# Islamic Azad University Khorasgan (Isfahan) Branch

• Isfahan, Isfahan, Iran
Recent publications
Two experiments were performed to explore the effect of dietary supplemental different sources and particle sizes of calcium (Ca) on growth performance, bone mineralisation, blood attributes, and calbindin gene expression in broiler quail. In experiment 1, 480-day old broiler Japanese quail (Coturnix japonica) were allotted to four dietary treatments based on a factorial arrangement (2 × 2) consisting of basal diets formulated either with limestone or oyster shell with coarse or fine particles. Supplemental coarse oyster shell impaired growth performance and Ca intake compared to coarse limestone (p < .05). The concentration of blood Ca was lower in birds who received supplemental coarse or fine oyster shell than coarse limestone (p < .05). Higher expression of calbindin gene observed in birds fed on the coarse oyster shell (p < .05). In experiment 2, a total of 360 Japanese quail assigned to experimental treatments of feeding: (1) control: a basal diet; (2) choice feeding between a Ca deficient diet and limestone with coarse (granulated) and fine particles; (3) choice feeding between a Ca deficient diet and oyster shell with coarse and fine particles. All birds preferred to use fine Ca particles across the first week of the experiment (p < .05) whereas tended to consume higher fine oyster shell during the entire rearing period (p < .05). Feed conversion ratio impaired in birds subjected to choice feeding (p < .05). Overall, coarse oyster shell decreased the growth of birds in the first experiment. The overall growth of choice-fed birds depressed compared to when received one conventional feed. • HIGHLIGHTS • Growth of quail decreased when they fed on diets containing coarse oyster shell. • Higher expression of calbindin gene observed in quail received coarse oyster shell. • Quail tended to use a separate source of Ca when fed with a Ca deficient diet.
Introduction: In the past two decades, there has been a growing line of research on the possible effects of psychological interventions on patients with inflammatory bowel disease (IBD). This study aimed to evaluate the qualitative validity of a lifestyle-based intervention in patients with ulcerative colitis (UC) by examining their experiences. Methods: This study employed a concurrent embedded mixed methods design. To this end, a qualitative study was conducted in the form of a clinical trial that applied a lifestyle-based intervention to patients with ulcerative colitis. The patients’ experiences were assessed twice through the focus group interviews. The data from both interviews (posttest and follow-up phases) were analyzed using thematic network analysis. Results: Based on the results of this study, 3 global themes, 10 organizing themes, and 21 basic themes were identified and summarized in three thematic networks of benefits, barriers, and disadvantages. Benefits included satisfaction with attending the meetings, knowledge acquisition, cognitive, emotional, and behavioral changes, and partial physical improvement; barriers included physical symptoms, need for retraining, giving importance to the topic, and restrictions in physical activities; and the disadvantages included the negative impact of the group and the negative impact of the training program. Conclusion: The results of this study confirmed the qualitative validity of a lifestyle-based intervention in a group of patients with ulcerative colitis by demonstrating the educational and therapeutic effects of the intervention and its acceptability.
This study aimed to survey ozone-membrane processes for advanced treatment of secondary effluent in the industrial estate wastewater treatment plant. The performance of a pilot-scale system combining chemical treatment (coagulation, flocculation, sedimentation), sand filtration, ultrafiltration, activated carbon, and reverse osmosis were evaluated without and with ozonation at three different points of the set up. Ozone at the reaction time of 30 min and concentration of 24 ppm was injected before chemical treatment, before UF and before RO. UV254, COD, TOC, TSS, TDS, pH, turbidity and ozone efficiency were evaluated. For estimating the value of UV254, a random forest (RF) model was presented. The model uses supervised learning to estimate UV254 from an input vector consisting of step, location pH, temperature, electrical conductivity, and turbidity. The residue of organic matters, as UV254, that enter the membrane systems (UF and RO) were 0.125, 0.080, and 0.198 cm⁻¹, respectively, which is desirable compared to the ozone-free state which is equal to 0.251 cm⁻¹. Ozonation before UF, showed the lowest value (0.080 cm⁻¹). TOC concentrations in the step of ozonation before UF were 12.1, 11.2, 10.8, 7.7, and 0.75 mg/l after SF, ozonation, UF, AC, and RO, respectively. Estimation of UV254 using RF-BO method represents MAE, MSE, and RMSE indexes equal to 0.01632, 0.00044191, and 0.021022, respectively. The results showed better efficiency of ozone injection before UF, compared to the other two cases. In the UV254 estimation section, the model shows enhanced accuracy in terms of error indexes in comparison with SVM-BO and GPR-BO methods.
Depression is a frequent mood disorder that might impair the brain-gut axis. In this study, we divided 30 mice into five groups: untreated mice, mice with depression-like behaviors, mice with depression-like behaviors treated with consumed leucine, mice with depression-like behaviors treated with exercise training, mice with depression-like behaviors treated with exercise training along with consumed leucine. According to artificial intelligence biological analysis, we found some mediators such as lncRNAs profile and Kdr/Vegfα/Pten/Bdnf interactions network in the hippocampus region and ileum tissue which could be decisive molecules in the brain-gut axis. Moreover, KDR as a principal cutpoint protein in the network was identified as the pharmaceutical approach for major depressive ameliorating based on pharmacophore modeling and molecular docking outcomes. Furthermore, we indicated that the mRNA and protein level of the Pten enhanced and Vegfα/Kdr/Bdnf mRNAs, as well as the protein level of KDR, decreased in mice with depression-like behaviors. Moreover, exercise and leucine ameliorated the brain-gut axis in mice with depression-like behaviors. Exercise and leucine regulated the lncRNAs network in the hippocampus and ileum of mice with depression-like behaviors. We suggest that the lncRNAs profiles could be considered as diagnosis and prognosis biomarkers, and exercise + leucine might be a practical approach to improve depression.
One of the major problem in constructing liners that are exposed to leachate is that every material is not able to prevent transmission of contaminant to protect water resource. Lack of water resources worldwide demands for a prompt measure in order to protect extant resources and to minimize wastage growing threat on the environment. In this study, one & two-dimensional (1-D) & (2-D) diffusion test of chloride ion coupled with conductivity were conducted on Ceramic Powder Waste-Bentonite mixture (CPW-B) to investigate the capability of its use as contaminant barrier liner and its potential impact on surroundings. Parameters considered for the laboratory study were Bentonite content (BC) and Leachate height (LH). The test results indicate that there is a significant improvement in diffusion coefficient of the mixture compared with pure CPW. The compound is able to meet the standards when 30% dry weight of bentonite at least is added in CPW-B mixtures. Furthermore, the hydraulic conductivity of compounds in various pressures and variety of bentonite content was determined by the flexible wall triaxial hydraulic conductivity apparatus. The obtained hydraulic conductivities is in the range of values recommended for the compacted clayey liners and therefore, this material is acceptable in terms of advection transport.
Detection and reduction of global positioning system (GPS) jamming threats are inevitable considering importance of satellite navigation in different applications such as fixed and moving platforms. Different methods utilizing statistical/spectral signal processing, time/frequency transforms and antenna array have been introduced. In this paper, a new method based on random matrix theory is proposed for detection and reduction of GPS jamming threat. By using the concept of Wigner matrix and introducing spiked matrix model, our proposed method is based on Karhunen–Loeve transform (KLT) by distinguishing eigen-values through systematic (analytic) thresholding. The authentic (cleaned) signal is reconstructed by projecting received signal on the eigen-functions domain where jamming components can be better removed. The objective is to detect the presence of jamming in the early stage of jamming attack (early warning) and then trying to reduce the jamming effect (mitigation). Different parameters including acquisition metric, position deviation, cross ambiguity function and run-time have been evaluated in simulation part to provide a good preview. According to the simulation results, the proposed method has better performance in comparison with some reference algorithms in terms of detection and false alarm probabilities and acquired satellites. At least 2.5 dB improvement in detection is achieved for the proposed algorithm. The run-time is reduced about 30% compared with wavelet packet coefficients transforms. Also, the overhead computational complexity for covariance matrix estimation (Om3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$O\left( {m^{3} } \right)$$\end{document}) is reduced compared to conventional covariance matrix estimation-based eigen-decomposition methods.
Background Natural nutrition and physical training have been defined as non-pharmacochemical complementary and alternative medicines to prevent and treat various pathogenesis. Royal jelly possesses various pharmacological properties and is an effective therapeutic supplement for halting neurodegeneration. Multiple sclerosis is a prevalent neurodegenerative disorder that manifests as a progressive neurological condition. Inflammation, hypoxia, and oxidative stress have been identified as significant hallmarks of multiple sclerosis pathology. Results In the present study, based on artificial intelligence and bioinformatics algorithms, we marked hub genes, molecular signaling pathways, and molecular regulators such as non-coding RNAs involved in multiple sclerosis. Also, microRNAs as regulators can affect gene expression in many processes. Numerous pathomechanisms, including immunodeficiency, hypoxia, oxidative stress, neuroinflammation, and mitochondrial dysfunction, can play a significant role in the MSc pathogenesis that results in demyelination. Furthermore, we computed the binding affinity of bioactive compounds presented in Royal Jelly on macromolecules surfaces. Also, we predicted the alignment score of bioactive compounds over the pharmacophore model of candidate protein as a novel therapeutic approach. Based on the q-RT-PCR analysis, the expression of the Dnajb1/Dnajb1/Foxp1/Tnfsf14 and Hspa4 networks as well as miR-34a-5p and miR155-3p were regulated by the interaction of exercise training and 100 mg/kg Royal Jelly (ET-100RJ). Interestingly, characteristics, motor function, a proinflammatory cytokine, and demyelination were ameliorated by ET-100RJ. Discussion Here, we indicated that interaction between exercise training and 100 mg/kg Royal jelly had a more effect on regulating the microRNA profiles and hub genes in rats with Multiple sclerosis.
Bone healing is comprised of a complex cascade of events to repair the fractured bone and gain functionality. This process is affected by numerous local and systemic factors such as the degree and extent of the injury, cardiovascular disorders, age, sex, chronic diseases, nutritional status, stimulants, and drugs used. The current study aimed to resolve the relationship of ibuprofen treatment and sex-specific bone healing in a rat model of the tibial fraction. The bone defect was inflicted by a tibial monocortical osteotomy with a 1-mm diameter. Male and female rats were injected with saline or ibuprofen (30 mg/kg/day) for 2 weeks post-surgery. Bone healing quality was assessed after 4 weeks of the experiment. Moreover, the serum IL1B level was measured and associated with bone healing quality measures. Only the female rats with ibuprofen treatment showed an integration of adjacent and cortical bones, which indicates an accelerated bone healing in these animals. In contrast, the males with no ibuprofen treatment had the highest serum IL1B concertation. In general, the serum IL1B was negatively correlated with bone cellularity. Our result suggests a beneficial effect of the short ibuprofen treatment on bone healing but mainly for females. This preliminary study encourages additional clinical and experimental research to adapt a sex-specific post-surgical analgesic treatment to improve the bone healing quality of the patients.
AimThis study was aimed to consider the effects of uphill (concentric, CON) and downhill (eccentric, ECC) treadmill exercise with Nano-BCAA supplementation on muscle protein expression of Akt and mTOR.Methods Thirty aging male Wistar rats were randomly divided into 6 groups of (n = 5 each group): control (healthy), uphill running (CON, 0 to + 15°), downhill running (ECC, 0 to − 15°), Nano-BCAA (BCAA with Nano-Chitosan), CON + Nano-BCAA, and ECC + Nano-BCAA. The exercise training was performed in an interval form, with 3 sessions per weeks lasting 8 weeks. BCAA (in Nano form) administered by gavage 3 sessions per week for 8 weeks. RT-PCR was used to measure gene expression of Akt and mTOR. As well, protein expression of mTOR was performed by the IHC method.ResultsAdministration of BCAA with CON and ECC increased the Akt gene expression (p < 0.05). Co-treatment of Nano-BCAA and exercises leads to much higher values of Akt than does single treatment. Compared to the healthy control group (without Nano-BCAA), co-treatment of CON + Nano-BCAA and ECC + Nano-BCAA showed a significant increase in the mTOR gene expression (p < 0.05).Conclusion The use of walking exercises, especially with a negative or positive slope, along with proper nutrition (taking healthy supplements such as BCAA) could be effective in strengthening muscle tissue, especially at the cellular level (increasing the Akt/mTOR activity). It can be an optimal alternative for those who cannot use resistance training at old age.
Cold-plasma modification of starch was used to increase its physiochemical characteristics. Independent variables were voltage (20, 22, 24, 26, and 28 kV), time (1, 3, 5, 7, and 9 min), and sample weight (1, 2, 3, 4, 5 g). To establish the level of change, water uptake and emulsifying activity were measured. The water uptake and emulsifying activity attained 3.47% and 91.38%, respectively, at 23.16 kV, duration of 6.99 min, and starch quantity of 2.39 g, respectively. When compared to control, the optimal modified starch showed considerably better solubility 15.6%, water adsorption 48.29%, and oil absorption 1.77%, as well as starch gel stiffness values 189.47 g. In addition, mayonnaise made with modified starch showed better emulsion and oxidation stability. Mayonnaise having modified starch seemed lighter, with a lightness of 91.51, than mayonnaise containing non-modified starch, with a lightness of 82.31. In mayonnaise, cold-plasma modified starch reduced syneresis while increasing emulsifying activity. After a month, the mayonnaise sample produced with modified starch had a superior odor, taste, texture, and overall acceptance than the control sample. Graphical abstract
The meta-analysis presented in this study aimed to evaluate the Chlamydia pneumoniae infection on serum lipid profile. Systematic electronic research was conducted using related keywords on PubMed, Scopus, and Web of Science by July 30th. Regarding 1296 articles found on the association between C. pneumoniae infection and serum lipid profile, 15 related studies were included in meta-analysis. A random-effect model was used to measure pooled estimates. All data were analyzed by CMA software. The results of the present study indicated that there was no significant relationship between C. pneumoniae infection and triglycerides (P = 0.167), cholesterol (P = 0.574), LDL (P = 0.228), and HDL (P = 0.723) in healthy people. Furthermore, no significant relationship was observed between C. pneumoniae infection and cholesterol (P = 0.647), LDL (P = 0.068), and HDL (P = 0.782) regarding the analysis of C. pneumoniae infection on serum lipid profile in patients with coronary artery disease (CAD). However, our study showed a significant change of triglycerides (P = 0.014) in patients with CAD. C. pneumoniae infection is positively associated with dyslipidemia in patients with CAD. C. pneumoniae infection is associated with higher triglycerides in patients; nevertheless, this association must be confirmed by prospective studies.
In this study, we have designed and investigated four new low-emitting fluorescent dyes consisting of sulfonamide derivatives with substitution groups in the LUMO moiety. In these dyes, sulfonamide linked with pyrazole group played an important role in complementing the acceptor moieties. The optical properties of dyes were evaluated by the UV–VIS absorption, photoluminescence spectroscopy and photoluminescence decay time analysis in the non-doped solid film. The strong effect of substitution by –NO2 group was impressive, when, the dyes ionization potential photon energy values reached to 5.58, 5.82, 5.83 and 6.07 eV. According to X-ray diffraction, dyes were not amorphous and value of crystallite size was ∼100 nm. The dyes have a promising application as a hole layer in dye sensitized solar cells (DSSCs), due to the separation distribution of HOMO-LUMO, thermal stability, small crystal size, high PLQY, high optical band gap and high electron affinity. Finally, the DSSCs devices were fabricated based on the synthesized dyes and the results showed that the efficiency of the DSSCs based on a dye with –NO2 group is higher (3.27%) than that of the other dyes.
Plant invasion is recognized as the second most severe threat to biodiversity, following habitat loss. As one of the world’s worst invasive alien plant species, Prosopis juliflora (Mesquite) has severely affected the majority of the Earth’s dry ecosystems. Hence, this study attempted to identify the distribution, dominance, and changes in the vegetation characteristics of Mesquite-invaded regions along a series of coastal ecosystems in Southern Iran. Mesquite and other tree/shrub types were successfully classified using a temporarily-median-filtered Landsat 8-OLI image with acceptable kappa coefficient and overall accuracy values of 80.66 and 84.75, respectively. The multi-resolution segmentation was used to divide the region into spectrally homogenous parcels, then calculating the percentage cover (dominance) of Mesquite relative to other tree/shrub types. Analysis of MODIS NDVI products in highly invaded parcels showed a steady increase in NDVI values from 0.27 to 0.53 during 2000–2020 with a significant difference (z = –3.12, 0.183, sig ≤ .05, 2-tailed) from that of the low-invaded regions whose NDVI values oscillated constantly in a range between 0.15 and 0.28. Mesquite distribution also showed a local invasion pattern from areas with a steady or saturated status to neighboring parcels. In regions susceptible to Mesquite invasion, constant investigation of uncommon changes in NDVI whose vegetation characteristics differ significantly from that expected in poor dry vegetation covers of southern Iran can be considered as a conservation tool to identify and manage areas with early Mesquite establishment.
Breast cancer is cancer that develops from the breast tissue and has been recognized as one of the most dangerous and deadly diseases that is the second leading cause of cancer deaths in women. To help doctors and radiologists to diagnose these tumors as well as decrease the time and increase the accuracy, many machine learning methods have been implemented by now. Most of these methods suffer from extracting some significant features that represent the boundary of tumors. This is due to the fact that benign and malignant tumors can be considered the same if some borders cannot segment properly. So, in this study, we propose an automatic breast tumor segmentation and recognition based on a shallow convolutional neural network that uses multi-feature extraction routes. Also, an image enhancement approach is used before applying the image into the model which leads to avoiding a very deep structure. Our strategy leads to improvement in detecting the border of tumors and boosts the classification accuracy of tumors. We evaluated our pipeline on Mammographic Image Analysis Society (Mini-MIAS) and Digital Database for Screening Mammography (DDSM) datasets. The developed model can localize and classify tumors with the accuracy of 0.936, 0.890, 0.871 on the DDSM, and 0.944, 0.915, 0.892 on the Mini-MIAS, for normal, benign, and malignant regions, respectively.
The effect of intercropping of hyssop (Hyssopus officinalis L.) from Lamiaceae with a medicinal legume, that is, fenugreek (Trigonella foenum-graecum L.) on the hyssop essential oil was investigated. The highest herbage and essential oil yields of hyssop were produced from sole cropping and also intercropped hyssop with fenugreek (3:1 ratio); however, the highest antioxidant activity was obtained from the intercropped hyssop with fenugreek (1:3 ratio). The highest contents of the major constituents in the hyssop essential oil such as cis- and trans-pinocamphone and β-pinene were obtained from sole cropped of hyssop and the intercropping of hyssop with fenugreek (3:1 ratio). In conclusion, the intercropping of hyssop with fenugreek can increase biodiversity and efficiency of using resources. Therefore, this strategy could be considered in order to recommend in simultaneous production of secondary metabolites in the herbs like hyssop in an agricultural land.
Biodegradable films based on mung bean protein (1, 3 and 5%) incorporated with cumin essential oil (EO) (0, 0.25 and 0.5 ml/g protein) were developed. Adding cumin oil and increasing the protein content enhanced the thickness, tensile strength and yellowness. Films incorporated with EO exhibited less water vapor permeability and water solubility, as compared to the control films. A higher antioxidant activity was also obtained by increasing the EO and protein ratios. Films with higher levels of protein displayed lower thermal stability with a lower degradation temperature, as suggested by thermo-gravimetric analyses. In addition, the incorporation of EO reduced thermal stability, as confirmed by the higher weight loss and lower degradation temperature. Furthermore, mung bean protein films containing 0.5 ml cumin oil/g protein had suitable physical characteristics, antioxidant activities, water barrier properties and thermal stability; thus, they can be used as appropriate biodegradable packaging materials for food preservation.
This study examined the steady‐state and dynamic rheological properties of molten dark chocolate produced from sorbitol, isomalt, and inulin sugar substitutes at 40°C. All samples had a shear‐thinning and thixotropic behavior. Bulk sweeteners, according to their molecular structures, could be effective on the apparent viscosity as well as yield stress. Dynamic oscillatory measurements of the considered molten samples showed the liquid‐like behavior of inulin and isomalt, and the weak gel‐like behavior of sucrose and sorbitol. Sugar substitution decreased the G′ and G″ values of the samples. Among the samples, only those containing sorbitol within 50–100 rad/s range obeyed the Cox–Merz rule. The data related to the obtained compliance (Jr) could be well fitted to the Kelvin model (R² = 0.994) as a function of time. Compliance values (Jr) were increased with the sugar substitution, thus showing that deformation and internal viscosity (ηr) were decreased with sugar substitution. According to the results of this study, sugar substitution remarkably influenced the structures of dark chocolate samples. For this reason, the use of bulk sweeteners mixture in the formulation can be recommended. Practical applications Over the past decennium, nutritive sweeteners are regarded as ingredients replacing the physical bulk as well as sweetness of sugar. Such products are also called “sugar replacers” or “bulk sweeteners.” Replacement of sucrose with bulking agents can lead to the reduction of calories, glycemic index, as well as preventing dental cavities. Therefore, it is necessary to make suitable products for people suffering from diabetes; accordingly, formulations have been developed using sugar replacers.
Institution pages aggregate content on ResearchGate related to an institution. The members listed on this page have self-identified as being affiliated with this institution. Publications listed on this page were identified by our algorithms as relating to this institution. This page was not created or approved by the institution. If you represent an institution and have questions about these pages or wish to report inaccurate content, you can contact us here.
606 members
• Environmental science
• Undepartment
• Faculty of Agriculture
• Faculty of Agriculture
Information