Istanbul University-Cerrahpaşa
Recent publications
The development of natural molecule-derived carbon nano dots (CNDs) marks a significant advancement in biocompatible and sustainable nanomaterials. Tryptophan, capable of crossing the blood-brain barrier (BBB), serves as a precursor to numerous pharmacologically active compounds, while isatin and its derivatives have demonstrated anti-tumor effects, including against brain cancers. This study aimed to synthesize fluorescent CNDs from tryptophan-isatin hybrid precursor and explore their applications in glioblastoma treatment. These CNDs were characterized using techniques such as TEM, SEM-EDS, FTIR, XPS, Raman spectroscopy and UV-Vis spectrophotometry. In vitro tests using the U-87 glioblastoma cell line evaluated cell viability, affinity, and BBB permeability. The CNDs, between 4-7 nm in size, exhibited blue and green fluorescence, with no cytotoxic effects observed at concentrations up to 25 µg/mL. The highest BBB permeability rate was determined as 4.3x10⁻⁵ cm/s. Additionally, the CNDs demonstrated radiotherapeutic properties, leading to a 51% reduction in cell viability. This research contributes to nanomedicine by introducing a novel biocompatible material with potential for targeted brain cancer imaging and therapy, while also suggesting broader applications beyond glioblastoma.
This study assesses the economic and technical feasibility of two resin extraction methods, Bore Hole Tapping (BH) and Bark Streak Tapping (BS), applied to Pinus brutia in the Korudağ Forest, Türkiye. Resin production from 758 trees was analyzed over six months to compare setup costs, operational expenses, labor costs, and yields. Additionally, a feasibility study involving 2500 trees was conducted to evaluate market, technical, and financial aspects. Results show that both methods incur high production costs, making resin production economically unviable under current market conditions. The BH method is particularly unfeasible due to significant initial investments and high operating costs. In contrast, the BS method, with lower costs, approaches viability at historically higher resin prices. Sensitivity analyses suggest that the BS method could become feasible with a significant rise in market prices. However, resin production from Pinus brutia remains economically unfeasible at present.
Calcium Oxide (CaO) is the best replica of logically plentiful earth metal oxides. CaO nanoparticles include sphere-shaped or faceted elevated surface area and magnetic nanostructured particles. The current study give the information regarding booming synthesis of calcium oxide nanoparticles using calcium chloride as precursor and Annona squamosa seed extract as capping agent. The main goal of using a biological approach to synthesize CaO NPs is to reduce the use of dangerous chemicals in the process, which will be more economical and environmentally friendly. This is the initial time seeds have been utilised for green nanoparticle deposition. The synthesized powder was golden yellow colour. The obtained CaO NPs have been characterized by X-ray diffraction, scanning electron microscope, ultra violet visible spectroscopy, Fourier transform infra-red, dynamic light scattering studies. The synthesized samples are applied for phytochemical screening, anti-bacterial, anti-fungal, antioxidant and anti-ulcer applications.
Aim The purpose of this study was to compare the effect of Kegel exercises plus abdominal exercises to Kegel only exercises on urinary incontinence severity, quality of life, and sleep quality in postmenopausal women with stress urinary incontinence (SUI). Methods This prospective, randomized controlled trial adhered to the CONSORT guidelines and included 70 postmenopausal women (35 in each group) diagnosed with SUI who attended an Obstetrics and Gynecology outpatient clinic in northern Turkey between May and November 2023. The experimental group performed Kegel and abdominal exercises, while the control group practiced Kegel exercises only. Both groups followed a 12‐week exercise program, with data collected through pre‐ and post‐tests and three face‐to‐face interviews during the intervention period. Results After the 12‐week exercise programs, both Kegel only and Kegel plus abdominal exercise combination decreased the severity of incontinence and improved quality of life and sleep quality in postmenopausal women with SUI ( p < 0.001). However, in this population, Kegel plus abdominal exercises give better results than Kegel only exercises ( p < 0.001). Conclusions According to the outcome of this evidence‐based study, it is recommended that exercise programs combining Kegel and abdominal exercises be established for postmenopausal women with SUI within the scope of conservative treatment. https://onlinelibrary.wiley.com/share/author/PXES9RIJ2ZGFHZZVJUAG?target=10.1111/jog.16233
Aim The aim of this study is to determine the effect of vitamin D replacement therapy on sleep habits in restless legs syndrome (RLS) patients with vitamin D deficiency. Methods The study was conducted between September 1, 2018, and September 1, 2019, at the Pediatrics outpatient clinic of Bezmialem Vakif University. 46 cases with RLS and 43 healthy controls between these dates were included in the study. The Children’s Sleep Habits Questionnare was filled out retrospectively by parents. Results While vitamin D supplementation was given to 20 children with RLS who were found to have vitamin D deficiency, the 26 patients without vitamin D deficiency did not receive supplementation. There was no significant difference between the treatment groups in terms of gender, age, and pre-treatment sleep habits. Compared to the pre-treatment period, post-treatment bedtime resistance, sleep onset delay, sleep anxiety, parasomnias, daytime sleepiness, and CSHQ total score were significantly improved in RLS cases with vitamin D deficiency. There were no significant differences in RLS patients without vitamin D supplementation. Other comparisons also showed no difference between groups. Conclusion There was no difference between the sleep habits of RLS cases with and without vitamin D deficiency. Sleep habits improved positively after vitamin D supplementation in patients with vitamin D deficiency compared to the pre-treatment period. There was no difference in the sleeping habits of RLS patients without vitamin D deficiency during the same period. Vitamin D supplementation can improve sleep habits in patients with RLS.
Objective Assessment of the efficacy and safety of rituximab (RTX) in treating thrombocytopenia of systemic lupus erythematosus (SLE) patients unresponsive to conventional treatments, highlighting its potential as an alternative to the expensive intravenous immunoglobulin (IVIG), and investigating the optimal number of RTX cycles for complete remission (CR). Methods A retrospective analysis was conducted on RTX utilization between 2016 and 2023 at our center. Medical records of SLE patients with thrombocytopenia, resistant to conventional treatments, were reviewed. Results 26 patients (21 females, five males) aged 52.1 ± 14.4 years were included. All patients received glucocorticoid (GC) treatment and 12 patients received IVIG before RTX administration. The median number of RTX cycles administered was 2.50 (IQR: 2-6). CR was achieved in 18 patients (69.2%), with 10 (38.5%) attaining CR during the initial treatment cycle. Four patients attained partial remission (PR), and four remained refractory. The median number of cycles needed to achieve CR during follow-up was 1.5 (IQR: 1-3.5). RTX significantly reduced the need for GCs, with only 7.7% of patients receiving prednisolone >5 mg afterward. Additionally, IVIG necessity decreased, with only 19.2% of patients requiring IVIG after completing 6 months of RTX treatment ( p < 0.046). The median platelet count significantly increased after RTX treatment ( p < 0.001) and the incidence of bleeding decreased from 76.9% to 34.6% after 6 months of RTX treatment, with none classified as life-threatening. No side effects were observed, except for hypogammaglobulinemia in one patient (3.8%). Conclusion RTX demonstrates efficacy and safety for SLE patients with thrombocytopenia unresponsive to conventional treatments, offering a potential alternative, and reducing reliance on GCs and IVIG.
The dual-functional nanostructures show great promise for biomedical applications, exhibiting selective cytotoxicity against cancer cells while also serving as a crucial component in textile screen-printing for smart materials. In this study, we successfully synthesized polyethylene glycol-hibiscus extract copper (II) oxide nanoparticles (PEG/HS/CuO NPs) using a simple one-step sonosynthesis method that leverages ultrasonic irradiation. Comprehensive characterization of the synthesized PEG/HS/CuO NPs was performed using transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM) coupled with energy-dispersive X-ray (EDX) analysis, and Fourier-transform infrared spectroscopy (FTIR). The incorporation of PEG/HS/CuO NPs into guar gum photochromic solution (GP) caused a significant color change after 6 ± 1 min of UV light exposure and resulted in visible coloration on cellulose-based textiles after screen printing, providing an alternative strategy for smart fabrics. Moreover, cytotoxicity experiments demonstrated the selective toxicity of green PEG/HS/CuO NPs against cancer cells. In this study, the human colon cancer cell line HCT116, breast cancer cell line MCF-7, and normal HUVEC cells were examined. PEG/HS/CuO NPs NPs induced apoptosis, cell cycle arrest, and down-regulation of CD44 antibody expression in MCF-7 cells, highlighting their potential as effective chemotherapy agents.
Cardiovascular computed tomography (CCT) is a versatile, readily available, and non-invasive imaging tool with high-resolution capabilities in many cardiovascular diseases (CVD). Our review explains the increased risk of CVD among patients with cancer due to chemoradiotherapies, shared risk factors and cancer itself and explores the expanding role of CCT in the detection, surveillance, and management of numerous CVD among these patients. Recent research has highlighted the versatility and enhanced resolution capabilities of CCT in assessing a wide range of cardiovascular diseases. Early detection of cardiac changes and monitoring of disease progression in asymptomatic patients with cancer may lessen the severity of CVD. It offers an essential means to assess for coronary artery disease when patients are either unable to safely undergo stress testing for ischemia evaluation or at risk of complications from invasive coronary angiography. Furthermore, CCT extends its utility to valvular diseases, cardiomyopathies, pericardial diseases, cardiac masses, and radiation-induced cardiovascular diseases, allowing for a comprehensive, noninvasive assessment of the entire spectrum of cancer treatment associated CVD. Looking to the future, the integration of artificial intelligence and machine learning algorithms holds potential for automated image interpretation, improved precision and earlier detection of subclinical cardiac deterioration, allowing opportunities for earlier intervention and disease prevention. CCT is a useful imaging modality for assessing the myriad cardiovascular manifestations of diseases such as coronary artery disease, cardiomyopathies, pericardial disesaes, cardiac masses and radiation-induced cardiovascular diseases. CCT has several advantages. Readily available non-cardiac chest CT scans of patients with cancer may help with improved cardiovascular care, enhanced ASCVD risk stratification and toxicity surveillance.
In this study, a simple, rapid, and sensitive capillary electrophoresis (CE) method was developed that allows simultaneous analysis of zonisamide (ZNS), rufinamide (RFN), and lamotrigine (LMT) in pharmaceutical preparations. This study introduces the first application of CE for the simultaneous determination of ZNS, RFN, and LMT in pharmaceutical dosage forms. For the comparison a High-Performance Liquid Chromatography (HPLC) method was developed. In CE method, detection was achieved using a photodiode array detector (DAD) at a wavelength of 210 nm. A capillary with an internal diameter of 75 µm and an effective length of 40 cm was used for separation. The optimum conditions were achieved using 35 mM SDS, 6 mM borate, 10 mM phosphate buffer (pH 9.00) containing 5% isopropyl alcohol (IPA), and applying a potential of 15 kV. Under these conditions, the migration times of ZNS, RFN and LMT were observed to be 5.99 min, 6.77 min and 8.46 min, respectively. In HPLC method, detection was achieved using a photodiode array detector at a wavelength of 210 nm. A C18 column (4.6 × 100.0 mm, 3.5 µm i.d.) was used for separation, with a mobile phase consisting of acetonitrile and pH 4.0 50 mM phosphate buffer (18:82, v/v) at a flow rate of 1.0 mL min ⁻¹ . In this method, the retention times of ZNS, RFN and LMT were observed to be 6.41 min, 7.29 min and 4.95 min, respectively. The validity of the developed methods was examined through parameters such as linearity, precision, accuracy, sensitivity, stability, and robustness. In CE method, the limit of detection (LOD) values for ZNS, RFN and LMT were calculated as 0.035 μg mL ⁻¹ , 0.016 μg mL ⁻¹ and 0.007 μg mL ⁻¹ , respectively. For HPLC method, the LOD values were determined as 0.003 μg mL ⁻¹ , 0.002 μg mL ⁻¹ for RFN and 0.001 μg mL ⁻¹ for LMT. Both developed methods were successfully applied to pharmaceutical dosage forms and shown to be compliant with United States Pharmacopeia (USP 47 - NF 42). In conclusion, both methods developed in our study yielded comparable results in terms of robustness and analysis time. HPLC demonstrated higher sensitivity compared to CE and is preferred for analyses at very low concentrations, while CE is ideal for green chemistry applications due to its minimal solvent and sample consumption.
Objective: Posttraumatic stress disorder (PTSD) is a common mental disorder in individuals affected by earthquake. This study aimed to investigate the prevalence of PTSD in earthquake survivors affected by two earthquakes with magnitudes 7.7 and 7.6, which occurred 9 hr apart in the southeastern part of Turkey on February 6, 2023, with a 1-year follow-up, and to examine possible factors for the diagnosis of PTSD in the first year after the earthquakes. Method: The sample consisted of 400 earthquake survivors living in three tent cities in Adıyaman city. The 12th-month follow-up step continued with 153 of 400 earthquake survivors. Each participant completed the PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders, fifth edition along with a sociodemographic data form. A face-to-face clinical interview was conducted with each participant by using Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, fifth edition Disorders–Clinician Version. Results: The prevalence of PTSD in earthquake survivors was 44.8% in the first month after the earthquakes, 30.4% in the sixth month, and 19.6% in the 12th month. Rescued from under debris (p < .001, OR: 4.2, 95% CI [2.6, 6.8]), death of a relative in debris (p = .039, OR: 1.2, 95% CI [1, 2.4]), and reexperiencing scores (p = .019, OR: 1.7, 95% CI [0.8, 2.7]) 1 month after earthquakes predicted PTSD diagnosis 12 months after earthquakes. Conclusions: Although the prevalence of PTSD decreased in the first year after the earthquakes, approximately one fifth of earthquake victims still had a diagnosis of PTSD. Rescued from under debris, the death of a relative in debris, and postearthquake higher reexperiencing scores may be associated with a diagnosis of PTSD 1 year after the earthquakes.
Background One anastomosis gastric bypass (OAGB) currently stands as the third most common metabolic and bariatric surgical procedure with increasing popularity worldwide. Iron deficiency anemia (IDA) is the most prevalent anemia observed after gastric bypass procedures. Methods This systematic review and meta-analysis aimed to assess the overall incidence of IDA and identify the effect of biliopancreatic limb (BPL) length on the incidence of IDA in patients undergoing OAGB by a systematic literature search in PubMed, Web of Sciences, and Scopus. Results Twenty-six studies including 11,015 patients were finally included for review. The mean age and mean BPL lengths were 40.1 ± 7.2 years and 190.4 ± 29.2 cm respectively. The IDA prevalence after OAGB was 16% and BPL length was shown to predict IDA rates after OAGB (p = 0.042). Specifically, 8% of patients with a BPL length of 150–179 cm, 12% of patients with a BPL length of 180–199 cm, and 9% of patients with a BPL length of ≥ 200 cm experienced IDA. Conclusion Despite the promising trends of performed OAGB worldwide, further studies are required to ascertain the risks related to this procedure and refine the surgical techniques.
Background AI-powered chatbots have spread to various fields including dental education and clinical assistance to treatment planning. The aim of this study is to assess and compare leading AI-powered chatbot performances in dental specialization exam (DUS) administered in Turkey and compare it with the best performer of that year. Methods DUS questions for 2020 and 2021 were directed to ChatGPT-4.0 and Gemini Advanced individually. DUS questions were manually entered into AI-powered chatbot in their original form, in Turkish. The results obtained were compared with each other and the year’s best performers. Candidates who score at least 45 points on this centralized exam are deemed to have passed and are eligible to select their preferred department and institution. The data was statistically analyzed using Pearson’s chi-squared test (p < 0.05). Results ChatGPT-4.0 received 83.3% correct response rate on the 2020 exam, while Gemini Advanced received 65% correct response rate. On the 2021 exam, ChatGPT-4.0 received 80.5% correct response rate, whereas Gemini Advanced received 60.2% correct response rate. ChatGPT-4.0 outperformed Gemini Advanced in both exams (p < 0.05). AI-powered chatbots performed worse in overall score (for 2020: ChatGPT-4.0, 65,5 and Gemini Advanced, 50.1; for 2021: ChatGPT-4.0, 65,6 and Gemini Advanced, 48.6) when compared to overall scores of the best performer of that year (68.5 points for year 2020 and 72.3 points for year 2021). This poor performance also includes the basic sciences and clinical sciences sections (p < 0.001). Additionally, periodontology was the clinical specialty in which both AI-powered chatbots achieved the best results, the lowest performance was determined in the endodontics and orthodontics. Conclusion AI-powered chatbots, namely ChatGPT-4.0 and Gemini Advanced, passed the DUS by exceeding the threshold score of 45. However, they still lagged behind the top performers of that year, particularly in basic sciences, clinical sciences, and overall score. Additionally, they exhibited lower performance in some clinical specialties such as endodontics and orthodontics.
Aim This study aimed to investigate the potential mediating role of turnover intention in the relationship between job burnout and quiet quitting among nurses and shed light on the associations between job burnout, turnover intention and quiet quitting intention. Design This study was designed as a descriptive, cross‐sectional study. Methods A total of 317 nurses were selected using convenience sampling approach from a training and research hospital in Turkey. Quiet quitting, job burnout and turnover intention data were collected using the self‐reported questionnaires using paper‐and‐pencil versions. Pearson correlation analysis, independent sample t‐test and mediation analysis was conducted with Process v4.3. Results Statistically significant associations among job burnout, turnover intention and quiet quitting were found (p < 0.05). Job burnout had a positive effect on turnover intention (β = 0.339, p < 0.001) and quiet quitting (β = 0.245, p < 0.001). Additionally, turnover intention had a positive and significant effect on quiet quitting intention of nurses (β = 0.336, p < 0.001). Moreover, mediation analysis revealed that the association of job burnout with quiet quitting was partially mediated by turnover intention (β = 0.034, 95% CI [0.019, 0.054]). Conclusion This study enrich our understanding of the associations among study variables and suggest that focusing solely on job burnout without considering the mediating effects of turnover intention might not be adequate for reducing the quiet quitting intention among nurses. Impact This study shed light on how job burnout and turnover intention of nurses affect their quiet quitting intention. It has been proven that turnover intention is a significant factor in the relationship between job burnout and quiet quitting. These findings could provide guidance for managers in the administration of nurses. Patient or Public Contribution No patient or public contribution.
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3,470 members
Deniz Palamar
  • Department of Physical Medicine and Rehabilitation
Eyup Kara
  • Department of Audiology
Nurten Kaya
  • Faculty of Health Sciences
Murat Uludag
  • Department of Physical Medicine and Rehabilitation
Matem Tunçdemir
  • Department of Medical Biology
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Istanbul, Turkey