Cardinal Stefan Wyszyński University in Warsaw

Chronopsychological research typically applied the morningness-eveningness dimension , resulting in a distinction between morning, intermediate, and evening chrono-types. However, in recent years, new measures have been developed that transcend the traditional "morning larks" vs. "night owls" dichotomy and better capture the complexity of individual differences in circadian rhythmicity. One such measure that addresses the multidimensional character of the circadian rhythm is the Morningness-Eveningness-Stability Scale improved (MESSi) which comprises three dimensions: morning affect, eveningness, and distinctness. However, delineating specific chronotypes using the cutoff points, as was commonly done for other established scales, is not possible in the case of MESSi due to its multidimensionality. In the present paper, we provide a first attempt to introduce a cluster-based approach to deal with MESSi scores. For this purpose, we determined the number of clusters to be extracted using data from our previous study conducted in Poland (N = 1106). Next, we attempted to replicate this cluster solution in another Polish sample (N = 768) and a German sample (N = 637). Finally, we also intended to illustrate how individuals assigned to the established clusters differ in terms of sleep parameters and other differential variables such as positive and negative affect, personality traits, depressive and anxiety symptoms, self-regulation, and self-efficacy. After segmenting MESSi scores by cluster analysis in the three samples we found support for a four-cluster solution, including four circadian profiles which we propose to label "interme-diate-finches", "hardy larks", "night owls", and "vulnerable larks". This is the first attempt to introduce a cluster-based, multi-dimensional approach to dealing with MESSi scores.

Biblical didactics is an important element of confessional religious education. In traditional settings, it is primarily associated with working with the text, alone or in groups, in plenary discussion or pantomime. Nowadays, however, young people are increasingly acquiring their knowledge — including about the Bible — on the Internet, using new technologies such as conversational Artificial Intelligence (AI), of which ChatGPT (Generative Pre-trained Transformers) is perhaps the best-known example. In this context, the following article seeks to answer the question of whether, and if so to what extent, ChatGPT can be a helpful tool for teaching the Bible in the classroom. To answer this question, the authors present a theoretical framework that encompasses both foundational insights into conversational AI and ChatGPT, as well as their implications for religious education and biblical teaching in Germany. In the next step, based on J. Theis’ five-step model of Bible didactics [(1) initial perception; (2) analysis of the text; (3) in-depth reflection; (4) critical interpretation; (5) creative assimilation], ways of using ChatGPT in biblical teaching in the classroom are presented and their potential limitations are discussed. The article concludes with six final theses that summarise the investigation findings and offer some suggestions for the future.

Doxorubicin ( DOX ) is a cytostatic drug with a broad spectrum of anticancer activity that has been used in oncology for over 50 years. Among many adverse effects in humans, the most dangerous is late dilated cardiomyopathy, which appears even years after completion of therapy. However, in cats, the critical organ for the toxic effects of DOX is the kidney. Herein, nephrotoxicity is manifested as azotemia. The main aim of our study was to evaluate the protective effect of dexrazoxane ( DEX ) and carvedilol ( CVD ) against the nephrotoxic effects of DOX . Nephrotoxicity studies were performed in a rat model of repeated DOX administration. Analyzed blood morphological, biochemical and histopathological findings revealed that DEX has a dual effect: it positively impacts DOX -induced histological alterations and creatinine levels while negatively affecting urea concentration. Thus, the results do not support univocally recommend DEX to prevent nephrotoxicity caused by DOX in cats. However, further studies using initially lower doses of DEX are needed to assess the prevention of nephrotoxicity in cats clinically treated with DOX .

Russia's aggression against Ukraine and the efforts to prosecute the perpetrators have renewed the debate regarding domestic and international criminal jurisdiction over the crime of aggression. Given the interstate nature of this crime and its link to an act of aggression, the existence of which can be determined by the Security Council, the International Law Commission's (ILC) relatively restrictive approach to the exercise of criminal jurisdiction prevailed, at least until 2022. Against this background, the discussion regarding the establishment of a Special Tribunal for the crime of aggression against Ukraine has significantly influenced the trajectory of the understanding of general international law concerning individual criminal responsibility for the crime of aggression. The interpretative paths adopted in the mid-1990s are gradually being abandoned. At the same time, an intense ongoing debate concerning the understanding of the phrase " international criminal courts, where they have jurisdiction" has not led to any conclusive arrangements. Still, what is known is that there is a certain group of states for which such courts can be created through bilateral agreement between the state concerned and the United Nations, on the recommendation of the UN General Assembly.

We propose a new, simple and efficient procedure of light-driven deoxygenation of solutions based on hydroperoxides formation upon irradiation. Efficient and fast removal of molecular oxygen is caused by photosensitized generation of singlet oxygen, which then reacts with the solvent (2-methyltetrahydrofuran or tetrahydrofuran). Oxygen depletion makes it possible to observe processes normally undetectable in non-degassed liquid samples at room temperature, such as phosphorescence and triplet-triplet annihilation. The potential of the proposed protocol is demonstrated by recording of previously unknown phosphorescence of palladium complex of octaethylporphycene.

Biodiversity experiments revealed that plant diversity loss can decrease ecosystem functions across trophic levels. To address why such biodiversity-function relationships strengthen over time, we established experimental mesocosms replicating a gradient in plant species richness across treatments of shared versus non-shared history of (1) the plant community and (2) the soil fauna community. After 4 months, we assessed the multitrophic functioning of soil fauna via biomass stocks and energy fluxes across the food webs. We find that soil community history significantly enhanced belowground multitrophic function via changes in biomass stocks and community-average body masses across the food webs. However, variation in plant diversity and plant community history had unclear effects. Our findings underscore the importance of long-term community assembly processes for soil fauna-driven ecosystem function, with species richness and short-term plant adaptations playing a minimal role. Disturbances that disrupt soil community stability may hinder fauna-driven ecosystem functions, while recovery may require several years.

We test the theory that personality incoherence may instigate personality change in the context of personal values. Values’ near-universal organization makes value incoherence assessment straightforward. The study included 13 longitudinal samples from seven cultures (Australia, Israel Palestinian citizens, Israel Jewish majority, Italy, Poland, Portugal, and Switzerland), total N = 7,126, and T1 M age ranging between 6 and 18. Each participant reported values between two- and six-times. Using unfolding analysis, we calculated the fit of the internal value structure of each participant at the first time point to the value structure in their sample (normative structure) and to the theoretical structure of values. We estimated value change using Growth Curve Modeling (when at least three measurement times were available) and the difference between T1 and T2 in each sample. We correlated value incoherence with value change and estimated the effect across samples using a meta-analysis. Incoherence with the structure of values predicted greater value change. The associations were stronger when participant’s value structures were compared to the normative value structure at T1 than when they were compared to the theoretical structure. A meta-regression analysis indicated that effects were not moderated by age. We discuss possible underlying processes and implications for personality development.

A dual-wavelength high-accuracy universal polarimeter was applied to the circular birefringence and optical activity measurement in potassium titanyl phosphate (KTP) nonlinear crystal. The experimental setup used two single-mode He-Ne lasers with close wavelengths of 594 and 633 nm as light sources. Measurement has been carried out for two crystal settings in directions of a 45-degree relative angle to the [100] and [010] crystallographic axes. Multiple light reflections inside the crystal sample were considered when processing the results of the polarimetric measurements. The results have been analysed using the optical transmission function for the polariser-sample-analyser system, and 2D intensity contour maps made it possible to determine the phase parameters, systematic errors, and eigenwaves ellipticity. It was found that the gyration tensor component of the KTP crystal is equal to g12 = 1.4 ⋅ 10−5 which in terms of optical rotatory power corresponds to the very small magnitude of the rotation value of 2.3 deg/mm.

Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism. The genetic defect in WD affects the ATP7B gene, which encodes the ATP7B transmembrane protein, which is essential for maintaining normal copper homeostasis in the body. It is primarily expressed in the liver and acts by incorporating copper into ceruloplasmin (Cp), the major copper transport protein in the blood. In conditions of excess copper, ATP7B transports it to bile for excretion. Mutations in ATP7B lead to impaired ATP7B function, resulting in copper accumulation in hepatocytes leading to their damage. The toxic “free”—unbound to Cp—copper released from hepatocytes then accumulates in various organs, contributing to their damage and clinical manifestations of WD, including hepatic, neurological, hematological, renal, musculoskeletal, ophthalmological, psychiatric, and other effects. While most clinical manifestations of WD correspond to identifiable organic or cellular damage, the pathophysiology underlying its psychiatric manifestations remains less clearly understood. A search for relevant articles was conducted in PubMed/Medline, Science Direct, Scopus, Willy Online Library, and Google Scholar, combining free text and MeSH terms using a wide range of synonyms and related terms, including “Wilson’s disease”, “hepatolenticular degeneration”, “psychiatric manifestations”, “molecular mechanisms”, “pathomechanism”, and others, as well as their combinations. Psychiatric symptoms of WD include cognitive disorders, personality and behavioral disorders, mood disorders, psychosis, and other mental disorders. They are not strictly related to the location of brain damage, therefore, the question arises whether these symptoms are caused by WD or are simply a coincidence or a reaction to the diagnosis of a genetic disease. Hypotheses regarding the etiology of psychiatric symptoms of WD suggest a variety of molecular mechanisms, including copper-induced CNS toxicity, oxidative stress, mitochondrial dysfunction, mitophagy, cuproptosis, ferroptosis, dysregulation of neurotransmission, deficiencies of neurotrophic factors, or immune dysregulation. New studies on the expression of noncoding RNA in WD are beginning to shed light on potential molecular pathways involved in psychiatric symptomatology. However, current evidence is still insufficient to definitively establish the cause of psychiatric symptoms in WD. It is possible that the etiology of psychiatric symptoms varies among individuals, with multiple biological and psychological mechanisms contributing to them simultaneously. Future studies with larger samples and comprehensive analyses are necessary to elucidate the mechanisms underlying the psychiatric manifestations of WD and to optimize diagnostics and therapeutic approaches.

Intensive parenting (IP) is a contemporary parenting norm that emphasizes investing in children for their optimal growth and often strains parental resources. It demands centering family life around children and providing them with stimulating environments. Previous studies predominantly link IP to socioeconomic factors, overlooking its psychological determinants. Our research explores how support for IP is tied to individuals’ value systems. We use data from CRONOS online survey, conducted as a part of the European Social Survey (ESS) in 2016–2018. It covered over 1,500 people aged 18 and older. The survey included items that allowed the measurement of two central dimensions of IP: child-centeredness and stimulation (dependent variables in our study). To measure individuals’ values (our explanatory variables), we use ESS Schwartz’s value scale. Our analyses also controlled for key socioeconomic variables (country, sex, age, education, parity). Regression analysis reveals that tradition and security values positively correlate with both dimensions of intensive parenting, highlighting motivations to preserve traditions and ensure a secure future for children. Centering family’s life around children is additionally linked to benevolence, while the stimulation dimension – to achievement and (negatively) to universalism. This suggests that different aspects of IP may be motivated to some extent differently. Highlights • Childrearing standard of intensive parenting (IP) is tied to human values. • Importance of tradition and security is a shared core for different aspects of IP. • Child-centeredness ties additionally to caring for family wellbeing. • Providing children with stimulation appears to be additionally fueled by the need of achievement. • Depending on how IP is motivated, it may carry different consequences for children and parents.

Alpha-synuclein (α-syn) is a 140-amino-acid, intrinsically disordered, soluble protein that is abundantly present in the brain. It plays a crucial role in maintaining cellular structures and organelle functions, particularly in supporting synaptic plasticity and regulating neurotransmitter turnover. However, for reasons not yet fully understood, α-syn can lose its physiological role and begin to aggregate. This altered α-syn disrupts dopaminergic transmission and causes both presynaptic and postsynaptic dysfunction, ultimately leading to cell death. A group of neurodegenerative diseases known as α-synucleinopathies is characterized by the intracellular accumulation of α-syn deposits in specific neuronal and glial cells within certain brain regions. In addition to Parkinson’s disease (PD), these conditions include dementia with Lewy bodies (DLBs), multiple system atrophy (MSA), pure autonomic failure (PAF), and REM sleep behavior disorder (RBD). Given that these disorders are associated with α-syn-related neuroinflammation—and considering that SARS-CoV-2 infection has been shown to affect the nervous system, with COVID-19 patients experiencing neurological symptoms—it has been proposed that COVID-19 may contribute to neurodegeneration in PD and other α-synucleinopathies by promoting α-syn misfolding and aggregation. In this review, we focus on whether SARS-CoV-2 could act as an environmental trigger that facilitates the onset or progression of α-synucleinopathies. Specifically, we present new evidence on the potential role of SARS-CoV-2 in modulating α-syn function and discuss the causal relationship between SARS-CoV-2 infection and the development of parkinsonism-like symptoms.

Haemophilus influenzae is an aerobic gram-negative bacillus that can colonize the upper respiratory tract in humans. However, it is rarely recognized as a cause of invasive infections in adults. We analyzed invasive H. influenzae infections in patients hospitalized at the Cardinal Stefan Wyszyński Regional Specialist Hospital in Lublin (WSS) from January 1, 2022, to May 31, 2024. We observed a significantly higher number of invasive infections caused by this pathogen compared to the previous months analyzed (3 cases per month vs. 0.095 cases per month; p<0.05). Failure of empirical antibiotic therapy is often due to multidrug resistance of detected strains. The increasing trend of invasive H. influenzae infections is also reported by the National Reference Center for Bacterial Infections of the Central Nervous System.

This chapter critically analyzes interpretations of the “eclipse of Darwinism.” Ernst Mayr’s philosophy, influenced by Darwinian epistemology, reveals a Whiggish historiography that emphasizes the centrality of Darwinism and dismisses non-Darwinian theories as unscientific. Peter Bowler’s interpretation follows Thomas Kuhn’s philosophy by assuming the existence of a single dominant paradigm. This leads to the view that Darwinism was considered unscientific, which contradicts historical data. It is also revealed that P. Bowler, like E. Mayr, attributes non-Darwinian theories to psychologism and ideological factors. Modern proposals include Marck Largent’s triumphalist perspective, which treats the “eclipse” as a mere preparation for the modern synthesis. Critical analysis of M. Largent’s interpretation raises questions about the study of the “eclipse” independently of modern science and highlights problems of presentism. The chapter concludes with a summary proposing a non-presentist historiography, based on Hasok Chang’s pluralism, to study the “eclipse” as a distinct period in the history of science and to recognize its relations with the emerging modern synthesis.

This chapter provides a historical overview of the “eclipse” period in evolutionary biology, covering early pre-Darwinian theories and then Charles Darwin’s theory, influenced by T. R. Malthus, C. Lyell, and A. von Humboldt. Other Darwinists such as A. R. Wallace and A. Weismann are also discussed. The chapter examines three strands of anti-Darwinian theory. The first, neo-Lamarckism, is divided into teleological creationism, orthogenetic evolution, and environmentalism. The second, orthogenesis, is examined through the theories of C. von Nägeli, T. Eimer, H. F. Osborn, and L. Berg. The third, Mendelism, includes mutationism and saltationism and discusses the views of H. de Vries, T. H. Morgan, W. Bateson, and J. Lotsy. The chapter concludes by tracing how these theories were superseded by the synthetic theory of evolution. The chapter concludes with an examination of the modern synthesis, highlighting T. Dobzhansky’s work in Genetics and the Origin of Species. The contributions of the naturalists G. G. Simpson, G. Ledyard Stebbins, E. Mayr, and J. Huxley, who adopted Dobzhansky’s ideas, are also discussed.

This chapter explores a new interpretation of the “eclipse of Darwinism” using Larry Laudan’s reticulated model of scientific rationality. L. Laudan rejects permanent universal principles and demarcation lines and emphasizes the interplay of ontology, methodology, and axiology in scientific theories. This model is used to analyze the disputes between Darwinists and non-Darwinians during the “eclipse.” In the analysis that follows, the theories from Chap. 2 are reinterpreted using the reticulated model, highlighting non-purely scientific arguments against Darwin. Laudan’s framework emphasizes that scientific criticism justifies the need for a counter-theory, taking into account the philosophical impact on theory building. The research hypothesis posits that non-Darwinian theories have sought to address the contradiction at the meta-level of Darwin’s theory by correcting the inappropriate use of essentialist terms. The structure of the modern synthesis is then analyzed, focusing on the concept of species proposed by the architects. It is shown that they adopted a nominalist stance in order to circumvent the problem of species in evolutionism, explicitly addressing what had been an implicit problem since Darwin, without finding a definitive solution.