Assiut University
  • Asyūţ, Assiut, Egypt
Recent publications
Increasing evidence shows the role of perceived risk in customers' attitude and intention to use online shopping services. However, the literature shows disagreement regarding the types of risks that influence purchase intention. Therefore, this study aims to empirically identify the most relevant sources of risks and uncertainties associated with online shopping services and to investigate the influence of sociodemographic characteristics (e.g., gender, age, and online shopping experience) on the levels of perceived risk using data collected through a survey questionnaire. A total of 558 participants were selected across three countries (Jordan, Saudi Arabia, and Kuwait). The responses were evaluated using structural equation modeling and multigroup analysis. The analysis showed that of the tested types of risks and uncertainty, only three had a significant influence on customers' purchase decisions: financial risk, information risk, and privacy risk. Regarding the moderating role of sociodemographic variables, the analysis showed that previous experience has a significant moderating effect. At the same time, gender and age were found not to affect the relationship between perceived risks and customers' purchase intention. These findings may help online stores understand customers’ concerns when considering online shopping. The limitations and theoretical and managerial implications of the present study are discussed.
Edible Mushrooms have been valued as a valuable food source due to its nutritional and medicinal characteristics. Edible mushrooms contain various bioactive components such as proteins, polyunsaturated fatty acids, polysaccharides, dietary fibers, amino acids, vitamins, and minerals. They have essential health effects, such as antioxidant, antimicrobial, immune-stimulatory, and anticancer, cholesterol-lowering properties. Because of their nutritional and medicinal benefits, mushrooms have become increasingly popular in recent years all over the world. Mushrooms were considered immortality plants in Ancient Egypt and were given to mankind by the god Osiris. Mushrooms were declared a delicacy reserved only for Egyptian nobility due to their distinct flavor. The current study focuses on the common species of edible mushrooms in Egypt and their different bioactive ingredients, nutritional values and the health benefits.
A crucial issue is choosing an appropriate model. Additionally, in earlier studies, it was difficult to estimate the unknown variables on the progressing type-II-censoring method. Thus, in this study, a Power Generalised Weibull Distribution (PGWD) has been introduced. This distribution is also known as a generalisation of the Weibull distribution. The Power Generalized Weibull (PGW) parameters have been estimated in this paper utilising the maximum likelihood (ML) approach, the maximum product spacing (MPS) technique, and the Bayesian assessment approach under squared error of loss functions (SELF). The assessment is carried out using progressively type-II censored data, and Monte Carlo Simulation has been utilized to compare the three techniques. The PWGD's Bayes estimators have been computed using the Lindley Approximation (LiA) approach. LiA has been used to present the Bayesian assessment predicated on SELF under the presumption of a natural conjugate-prior. Three alternative optimality metrics, including mean squares of error (MSE), relative efficiency (RE), and bias have been used to identify the best censoring strategy. It was found that Bayesian estimation behaves very better for PGWD, wherein MSE and Bias drop than other approaches, with regard to the natural conjugated prior.
Novel unsaturated polyesters based on indazole moiety in the main chain are prepared by interfacial polycondensation of two different indazoline monomers with an acid chloride. The producing copolyesters were confirmed and described by different techniques including Fourier-transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance (¹H-NMR). Their crystallinity and thermal stability are measured through X-ray powder (XRD) and thermogravimetric analysis (TGA) and show that they have good thermal stability which is affected by their crystallinity. The morphological features of the synthesized copolyesters were tested by scanning electron microscopy (SEM). Moreover, the resulting copolyesters were intended to be utilized as a catalyst in the preparation of polysubstituted imidazoles produced by three-component ammonium, and acetate 1,2-diketone with an aldehyde under mild conditions. The corrosion mitigation features of the fabricated unsaturated copolyesters as inhibitors for mild steel corrosion in molar hydrochloric acid were investigated. The unsaturated copolyesters exhibited respectable inhibition characteristics owing to robust adsorption on the metal interface and the construction of a defensive layer. The maximum protection capacity values ranged from 94.87 to 98.41% in the presence of 100 ppm of copolyesters. Adsorption of the unsaturated polyesters followed the Langmuir isotherm. Potentiodynamic polarization (PDP) examinations showed that the studied unsaturated polyesters were mixed-kind inhibitors.
This paper fosters both uniform spaces and way below relations with an innovative analysis of their mutual relationships. A new concept of uniform spaces based on a way below relation (LB-fuzzifying uniform space, or LBFU space, for short) will be introduced and investigated. With this aim, first some fundamental concepts in L-fuzzifying topological spaces will be studied. Then, we shall explore some L-fuzzifying topological spaces induced by an LBFU space. Furthermore, new concepts of interior, closure, bases and subbases relative to an LBFU topology will be established. Finally, the continuity of functions between LBFU spaces will be introduced and investigated.
Background This case report is important because of its rarity and because it enriches the scientific community with its detailed operative pictures. Case reports A newborn male infant had intestinal obstruction due to congenital caecal exstrophy. Limited resection and ileoascending anastomosis are used in surgical repair. The infant had a good outcome. Discussion This case is distinct from cloacal exstrophy, or it may be considered a subtype of it, because it lacks all of the cloacal exstrophy components except the caecal fissure. Conclusion Early intervention in newborns with an opened caecum is important for a good outcome.
Toll-like receptors (TLRs) control both innate and adaptive immunity with a wide expression on renal epithelial cells and leukocytes. Activation of TLRs results in the production of cytokines, chemokines and interferons along with activation of the transcription factor NF-κB, resulting in inflammatory perturbations. TLR4 signaling pathway is the most extensively studied of TLRs. TLR4 is expressed on renal microvascular endothelial and tubular epithelial cells. So, targeting TLR4 modulation could be a therapeutic approach to attenuate kidney diseases that are underlined by inflammatory cascade. Medicinal plants with anti-inflammatory activities display valuable effects and are employed as alternative sources to alleviate renal disease linked with inflammation. Flavonoids and other phytochemicals derived from traditional medicines possess promising pharmacological activities owing to their relatively cheap and high safety profile. Our review focuses on the potent anti-inflammatory activities of twenty phytochemicals to verify if their potential promising renoprotective effects are related to suppression of TLR4 signaling in different renal diseases, including sepsis-induced acute kidney injury, renal fibrosis, chemotherapy-induced nephrotoxicity, diabetic nephropathy and renal ischemia/reperfusion injury. Additionally, molecular docking simulations were employed to explore the potential binding affinity of these phytochemicals to TLR4 as a strategy to attenuate renal diseases associated with activated TLR4 signaling.
Chronic pelvic pain (CPP) is a prevalent condition in middle-aged women that represents a heavy social impact on the quality of life of those females. Treatment of pelvic congestion syndrome is a complex and controversial issue, but treatment can be one of 3 lines: medical therapy, endovascular treatment, and surgical intervention. The endovascular line was first introduced in 1993 and has been popular over other lines of treatment methods. This retrospective study was conducted in a tertiary university hospital over 24 months, from March 2019 to March 2021. Forty patients with PGS were managed by left ovarian vein TCFS. The Institutional Review Board waived the need for ethics approval or informed consent to use anonymized and retrospectively analyzed data. The mean age of enrolled women was 33.80 ± 6.54 years, ranging between 20 and 45 years. Trans-catheter ethanolamine foam embolization is an effective and safe method to treat pelvic and atypical lower limb varices.
Microbial sensors play an essential role in maintaining cellular homeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases. Recently we have confirmed that ELMO1 (Engulfment and Cell Motility Protein-1) present in cytosol is involved in pathogen sensing, engulfment and intestinal inflammation. Here, we show that ELMO1 interacts with another sensor, NOD2 (Nucleotide-binding oligomerization domain-containing protein 2), that recognizes bacterial cell wall component muramyl dipeptide (MDP). The polymorphism of NOD2 is linked to Crohn’s disease (CD) pathogenesis. Interestingly, we found that overexpression of ELMO1 and mutant NOD2 (L1007fs) were not able to clear the CD-associated adherent invasive E. coli (AIEC-LF82). The functional implications of ELMO1-NOD2 interaction in epithelial cells were evaluated by using enteroid-derived monolayers (EDMs) from ELMO1 and NOD2 KO mice. Subsequently we also assessed the immune response in J774 macrophages depleted of either ELMO1 or NOD2 or both. The infection of murine EDMs with AIEC-LF82 showed higher bacterial load in ELMO1-KO, NOD2 KO EDMs, and ELMO1 KO EDMs treated with NOD2 inhibitors. The murine macrophage cells showed that the downregulation of ELMO1 and NOD2 is associated with impaired bacterial clearance that is linked to reduce pro-inflammatory cytokines and reactive oxygen species. Our results indicated that the crosstalk between microbial sensors in enteric infection and inflammatory diseases impacts the fate of the bacterial load and disease pathogenesis.
Infections caused by bacteria are a significant issue on a global scale, and imperative action is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant-derived compounds that have a variety of potentially useful bioactivities. These activities include immediate antimicrobial properties, synergistic effect with antimicrobials, ferocious repression of pathogenicity, anti-urease activity etc. This review summarizes current studies concerning anti-urease actions of flavonoids as well as structural-activity correlation investigations of the flavonoid core structure. It is possible that if researchers investigate the many structural changes that may be made in flavonoid rings, they'll be able to build up novel compounds that have powerful and effective anti-urease properties.
Nitrate contamination of groundwater has become a serious threat to the environmental health. In this study, nano zerovalent iron (nZVI) and granular activated carbon (GAC) were fabricated and characterized by some advanced analytical techniques including SEM, BET, XRD, and FTIR to investigate their structural properties. Batch experiments were conducted for the adsorption of nitrate from water. The effect of various parameters including pH, adsorbent dose, initial nitrate concentration, and contact time was investigated. The nZVI showed maximum adsorption capacity (qmax) of 104.20 mg/g for nitrate at optimum conditions (pH 2, initial concentration 50 ppm, adsorbent dose 3.75 g/L at room temperature), while GAC has shown qmax 81.07 mg/g at optimum conditions (pH 6, initial concentration 50 ppm, adsorbent dose 3.75 g/L at room temperature). Equilibrium data of nitrate adsorption by nZVI and GAC followed the Langmuir isotherm (R² = 0.999) and pseudo-second-order kinetic model. ANOVA and RCBD approaches were used to evaluate and check the significant level of various parameters.
A thin film of 7-oxo-thiazolopyrimidine-3,8-dicarbonitrile derivative [7-ThPyDi] TF was prepared using a spin coating technique. The surface morphology and molecular structure are studied using various techniques such as XRD, FTIR, and scanning electron microscope (SEM). Moreover, the quantum chemical calculations were carried out through time-dependent density functional theory (TD-DFT) to investigate some reactivity descriptors such as softness and electronegativity. Also, Au/[7-ThPyDi] TF /p-Si/Al heterojunction diodes were fabricated. It was revealed that the energy bandgap value of [7-ThPyDi] as an organic thin film is 3.58 eV for direct transitions and 3.94 eV for indirect transitions, respectively, and this value falls within the semiconductor material range. The atomic force microscope demonstrated that the surface roughness of the thin film is approximately 32.2 nm. Because of its high refractive index, this material has the potential application as an antireflection coating for solar cells and as lenses with a wide focal range. We investigated a blue luminescent thiazolopyrimidine compound; the maximum emission in the more aggregated state (higher solution concentration) exhibits a notable blue shift compared to the more diluted solution. This uncommon phenomenon has been understood by structural analyses using density functional theory. The chemical structure of the molecule [planar conjugated cores and strong polar groups (–CO and –CN)] enables it to interact with both itself and the polar solvent. The intermolecular interactions result in the bending of the conjugated plane. As a result, the blue shift happens upon aggregation when the conjugated effect becomes weaker. The studied molecule gave different emission colors (blue, yellow, and reddish green) depending on the molecular packing.
Background All patients receiving sedation to facilitate endoscopic procedures should have monitoring of cardiorespiratory parameters before, during, and after administration of sedation/analgesia. We evaluated the effects of different O2 flow rates on the non-invasive CO2 monitoring (EtCO2) in adult patients that were breathing spontaneously under moderate sedation during ERCP. Methods This prospective randomized double-blind study was conducted on 120 patients assigned randomly to one of the three equal groups (n = 40) (Group I; 2 L/min oxygen flow rate, Group II; 4 L/min oxygen flow rate, and Group III; 6 L/min oxygen flow rate). Primary outcome was EtCO2 at the end of procedure. Secondary outcomes included peripheral O2 saturation, hemodynamics, time to recovery, total propofol dose, patients’ satisfaction, sedation score, and complications. Results EtCO2 increased significantly between the studied groups at pre-intervention, induction, 5, 10, 20, and 30 min but without any clinical significance (p-value ˂ 0.05). The HR changes were statistically significant at 10 and 20 min after induction of anesthesia. While SpO2, MBP, and RR differences were statistically not significant between groups throughout the whole study periods (p-value >0.05). Arterial blood gas analysis showed PCO2 was significantly different between the study groups but still within the normal range of readings, while pH and HCO3 showed statistically insignificant differences between the three groups. Conclusion The study demonstrated that different O2 flow rates did not affect the non-invasive EtCO2 measurements by the Dual-Guard device during moderate sedation in patients undergoing ERCP. Non-invasive EtCO2 monitoring can provide an early warning sign of hypoventilation during moderate sedation.
The telocytes (TCs) are novel interstitial cells that have been overlooked for a long time due to their histologic similarity to other stromal cells. TCs can be separated from the stromal cells based on their distinct immunohistochemical, ultrastructural, and molecular features. Functionally, TCs are involved in the tissue renewal, mechanical support, and immune modulation. These cells are also involved in the signal transduction either through their direct interactions with the neighboring cells or through the paracrine signaling via extracellular vesicles. TCs are damaged in several inflammatory and fibrotic conditions such as ulcerative colitis, Crohn's disease, hepatic fibrosis, psoriasis, and systemic sclerosis. The transplantation of TCs in the damaged tissue can promote tissue regeneration. Therefore, enhancing tissue TCs either by their transplantation or by promoting their survival and growth using novel medications represents novel therapeutic strategy in the future. In this review, we addressed several aspects of TCs including their origin, distribution, morphologic features, and functions. We also discussed their involvement of the cutaneous TCs in the development various pathologic conditions.
Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the effect of the macrolide antibiotic azithromycin (AZM) on oxidative stress, inflammatory response, and necroptosis in the lungs of CIS-administered rats, pinpointing the involvement of PPARγ, SIRT1, and Nrf2/HO-1 signaling. The rats received AZM for 10 days and a single dose of CIS on the 7th day. CIS provoked bronchial and alveolar injury along with increased levels of ROS, MDA, NO, MPO, NF-κB p65, TNF-α, and IL-1β, and decreased levels of GSH, SOD, GST, and IL-10, denoting oxidative and inflammatory responses. The necrop-tosis-related proteins RIP1, RIP3, MLKL, and caspase-8 were upregulated in CIS-treated rats. AZM effectively prevented lung tissue injury, ameliorated oxidative stress and NF-κB p65 and pro-in-flammatory markers levels, boosted antioxidants and IL-10, and downregulated necroptosis-related proteins in CIS-administered rats. AZM decreased the concentration of Ang II and increased those of Ang (1-7), cytoglobin, PPARγ, SIRT1, Nrf2, and HO-1 in the lungs of CIS-treated rats. In conclusion , AZM attenuated the lung injury provoked by CIS in rats through the suppression of inflammation , oxidative stress, and necroptosis. The protective effect of AZM was associated with the up-regulation of Nrf2/HO-1 signaling, cytoglobin, PPARγ, and SIRT1.
Background Despite the documented effects of the coronavirus disease 2019 (COVID-19) on spermatogenesis, the reversibility of these effects is uncertain. We aimed to assess the changes of sperm quality between the infection and recovery phases of COVID-19 in reproductive-aged men. The semen quality of men with mild-to-moderated COVID-19 (defined by the degrees of symptoms and chest involvement on computed tomography) was studied during October, 2020–May, 2021 at our hospital. Two semen samples were analyzed at timings estimated to represent spermatogenic cycles during the infection and recovery phases of COVID-19. Results A total of 100 patients were included with mean ± SD (range) age of 24.6 ± 3.3 (21–35) years. During infection, 33% of patients had abnormal semen quality. However, a significant reduction was found in this abnormality from 33 to 11% ( P < 0.001) after recovery from infection. In a comparison of the two semen analyses, there were significant improvements in the mean values of sperm progressive motility ( P =0.043) and normal morphology ( P < 0.001). However, the mean sperm concentration showed a statistically insignificant increase ( P = 0.844). Conclusions In reproductive-aged patients with mild-to-moderate COVID-19, the effects on seminal quality were recoverable, represented by significant improvements in the means of progressive sperm motility and normal morphology between the infection and recovery phases of COVID-19. Trial registration ClinicalTrials, NCT04595240 .
The large-scale dissemination of coronavirus disease-2019 (COVID-19) and its serious complications have pledged the scientific research communities to uncover the pathogenesis mechanisms of its etiologic agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Methods of unveiling such mechanisms are rooted in understanding the viral agent’s interactions with the immune system, including its ability to activate macrophages, due to their suggested role in prolonged inflammatory phases and adverse immune responses. The objective of this study is to test the effect of SARS-CoV-2-free proteins on the metabolic and immune responses of macrophages. We hypothesized that SARS-CoV-2 proteins shed during the infection cycle may dynamically induce metabolic and immunologic alterations with an inflammatory impact on the infected host cells. It is imperative to delineate such alterations in the context of macrophages to gain insight into the pathogenesis of these highly infectious viruses and their associated complications and thus, expedite the vaccine and drug therapy advent in combat of viral infections. Human monocyte-derived macrophages were treated with SARS-CoV-2-free proteins at different concentrations. The phenotypic and metabolic alterations in macrophages were investigated and the subsequent metabolic pathways were analyzed. The obtained results indicated that SARS-CoV-2-free proteins induced concentration-dependent alterations in the metabolic and phenotypic profiles of macrophages. Several metabolic pathways were enriched following treatment, including vitamin K, propanoate, and the Warburg effect. These results indicate significant adverse effects driven by residual viral proteins that may hence be considered determinants of viral pathogenesis. These findings provide important insight as to the impact of SARS-CoV-2-free residual proteins on the host cells and suggest a potential new method of management during the infection and prior to vaccination.
Background Regarding risk stratification of intermediate-risk pulmonary embolism, data are still not sufficient. Transthoracic echocardiography parameters may be useful in risk evaluation in those patients. Some novel echocardiographic indices mainly tricuspid regurgitation peak gradient (TRPG), pulmonary artery acceleration time, and tricuspid annulus plane systolic excursion (TAPSE) were evaluated showing that they may be used for risk stratification of normotensive cases with acute pulmonary embolism (APE). Results The studied cases were subdivided into two classes: Class I with intermediate-low-risk pulmonary embolism included 32 patients (53.3%) and class II with intermediate high-risk pulmonary embolism involved 28 cases (46.7%). Dyspnea, tachypnea, troponin level, RVD, RVD/LVD, TR velocity, and TRPG/TAPSE were statistically higher in cases of class II than that of class I ( p < 0.001). On the other hand, TAPSE and PA acceleration time were markedly lower in the case of class II than that of class I ( p < 0.001). Ten cases (35.7%) of group II required thrombolytic agents with a significant difference ( p <0.001). Conclusions RVD/LVD ratio, TAPSE, TRPG/TAPSE ratio, and PA acceleration time are echocardiographic parameters that might be helpful for risk stratification of cases with moderate-risk pulmonary embolism. The addition of elevated levels of cardiac troponins to imaging and clinical findings can improve PE-related risk identification. Trial registration NCT04020250 . Registered on 16 July 2019.
In this study, we investigated the enhanced charge transfer (CT) behaviors of single-walled carbon nanotubes (f-SWCNTs) and copper oxide (CuO)-reinforced poly(o-anisidine-co-o-toluidine) nanocomposites. Prior this study, the targeted nanocomposite materials were fabricated using an in situ oxidative polymerization tool. FT-IR, XRD, and SEM techniques were used to confirm the formation of the pure POA-co-POT copolymer and its related nanocomposites in the presence of f-SWCNTs and CuO nanoparticles. The enhancement of the thermal behavior and conductivity in the presence of either f-SWCNTs or f-SWCNTs/CuO confirms the well-dispersed filler on the polymeric matrix. Additionally, steady-state and time-resolved measurements were performed to monitor the influence of f-SWCNTs and CuO on the optical properties and CT related to the copolymerization process. Our fabricated materials showed a quenching of 25% and 31% in the presence of 10% f-SWCNTs, and 2% f-SWCNTs + 15% CuO, respectively. These findings provided strong evidence for the fast charge transfer within the fabricated nanocomposite, which matched the time-resolved results. The fs measurements showed that the ground state bleach (GSB) kinetics was more rapid in the presence of 10% f-SWCNTs compared to that of the free copolymer, while in the presence of 10% CuO, the electron transfer (ET) was faster, which decayed rapidly with a 0.6 ps time constant supporting the metallic nature of the composite. Our findings suggested that the incorporation of f-SWCNTs and CuO into a polymer matrix can close the gap resulting from polymer limitation.
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4,402 members
Safaa A. Mahran
  • Department of Physical Medicine,Rheumatology and Rehabilition
Shehata E. Abdel Raheem
  • Department of Civil Engineering
Sherif Mohamed
  • Department of Chest Diseases and Tuberculosis
Mohammed Khairy
  • Department of Obstetrics and Gynecology
Ahmed M Kotb
  • Department of Anatomy and Histology
Information
Address
Assiut University Hospital street, Hospital of Neurology and Psychiatry, floor 7, room 4, 71516, Asyūţ, Assiut, Egypt
Head of institution
Prof. Tarek Abdulah Elgamal
Website
http://www.aun.edu.eg