Authors: Kevin O’Donnell, William Porter III, Wes Spaulding, Florin Dan, T. Fowler, Britt Venchura
Purpose: The purpose of this study was to assess the performance of AFFINISOL™ HPMCAS HP polymers in hot melt extrusion with regards to both extrusion performance, and performance of the resulting solid dispersions. Furthermore, this study was performed to determine differences in dissolution performance between solid dispersions prepared with HPMCAS HP and standard grades of HPMCAS as well as differences in thermal properties between the two polymer types.
Purpose: The purpose of this study was to assess the performance of AFFINISOL™ HPMCAS HP polymers in hot melt extrusion with regards to both extrusion performance, and performance of the resulting solid dispersions. Furthermore, this study was performed to determine differences in dissolution performance between solid dispersions prepared with HPMCAS HP and standard grades of HPMCAS as well as differences in thermal properties between the two polymer types.