Gujarat University
  • Ahmedabad, GUJARAT, India
Recent publications
Agriculture plays an important role in Indian economy. In recent era applications and technology usage is drastically increased. To fulfill the demand in Agriculture, it is important to know the information need of the farmer. Farmer’s Information Need can be satisfied by the varied human stakeholders in Agriculture or by the technology use. We have prepared Agriculture Questionnaire to know the farmer’s information need. Our Agriculture Survey is filed as copyright, detailed in [1], We have conducted survey to the varied demography of the farmer on different time and at different location. To improve the accuracy of the survey, we have interviewed the stakeholders on one-to-one basis directly. Our survey to the agriculture stakeholders of Gujarat also enables and facilitate us examining the channels of information communication, gathering information need and knowing varied need in natural Guajarati language. Facts and figures of the survey leads to the necessity of intelligent retrieval system.
Background Researchers now have a new avenue to investigate when it comes to miRNA-based therapeutics. miRNAs have the potential to be valuable biomarkers for disease detection. Variations in miRNA levels may be able to predict changes in normal physiological processes. At the epigenetic level, miRNA has been identified as a promising candidate for distinguishing and treating various diseases and defects. Main body In recent pharmacology, plants miRNA-based drugs have demonstrated a potential role in drug therapeutics. The purpose of this review paper is to discuss miRNA-based therapeutics, the role of miRNA in pharmacoepigenetics modulations, plant miRNA inter-kingdom regulation, and the therapeutic value and application of plant miRNA for cross-kingdom approaches. Target prediction and complementarity with host genes, as well as cross-kingdom gene interactions with plant miRNAs, are also revealed by bioinformatics research. We also show how plant miRNA can be transmitted from one species to another by crossing kingdom boundaries in this review. Despite several unidentified barriers to plant miRNA cross-transfer, plant miRNA-based gene regulation in trans-kingdom gene regulation may soon be valued as a possible approach in plant-based drug therapeutics. Conclusion This review summarised the biochemical synthesis of miRNAs, pharmacoepigenetics, drug therapeutics and miRNA transkingdom transfer.
CdO–ZnO core-shell nanoparticles (CSN) were successfully synthesized by two step assisted chemical sol gel method. The structural properties of synthesized CSN have been analyze by X-ray diffraction (XRD) method, XRD pattern shows a uniform, homogenous phase formation of nano crystals. Microstructural properties of prepared CSN have been analyze by FESEM and HRTEM methods, Surface morphology of the CSN was investigated using FESEM, which shows dense growth and thin layer of ZnO shell over CdO core where as crystallinity of the CSN have been observed from HRTEM images, HRTEM reassures the particle size as obtained from XRD analysis. The optical properties and optical band gap of CSN is obtained from UV–Visible spectroscopy. Raman modes obtained from Raman spectroscopy distinctly identify the CdO and ZnO phonon vibrational modes. The electrical properties have been investigated by temperature dependent dielectric measurement. Moreover, the impedance behavior at different temperature has been investigated by impedance spectroscopy.
Pusa 391, a mega desi chickpea variety with medium maturity duration is extensively cultivated in the Central Zone of India. Of late, this variety has become susceptible to Fusarium wilt (FW), which has drastic impact on its yield. Presence of variability in the wilt causing pathogen, Fusarium oxysporum f.sp. ciceri (foc) across geographical locations necessitates the role of pyramiding for FW resistance for different races (foc 1,2,3,4 and 5). Subsequently, the introgression lines developed in Pusa 391 genetic background were subjected to foreground selection using three SSR markers (GA16, TA 27 and TA 96) while 48 SSR markers uniformly distributed on all chromosomes, were used for background selection to observe the recovery of recurrent parent genome (RPG). BC 1 F 1 lines with 75-85% RPG recovery were used to generate BC 2 F 1. The plants that showed more than 90% RPG recovery in BC 2 F 1 were used for generating BC 3 F 1. The plants that showed more than 96% RPG recovery were selected and selfed to generate BC 3 F 3. Multi-location evaluation of advanced introgression lines (BC 2 F 3) in six locations for grain yield (kg/ha), days to fifty percent flowering, days to maturity, 100 seed weight and disease incidence was done. In case of disease incidence, the genotype IL1 (BGM 20211) was highly resistant to FW in Junagarh, Indore, New Delhi, Badnapur and moderately resistant at Sehore and Nandyal. GGE biplot analysis revealed that IL1(BGM20211) was the most stable genotype at Junagadh, Sehore and Nandyal. GGE biplot analysis revealed that IL1(BGM 20211) and IL4(BGM 20212) were the top performers in yield and highly stable across six environments and were nominated for Advanced Varietal Trials (AVT) of AICRP
Populations in urban centers of developing countries have increased very significantly during the post-1960 period, primarily due to urbanization. Rates of population growth during this period simply overwhelmed their financial, institutional, and technical capacities to manage all types of basic services, including the provision of clean water and proper wastewater management. Surprisingly, issues of access to clean water and sanitation at major international forums of very senior policymakers were first raised during the United Nations Conference, in Vancouver, in 1976. It recommended that everyone should have access to clean water by 1990. Subsequently, Millennium Development Goals set the target that, by 2015, the number of people not having access to clean water should be reduced by half, compared to 1990. The United Nations claimed that this target was met in 2010. However, this is not true. Thereafter, the Sustainable Development Goals stipulated that everyone should have access to clean water by 2030. Current developments indicate that this goal is highly unlikely to be reached. This paper objectively reviews the progress of urban water security in developing countries from the post-1960 period, analyses why international targets were missed in the past, and what can be done to ensure urban water security in developing countries in the future.
Microbial surfactants are amphiphilic surface-active substances aid to reduce surface and interfacial tensions by accumulating between two fluid phases. They can be generically classified as low or high molecular weight biosurfactants based on their molecular weight, whilst overall chemical makeup determines whether they are neutral or anionic molecules. They demonstrate a variety of fundamental characteristics, including the lowering of surface tension, emulsification, adsorption, micelle formation, etc. Microbial genera like Bacillus spp., Pseudomonas spp., Candida spp., and Pseudozyma spp. are studied extensively for their production. The type of biosurfactant produced is reliant on the substrate utilized and the pathway pursued by the generating microorganisms. Some advantages of biosurfactants over synthetic surfactants comprise biodegradability, low toxicity, bioavailability, specificity of action, structural diversity, and effectiveness in harsh environments. Biosurfactants are physiologically crucial molecules for producing microorganisms which help the cells to grasp substrates in adverse conditions and also have antimicrobial, anti-adhesive, and antioxidant properties. Biosurfactants are in high demand as a potential product in industries like petroleum, cosmetics, detergents, agriculture, medicine, and food due to their beneficial properties. Biosurfactants are the significant natural biodegradable substances employed to replace the chemical surfactants on a global scale in order to make a cleaner and more sustainable environment.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease influenced by genetics, non-genetic, and environmental factors that modulate miRNA expression. Currently, no miRNA data are available for HS. In this study, we profiled DNA methylation patterns of miRNA genes associated with HS susceptibility. Objectives: Identify miRNA gene methylation profiles associated with HS susceptibility. This study examined the methylation patterns of DNAs from 24 healthy controls and 24 patients with HS using Illumina Infinium MethylationEPIC BeadChip array analysis. methylation patterns of miRNA genes were analyzed using Ingenuity Pathway Analysis (IPA) to explore the inversely correlated pathways regulated by miRNAs. Results: We identified 60 CpG sites representing 65 unique microRNA genes including 54 hypomethylated and 6 hypermethylated CpGs as potentially associated with HS. Some of these CpGs were found to be critical for skin function, such as miR-29, miR-200, miR-205, miR-548, and miR-132. The miR-192 is implicated in non-alcoholic fatty liver disease. The miR-200c gene was identified as a vital determinant in regulating skin repair after injury and may contribute to age-associated alterations in wound repair. miR-132 was significantly upregulated during the inflammation phase of wound repair, enhancing the activity of STAT3 and ERK pathways that promote keratinocyte proliferation. Conclusions: Epigenetically altered microRNA genes are implicated in wound healing, inflammation, keratinocyte proliferation, and wound modulation. This is the first study to analyze methylation profiles of miRNA genes in the HS population, highlighting the unique role that miRNAs might play in diagnosing and treating HS.
Papain-like protease (nsp-3; non-structural protein) of novel corona virus is an ideal target for developing drugs as it plays multiple important functions for viral growth and replication. For instance, role of nsp-3 has been recognized in cleavage of viral polyprotein; furthermore, in infected host it weakens the immune system via downregulating the production of type I interferon. This downregulation is promoted by removal of ubiquitin-like interferon-stimulated gene 15 protein (ISG15) from interferon-responsive factor 3 (IRF3) protein. Among known inhibitors of SARS-CoV-PLpro GRL0617 is by far the most effective inhibitor. As PLpro of SARS-CoV2 is having more than 80% similarity with SARS-CoV-PLpro, GRL0617 is reported to be effective even against SARS-CoV2. Owing to this similarity, certain key amino acids remain the same/conserved in both proteins. Among conserved amino acids Tyr268 for SARS-CoV2 and Tyr269 for SARS-CoV produce important hydrophobic interactions with aromatic rings of GRL0617. Here, in this study antibacterial compounds were collected from ZINC database, and they were filtered to select compounds that are having similar structural features as GRL0617. This filtered library of compound was then docked with SARS-CoV and CoV2-PLpro. Five hits were noted that were able to interact with Tyr268 (SARS-CoV2) and Tyr269 (SARS-CoV). Further, best hit 2-(2-((benzofuran-2-carboxamido)methyl)-5-methoxy-1H-indol-1-yl)acetic acid (ZINC44459905) was studied using molecular dynamic simulation where stability of protein–ligand complex as well as stability of produced interactions was noted. Graphic abstract
The rapid evolution of science compels renewal of a knowledge-based policy, particularly in cold regions. In the Arctic and Himalayas, which have undergone a significant climate change, there is a disconnect between scientific knowledge and the practices of policy. The rising air temperatures, decreasing ice and snow, increasing precipitation and plastic waste pollutants and the Atlantification of the Arctic Ocean by receiving warmer and saltier water from the Atlantic Ocean call for scientific research questions to strengthen the linkage between science and policy. The Arctic amplification can have remote impacts on other parts of the globe through oceanic and atmospheric teleconnections. Hence, researchers need to push the frontiers of scientific discoveries through multidisciplinary and collaborative approaches in the Arctic Ocean along with connections to the Third Pole – Himalayas. The overall objectives of this paper are to explore how a comparison of the Arctic and the Third Pole is valuable for understanding the Arctic and global biogeophysical processes in this epoch of anthropogenic climate change; provide a strong linkage between the Arctic scientific research and its relevance to society; and help advance a more sustainable future for the Arctic, the Third Pole and the globe.
Resorcin[4]arenes functionalized amide based supramolecular derivatives (E1‐E9) were produced in high yield using microwave irradiation (MWI) and characterized using spectroscopic techniques such as 1H‐NMR, IR spectroscopy, and Mass spectrometry. Antimicrobial, anti‐malarial, anti‐tuberculosis, and anti‐oxidant properties of amide‐based supramolecular hosts were investigated. The majority of the compounds showed exceptional antibacterial activity. Some compounds showed promising antifungal, antimalarial, antituberculosis, and antioxidant properties. Additions to this, few selected derivatives were further tested for their mesomorphic study with formation of columnar type self‐assembly. The liquid crystalline properties were studied by using polarizing optical microscope (POM), differential scanning calorimetry (DSC) and further confirmed by PXRD techniques. All the synthesized supramolecules showed good thermal properties with respect to liquid crystalline mesophase range. A new family of biological active supramolecular resorcin[4]arene derivatives with liquid crystalline properties were synthesized by microwave irradiation in high yields.
The novel and greener approach toward the co-production of hydrolytic enzymes in a single-cultivation medium with inexpensive substrates can bring down the production costs. Likewise, the natural and industrial organic biomass/solid are all nutritionally rich substrates waiting for free use in industries such as food, biofuel, etc. Valorization must broaden its applications in industries and households with a step towards a sustainable environment. The biofuel approach can be projected as one of the most promising deputations to meet future energy demands, in reduction of the environmental pollution due to excessive fossil fuel consumption. The present review highlights the multifaceted stature of microbial enzymes in this direction and possible implications mainly in the food industry and biofuel with the global impact of similar bio-based industries. In this review, design scale-up, fermentation cost, energy needs, and agro-food waste management have been meticulously delineated.
Fusarium is a phytopathogenic mold that belongs to ascomycetes group which are frequently associated with a range of plant diseases such as root and stem rots, blights, and wilts. The mycotoxins produced by Fusarium sp. are responsible for its invasion into fresh fruits and vegetables during storage, causing various rots and spoilage. Conventional approaches for control of Fusarium include the use of fungicides which leads to disruption of indigenous rhizospheric microflora. Therefore, the need of the hour is to design a strategy that selectively targets the phytopathogens without interfering with the natural functioning of the plant and its rhizosphere. Genome mining has enabled the prediction, prioritization, and identification of effector genes (foa, foc, avr and lys) in Fusarium which has extended the existing understanding of host-pathogen interaction that could pave a path towards sustainable genetic immunization of plant against related phytopathogens. Gene clusters in plant growth promoting microbes such as, ituDABC (Bacillus sp.) and phlACBD (Pseudomonas sp.) are identified to be involved in production of iturin and 2,4 –diacetylphloroglucinol, respectively, to control the proliferation of Fusarium. This review describes the microbiological understanding of Fusarium for phytopathogens along with recent developments in its biocontrol by incorporating molecular and computational biology approaches.
A previous research and studies have established the significance of describing Staphylokinase as a thrombolytic treatment, particularly in patients with cardiovascular disease, stroke, and other life-threatening disorders. Staphylokinase plays a significant part in the coagulation process through formation plasmin-Staphylokinase complex on the surface of the clot which activates plasminogen is generated by some strains of Staphylococcus aureus . The publication described the use of the E. coli strain BL12DE3 to produce the protein via the pET21a transporter is predicated on the use of a chemical stimulator (IPTG) which plays an important role in regulating protein recombinant by stimulating protein synthesis. Strain BL12DE3 activates T7 polymerase, encoding LacI via the pET21a transporter. It has been demonstrated that the IPTG inducer achieves the maximum level of protein expression in the shortest amount of time. A Staphylokinase was generated as a soluble protein in excess of 45% by SDS-PAGE and subsequently purified by chromatography.
With the growing importance of information in organisational management and the advancement of information technology, there are now business application systems that assist companies and institutions in making more informed decisions and increasing high organisational efficiency. A company, for example, can use business intelligence, information, and environmental indicators to compare trends and forecast how they will change in the future. Today, business intelligence is one of the most important concepts for management and organisations seeking to lead in global markets and maximise the effectiveness of all of their business activities and processes. The management of a large volume of data can be a time-consuming task if the information is not properly classified and made available when needed. This is especially true in higher education, where massive amounts of data and analytics go unreported during each session. Universities collect a massive amount of data every year, from the time a student enrols to the time he or she completes a course. This data relates to admissions, student enrollment, courses, workshops, seminars, conferences, studios, attendance, financial resources, infrastructure development, and other topics. The most important responsibility is to compile data when this data needs to be expressed in an understandable format so that the Vice-Chancellor, Directors, Head of Department, Professor, and other high-ranking administrators can quickly understand the performance of ongoing tasks. Business Intelligence (BI) has developed dashboard technology that visualises trends and patterns, allowing for a more reliable and strategic approach. This paper discusses the significance of Business Intelligence (BI) and dashboard technology in higher education institutions (HEI). It is a data-driven, mission-updated, and student-centered BI dashboard that will not only keep decision-makers informed, but will also assist them in strategic planning and decision-making.
This study highlights the development of a lab-scale, indigenously designed; Packed-Bed Biofilm Reactors (PBBR) packed with brick pieces. The developed biofilm in the reactor was used for the decolourisation and biodegradation of the textile industry effluent. The PBBR was continuously operated for 264 days, during which 301 cycles of batch and continuous treatment were operated. In batch mode under optimised conditions, more than 99% dye decolourisation and ≥ 92% COD reduction were achieved in 6 h of contact time upon supplementation of effluent with 0.25 g L − 1 glucose, 0.25 g L − 1 urea, and 0.1 g L − 1 phosphates. A decolourisation rate of 133.94 ADMI units h − 1 was achieved in the process. PBBR, when operated in continuous mode, showed ≥ 95% and ≥ 92% reduction in ADMI and COD values. Subsequent aeration and passage through charcoal reactor assisted in achieving ≥ 96% reduction in COD and ADMI values. An overall increase of 81% in dye-laden effluent decolourisation rate, from 62 mg L − 1 h − 1 to 262 mg L − 1 h − 1 , was observed upon increasing the flow rate from 18 mL h − 1 to 210 mL h − 1 . Dye biodegradation was determined by UV-Vis and FTIR spectroscopy and toxicity study. SEM analysis showed the morphology of the attached-growth biofilm.
Background and Objective Andrographis paniculata belonging to Acanthaceae family is well-known potential hepatoprotective herb. The role of diet on human health and diseases including Hepatocellular Carcinoma has been demonstrated by innumerable studies which have also testified that plant-derived micro-RNAs, transferred to animals via oral consumption wherein it alters host gene expression and this provides the evidence for inter-species gene regulation. Herein, we aim to explore the role of predicted miRNAs of A. paniculata on human health. Methods and Results In the present study, A. paniculata miRNAs have been predicted and their impact on human transcriptome is uncovered by employing computational approach. By implementing miRNA prediction on A. paniculata genomic data and plant miRNA sequences present in miRBase repository, we have identified 20 miRNAs which are confined to 16 miR families. 197 human target genes were predicted for the identified miRNAs, which were further subjected to Gene Ontology analysis and network analysis revealing their significant role in various biological processes and signaling pathways. The identified hub proteins HGF, NRP2 and CCND1 show their significant involvement in cancerous pathways including STAT3, MAPK, TGF-β, mTOR and VEGFR pathways. Deregulation of these pathways has been reported as oncogenic response involved in Hepatocellular Carcinoma, cell proliferation and metastasis. Conclusion The findings of our study suggest potentially beneficiary role of A. paniculata miRNAs in regulating cancer via cross-species genetic regulation. Conclusively, our study sustains the promising theory of inter-species gene regulation.
The anti‐microbial, anti‐tubercular, anti‐malarial, and anti‐oxidant properties of a series of benzimidazole hybrid thiosemicarbazide derivatives (7a‐o) were investigated in vitro. IR, 1H‐NMR, 13C‐NMR, and ESI‐MS spectra were used to describe and elucidate the synthesized compounds. The majority of the compounds studied have excellent antibacterial and antioxidant properties. In addition, an in silico investigation was conducted. By calculating ADME‐Tox descriptors, all freshly synthesised molecules were shown to have outstanding pharmacokinetic properties, indicating that these derivatives could be used as a basis for the development of some novel active drugs. A SAR (structure‐activity relationship) was also briefly described. This article is protected by copyright. All rights reserved.
The role of Indian ethos in management practices is explored by several management scholars and practitioners. Professor Sitangshu Kumar Chakraborty (popularly known as Professor S. K. Chakraborty, hereinafter referred to as SKC in this article) is one of the pioneering scholars of human value-oriented management practices and has made significant contributions in linking the management knowledge and practices to classical Indian ethos and Vedantic wisdom. In today’s technologically advanced and economically fast-paced world, there is a rising concern about falling human values in work and in personal life, which must be addressed to understand the deeper meaning of work and a higher purpose in life. SKC’s innovative approaches to human values in management education for practising managers are quite significant in this regard. This article is a sincere attempt to explore and synthesize the contributions of SKC to the human value-oriented management that evolved around the fundamental pillars of classical Indian ethos and Vedantic wisdom and the implication of those values for today’s managers to realign their managerial practices. This article is based on a bibliometric analysis of published articles drawn from secondary sources and is a tribute to the life and legacy of SKC on human value-based management.
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Shrivastav Pranav S
  • Department of Chemistry
Nita H. Shah
  • Department of Mathematics
Manharlal Patel
  • Department of Statistics
Devayani R Tipre
  • Department of Microbiology & Biotechnology
Gurudutta Japee
  • Department of Commerce
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