Generalitat de Catalunya

This commentary paper emphasises the pivotal role of effective communication in the field of podiatry and advocates for its comprehensive integration into the educational curriculum. It argues that the combination of strong academic performance and well-developed communication skills equips podiatry students to improve diagnoses and successful future treatment outcomes. These skills should be comprehensively taught and carefully assessed as part of the patient-centered care approach for podiatry students. The paper explores the multifaceted role of communication in podiatry, highlighting its importance in various aspects of the profession. These include building rapport with patients, interpreting complex medical information, and fostering a therapeutic alliance that is conducive to successful treatment outcomes. It also underscores the significance of communication in collaborating with interdisciplinary teams and advocating for patient wellbeing. Proficiency in communicating with patients can contribute to the development of a wide range of career competencies in podiatric medicine, including clinical skills, research and innovation, cultural competence, and effective teamwork, both nationally and internationally. The paper also delves into various topics such as gathering patient history, explaining diagnoses and treatment options, providing patient education, and enhancing patient outcomes through interprofessional practice. This commentary paper explores the role of communication in research participation and the teaching and assessment of communication skills through innovative methods such as role-playing, simulations, and standardized patients. In conclusion, by reiterating that the essence of podiatry extends beyond technical proficiency to include meaningful interactions between the podiatrist and the patient, which are facilitated by strong communication skills. This paper may serve as a call to action for universities nationally and internationally to place greater emphasis in integrating and thoroughly assessing communication skills in their podiatric medicine programs.

In this study we have compiled the information from official databases about Iberian ibex, Capra pyrenaica, hunting yields, hunting trophies and hunting licenses in the Spanish regions where the species is present and hunted. Such quotas showed an increasing trend between 2005–2021 and, on average, during this period, ≈ 6400 animals were yearly harvested. Despite this number decreased in 2019 and 2020 (in this last year, mainly due to the lock down caused by the COVID pandemia), the annual quota raised, reaching over 12,000 ibexes in 2021. The number of trophies increased since the 1970s and peaked in the period 2001–2005, and then declined during the period 2006–2020. At national level, the number of hunting licenses decreased from 2006 to 2021 by a 36.5%. The regional average hunting yield was significantly correlated with a regional-based ibex abundance estimation. The current situation of continued population increase together with the trophy reduction might suggest that the overall population is exceeding the carrying capacity. In this context, if hunting activity was one of the main factors involved in local extinction of the species, currently it should be considered a tool for sustainable managing of ibex populations in an scenario of increasing demographic trends and generalized absence of predators.

Wealth is a central determinant of life chances and intergenerational status persistence in modern societies. Despite increasing attention, sociologists traditionally overlooked its role in class-based economic disparities, while most economists focused on the elites' accumulation. This article combines sociological and economic perspectives to test whether big occupational classes, the most standardised and operationalisable approach, depict the wealth distribution. Drawing from the Luxembourg Wealth Study (2002-2018) in five European countries, we explore (1) how wealth is distributed and stratified by big occupational classes over time and cross-nationally and (2) to what extent classes account for aggregate wealth inequality trends compared with income. Unlike bold claims on class 'death' or 'decomposition', inequality of outcomes in wealth accumulation is firmly rooted across big occupational classes in contemporary capitalism, potentially harming social mobility in future generations. Still, occupational classes better capture between-group income inequality and stratification than wealth, emphasising the importance of economic resources beyond labour market attachment. Against the backdrop of previous research and our findings, we discuss the role of wealth in contemporary class analysis.

In the educational context, the transmission of scientific evidence to the classroom is essential to improve the quality of education and to develop effective research-based practices. However, in the interplay between teachers, researchers, political and educational institutions, there are a number of barriers that hinder this transmission. According to several studies, these difficulties arise from the lack of teacher training, work overload, the difficulty of accessing scientific articles, the existence of unethical behaviour and the instability of the Spanish educational system. Approaching the teaching reality with the will to strengthen this link will allow making proposals that will have a significant impact on their teaching practices. Thus, the objective of this work is to design and validate a questionnaire that measures self-perception on the use of scientific knowledge in teaching practice. This tool, intended for future teachers and active teachers, will allow the collection of perceptions on barriers and facilitators for the implementation of scientific evidence in the classroom. Based on a quantitative research approach, the content of the questionnaire was validated by means of an expert judgment. Then, a pilot test was carried out with the participation of 278 future teachers of the Master's Degree in Teacher Training of 4 Catalan universities. Finally, an analysis of reliability and construct validity was carried out by means of an Exploratory Factor Analysis (EFA). The result has been the validation of a tool that will allow a more detailed understanding of the phenomenon of barriers between educational scientific evidence and teachers. This will facilitate the detection of strengthening pathways between educational research and classroom practices, promoting a more effective implementation of scientific evidence that will result in a continuous, more effective and more efficient improvement of education.

Purpose Mother-Infant Interaction (MII) is the first dynamic relationship that focuses on both mother-infant involvement and dyadic coordination and is associated with infant development. The main objective of this review is to summarize the evidence on the quality of MII in mothers with Severe Mental Illness (SMI). Method A systematic search for cross sectional, cohort or case control studies has been carried out in PubMed, Web of Science, PsycINFO and Scopus to extract studies addressing the relationship between the quality of MII and SMI. Results A total of 15 studies with a sample of 992 women were included. Studies showed worst outcomes for MII in mothers with psychotic disorder and bipolar disorder. The impairments were more pronounced in psychotic disorders. Conclusions There is evidence of impaired MII in SMI. Social cognition (SC) is essential for understanding and responding to infant cues, so it could partially explain the associations between SMI and interaction outcomes. The current evidence is limited due to substantial heterogeneity and methodological limitations in the studies. Therefore, such findings should be interpreted with caution.

Waste management presents a significant challenge for agri-food industries, but also an opportunity to recover valuable bioactive compounds, particularly phenolics, aligning with circular economy principles. This study compares the efficacy of conventional solvents and natural deep eutectic solvents (NADES) in extracting polyphenols from olive leaves using the scalable techniques of solid–liquid extraction (SLE) with mechanical stirring and microwave-assisted extraction (MAE). Key factors affecting extraction yield, including solvent composition, time, and temperature were investigated. Extraction efficiency was evaluated by measuring total polyphenol content (TPC) by high-performance liquid chromatography (HPLC), antioxidant capacity (FRAP assay), and individual phenolic compounds, also quantified using HPLC. Additionally, differential pulse voltammetry (DPV) was employed to evaluate the antioxidant quality of the extracts. NADES demonstrated superior extraction performance compared to conventional solvents, with the choline–glycerol system showing the highest efficiency. The combination of MAE and NADES emerged as a green and sustainable alternative to traditional methods, offering improved yield and speed. In contrast, SLE with water or ethanol/water mixtures required extended times or higher temperatures for comparable results but offered easier scalability for industrial applications.

Smartwatch technology is increasingly being used to support the management of chronic health conditions. Yet, many new digital health innovations fail because the correct foundations are not well established. This exploratory study aims to uncover the challenges experienced during the setup phase of a smartwatch intervention, to support the prototype development of a digital health intervention for children. Five children with a chronic health condition were asked to wear a smartwatch for 14 days that collects health data (pain levels, medication adherence, and physical activity performance). To explore the experiences of these children, their parents and the research team, all written records were analysed using READ’s four steps of document analysis and reported using the Standards for Reporting Qualitative Research checklist. The following three themes emerged: 1.) Infrastructure limitations: inexpensive smartphones prevented connection, and outpatient clinics’ internet black spots constrained setup and training; 2.) Personal phone restrictions: limited setup, training, and engagement; 3.) Elimination of the parent’s phone: provided children with digital support (a smartphone, pre-installed apps, cellular data) to allow active participation. Overall, we identified barriers hindering the use of smartwatch technology in clinical practice. More resources are needed to ensure paediatric preparedness for digital health support.

Background In Catalonia, infants <6 months old were eligible to receive nirsevimab, a novel monoclonal antibody against respiratory syncytial virus (RSV). We aimed to analyze nirsevimab’s effectiveness in hospital-related outcomes of the seasonal cohort (born during the RSV epidemic from October to January 2024) and compared them with the catch-up cohort (born from April to September 2023). Methods Retrospective cohort study of all infants born between October 1, 2023, and January 21, 2024, according to their immunization with nirsevimab (immunized and nonimmunized). We followed individuals until the earliest of an outcome—hospital emergency visits, hospital admission or pediatric intensive care unit (PICU) admission due to RSV-associated or all-causes bronchiolitis—death or the end of the study. We used the Kaplan-Meier estimator and fitted Cox regression models using a calendar time scale to estimate hazard ratios (HRs) and their 95% confidence interval (CI). Sensitivity analysis was performed through matching. Results Among 15,341 infants, a dose of nirsevimab led to an adjusted HR for hospital admission, PICU admission and emergency visits due to RSV bronchiolitis of 0.26 (95% CI: 0.17–0.39), 0.15 (95% CI: 0.07–0.28) and 0.46 (95% CI: 0.23–0.90), respectively. For all-causes bronchiolitis, the former adjusted HRs were 0.45 (95% CI: 0.31–0.63), 0.23 (95% CI: 0.13–0.41) and 0.49 (95% CI: 0.35–0.68), respectively. Conclusions Nirsevimab was associated with reductions of 74% and 85% hospitalizations and PICU admissions regarding RSV-associated bronchiolitis, respectively. These percentages are slightly lower than those for the catch-up cohort. This information may help the implementation of RSV-immunization campaigns by public health authorities.

Alzheimer’s disease (AD) poses a global health challenge, demanding innovative approaches for effective treatments. Clerodendrum infortunatum Linn. (Lamiaceae) is a shrub traditionally used as a medicinal plant to treat inflammation, skin diseases, and bronchitis. This study aims to identify the main bioactive metabolites in C. infortunatum using LC-QTOF-MS/MS and investigate its potential in protecting against cognitive decline in rats with scopolamine-induced AD disease. Metabolite profiling was performed on the methanol extract of the plant’s aerial parts using LC-QTOF-MS/MS. The inhibitory activity of the acetylcholinesterase enzyme was measured in vitro. To evaluate the cognitive effects, the methanol extract was orally administered at three doses (100, 200, and 400 mg/kg) to scopolamine-induced AD rats, and their cognitive functions were assessed using the novel object recognition test. Additionally, acetylcholinesterase enzyme activity, as well as the levels of acetylcholine, dopamine, noradrenaline, glutathione, malondialdehyde, tumor necrosis factor-α, interleukin-1β, and amyloid-β in the rat hippocampus, were measured using ELISA, followed by histopathological evaluation. A total of 79 metabolites, spanning various chemical classes, such as organic acids, phenolic acids, phenylpropanoids and phenylethanoids, flavonoids, coumarins, other phenolics, and fatty acids and their derivatives, were identified. The results showed that the extract promoted enhanced cognitive functions in the novel object recognition test. Scopolamine administration significantly altered the acetylcholinesterase enzyme activity and biomarker levels in the rat’s hippocampus. However, treatment with C. infortunatum at 200 and 400 mg/kg almost restored these neurotransmitter levels to normal, which was further confirmed by histopathological analysis. This study demonstrates the therapeutic potential of C. infortunatum in mitigating cognitive decline in AD, with its first metabolite profiling revealing a range of bioactive compounds. The extract improved cognitive function in scopolamine-induced AD rats, restored acetylcholinesterase activity, normalized neurotransmitter levels, and reduced oxidative stress and inflammation. These findings suggest that C. infortunatum is a promising candidate for the development of natural therapies targeting AD.

Many plants are reported to enhance cognition in amnesic-animal models. The metabolite profile of Cordia dichotoma fruit methanolic extract (CDFME) was characterized by LC-QTOF-MS/MS, and its total phenolics content (TPC) and total flavonoids content (TFC) were determined. In parallel, its cognitive-enhancing effect on scopolamine (SCOP)-induced AD in rats was evaluated. The TPC and TFC were 44.75 ± 1.84 mg gallic acid equiv. g⁻¹ sample and 5.66 ± 0.67 mg rutin equiv. g⁻¹ sample, respectively. In total, 81 metabolites were identified, including phenolic acids, lignans, coumarins, amino acids, fatty acids, and their derivatives, fatty acid amides, polar lipids, terpenoids, and others. The most abundant metabolites identified were quinic acid, caffeoyl-4′-hydroxyphenyllactate, rosmarinic acid, and oleamide. CDFME (200 mg kg⁻¹) was found to significantly enhance recognition memory in the novel object recognition test. Furthermore, it nearly corrected acetylcholinesterase (AChE), acetylcholine, noradrenaline, and dopamine hippocampal levels, which changed due to SCOP. Further in silico validation of the in vivo results was conducted, focusing on the most abundant metabolites. Molecular docking showed that rosmarinic acid, caffeoyl-4′-hydroxyphenyllactate, sebestenoid C, and sagerinic acid exhibited the greatest affinity for receptor binding against AChE. However, molecular dynamics and mechanics calculations clarified that the complex of caffeoyl-4′-hydroxyphenyllactate with AChE was the most stable one. This study represents the first comprehensive metabolite profiling of CDFME to assess its cognition-enhancing effect both in vivo and in silico. These results demonstrate that CDFME protects against SCOP-induced cognitive impairment. Thus, additional preclinical and clinical studies on CDFME may provide an attractive approach in pharmacotherapy and AD prophylaxis.

Recent years have seen the development of various classifications of muscle injuries, primarily based on the topographic location within the bone-tendon–muscle chain. This paper proposes an enhanced nomenclature for muscle injuries that incorporates histoarchitectural definitions alongside topographic classifications, emphasizing the importance of connective tissue damage characterization. A detailed understanding of the distinct anatomical and histological characteristics of tendon, aponeurosis, and fascia is essential for consistent terminology. Tendons, aponeuroses, and fasciae, while all composed of dense connective tissue, differ in collagen fiber orientation and structural organization. Tendons feature longitudinally aligned fibers suited for high tensile forces and muscle-to-bone connections. Aponeuroses have perpendicular collagen fiber layers, allowing for force distribution and support for both longitudinal and transverse traction. Fasciae exhibit loosely organized fibers providing flexibility and movement between muscles. The continuity and differences within the musculotendinous frameworks, particularly at the musculotendinous junction (MTJ), elucidate the higher frequency of injuries at these sites compared with tendons, highlighting the MTJ's role as a stress-absorbing 'safety valve.'

Mountain environments pose challenges for accurately assessing the population size of ungulates, which may hamper confidence in using abundance estimates for decision-making. Thus, evaluations of the accuracy of methods using known-size populations are valuable. Here, we tested the accuracy of direct counts and distance sampling to assess the size of a fenced population of Iberian ibex (Capra pyrenaica) of known size. We evaluated the influence of observer expertise (beginners and experts) on the detection error of female and male ibexes and whether training improved accuracy. The ibex population comprised 18 individuals (ten males and eight females) living in a 17-ha enclosure in northeastern Spain. After 27 surveys, experts detected 16% more ibexes than beginners. Male ibexes were ~ 13% easier to detect than females, and experts were more accurate than beginners in sexing individuals. Additionally, the detection error in absolute counts was similar among beginners but different among experts (> 10%). Despite reducing detection error over subsequent surveys, under-detection was > 50% in all events (> 85% and > 67% for beginners and experts, respectively). Our data indicate a systematic underestimation of direct counts of our mountain ungulate populations and the contribution of expertise to improving accuracy. Our results show that managers assessing mountain ungulate populations for management purposes should consider alternative methods.

Introduction We aimed to explore the impact of the COVID‐19 pandemic and the resulting restrictions on the emotional state of people with type 2 diabetes mellitus (T2DM) and/or hypertension in Ecuador and Spain. Given the differences in sociopolitical and socioeconomic contexts between these two countries, the research focused on how these diverse environments and their management of social policies and pandemic strategies influenced the emotional well‐being of individuals with chronic illnesses. Methods We conducted 36 semi‐structured telephone interviews between August and December 2020 with adults diagnosed with T2DM and/or hypertension (19 in Ecuador, 17 in Spain). The interviews were recorded, anonymized and transcribed for thematic analysis. This approach allowed us to systematically identify and analyse themes related to the participants' emotional experiences during the pandemic. Results The results revealed a significant deterioration in the emotional state of participants, attributable to the stress generated by the health crisis and concerns related to their chronic illnesses. The situation elicited a range of emotions among participants, from boredom and apathy to fear, uncertainty and depression. The study highlighted how the impact on emotional well‐being was shaped by the interplay between conjunctural determinants (measures to control COVID‐19 infections) and structural factors driving inequalities (social class, gender, ethnicity). Conclusion We developed a conceptual framework illustrating how measures to control COVID‐19 infections directly influenced economic, health and social determinants, which interacted with pre‐existing inequalities and had a differential impact on individuals' emotional well‐being. This framework can be useful for designing more effective and equitable social policies during future health crises, ensuring they address social needs and safeguard psychological and emotional well‐being, particularly among vulnerable groups such as those with chronic illnesses. Patient and Public Contribution Thirty‐six participants diagnosed with T2DM and/or hypertension (19 in Ecuador, 17 in Spain) contributed to the study by sharing their emotional experiences during the pandemic. Their detailed accounts enriched the research by providing valuable insights into how the pandemic affected their emotional well‐being. There was no additional involvement or contribution from the public in the design, conduct, analysis or interpretation of the study, nor in the preparation of the manuscript.

Chimpanzees use spatiotemporal cognition for fruit foraging by remembering tree locations and fruiting seasons. However, the spatiotemporal cognition behind exploiting other foods has rarely been studied. Here, we investigate whether chimpanzees use memory to exploit concealed, underground army ant nests. We analyse 679 chimpanzee visits to four nests recorded during five years (2018–2022) using camera traps in a savanna habitat. We explore if chimpanzees intentionally revisit nests, study how they detect ants, and assess ant availability and chimpanzee ant consumption. Nests are concealed, scarce, and intermittently reoccupied, yet chimpanzees eat ants frequently. We find that out of 34 identified chimpanzees who visit the nests, 23 revisit at least one. Chimpanzees visit nest sites significantly more often than similar sites without nests. Individuals revisit significantly sooner and inspect significantly longer nests where they have more recently encountered ants. The apes use sight, smell, taste, touch, and probing tools, to detect ants inside nests. We provide the first evidence suggesting that chimpanzees use spatial and episodic-like memory to exploit concealed social insects throughout multiple years. Our results expand our understanding of the cognitive strategies behind chimpanzee insectivory, suggesting it may have played an important role in the evolution of primate spatiotemporal cognition.

Blood lactate concentrations in capillary samples obtained from the ear lobe or from the finger tip are used indistinctly, since they are considered equivalents. The aim of the study reported in this paper was to verify whether that assumption is valid due to the practical implications which any possible differences between these two sampling sites would have in the planning and assessing of an athletic training program. Twenty six healthy male athletes competing in different sports at the national level (9 rowers, 7 cyclists and 10 runners) were studied during the performance of a graded exercise test up to the point of exhaustion, on specific ergometers. In each group, capillary blood samples were obtained simultaneously from both the ear lobe and the finger tip at three different times during the test: 1) in resting conditions; 2) when exercising at a submaximal work load and 3) seven minutes after the point of exhaustion. Significant differences were found between the blood lactate concentrations of samples obtained from the ear lobe and from the finger tip (p< 0.001). The method error of repeated measurements for lactate concentrations from paired samples obtained in resting conditions was 27%, when exercising at a submaximal work load, 16% and at maximal work load, 3%. Capillary blood samples collected from the finger tip consistently showed higher values in lactate concentration than those obtained, at the same time, from the ear lobe.