Atomic Energy and Alternative Energies Commission
Recent publications
Removal/reinstallation of all Test Blanket System (TBS) equipment present in the Port Cell is required during the ITER Long Term Shutdown. TBS shall be designed so that occupational radiation exposure can be As Low As Reasonably Achievable (ALARA) over the life of the plant to follow the ITER Policy. The expected level of radiation in this area still allows performing maintenance tasks hands-on. However, the cumulated dose could be significant for operators. Classical Dose Reduction Measure (DRM) is to deploy Remote Handling systems. Consequently, use of robotized equipment, remotely operated means or collaborative robotics, have been investigated. Taking advantage of new digital technologies such as digital assistances, is expected to help operators during complex remote operations under limited vision conditions. Experiments were performed on a set of three TBS maintenance representative tasks: remote visual inspection of DN80 pipe, dye penetrant testing operation on pipe and dexterity test. A panel of remote handling equipment operators of different skill level was selected and involved onto these tasks. The results prove without ambiguity that for all operators the quality of the task execution is significantly improved when using digital assistances
Human spaceflight is entering a new era of sustainable human space exploration. By 2030 humans will regularly fly to the Moon’s orbit, return to the Moon’s surface and preparations for crewed Mars missions will intensify. In planning these undertakings, several challenges will need to be addressed in order to ensure the safety of astronauts during their space travels. One of the important challenges to overcome, that could be a major showstopper of the space endeavor, is the exposure to the space radiation environment. There is an urgent need for quantifying, managing and limiting the detrimental health risks and electronics damage induced by space radiation exposure. Such risks raise key priority topics for space research programs. Risk limitation involves obtaining a better understanding of space weather phenomena and the complex radiation environment in spaceflight, as well as developing and applying accurate dosimetric instruments, understanding related short- and long-term health risks, and strategies for effective countermeasures to minimize both exposure to space radiation and the remaining effects post exposure. The ESA/SciSpacE Space Radiation White Paper identifies those topics and underlines priorities for future research and development, to enable safe human and robotic exploration of space beyond Low Earth Orbit.
The synthesis of four clickable sydnone‐heptamethine cyanine derivatives is described in this article. The synthetic route is based on a palladium‐cross coupling reactions of sydnone boronates affording the desired sydnone‐cyanine conjugates in only 5 steps. These compounds were shown to react smoothly with cyclooctynes to form the corresponding pyrazoles clicked products quantitatively at room temperature and with rate constants up to 18 M‐1.sec‐1, affording new interesting tools for biorthogonal fluorescent labelling of (bio)molecules. Fluorescence properties of both sydnone‐ and pyrazole‐cyanines are described, as well.
Megaherbivores have pervasive ecological effects. In African rainforests, elephants can increase aboveground carbon, though the mechanisms are unclear. Here, we combine a large unpublished dataset of forest elephant feeding with published browsing preferences totaling nearly 200,000 records covering >800 plant species and with nutritional data for 145 species. Elephants increase carbon stocks by: 1) promoting high wood density trees via preferential browsing on leaves from low wood density species, which are more palatable and digestible; and 2) dispersing seeds of trees that are relatively large and have the highest average wood density among tree guilds based on dispersal mode. Loss of forest elephants could cause an increase in abundance of fast-growing low wood density trees and a 6% to 9% decline in aboveground carbon stocks due to regeneration failure of elephant-dispersed trees. These results demonstrate the importance of megaherbivores for maintaining diverse, high-carbon tropical forests. Successful elephant conservation will contribute to climate mitigation at a globally-relevant scale.
Post‐transcriptional modifications of tRNA nucleotide are important determinants in folding, structure and function. In this communication we successfully achieved the identification and characterization of a new modified base named 2‐methylthio‐methylenethio‐N6‐(cis‐4‐hydroxyisopentenyl)‐adenosine present at position 37 in some tRNAs. We also showed that this new modified adenosine is derived from the known 2‐methylthio‐methylenethio‐N6‐(isopentenyl)‐adenosine nucleoside by a catalytic cycle of the tRNA‐diiron monooxygenase enzyme, MiaE present in Salmonella typhimurium.
Breast cancer (BC) is the most diagnosed cancer in women worldwide. In estrogen receptor (ER)-positive disease, anti-estrogens and aromatase inhibitors (AI) improve patient survival, however many patients develop resistance. Dysregulation of apoptosis is a common resistance mechanism, thus agents that can reinstate activity of apoptotic pathways represent promising therapeutics for advanced drug-resistant disease. Emerging targets in this scenario include microRNAs (miRs). To identify miRs modulating apoptosis in drug-responsive and -resistant BC, a high-throughput miR inhibitor screen was performed, followed by high-content screening microscopy for apoptotic markers. Validation demonstrated that miR-361-3p inhibitor significantly increases early apoptosis and reduces proliferation of drug-responsive (MCF7), plus AI-/antiestrogen-resistant derivatives (LTED, TamR, FulvR), and ER- cells (MDA-MB-231). Importantly, proliferation-inhibitory effects were observed in vivo in a xenograft model, indicating potential clinical application of miR-361-3p inhibition. RNA-seq of tumour xenografts identified FANCA as direct miR-361-3p target, and validation suggested miR-361-3p inhibitor effects might be mediated in part through FANCA modulation. Moreover, miR-361-3p inhibition resulted in p53-mediated G1 cell cycle arrest through activation of p21 and reduced BC invasion. Analysis of publicly-available datasets showed miR-361-3p expression is significantly higher in primary breast tumours versus paired normal tissue, and is associated with decreased overall survival. In addition, miR-361-3p inhibitor treatment of BC patient explants decreased levels of miR-361-3p and proliferation marker, Ki67. Finally, miR-361-3p inhibitor showed synergistic effects on BC growth when combined with PARP inhibitor, Olaparib. Together, these studies identify miR-361-3p inhibitor as potential new treatment for drug-responsive and -resistant advanced BC.
In humans, exposure to electromagnetic millimeter waves (MMW) has a hypoalgesic effect. In animals, this effect has been shown to depend on innervation density of the area exposed. This study aims to assess hypoalgesic and parasympathetic effects of MMW applied on the palmar side of the wrist in healthy participants. In a within-subject design, 10 healthy participants had the palmar side of their wrist exposed to MMW (61.25 GHz, 17 mW/cm²) for 30 minutes, 1 h, & 1 h30, and 30 minutes of sham exposure. Experimental pain was induced after the exposure sessions with the Cold Pressor Test, and pain threshold and pain tolerance values were compared to that of the sham condition. Participants’ heart rate and blood pressure were measured before and after exposures. Finally, innocuity of the exposure system was controlled with a pre-post exposure visual examination scale and skin temperature measured by a thermal camera. Exposure to 30 minutes, but not 1 h or 1 h30, of MMW led to significant increases in pain thresholds compared to the sham condition, but no increase of pain tolerance. All conditions led to decreased heart rate, while no change in blood pressure was observed. No change in skin state or temperature was observed for any of the conditions. MMW applied on the inner part of the wrist diminish pain sensations more effectively than placebo, and seem to increase parasympathetic activities, while remaining innocuous. Building a miniaturized MMW emission system to be worn on the wrist would provide access to ambulatory MMW therapy for pain management.
Misinformation spreads fast in times of crises, corroding public trust and causing further harm to already vulnerable communities. In earthquake seismology, the most common misinformation and misleading popular beliefs generally relate to earthquake prediction, earthquake genesis, and potential causal relations between climate, weather and earthquake occurrence. As a public earthquake information and dissemination center, the Euro-Mediterranean Seismological Center (EMSC) has been confronted many times with this issue over the years. In this paper we describe several types of earthquake misinformation that the EMSC had to deal with during the 2018 Mayotte earthquake crisis and the 2021 La Palma seismic swarm. We present frequent misinformation topics such as earthquake predictions seen on our communication channels. Finally, we expose how, based on desk studies and users’ surveys, the EMSC has progressively improved its communication strategy and tools to fight earthquake misinformation and restore trust in science. In this paper we elaborate on the observed temporality patterns for earthquake misinformation and the implications this may have to limit the magnitude of the phenomenon. We also discuss the importance of social, psychological and cultural factors in the appearance and therefore in the fight against misinformation. Finally, we emphasize the need to constantly adapt to new platforms, new beliefs, and advances in science to stay relevant and not allow misinformation to take hold
SCCS scientific opinion on Butylated hydroxytoluene (BHT), SCCS/1636/21 B. Granum; U. Bernauer; L. Bodin; Q. Chaudhry; P.J. Coenraads; M. Dusinska; J. Ezendam; E. Gaffet; C. L. Galli; E. Panteri; V. Rogiers; Ch. Rousselle; M. Stepnik; T. Van Haecke; S. Wijnhoven; A. Koutsodimou; W. Uter; N. von Goetz Regulatory Toxicology and Pharmacology (2022) 105312 Available online 21 December 2022 DOI : 10.1016/j.yrtph.2022.105312
It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are prominent modulators of those changes. On the other hand, trace eyeblink conditioning, an associative motor learning task, requires the active participation of hippocampal circuits. However, the involvement of NCAM, PSA-NCAM, and L1 in this type of learning is not fully known. Here, we aimed to investigate the possible time sequence modifications of such neural cell adhesion molecules in the hippocampus during the acquisition of a trace eyeblink conditioning. To do so, the hippocampal expression of NCAM, PSA-NCAM, and L1 was assessed at three different time points during conditioning: after one (initial acquisition), three (partial acquisition), and six (complete acquisition) sessions of the conditioning paradigm. The conditioned stimulus (CS) was a weak electrical pulse separated by a 250-ms time interval from the unconditioned stimuli (US, a strong electrical pulse). An acquisition-dependent regulation of these adhesion molecules was found in the hippocampus. During the initial acquisition of the conditioning eyeblink paradigm (12 h after 1 and 3 days of training), synaptic expression of L1 and PSA-NCAM was transiently increased in the contralateral hippocampus to the paired CS-US presentations, whereas, when the associative learning was completed, such increase disappeared, but a marked and bilateral upregulation of NCAM was found. In conclusion, our findings show a specific temporal pattern of hippocampal CAMs expression during the acquisition process, highlighting the relevance of NCAM, PSA-NCAM, and L1 as learning-modulated molecules critically involved in remodeling processes underlying associative motor-memories formation.
Blast waves generated by energetic materials involve very fast time variations in the pressure. One important issue for blast wave metrology is the accurate measurement (typical precision in the range of ±5% or better) of the static overpressure peak. For most near field configurations, this measurement requires ultra-fast sensors with response times lower than a few microseconds. In this paper, we design, model, fabricate and characterize a new ultra-fast sensor using piezo-resistive gauges at the center of a miniaturized and rectangular silicon membrane. When a pressure step of 10 bar is applied to the membrane, the signal delivered to the sensor output presents dampened oscillations, with a resonant frequency of 20.6 MHz and quality factor of 24,700 ns after the arrival of the shock wave. After removing undesirable drifts that appear after 700 ns, we may expect the sensor to have a response time (at ±5%) of 1.2 µs. Consequently, the proposed pressure sensor could be advantageously used for the accurate measurement of static overpressure peaks in blast wave experiments.
Down syndrome (DS) is caused by human chromosome 21 (HSA21) trisomy. It is characterized by a poorly understood intellectual disability (ID). We studied two mouse models of DS, one with an extra copy of the Dyrk1A gene (189N3) and the other with an extra copy of the mouse Chr16 syntenic region (Dp(16)1Yey). RNA-seq analysis of the transcripts deregulated in the embryonic hippocampus revealed an enrichment in genes associated with chromatin for the 189N3 model, and synapses for the Dp(16)1Yey model. A large-scale yeast two-hybrid screen (82 different screens, including 72 HSA21 baits and 10 rebounds) of a human brain library containing at least 10 ⁷ independent fragments identified 1,949 novel protein–protein interactions. The direct interactors of HSA21 baits and rebounds were significantly enriched in ID-related genes ( P -value < 2.29 × 10 ⁻⁸ ). Proximity ligation assays showed that some of the proteins encoded by HSA21 were located at the dendritic spine postsynaptic density, in a protein network at the dendritic spine postsynapse. We located HSA21 DYRK1A and DSCAM, mutations of which increase the risk of autism spectrum disorder (ASD) 20-fold, in this postsynaptic network. We found that an intracellular domain of DSCAM bound either DLGs, which are multimeric scaffolds comprising receptors, ion channels and associated signaling proteins, or DYRK1A. The DYRK1A-DSCAM interaction domain is conserved in Drosophila and humans. The postsynaptic network was found to be enriched in proteins associated with ARC-related synaptic plasticity, ASD, and late-onset Alzheimer’s disease. These results highlight links between DS and brain diseases with a complex genetic basis.
Introduction Malgré des progrès thérapeutiques considérables, la néphropathie lupique (NL) reste grevée d’une morbidité importante avec une évolution vers l’insuffisance rénale terminale autour de 10 à 20 % à 15 ans. L’identification de facteurs prédictifs d’évolution vers l’insuffisance rénale est un enjeu essentiel de la prise en charge du lupus systémique (LS). Actuellement une protéinurie à 1 an inférieure à 0,7 g/24 h est considérée comme étant un marqueur d’évolution favorable de l’atteinte rénale à long terme. Nous avons cherché à déterminer les facteurs précoces associés à une détérioration de la fonction rénale à long terme, basé sur les données de vie réelle de patients atteints de NL de classe les plus sévères (III-IV ± V). Patients et méthodes Nous avons étudié les facteurs prédictifs d’une l’évolution défavorable de la fonction rénale à long terme définie par un débit de filtration glomérulaire (DFG) inférieur à 60 mL/min/1,73 m², la dialyse, la greffe rénale ou le décès. Cent cinquante et un patients atteints de LS (133 (81 %) femmes, d’âge moyen 34 ans, 37 % d’origine afro-antillaise, 14 % de lupus pédiatriques, index d’activité (IA) et index de chronicité (IC) moyens de 32 % et 25 % respectivement) avec une atteinte rénale de classe III ou IV, ± V ont été inclus. Tous les patients ont été traités selon les recommandations internationales. Le début du suivi est défini par la date de biopsie rénale. Les données épidémiologiques, cliniques, histologiques et biologiques avant (depuis les premiers signes de LS) et après (jusqu’à la dernière visite du patient dans le centre) la PBR ont été recueillies. Les facteurs prédictifs de l’évolution de la fonction rénale à long terme et du DFG à 1 an ont été déterminés par régression logistique. Résultats Après une durée médiane de suivi de 5,9 ans (IQR : 3,5–9,0), 27 % des patients présentaient une insuffisance rénale chronique et 9 % une insuffisance rénale terminale. Après 1 an de traitement, le ratio protéinurie/créatininurie (RPC) moyen a décru de 0,26 ± 0,27 g/mmol au début de l’étude (j0) à 0,12 ± 0,18 g/mmol à 1 an (p < 10⁻⁶). Le DFG moyen n’était pas significativement différent entre l’inclusion et le 12e mois (93 ± 41 mL/min/1,73 m² versus 93 ± 37 mL/min/1,73 m², p = 0,95). En régression logistique multivariée, la seule variable indépendamment associée à l’évolution défavorable à long terme est le DFG à 1 an (OR : 0,96, p < 10⁻⁴). La valeur prédictive du RPC à 1 an n’était pas significativement associée à une évolution rénale défavorable (p = 0,085). La capacité du DFG à 1 an pour identifier une bonne ou une mauvaise évolution de la fonction rénale à long terme (AUC 0,87) est meilleure que celle du RPC à 1 an (AUC 0,67). La génération de courbes ROC nous a également permis de déterminer des valeurs seuils du DFG à 1 an (83 mL/min/1,73 m²) et du RPC à 1 an (0,09 g/mmol), maximisant la sensibilité et la spécificité. Conclusion Au cours des NL de classe III-IV ± V, le DFG à 1 an est le facteur prédictif prédominant de l’évolution de la fonction rénale à long terme. Le RPC à 1 an semble moins bien prédire la fonction rénale à long terme.
Introduction Malgré les progrès considérables des traitements de la néphropathie lupique (NL), la morbidité rénale reste élevée, avec une évolution vers l’insuffisance rénale terminale, autour de 10 à 20 % à 15 ans. Dans ce contexte, l’identification de facteurs prédictifs précoces d’évolution vers l’insuffisance rénale est un enjeu essentiel de la prise en charge thérapeutique du lupus systémique (LS). Dans une étude préliminaire nous avons identifié le débit de filtration glomérulaire (DFG) à 1 an comme le facteur prédictif prédominant de l’évolution de la fonction rénale à long terme. Nous avons voulu identifier les facteurs corrélés à un ratio protéinurie/créatininurie (RPC) à 1 an inférieur à 0,07 g/mmol (valeur seuil classique trouvée dans la littérature), à un DFG à 1 an supérieur à 83 mL/min/1,73 m² (valeur seuil déterminée lors d’une étude préliminaire) et finalement au DFG à 1 an, basé sur les données de vie réelle et prenant en compte tous les paramètres connus susceptibles d’impacter l’évolution de la fonction rénale, et restreint aux classes de NL les plus sévères (classe III-IV ± V). Patients et méthodes Cent cinquante et un patients atteints de LS (133 femmes, 34 ans en moyenne, 37 % d’origine géographique afro-antillaise, 14 % de formes à début pédiatrique, index d’activité (IA) et index de chronicité (IC) moyens de 32 % et 25 % respectivement) avec une atteinte rénale de classe III ou IV, ± V ont été inclus. Tous les patients ont été traités selon les recommandations internationales. La ponction biopsie rénale (PBR) marque le début de l’étude et a été effectuée à un moment indifférent de l’histoire de la maladie du patient. Les données épidémiologiques, cliniques, histologiques et biologiques avant (depuis les premiers signes de LS) et un an après la PBR ont été recueillies. Les facteurs prédictifs ont été déterminés par régression logistique (pour les deux valeurs seuil) et par régression linéaire (pour la valeur du DFG à 1 an) et des comparaisons avec d’autres méthodes prédictives ont été effectuées. Résultats Après 1 an de traitement, 100 patients (66 %) ont un RPC inférieur à 0,07 g/mmol et 106 (70 %) ont un DFG supérieur à 83 mL/min/1,73 m². En comparant les deux seuils on a pour le DFG une sensibilité de 0,86 et une spécificité de 0,77 et pour le ratio on a respectivement 0,75 et 0,56. En régression logistique multivariée, plusieurs variables sont significativement associées à la prédiction du RPC à 1 an 0,07 g/mmol, telles que l’observance (p < 10⁻³) et une faible dose de prednisone (p = 0,036). En régression logistique multivariée, plusieurs variables sont significativement associées à la prédiction de DFG à 1 an, telles que l’observance (p = 0,035), l’IC à la PBR de j0 (p < 10⁻³) et le DFG à j0 (p < 10⁻⁵). En régression linéaire multivariée, plusieurs variables sont significativement associées à la prédiction du DFG à 1 an, telles que l’âge (p = 0,003), l’IC à la PBR de j0 (p < 10⁻⁶), l’hypertension artérielle (p = 0,036) et le DFG à j0 (p < 10⁻¹⁶). Les mêmes variables significatives sont retrouvées en utilisant les forêts aléatoires. Conclusion Le facteur prédictif prédominant du DFG à 1 an est le DFG à j0. On trouve également l’IC, il faudrait ainsi agir sur l’inflammation du rein lors de la poussée rénale mais également sur le tissu cicatriciel. Il est essentiel de porter une attention particulière aux patients ayant une hypertension artérielle. Enfin, on retrouve l’âge comme facteur prédictif, il est ainsi important de dépister très régulièrement la protéinurie, révélatrice de l’atteinte rénale du LS. En agissant sur ces facteurs, il serait possible d’améliorer le DFG à 1 an, ou du moins d’éviter d’en perdre, pour ensuite pouvoir agir sur l’évolution de la fonction rénale à long terme et diminuer le risque d’être en insuffisance rénale à long terme.
Background Alzheimer’s disease (AD) is characterized by intracerebral accumulation of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These lesions induce synaptic dysfunctions that are strongly correlated with cognitive decline. Intracerebral infusion of well-defined Aβ seeds from synthetic or recombinant non-mutated Aβ1−40 or Aβ1−42 peptides can increase Aβ plaque depositions several months after the infusion. Familial forms of AD are associated with mutations in the amyloid precursor protein (APP) that induce the production of Aβ peptides with different structures. The Aβosa mutation (E693Δ) is located within the Aβ sequence and thus the Aβosa peptides have different structures and properties as compared to non-mutated Aβ1−42 peptides (Aβwt). Here, we wondered if a single exposure to this mutated Aβ can worsen AD pathology as well as downstream events including cognition, cerebral connectivity and synaptic health several months after the inoculation compared to non-mutated Aβ. Method To answer this question we inoculated Aβ1−42-bearing Osaka mutation (Aβosa) in the dentate gyrus of APPswe/PS1dE9 mice at the age of two months. The inoculated mice were analyzed at 4 months post-inoculation by cognitive evaluation and functional MRI to assess cerebral connectivity. Aβ and tau lesions as well as synaptic density were evaluated by histology. The impact of Aβosa peptides on synaptic health was also measured on primary cortical neurons. Results Remarkably, compared to Aβwt, the intracerebral administration of Aβosa induced cognitive impairments, synaptic impairments and a reduction of the connectivity between different brain regions, 4 months post-inoculation. Aβ plaque depositions but not tau lesions were increased and Aβ oligomeric patterns were modified. Conclusion This is the first study showing long-term functional toxicity of Aβ seeds. It shows that a single, sporadic event as Aβosa inoculation can worsen the fate of the pathology and clinical outcome several months after the event. Extrapolation of this discovery suggests that any event that modulates focally Aβ aggregation process in the time-course of AD can be responsible for the heterogeneity of AD clinical outcome.
Astrocytes are key partners for neurons in the brain. Under pathological conditions, such as neurodegenerative diseases, astrocytes change and become reactive. Even if this response was described more than a hundred years ago, many questions remain about how the reactive state of astrocytes is controlled, and how it impacts their homeostatic functions and surrounding cells. We have developed molecular tools to modulate and monitor reactive astrocytes in situ, and shown that these cells have multiple and context‐dependent effects in neurodegenerative diseases. We further aim to identify new molecular targets to promote neuroprotective functions in reactive astrocytes and identify astrocyte‐based biomarkers for brain diseases.
In 2011, the Fukushima Dai-Ichi Nuclear Power Plant (FDNPP) accident released significant quantities of radionuclides into the environment. Japanese authorities decided to progressively reopen the Difficult-To-Return Zone after the decontamination of priority reconstruction zones. These areas include parts of the initially highly contaminated municipalities located to the north of the FDNPP, including Namie Town, an area drained by the Ukedo and Takase Rivers. Eleven years after the accident, research focused on the spatial distribution of plutonium (Pu) and radiocesium (Cs) isotopes at contrasted individual locations. To complement previous results, the current research was conducted on flood sediment deposits collected at the same locations after major flooding events during eleven fieldwork campaigns organised between 2013 and 2020 at the outlet of the Ukedo and Takase Rivers (n = 22). The results highlighted a global decrease of the Pu and 137Cs contents in sediment with time during the abandonment phase in the region, from 2013 (238.20 fg g−1) to 2020 (4.28 fg g−1). Furthermore, based on the analysis of the 240Pu/239Pu isotopic ratios, the plutonium transiting these rivers (range: 0.166 – 0.220) essentially originated from the global fallout (0.180 ± 0.014 (Kelley et al., 1999)). Sediment showed contrasted properties in the two investigated rivers, which is likely mainly the result of the occurrence of Ogaki Dam on upper sections of the Ukedo River as it strongly impacts the material supply from this river to the Pacific Ocean. A statistical analysis highlighted the strong correlation between Pu activity concentrations and 137Cs activities in both rivers, confirming that both radionuclides are transported with a similar pathway. Despite it was detected early after the accident (2011–2013), the current research demonstrates that plutonium originating from FDNPP is no longer detected in these rivers draining the Difficult-To-Return Zone at the onset of the reopening of the area to its former inhabitants.
Sleep is an important contributor for neural maturation and emotion regulation during adolescence, with long-term effects on a range of white matter tracts implicated in affective processing in at-risk populations. We investigated the effects of adolescent sleep patterns on longitudinal changes in white matter development and whether this is related to the emergence of emotional (internalizing) problems. Sleep patterns and internalizing problems were assessed using self-report questionnaires in adolescents recruited in the general population followed up from age 14 to 19 years (N=111). White matter structure was measured using diffusion tensor imaging (DTI) and estimated using fractional anisotropy (FA). We found that longitudinal increases in time in bed (TIB) on weekends and increases in TIB-variability between weekdays to weekend, were associated with an increase in FA in various interhemispheric and cortico-striatal tracts. Extracted FA values from left superior longitudinal fasciculus mediated the relationship between increases in TIB on weekends and a decrease in internalizing problems. These results imply that while insufficient sleep might have potentially harmful effects on long-term white matter development and internalizing problems, longer sleep duration on weekends (catch-up sleep) might be a natural counteractive and protective strategy.
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5,056 members
Pierre Parot
  • Direction des Sciences du Vivant (DSV)
Nebhen Jamel
  • IRFU - Institut de Recherche sur les lois Fondamentales de l'Univers
Loic Martin
  • Medicines and Healthcare Technologies (DMTS)
Önder Gürcan
  • Laboratory of Research on Software-intensive Technologies (LIST)
CEA, Gif-sur-Yvette, France
Head of institution
François JACQ