Bülent Ecevit Üniversitesi
Recent publications
In this study, the three-dimensional (3D) near-fault earthquake performance of the Oroville dam is examined considering a special material model and various seismic boundary conditions. The 3D finite-difference model of the Oroville EF dam is modeled using the finite difference method. Burger Creep (BC) material model is utilized for the foundation and dam body materials. Special interface elements are taken into account between the dam body and foundation. Fix, free field, and quiet seismic boundary conditions are considered for 3D nonlinear earthquake analyses. Total six various strong near-fault earthquakes are used in the 3D analyses. According to the non-linear earthquake analyses, principal stresses, horizontal and vertical displacements for three nodal points are assessed in detail and numerical results are compared for reflecting and non-reflecting seismic boundary conditions. It is clearly understood that seismic boundary conditions should not be utilized randomly for 3D modeling and analysis of EF dams. © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Background Bruxism is defined as repetitive jaw-muscle activity characterized by the grinding and clenching of teeth. The prevalence of bruxism in children is extensive, and it can cause irregularities in dental arches. The study aimed to investigate the presence of any effects of bruxism on maxillary arch length and width in children using three-dimensional (3D) digital model analysis. Method This study evaluated 30 children with bruxism. For every child with bruxism, a case control without bruxism was selected and matched for gender, age, and dentition. Digital models of the patients’ maxilla were obtained with a 3D intraoral scanner, and width and length measurements between the reference points on the maxilla were obtained on the digital models. Results The mean age of the study group was 9.13 ± 1.27. Insıgnificance differences were found between females and males within and between groups in terms of maxillary width and length. Insignificant difference was found between the control and study groups when the lengths of 3R-3L, 4R-4L, 5R-5L, 6R-6L, and IP-M were compared ( p > 0.05). Conclusion Based on the study results, there were no differences in the maxillary arch length and width in patients with bruxism and patients without bruxism.
A newly synthesized xanthate functionalized chlorinated polypropylene (PP-Xa) was used as adsorbent for the orbital shaker based on dispersive solid phase microextraction (OS-DSPME) of caffein from several tea, coffee, energy drink, coca-cola and chocolate samples using UV-vis. spectrophotometer. Synthesized PP-Xa was characterized using Fourier Transform Infrared spectroscopy (FTIR-ATR) and nuclear magnetic resonance spectroscopy (¹H NMR). Various parameters like pH, PP-Xa amount, extraction time, type of eluent and its volume were optimized. Linear range, detection limit (LOD), limit of quantification (LOQ), relative standard deviation (RSD), recovery values, and enrichment factor (EF) were found 90–1000 μg L⁻¹, 27.3 µg L⁻¹, 90 µg L⁻¹, 1.9–2.6%, 98 ± 2%, and 167, respectively. Adsorption capacity of PP-Xa was found 271.9 mg g⁻¹. Standard addition and reference method were used for confirm the accuracy of present method.
This study examines the impact of a translanguaging-driven in-service training on English as a Foreign Language (EFL) teachers’ professional identity re-construction. Grounded in complexity theory, the study is based on pre-, while- and post-training interviews with twelve teachers, their reflective journals, online discussions on LMS CANVAS, video-enhanced observations and the trainer first author's reflective journals. The data sets were analysed adopting grounded theory to induce emerging identities. It was found that each participating teacher developed one of three new identities: a) Translanguaging-Romanticised User, b) Translanguaging-Aware User, and c) Translanguaging-Inspired User. Implications for in-service teacher training are discussed.
Psoriasis is a common, chronic, inflammatory skin disease that involves changes taking place as a result of activation of the immune system. Suppressor of cytokine signaling proteins (SOCS) are intracellular proteins that act as endogenous inhibitors of proinflammatory pathways triggered by various cytokines. In this study, the relationship between psoriasis disease and SOCS gene polymorphisms is investigated in relation to the pathogenesis of psoriasis to clarify the psoriasis susceptibility profile. The SOCS3 rs4969169 and SOCS7 rs3748726 polymorphisms were detected using the polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) method. The study was approved by the Clinical Research Ethics Committee of Bulent Ecevit University and performed in accordance with the ethical standards established in the 1964 Declaration of Helsinki and later amendments. All participants were informed of the parameters of the study, and they signed consent forms before being included. Statistical analysis was performed using the SPSS 18.0 (SPSS Inc.) package program. For the SOCS3 rs4969169 genotype frequency, the CC/CT genotypes represented 67%/33% in the patient group and 73%/27% in the control group. For the SOCS7 rs3748726 genotype frequency, the TT/TC/CC genotypes made up 89%/9%/1% in the patient group and 91%/8%/1% in the control group. The polymorphisms of SOCS3 rs4969169 and SOCS7 rs3748726 were found to have no effective role in the pathogenesis of psoriasis. This is the first study to investigate this topic, and further studies with larger, more ethnically diverse samples are encouraged. The polymorphisms of SOCS3 rs4969169 and SOCS7 rs3748726 were found to have no effective role in the pathogenesis of psoriasis. This is the first study to investigate this topic, and further studies with larger, more ethnically diverse samples are encouraged.
We report the radioprotective attitude of Annona muricata (AM) leaf extract as antioxidant material to prevent cellular damage in the ileum tissue. The protective effects of an ethyl acetate extract of AM leaves are comprehensively investigated against radiation-induced ileal damage in numerous rats. Thirty-two adult female rats were separated into 4 groups (3 intervention groups and 1 control) as follows: controls received 0.01 mL/kg distilled water, the AM group received 300 mg/kg AM leaf extract, the ionizing radiation (IR) group received a single dose of whole body radiation (8.3 Gy) after 0.01 mL/kg saline treatment, and the AM + IR group received 300 mg/kg AM leaf extract treatment and were subjected to whole body radiation (8.3 Gy) 1 h after the last gavage. All treatments are administered by oral gavage once a day for 9 days. At the end of the experiment, biochemical total oxidant status (TOS, interleukin-6, and caspase) and histological examinations are performed on blood samples as well as ileum tissue. TOS levels are found to be significantly high in rats, which received irradiation, and those in the AM group when compared to controls. These findings suggest that AM has radioprotective effects on ileum tissue, likely because of its antioxidative properties. The findings of this research may contribute to the minimizing of major side effects induced by excessive radiation exposure in patients undergoing radiotherapy and may serve as a significant impetus for further assessments. However, future studies are highly recommended to confirm safety and to determine extraction technique and dosage before human use can be considered.
In this research, the aim was to evaluate a simulation-based learning environment in the context of conditional probability. The study group consisted of 44 prospective mathematics teachers of the Probability and Statistics Teaching course. The data were collected through three probability problems, a survey form for the simulation-based learning environment, and observations. The research was conducted within the scope of the Probability and Statistics Teaching course. In the lessons, conducted in a simulation-based learning environment with distance education, the prospective teachers were asked to solve the questions asked and send the solutions using smartphones. The different ways of thinking that emerged are put forward by the researcher. Then, simulations developed by the researcher were used for the problems, and the prospective teachers were asked to make observations and take notes on important issues. In the last stage, there was a class discussion about the related problems. After the simulation-based learning activities, the prospective teachers were asked to evaluate the learning environment. The data obtained were evaluated qualitatively, and the prospective teachers' ways of thinking about problems, changing thoughts with the use of simulations, and their views on the learning environment are presented as direct quotations. The research findings revealed that the designed learning environment offers unique opportunities for prospective teachers to think about situations with mathematics content and to experience different methods of teaching and learning mathematics. The learning environment provided prospective teachers with the opportunity to understand and evaluate the contribution of simulations to problem-solving and the opportunities they provide for discussion, reflection, and collaboration in a meaningful context. It was concluded that simulations could become a powerful tool and an effective learning environment for learners.
Decent work (DW) has emerged as a growing paradigm for all, entailing fundamental principles and rights at work which can pervade all human resource management (HRM)practices. While studies on DW are generally examined on macro levels, such as social, economic, legal, and political, the rising emphasis to realize the Sustainable Development Goal (SDG) No. 8 of the UN and highlight the importance of quality of employment in this paper we draw our attention to the DW concept at the micro level The purpose of this study is to explore whether DW is associated with ‘employee performance’ and ‘intention to leave’. Additionally, the aim is to investigate whether work–family conflict (WFC) and family–work conflict (FWC) can serve as moderating variables under the job demands–resources (JD–R) model. Data were collected from employees working for 392 organisations, who represented their companies at a national career fair in Turkey. The results have revealed the role and importance of securing DW as a significant job resource for sustaining positive employee outcomes, including high performance and a reduced intention to leave. Furthermore, the study has shown that while WFC has moderating effects on performance and employees’ turnover intentions, FWC serves as a moderating variable, weakening the relationship between DW and intention to leave in case of adverse family demands.
Background: Relevant studies have indicated that hepatic mast cells may have potential roles in the progression of cholestasis and cholestasis-induced itch. We aimed to compare the effects of cromolyn sodium and other medications on cholestatic pruritus, serum biochemistry, histamine, total bile acids, autotaxin, liver histopathology, and mast cell distribution in tissues in an experimental cholestasis model conducted by bile duct ligation. Methods: Rats received the determined treatment consecutively for 10 days in addition to bile duct ligation. On the 5th and 10th days of the experiment, the rats' itching behaviors were observed for 5 minutes. After 10 days, blood and tissue samples were taken. Results: Significant decreases in serum histamine and autotaxin levels, plasma total bile acids, total bilirubin, and biliary enzymes were reported only in cromolyn sodium-treated rats compared to the control group. In immunohistochemistry of the liver samples, the peribiliary mast cells stained positive for autotaxin. Except for bile duct infarctus, all histopathological findings of cholestasis significantly improved only in cromolyn sodium-treated and sertraline-treated rats. The liver and peritoneal mast cells significantly decreased only in cromolyn sodium-treated rats compared to the control group. On the 10th day of the experiment, the mean duration of itching was significantly lower in all groups, except for naloxone- and ondansetron-treated rats. Conclusion: Cromolyn sodium has promising antipruritic efficacy and provides biochemical and histopathological recovery of the relevant parameters of cholestasis induced by bile duct ligation. For the first time in the literature, we showed that peribiliary mast cells can produce autotaxin, which is a very important pruritogenic signal in the setting of cholestasis.
Prof. Srinivasa Sourirajan is remembered by the desalination and membrane community as the “Father of Reverse Osmosis”. He passed away at the age of 98 peacefully in his beloved city Ottawa (Canada). His legacy will be remembered by the scientific community “membrane science, membrane processes, desalination and engineering”. His research studies were not only novel, but also very creative and even visionary. He offered a priceless gift to humanity by bringing clean water to all those in need through the presentation of reverse osmosis technology together with its appropriate membranes for water treatment, including desalination. This technology has now gained worldwide interest as it is able to produce clean water at a lower cost compared to other separation processes. His scientific contribution also pioneered other research areas. He developed novel research methodologies in geophysics while in catalysis he produced unleaded gasoline to help with the smog issue. He was nominated for the Nobel Prize three times. Prof. Sourirajan had also an exceptional humanitarian attribute. He played a significant role in bringing the Indian community to Ottawa. In the present paper we apply machine learning for his extraordinary and original scientific contribution. The results reveal how influential scientist he was.
In this paper, we investigate the generalized Fibonacci (Horadam) polynomials and we deal with, in detail, two special cases which we call them $(r,s)$-Fibonacci and $(r,s)$-Lucas polynomials. We present Binet's formulas, generating functions, Simson's formulas, and the summation formulas for these polynomial sequences. Moreover, we give some identities and matrices associated with these sequences. Finally, we present several expressions and combinatorial results of the generalized Fibonacci polynomials.
Objective: To determine the mechanistic roles of oxidative stress, inflammation and genotoxicity parameters in patients with work related asthma (WRA) and silicosis. Methods: Thirty eight healthy office workers, 27 employees with a history of exposure and no disease, 24 employees with WRA and 23 employees with silicosis were included in this study. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), malondialdehyde (MDA), interleukins (IL) 17, 23 and 27 levels were measured in the serum. Genotoxic damage was evaluated by calculating the frequency of micronuclei (MN) in swab samples and 8-OHdG in serum. Results: Serum SOD, CAT, GPx, MDA, 8-OHdG, IL-17, IL-23 and IL-27 levels were found to be statistically significantly higher in the exposure, WRA, and silicosis compared to control group. The frequency of MN in buccal epithelial cells of patient group was found to be significantly higher than the control group. Conclusion: These results may provide information for molecular mechanisms and early diagnosis of WRA and silicosis and will be a guide for taking precautions in early period.
To evaluate of hepatitis serology and reactivation frequency in patients with rheumatic disease receiving biologic agents. Our study included patients with inflammatory rheumatic diseases from 23 centers, who were followed up with biological therapy. Demographic and clinical characteristics of the patients, duration of drug use and hepatitis serology and the state of viral reactivation were analyzed. A total of 4060 patients, 2095 being males, were included in our study. Of the patients, 2463 had Ankylosing Spondylitis (AS), 1154 had Rheumatoid Arthritis (RA), 325 had Psoriatic Arthritis (PsA), and 118 had other inflammatory rheumatic diseases. When the viral serology of the patients was evaluated, 79 patients (2%) who were identified as HBs Ag positive, 486 (12%) patients who were HBs Ag negative and anti-HBc IgG positive and 20 patients (0.5%) who were anti-HCV positive. When evaluated on a disease-by-disease basis, the rate of HBsAg was found to be 2.5% in RA, 2% in AS and 0.9% in PsA. Viral reactivation was detected in 13 patients while receiving biologic agents. HBs Ag was positive in nine patients with reactivation and negative in four patients. Anti-HBc IgG, however, was positive. Six of these patients had AS, four had RA, and three had PsA. The development of hepatitis reactivation in 11.4% of HBs Ag positive patients and 0.82% of anti-HBc IgG positive patients due to the use of biologic agents is an important problem for this group of patients. Antiviral prophylaxis is recommended to be started especially in patients who are HBs Ag positive and who are using biologic agents due to viral reactivation. Therefore, it is important to carry out hepatitis screenings before biologic agent treatment and to carefully evaluate the vaccination and prophylaxis requirements.
Carotenoids are natural lipid-soluble pigments that produce yellow to red colors in plants as well as providing bright coloration in vegetables and fruits. Lutein belongs to the xanthophyll subgroup of the carotenoid family, which plays an essential role in photosynthesis and photoprotection in nature. In the human body, lutein, together with its isomer zeaxanthin and its metabolite meso-zeaxanthin, accumulates in the macula of the eye retina, which is responsible for central, high-resolution, and color vision. As a bioactive phytochemical, lutein has essential physiological functions, providing photoprotection against damaging blue light, along with the neutralization of oxidants and the preservation of the structural and functional integrity of cellular membranes. As a potent antioxidant and anti-inflammatory agent, lutein unfortunately has a low bioavailability because of its lipophilicity and a low stability as a result of its conjugated double bonds. In order to enhance lutein stability and bioavailability and achieve its controlled delivery to a target, nanoscale delivery systems, which have great potential for the delivery of bioactive compounds, are starting to be employed. The current review highlights the advantages and innovations associated with incorporating lutein within promising nanoscale delivery systems, such as liposomes, nanoemulsions, polymer nanoparticles, and polymer–lipid hybrid nanoparticles, as well as their unique physiochemical properties.
The TROPOMI (TROPOspheric monitoring instrument) onboard Sentinel-5 Precursor (S5P) satellite provides high spatial resolution data of carbon monoxide (CO) while the MAIAC (Multiangle Implementation of Atmospheric Correction) is a newly developed algorithm applied to MODIS collection 6 observations to retrieve AOD (Aerosol Optical Depth) at a high spatial resolution of 1 km. The present study utilized the MAIAC AOD from MODIS Terra and Aqua polar-orbiting satellites between March 2000 to December 2021 and CO from Sentinel-5P during the available period July 2018-December 2021 over Pakistan. Moreover, we used three trend techniques (Linear regression, Mann–Kendall (MK), and Theil-Sen’s Slope) to examine the trends of AOD and CO over Pakistan. The results show that both AOD and CO have high values over central Punjab, western Balochistan, central Sindh, and Khyber Pakhtunkhwa. The mean annual high AOD of > 1.2 is observed in eastern Punjab because of an increase in urbanization, industrialization, and economical activities whereas the AOD of ~ 1.0 is observed over Balochistan, Sindh, and a few parts of Khyber Pakhtunkhwa. The highest mean annual CO of ˃0.03 mol/m^2 is seen over central Punjab, Sindh, and Khyber Pakhtunkhwa. The results show that seasonal mean MAIAC AOD ranging from 0.7 to > 0.9 was seen over Punjab and Sindh province during the monsoon season whereas the lowest AOD is detected in the winter season over few parts of Balochistan. In contrast, the highest mean seasonal CO ranging from 0.040 to > 0.055 mol/m^2 was seen in the winter season over Punjab. The lowest CO concentration is observed in the winter season over the northern region of Pakistan. Non-parametric analyses (MK and Theil-Sen’s slope) also show an increasing trend of CO over Pakistan from 2018 to 2021. Furthermore, we have also investigated the trends of AOD and CO over selected cities of Pakistan using linear regression, MK test, and Theil-Sen’s slope to reveal long-term air pollution trends.
In this study, a novel PVC‐based membrane containing (E)‐2‐(1‐(4‐(3‐(4‐chlorophenyl)ureido)phenyl)ethylidene)hydrazine carbothioamide (5) as an electroactive component (ionophore) along with potassium tetrakis (p‐chlorophenyl) borate (KTpClPB) and bis(2‐ethylhexyl)adipate (DEHA) in the ratio 4.0 : 32.0 : 1.0 : 63.0 (ionophore:PVC:KTpClPB:DEHA) (w/w) was used to develop a lead(II)‐selective potentiometric sensor. The sensor exhibited a Nernstian response over a wide concentration range from 1.0×10−5 to 1.0×10−1 mol L−1 with a slope of 28.0±2.0 mV/decade, and a detection limit of 1.65×10−6 mol L−1. It displayed very good selectivity towards Pb(II) ions over other cationic species. The lead(II)‐selective sensor showed a fast response time of 5 s, good repeatability, and it worked in the broad pH range of 5.0–11.0. The sensor could be used as an indicator electrode in the quantification of Pb(II) by potentiometric titration against ethylenediaminetetraacetic acid (EDTA). In addition, this sensor was applied for the direct determination of Pb(II) in different water samples including spring water, purification water, commercial water, waste water and in a waste battery sample. In this study, a highly selective potentiometric sensor for Pb(II) ions was developed. The sensor has advantages such as high selectivity, short response time, long lifetime, low cost, low detection limit, good repeatability and stability. As a result, the developed sensor can be considered as an alternative analytical tool for the determination of Pb(II) in different real samples.
Introduction COVID-19 had direct and indirect impacts on both mental health and healthcare systems. Evaluating urgent psychiatric consultations may be useful to determine the effects of COVID-19 pandemic since it reflects the condition of psychiatric patients and healthcare systems Objectives This study aims to determine the quantitative or qualitative changes in emergency psychiatry consultations after COVID-19 pandemic. Methods The socio-demographic characteristics and clinical features of two hundred thirty three patients were retrospectively collected and analyzed in order to compare the emergency psychiatry consultations before (between the dates 11 th of March 2019-10 th of March 2020) and after (between 11 th of March 2020-10 th of March 2021) the COVID-19 pandemic. Results The ratio of patients consulted to psychiatry to total emergency department increase after pandemic (%0.03 vs %0.07). Among these patients, the diagnosis of ‘alcohol and substance use disorder’ (%6.1 vs. %15.4) (p=0.03) increased while the diagnoses of ‘obsessive compulsive disorder (5.3% vs. 0%)(p=0.01) and bipolar disorder (%21.1 vs. %20.5) (p=0.02) decreased. Hostility among patient during consultation increased (%19.1 vs. %30.8)(p=0.04). Suicidal thoughts decreased (%25.2 vs. %14.5) (p=0.04). Furthermore, voluntary inpatient treatment (%20.9-%34.2) (p =0.02) increased, transfer to another clinic (%25.2 vs. %12) (p=0.01) and outpatient treatment (%46.1 vs. %42.7) (p=0.01) decreased. An increase in oral treatments (%10.4 vs. %26.5) (p=0.02) and decrease in parenteral treatments (%71.3 vs. 54.7) ( p=0.01) were also reported. Conclusions Our findings confirmed that after COVID-19 spread the clinical features diagnosis, and treatment modality have changed among urgent psychiatric consultations. Disclosure No significant relationships.
Aim: To determine effect of ultrasound-guided serratus anterior plane block (SAPB) on intraoperative opioid consumption in patients undergoing oncoplastic breast surgery under general anesthesia. Methods: This study was conducted as a prospective, randomized controlled trial. Forty-four patients enrolled, aged 18 to 75 years with American Society of Anesthesiologists physical status I to III, undergoing elective oncoplastic breast surgery. Patients were randomly allocated to receive SAPB with 20 mL of 0.25% bupivacaine + general anesthesia (group SAPB) or only general anesthesia (group control). The primary outcome was assessing the effect of SAPB on intraoperative remifentanil consumption. Patients were assessed for emergence time, hemodynamic parameters, doses of rescue drugs used to control hemodynamic parameters, and duration of stay in the recovery room. Results: Preoperative SAPB with 0.25% bupivacaine reduced intraoperative opioid consumption (851.2 ± 423.5 vs 1409.7 ± 756.1 µg, P = .019). Emergence time was significantly shorter in group SAPB (6.19 ± 1.90 minutes) compared to group control (9.50 ± 2.39 minutes; P < .001). There were no significant differences in the doses of rescue drugs used for systolic blood pressure and heart rate between the groups. Conclusions: Preoperative SAPB with bupivacaine reduced intraoperative opioid consumption and shortened emergence time and duration of stay in the recovery unit, and hemodynamic stability was maintained without block-related complications.
This study focuses on the novel perspective of marine ORC systems with a detailed marine diesel generator plant simulation integrated with an ORC system model to evaluate environmental impacts and energy efficiency increments by reducing the number or the load of generators by using the ORC system support during operation. It is aimed to analyze the fuel-saving potential and sustainability performance of the power generation plant of a tanker ship when an ORC is integrated. The thermodynamic system simulation determined the fuel consumption of the plant within two years regarding six operation modes. The results show that the optimum working fluid is R1336mzz (Z) for the evaporation pressure of 16 bar. Organic Rankine cycle system integration provided a total fuel-saving of 15% from diesel generators and the total fuel consumption of the vessel was reduced by 5.16%. The sustainability performance of the system was ensured with a novel operation-dependent approach that enhances the exergetic sustainability assessment by considering the operation modes of the vessel and the time spent on these operations for a certain time. The load reduction in the generators resulted in better sustainability performance and the operation-dependent indicators were affected by operations having more working hours.
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1,422 members
Bülent Altinsoy
  • Pulmonology
Burak Coban
  • Department of Chemistry
Silay Ugurbas
  • Department of Ophthalmology
Farabi Kampüsü, İncivez, Merkez, Zonguldak, 67100, Zonguldak, Turkey
Head of institution
Prof. Dr. Mustafa ÇUFALI
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