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  • No preview · Conference Paper · May 2015
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    ABSTRACT: a b s t r a c t We investigated the effects of silver nanomaterials (AgNMs) on five well-characterized soils with distinct physicochemical properties using two standardized test systems. The carbon transformation test (OECD 217) showed minimal sensitivity whereas the ammonia oxidizing bacteria test (ISO 15685) showed extreme sensitivity over 28 days of exposure. AgNM toxicity was compared with the physicochemical properties of the soils, revealing that toxicity declined with increasing clay content and increasing pH. AgNM toxicity did not appear to be affected by the organic carbon content of the soil. Our results showed that AgNM toxicity cannot be attributed to any single soil property but depends on the same parameters that determine the toxicity of conventional chemicals. Recommendations in the test guidelines for soil ecotoxicity studies are therefore applicable to AgNMs as well as conventional chemicals. article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
    Full-text · Article · Jan 2015 · Environmental Pollution
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    ABSTRACT: The amino acid taurine is required for development and functioning of the central and peripheral nervous system where it exerts osmoregulatory, neuromodulatory and anti-apoptotic actions. It is subject to cellular import by the taurine transporter slc6a6. Absence of the transporter and consequently, absence of taurine leads to several neurologic deficits and sensory losses. In a slc6a6 knockout mouse model, consequences of congenital taurine deficiency were assessed in nociceptive sensory processes. The formalin assay, hot plate assay, and summated generator potentials in response to local nociceptive stimulation with gaseous CO2 were applied. Reduced responsiveness of slc6a6(-/-) mice to nociceptive stimulation was observed in particular to chemical nociceptive stimuli. Scl6a6 knockout mice spent significantly less time licking the formalin injected paw and displayed smaller amplitudes of the nociceptive nasal mucosa potentials than wild type mice (p = 0.002 and 0.01 respectively). In contrast, withdrawal latencies on a hot plate did not significantly differ, suggesting that intracellular taurine deficits lead in particular to a hyposensitivity of nociceptive sensory neurons sensitive to noxious chemical stimulation. As hereditary absence of taurine affects biological processes of anatomical structure development, the altered nociceptive responses likely reflect consequences of compromised peripheral nervous system development.
    Full-text · Article · Dec 2013 · Neuroscience

Information

  • Address
    Forckenbeckstraße 6 , 52074 Aachen , Aachen, Germany
  • Head of Institution
    Prof. Dr. Rainer Fischer
  • Website
    http://www.ime.fraunhofer.de/
  • Phone
    +49 241 6085-12020
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Top publications last week by reads

 
Peptides 01/2016; DOI:10.1016/j.peptides.2016.01.016
76 Reads
 
Critical Reviews in Environmental Science and Technology 03/2014; 44(24). DOI:10.1080/10643389.2013.829767
16 Reads

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