent predictors for late atrial arrhythmia. Conclusion The presence of Crochetage sign may be used to predict the risk of late atrial arrhythmia development after transcatheter ASD closure.
PurposeEven though it is known that fear and poor sleep quality trigger emotional eating, whether fear of COVID-19 and poor sleep quality have effects on emotional eating during the COVID-19 pandemic is not clear. This study was performed to evaluate the effect of fear of COVID-19, sleep quality and sociodemographic characteristics such as age, gender, BMI on emotional eating during COVID-19 pandemic in Turkey.Methods The research data were collected via the ‘Participant Information Form’, the ‘Fear of COVID-19 Scale’, the ‘Pittsburgh Sleep Quality Index’, and the ‘Emotional Eating Scale’.ResultsFear of COVID-19 Scale score (β: 0.090, p < 0.05) and Pittsburgh Sleep Quality Index score (β: 0.289, p < 0.001) separately affected the Emotional Eating Scale score in the rate of 0.8% and 8.3%, respectively. Fear of COVID-19 Scale score (β: 0.042, p > 0.05), Pittsburgh Sleep Quality Index score (β: 0.246, p < 0.001), age (β: -0.259, p < 0.001), gender (β: -0.169, p < 0.001) and Body Mass Index (β: 0.275, p < 0.001) were affecting Emotional Eating scale score in rate of 18.3%. Fear of COVID-19 alone has a minimal effect on emotional eating, but when combined with variables such as sleep quality, BMI, age and gender, its effect on emotional eating disappears.Conclusions In the light of these results, it is recommended to screen all individuals in the society during the pandemic in terms of emotional eating, especially those who are young, female, have a high BMI, low sleep quality, and high fear of COVID-19 and nutrition education should be provided to these people.Level of evidenceLevel V, cross-sectional predictive study.
Aim: This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. Materials and Methods: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life. Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex and maternal hypertension were significantly related to lower PLT (p
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Mustafa Yavuz
  • History of Science Department
Ferruh Isman
  • Clinical Chemistry Laboratory
Mahmut Gumus
  • Faculty of Medicine
Bilal Çankır
  • Faculty of Health Sciences
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Prof. Dr. Gulfettin Celik
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